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Manivasagan, P.,Bharathiraja, S.,Bui, N.Q.,Lim, I.G.,Oh, J. Elsevier/North Holland 2016 International journal of pharmaceutics Vol.511 No.1
Polymer nanoparticles have gained significant attention as potential drug carriers for anticancer agents and molecular imaging. Biocompatible gold nanoparticles (AuNPs) were synthesized using chitosan oligosaccharide (COS) as a reducing and stabilizing agent and were subsequently loaded with paclitaxel (PTX) to demonstrate their use in drug delivery and photoacoustic imaging (PAI) of MDA-MB-231 cells. Paclitaxel-loaded chitosan oligosaccharide-stabilized gold nanoparticles (PTX-COS AuNPs) were spherical in shape with an average particle size of 61.86+/-3.01nm. PTX-COS AuNPs showed sustained and pH-dependent drug release profiles and exhibited strong cytotoxic effect against MDA-MB-231 cells through the induction of apoptosis with improved reactive oxygen species (ROS) generation and altered mitochondrial membrane potential (MMP) level. The cellular internalization of PTX-COS AuNPs was proven by fluorescence microscopy as well as flow cytometry. PTX-COS AuNPs were also evaluated as a new class of optical contrast agents for photoacoustic imaging (PAI). To the best of our knowledge, this is the first report that describes the use of PTX-COS AuNPs as novel agents for drug delivery and PAI of cancer cells. These results exposed the promising potential of PTX-COS AuNPs in the field of drug delivery, molecular imaging, and cancer therapy in the near future.
Manivasagan, Panchanathan,Nguyen, Van Tu,Jun, Seung Won,Hoang, Giang,Mondal, Sudip,Kim, Hyehyun,Doan, Vu Hoang Minh,Kim, Jeehyun,Kim, Chang-Seok,Oh, Junghwan Elsevier 2019 Journal of controlled release Vol.311 No.-
<P><B>Abstract</B></P> <P>Developing a novel multifunctional theranostic agent for cancer combination therapy has attracted tremendous attention in recent years. In this report, we designed and developed a new multifunctional nanocarrier based on anti-epidermal growth factor receptor antibody-conjugated and paclitaxel loaded-thiol chitosan-layered gold nanoshells (anti-EGFR-PTX-TCS-GNSs) as a theranostic agent for the first time used for fluorescence/photoacoustic dual-modal imaging-guided chemophotothermal synergistic therapy. The resulting anti-EGFR-PTX-TCS-GNSs showed excellent biosafety, biocompatibility, broad near-infrared (NIR) absorbance, photostability, fast and laser irradiation-controllable drug release, and higher targeting efficiency for efficient chemophotothermal combination therapy of cancer under the guidance of photoacoustic imaging (PAI). The combination therapy was investigated <I>in vitro</I> and <I>in vivo,</I> displaying a powerful anticancer efficiency. More importantly, an <I>in vivo</I> experiment of anti-EGFR-PTX-TCS-GNSs with laser irradiation showed heavy damage to the tumor tissue, killing the tumor cells almost completely. Anti-EGFR-PTX-TCS-GNSs also showed a powerful capacity to visualize tumors, and therefore it is considered a new PAI contrast agent for subsequent therapy. Histological analysis and TUNEL assay further showed much more apoptotic cells, confirming the value of anti-EGFR-PTX-TCS-GNSs. Our results provide a new concept and a promising strategy to develop a novel multifunctional nanotheranostic agent for future clinical applications in diagnosis and therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Manivasagan, Panchanathan,Alam, Moch Syaiful,Kang, Kyong-Hwa,Kwak, Minseok,Kim, Se-Kwon Springer-Verlag 2015 BIOPROCESS AND BIOSYSTEMS ENGINEERING Vol.38 No.6
<P>Advancement of biological process for the synthesis of bionanoparticles is evolving into a key area of research in nanotechnology. The present study deals with the biosynthesis, characterization of gold bionanoparticles by Nocardiopsis sp. MBRC-48 and evaluation of their antimicrobial, antioxidant and cytotoxic activities. The gold bionanoparticles obtained were characterized by UV-visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy dispersive X-ray analysis and transmission electron microscopy (TEM). The synthesized gold bionanoparticles were spherical in shape with an average of 11.57 +/- A 1.24 nm as determined by TEM and dynamic light scattering (DLS) particle size analyzer, respectively. The biosynthesized gold nanoparticles exhibited good antimicrobial activity against pathogenic microorganisms. It showed strong antioxidant activity as well as cytotoxicity against HeLa cervical cancer cell line. The present study demonstrated the potential use of the marine actinobacterial strain of Nocardiopsis sp. MBRC-48 as an important source for gold nanoparticles with improved biomedical applications including antimicrobial, antioxidant as well as cytotoxic agent.</P>
Manivasagan, Panchanathan,Jun, Seung Won,Nguyen, Van Tu,Truong, Nguyen Thanh Phong,Hoang, Giang,Mondal, Sudip,Santha Moorthy, Madhappan,Kim, Hyehyun,Vy Phan, Thi Tuong,Doan, Vu Hoang Minh,Kim, Chang-S The Royal Society of Chemistry 2019 Journal of materials chemistry. B, Materials for b Vol.7 No.24
<P>The development of a new generation of multifunctional nanomaterials as a drug delivery system for chemo-photothermal therapy is of great necessity. In this study, we first prepared folic acid-conjugated and doxorubicin-loaded chitosan oligosaccharide encapsulated gold nanorods (FA-COS-TGA-GNRs-DOX) as a new photothermal agent for the delivery of drugs and heat to tumor areas. FA-COS-TGA-GNRs-DOX nanomaterials combine the advantages of COS, GNRs, FA, TGA, and DOX and have excellent biocompatibility, strong absorbance in the near-infrared (NIR) region, photostability, photothermal conversion efficiency, high targeting efficiency, fast drug release under laser irradiation, and tumor cell killing efficiency. FA-COS-TGA-GNRs-DOX exhibited significantly greater cell killing after laser irradiation. The intracellular uptake behavior of the targeted FA-COS-TGA-GNRs-DOX was confirmed by flow cytometry, two-photon fluorescence microscopy (TPFM), and confocal laser scanning microscopy (CLSM). More interestingly, the tumors in the presence of FA-COS-TGA-GNRs-DOX under laser irradiation were efficiently ablated and did not recur, showing an outstanding combined therapy of tumors. The combination of photothermal therapy (PTT) and photoacoustic imaging (PAI) could accurately locate and fully destroy tumor tissues after the intravenous injection of FA-COS-TGA-GNRs-DOX. Hence, this work offers a new avenue to develop a novel class of multifunctional nanomaterials as a drug delivery system for cancer therapy.</P>
RETRACTED: Marine actinobacterial metabolites: Current status and future perspectives
Manivasagan, P.,Venkatesan, J.,Sivakumar, K.,Kim, S.K. G. Fischer 2013 Microbiological research Vol.168 No.6
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor. Authors and Editor agreed to retract this article because substantial parts of the text were copied from the following sources without proper attribution: Lam, K.S. (2006), Discovery of novel metabolites from marine actinomycetes. Current Opinion in Microbiology 9(3), pp. 245-251; Subramani, R., Aalbersberg, W. (2012), Marine actinomycetes: An ongoing source of novel bioactive metabolites. Microbiological Research 167(10), pp. 571-580; Dharmaraj, S. (2010), Marine Streptomyces as a novel source of bioactive substances. World Journal of Microbiology and Biotechnology 26(12), pp. 2123-2139. The authors apologize for this oversight and any inconvenience caused.
Manivasagan, Panchanathan,Bharathiraja, Subramaniyan,Santha Moorthy, Madhappan,Oh, Yun-Ok,Song, Kyeongeun,Seo, Hansu,Oh, Junghwan American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.17
<P>The development of novel photothermal ablation agents as cancer nanotheranostics has received a great deal of attention in-recent decades. Biocompatible fucoidan (Fu) is used as the coating material for gold nanorods (AuNRs) and subsequently conjugated with monoclonal antibodies against epidermal growth factor receptor (anti-EGFR) novel photothermal ablation agents for,cancer nanotheranostics because of their excellent biocompatibility, biodegradability, nontoxicity, water solubility, photostability, ease of Surface modification, strongly enhanced absorption in near-infrared (NIR) regions, target specificity, minimal invasiveness, fast recovery, and prevention. of damage to normal tissues: Anti-EGFRFu-AuNRs have an average particle size of 96.37 +/- 3.73 nm. Under 808 nm NIR laser at 2 W/cm(2) for 5 min, the ternperathre of the solution containing anti-EGFR Fu-AuNRs,(30 mu g/mL) increased by 52.1 degrees C. The anti-EGFR Fu-AuNRs exhibited high efficiency for the ablation of MDA-MB-231 cells in vitro. In viva- photothermal ablation exhibited that tumor tissues fully recovered without recurrence and finally were reconstructed with normal-tissues by-the 808 nm NIER. laser irradiatiOn after injection of anti-EGFR Fu-AuNRs. These results suggest that the anti-BUR Fu-AuNRs would be novel photoablation agents for future cancer nanotheranostics:</P>
Chlorin e6 conjugated copper sulfide nanoparticles for photodynamic combined photothermal therapy
Bharathiraja, S.,Manivasagan, P.,Moorthy, M.S.,Bui, N.Q.,Lee, K.D.,Oh, J. ELSEVIER SCIENCE B.V., AMSTERDAM 2017 PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY Vol.19 No.-
The photo-based therapeutic approaches have attracted tremendous attention in recent years especially in treatment and management of tumors. Photodynamic and photothermal are two major therapeutic modalities which are being applied in clinical therapy. The development of nanomaterials for photodynamic combined with photothermal therapy has gained significant attention for its treatment efficacy. In the present study, we designed chlorin e6 (Ce6) conjugated copper sulfide (CuS) nanoparticles (CuS-Ce6 NPs) through amine functionalization and the synthesized nanoparticles act as a dual-model agent for photodynamic therapy and photothermal therapy. CuS-Ce6 NPs showed enhanced photodynamic effect through generation of singlet oxygen upon 670nm laser illumination. The same nanoparticles exerted thermal response under an 808nm laser at 2W/cm<SUP>2</SUP>. The fabricated nanoparticles did not show any cytotoxic effect toward breast cancer cells in the absence of light. In vitro cell viability assay showed a potent cytotoxicity in photothermal and photodynamic treatment. Rather than singular treatment, the photodynamic combined photothermal treatment showed an enhanced cytotoxic effect on treated cells. In addition, the CuS-Ce6 NPs exert a photoacoustic signal for non-invasive imaging of treated cells in tissue-mimicking phantom. In conclusion the CuS-Ce6 NPs act as multimodal agent for photo based imaging and therapy.