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Sivakumar, T,Kumar, R Sambath,Perumal, P,Vamsi, MLM,Sivakumar, P,Kanagasabai, R,Baskaran, MV,Karki, Subhas S,Mazumder, UK,Gupta, M Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.4
The plant Bryonia laciniosa (Family: Cucurbitaceae) has been indicated for the treatment of various diseases one among which is cancer. The purpose of this study was investigating experimentally the possible anti-tumor effect and antioxidant role of Bryonia laciniosa leaves in animal model. The methanol extract of Bryonia laciniosa (MEBL) administered at the doses of 62.5, 125 and 250 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of MEBL on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with MEBL decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of MEBL also decreases the levels of lipid peroxidation and increased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). The present work indicates that the methanol extract of Bryonia laciniosa exhibited significant antitumor and antioxidant activity in vivo.
Biodiversity of Microalgae and Their Elemental Components from Veeranam Lake, Tamilnadu, India
Sivakumar, K.,Senthilkumar, R. The Korean Society of Limnology 2008 생태와 환경 Vol.37 No.1
An attempt was made in the Veeranam freshwater lake with the objectives to collect, identify, describe and document the algae occurring from March 2007 to August 2007. Qualitative and quantitative characterization of phytoplankton and analysis of physico-chemical parameters of water samples were carried out at monthly intervals during the study period in the western and eastern sides of the lake. It was found that the phytoplankton community embraced 68 genera belonging to four classes viz., Bacillariophyceae (40), Chlorophyceae (22), Cynophyceae (4) and Euglenophyceae (2). There were significant influences of various physico-chemical parameters on the phytoplankton population density. Commonly occurred genera, Oscillatoria (Cyanophyceae), Navicula (Bacillariophyceae) and Scenedesmus (Chlorophyceae), were subjected to energy dispersive spectroscopic analysis (EDS). They were found to accumulate different elements such as Zn, P, S, Ca, Mg, Fe, N, Si, Cl and Mn. Among these the member Cyanophyceae contained Zn, P, Mg, Ca, Mn, S and N. Bacillariophyceae Si, Zn, Mg, Cl, N, Fe, and Ca. Chlorophyceae Ca, Mg, N, Fe, Cl, Zn, Si and Mn. Thus these observations would determine the chemical dialogue between the cell structures and role of the elements. Further, it gives the clue about the phytoplankton growth requirements.
Reliability analyses of a prototype soil nail wall using regression models
Sivakumar Babu, G.L.,Singh, Vikas Pratap Techno-Press 2010 Geomechanics & engineering Vol.2 No.2
Soil nailing technique is being widely used for stabilization of vertical cuts because of its economic, environment friendly and speedy construction. Global stability and lateral displacement are the two important stability criteria for the soil nail walls. The primary objective of the present study is to evaluate soil nail wall stability criteria under the influence of in-situ soil variability. Finite element based numerical experiments are performed in accordance with the methodology of $2^3$ factorial design of experiments. Based on the analysis of the observations from numerical experiments, two regression models are developed, and used for reliability analyses of global stability and lateral displacement of the soil nail wall. A 10 m high prototype soil nail wall is considered for better understanding and to highlight the practical implications of the present study. Based on the study, lateral displacements beyond 0.10% of vertical wall height and variability of in-situ soil parameters are found to be critical from the stability criteria considerations of the soil nail wall.
Sivakumar Subramanian,A. S. Sekhar,B. V. S. S. S. Prasad 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.6
Leakage characteristics, influenced by centrifugal and thermal radial growth are determined computationally for a generic rotating labyrinthseal used in the gas turbine secondary air system. Three seal locations, namely, R25, R50 and R75 are represented by means ofvarying the rotor radius mimicking different radial positions of the seal from the shaft axis. The combined influence of seal location andits radial (Centrifugal and thermal) growth on the leakage performance is investigated for a wide-ranging speeds from 1000 to 3000 rad/s,temperatures ranging from 200 to 450 oC and pressure ratios varying from 1.1 to 2.5, for a chosen initial clearance of 500 micron. Acomparison of the effect of rotation and temperature gradient among different rotors shows that the radial growth and leakage flow ratessignificantly vary with the increasing radius.
Sivakumar, Allur Subramaniyan,Ochirbat, Chinzorio,Cho, Soo-Hyun,Yang, Jieun,Hwang, Inho Springer 2014 In vitro cellular & developmental biology Animal Vol.50 No.7
<P>The objective of this study was to evaluate antioxidant and antiapoptotic effects of a novel peptide (T.peptide) isolated from bovine and commercially available MPG peptide. The amino acid sequences of the T.peptide were (Glu-Val-Pro-Glu-Val-His-Glu-Glu-Val). The antioxidant activities of these peptides were determined by measuring the 1,1-diphenyl-2-picrylhydrazyl (DPPH?) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS+?) radical scavenging assays. The in vitro cytotoxicity of T.peptide and MPG peptide was determined against H2O2-induced C2C12 cells. H2O2-induced apoptosis in C2C12 cells were determined by mRNA expression of caspase-3. Moreover, the mRNA expression of tumor necrosis factor alpha (TNF-α) and nuclear factor kappa B (NF-κB) were assayed by reverse transcription polymerase chain reaction. The findings of the study indicate that the mRNA expression of TNF-α and NF-κB are significantly (p?<?0.05) increased in H2O2-induced C2C12 cells, whereas a significant decrease (p?<?0.05) in these mRNA expressions are observed when pretreated with T.peptide or MPG peptide. Pretreatment with MPG or T.peptides is also found to significantly (p?<?0.05) decrease the mRNA expression of caspase-3 in H2O2-induced C2C12 cells. The results of the study demonstrate that both T.peptide and MPG peptide could reduce the DPPH? and ABTS+? radical and inhibit cytotoxicity against H2O2-induced injury, resulting in prevention of free radical generation and subsequent apoptotic cell death, which indicates the potential of bovine meat as a source of antioxidant peptides.</P>
Drying and energy aspects of tapioca sago processing-An experimental field study
Sivakumar R.,Elayaperumal A.,Saravanan R. 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.6
The drying characteristics of tapioca sago were studied using four different drying methods--Open sun drying (OSD), Conveyor beltdrying (CBD), Bin drying (BD) and Fluidized bed drying (FBD)--in an industry located in Tamilnadu, India (Latitude: 11.494347° N;Longitude: 78.272264° E). The BD and FBD dryers were designed and fabricated as pilot scale models in the laboratory with respectivecapacity of 5 kg/h and 10 kg/h; CBD (1000 kg/h) and OSD are the commercial drying operations currently employed in industrial processing. The drying time, energy and exergy aspects of all the drying methods were compared along with the achieved final moisture content,color and quality of the dried products. The highest Energy utilization ratio (EUR) was found in CBD and FBD in the range of 20-76 % and 10-67 %, respectively. The exergy efficiency was initially low in all the cases but increased to 80 % towards the end of thedrying process.
Effect of heating location and size on mixed convection in lid-driven cavities
Sivakumar, V.,Sivasankaran, S.,Prakash, P.,Lee, J. Pergamon Press ; Elsevier Science Ltd 2010 COMPUTERS & MATHEMATICS WITH APPLICATIONS - Vol.59 No.9
A numerical study is performed to analyze the mixed convection heat transfer and fluid flow in lid-driven cavities with different lengths of the heating portion and different locations of it. The left wall has been heated fully or partially to a higher temperature, whereas the right wall is maintained at a lower temperature. Three different lengths of the heating portion and three different locations of it are used along the hot wall. The remaining portions of the left wall, and the top and the bottom walls of the cavity are insulated. The finite volume method is used to discretize the governing equations which are then solved iteratively. The velocities and pressure are coupled by the SIMPLE algorithm. Results are presented graphically in the form of streamlines, isotherms and velocity profiles. It is concluded that the heat transfer rate is enhanced on reducing the heating portion and when the portion is at middle or top of the hot wall of the cavity.
Sivakumar, M.,Omkumar, S. The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.6
The filter bank multicarrier modulation (FBMC) technique is one of multicarrier modulation technique (MCM), which is mainly used to improve channel capacity of cognitive radio (CR) network and frequency spectrum access technique. The existing FBMC System contains serial to parallel converter, normal QAM modulation, Radix2 inverse FFT, parallel to serial converter and poly phase filter. It needs high area, delay and power consumption. To further reduce the area, delay and power of FBMC structure, a new clock gating technique is applied in the QAM modulation, radix2 multipath delay commutator (R2MDC) based inverse FFT and unified addition and subtraction (UAS) based FIR filter with parallel asynchronous self time adder (PASTA). The clock gating technique is mainly used to reduce the unwanted clock switching activity. The clock gating is nothing but clock signal of flip-flops is controlled by gate (i.e.) AND gate. Hence speed is high and power consumption is low. The comparison between existing QAM and proposed QAM with clock gating technique is carried out to analyze the results. Conversely, the proposed inverse R2MDC FFT with clock gating technique is compared with the existing radix2 inverse FFT. Also the comparison between existing poly phase filter and proposed UAS based FIR filter with PASTA adder is carried out to analyze the performance, area and power consumption individually. The proposed FBMC with clock gating technique offers low power and high speed than the existing FBMC structures.