Envelope Proteins Pertain with Evolution and Adaptive Mechanism of the Novel Influenza A/H1N1 in Humans

( Mondal,Shakhinur Islam ),( Abdullah Zubaer ),( Simrika Thapa ),( Chinmoy Saha ),( Md. Asraful Alum ),( Md. Salman Reza ),( Arzuba Akter ),( Abul Kalam Azad ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.11

The novel swine-origin influenza A/H1N1 virus (S-OIV) first detected in April 2009 has been identified to transmit from humans to humans directly and is the cause of the currently emerged pandemic. In this study, nucleotide and deduced amino acid sequences of the hemagglutinin (HA) and neuraminidase (NA) of the S-OIV and other influenza A viruses were analyzed through bioinformatic tools for phylogenetic analysis, genetic recombination, and point mutation to investigate the emergence and adaptation of the S-OIV in humans. The phylogenetic analysis showed that the HA comes from triple reassortant influenza A/ H1N2 and the NA from Eurasian swine influenza A/H1N1, indicating that HA and NA descend from different lineages during the genesis of the S-OIV. Recombination analysis nullified the possibility of occurrence of recombination in HA and NA, denoting the role of reassortment in the outbreak. Several conservative mutations were observed in the amino acid sequences of the HA and NA, and these mutated residues were identical in the S-OIV. The results reported herein suggest the notion that the recent pandemic is the result of reassortment of different genes from different lineages of two envelope proteins, HA and NA, which are responsible for the antigenic activity of the virus. This study further suggests that the adaptive capability of the S-OIV in humans is acquired by the unique mutations generated during emergence.

Rapid Hydrogen Peroxide Detectable Multifunctional Synthetic Nanoenzyme Embedded Colorimetric Paper Biosensor

( Mondal ),안정만,최원호,이용규 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.0

Precursor-driven selective synthesis of hexagonal chalcocite (Cu₂S) nanocrystals: structural, optical, electrical and photocatalytic properties

Mondal, Gopinath,Bera, Pradip,Santra, Ananyakumari,Jana, Sumanta,Mandal, Tarak Nath,Mondal, Anup,Seok, Sang Il,Bera, Pulakesh The Royal Society of Chemistry 2014 NEW JOURNAL OF CHEMISTRY Vol.38 No.10

<P>The reaction of CuCl<SUB>2</SUB>·2H<SUB>2</SUB>O with the methyl ester of 3,5-dimethyl pyrazole-1-dithioic acid (mdpa) yields a blackish brown complex of composition, [Cu(mdpa)<SUB>2</SUB>][CuCl<SUB>2</SUB>]. The complex formed a well-defined crystal and is characterized by single-crystal X-ray diffraction, thermogravimetry (TG), and spectroscopic studies. The molecule possesses a distorted tetrahedral configuration with a CuN<SUB>2</SUB>S<SUB>2</SUB> chromophore with +1 oxidation state of copper. The TG study reveals that the molecule is a suitable precursor for copper sulfide nanoparticles. The low temperature thermal decomposition of the single-source precursor produces hexagonal chalcocite (Cu<SUB>2</SUB>S) nanostructures in ethylene diamine and ethylene glycol. A selective synthesis of copper-rich high chalcocite was obtained using the new precursor. The size and morphology of the synthesized Cu<SUB>2</SUB>S nanoparticles are guided by the precursor and likely to be less dependent on the solvent used in the experiment. The nanoparticles were characterized by X-ray diffraction, scanning electronic microscope, and UV-Vis spectroscopic studies. The optical band gap of the as-synthesized Cu<SUB>2</SUB>S nanoparticles is measured to be 1.80–2.40 eV. The Cu<SUB>2</SUB>S nanoparticles are found to be good catalysts in UV photo catalytic decomposition (90%) of Congo red (CR) dye following first-order reaction kinetics, and the reusability study of the Cu<SUB>2</SUB>S catalyst also shows excellent catalytic performance (80%).</P> <P>Graphic Abstract</P><P>A new single-source precursor, [Cu(mdpa)<SUB>2</SUB>][CuCl<SUB>2</SUB>], is used to prepare selectively high chalcocite (Cu<SUB>2</SUB>S) with excellent photodegradation of Congo red (CR). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4nj00584h'> </P>

Room-temperature synthesis of cobalt nanoparticles and their use as catalysts for Methylene Blue and Rhodamine-B dye degradation

Mondal, Arijit,Mondal, Asish,Mukherjee, Debkumar Techno-Press 2015 Advances in nano research Vol.3 No.2

Air stable nanoparticles were prepared from cobalt sulphate using tetra butyl ammonium bromide as surfactant and sodium borohydride as reductant at room temperature. The cobalt nanocolloids in aqueous medium were found to be efficient catalysts for the degradation of toxic organic dyes. Our present study involves degradation of Methylene Blue and Rhodamine-B using cobalt nanoparticles and easy recovery of the catalyst from the system. The recovered nanoparticles could be recycled several times without loss of catalytic activity. Palladium nanoparticles prepared from palladium chloride and the same surfactant were found to degrade the organic dyes effectively but lose their catalytic activity after recovery. The cause of dye colour discharge by nanocolloids has been assigned based on our experimental findings.

Free radical scavenging property of Annona reticulata leaves

Mondal, Susanta Kumar,Saha, Prerona,Mondal, NB,Mazumder, UK Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.3

Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and it is reported to have anticancer activity. Free radicals are known to be involved in various types of diseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluate free radical scavenging property of methanol extract of the leaves of Annona reticulata in some in vitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extract showed good dose-dependent free radical scavenging property in all the models. $IC_{50}$ values were found to be 3.22, 170.01, 25.12 and $140.12\;{\mu}g/ml$ respectively in DPPH, nitric oxide, superoxide and lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based on potassium ferricyanide reduction where dose dependant reducing capability was observed. Measurement of total phenolic compounds by Folin-Ciocalteu's phenol reagent indicated that 1mg of the extract contained $146.20\;{\mu}g$ equivalent of pyrocatechol. The findings ascertain promising free radical scavenging property of the extract and the antioxidant property of the extract may be due to the high content of phenolic compounds.

Advances in Floating Aerogenerators: Present Status and Future

Amit Kumar Mondal,Surajit Mondal,Vindhya Devalla,Paawan Sharma,Mukul Kumar Gupta 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.11

High altitude winds are considered to be the most favorable source of renewable energy in the future. In this paper, review has been conducted on harnessing of high altitude wind energy via floating type aero-generators. This new generation of systems employs tethered wings, aircrafts, multi-copters, balloons in order to harness the higher atmospheric winds. A number of systems based on different concepts have been analyzed and tested from mid-seventies, with a rapid acceleration in last couple of years. This paper presents a comprehensive overview of different technologies that have been designed/ built to harvest the energy of high altitude winds, highlighting the accomplished results, technological issues and classification of such systems have been proposed on the basis of their working and design. Apart from the Airborne Wind Energy or High-Altitude Wind Energy based systems, a brief overview on offshore floating wind turbines have also been provided.

Free radical scavenging property of Annona reticulata leaves

Susanta Kumar Mondal,Prerona Saha,NB Mondal,UK Mazumder 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3

Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and it is reported to have anticancer activity. Free radicals are known to be involved in various types of diseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluate free radical scavenging property of methanol extract of the leaves of Annona reticulata in some in vitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extract showed good dose-dependent free radical scavenging property in all the models. IC50 values were found to be 3.22, 170.01, 25.12 and 140.12 μg/ml respectively in DPPH, nitric oxide, superoxide and lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based on potassium ferricyanide reduction where dose dependant reducing capability was observed. Measurement of total phenolic compounds by Folin-Ciocalteu’s phenol reagent indicated that 1mg of the extract contained 146.20 μg equivalent of pyrocatechol. The findings ascertain promising free radical scavenging property of the extract and the antioxidant property of the extract may be due to the high content of phenolic compounds. Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and it is reported to have anticancer activity. Free radicals are known to be involved in various types of diseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluate free radical scavenging property of methanol extract of the leaves of Annona reticulata in some in vitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extract showed good dose-dependent free radical scavenging property in all the models. IC50 values were found to be 3.22, 170.01, 25.12 and 140.12 μg/ml respectively in DPPH, nitric oxide, superoxide and lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based on potassium ferricyanide reduction where dose dependant reducing capability was observed. Measurement of total phenolic compounds by Folin-Ciocalteu’s phenol reagent indicated that 1mg of the extract contained 146.20 μg equivalent of pyrocatechol. The findings ascertain promising free radical scavenging property of the extract and the antioxidant property of the extract may be due to the high content of phenolic compounds.

Endocrine Aspects of Oestrous Cycle in Buffaloes (Bubalus bubalis): An Overview

Mondal, S.,Prakash, B.S.,Palta, P. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.1

There is worldwide interest in buffalo as an animal for meeting the growing demands of meat, milk and work in the developing countries. One of the major constraints to full exploitation of the productive potential of buffalo has been its inherently low reproductive efficiency as reflected by late maturity, poor expression of oestrus, silent oestrus, irregular oestrous cyclicity, seasonality in breeding, anoestrus, low conception rate, long postpartum interval, repeat breeding etc. Ovarian cyclicity is regulated by endocrine and neuroendocrine mechanisms namely hypothalamic hormones, gonadotropins and ovarian steroids. Detailed endocrine investigations are suggested with special reference to the hypothalamo-hypophysial-ovarian axis to gain a better understanding of reproduction in buffalo and to modify it to derive the maximum benefit from this animal.

Alteration in Leukocyte Subsets and Expressions of FcγR and Complement Receptors among Female Ragpickers in Eastern India

Mondal, Nandan K.,Siddique, Shabana,Banerjee, Madhuchanda,Roychoudhury, Sanghita,Mukherjee, Sayali,Slaughter, Mark S.,Lahiri, Twisha,Ray, Manas R. Occupational Safety and Health Research Institute 2017 Safety and health at work Vol.8 No.2

Background: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. Methods: Seventy-four women ragpickers (median age, 30 years) and 65 age-matched control housemaids were enrolled. Flow cytometry was used to measure leukocyte subsets, and leukocyte expressions of $Fc{\gamma}$ receptor I (CD64), $Fc{\gamma}RIII$ (CD16), complement receptor 1 (CD35) and CR3 (CD11b/CD18), and CD14. Serum total immunoglobulin-E was estimated with enzyme-linked immunosorbent assay. Results: Compared with the controls, ragpickers had significantly (p < 0.0001) higher levels of CD8-T-cytotoxic, CD16+CD56+natural killer, and CD4+CD45RO+memory T-cells, but depleted levels of CD19+B-cells. The percentage of CD4+T-helper-cells was lower than the control group (p < 0.0001), but their absolute number was relatively unchanged (p = 0.42) due to 11% higher lymphocyte counts in ragpickers. In ragpickers, the percentages of CD14+CD16+intermediate and CD14dim CD16+nonclassical monocyte subsets were elevated with a decline in CD14+CD16-classical monocytes. The expressions of CD64, CD16, CD35, and CD11b/CD18 on both monocytes and neutrophils, and CD14 on monocytes were significantly higher in ragpickers. In addition, ragpickers had 2.7-times more serum immunoglobulin-E than the controls (p < 0.0001). After controlling potential confounders, the profession of ragpicking was positively associated with the changes. Conclusion: Ragpicking is associated with alterations in both innate (neutrophils, monocytes, and natural killer cell numbers and expression of complement and $Fc{\gamma}$ receptors) and adaptive immunity (numbers of circulating B cells, helper, cytotoxic, and memory T cells).

SOME RESULTS IN η-RICCI SOLITON AND GRADIENT ρ-EINSTEIN SOLITON IN A COMPLETE RIEMANNIAN MANIFOLD

Mondal, Chandan Kumar,Shaikh, Absos Ali Korean Mathematical Society 2019 대한수학회논문집 Vol.34 No.4

The main purpose of the paper is to prove that if a compact Riemannian manifold admits a gradient ${\rho}$-Einstein soliton such that the gradient Einstein potential is a non-trivial conformal vector field, then the manifold is isometric to the Euclidean sphere. We have showed that a Riemannian manifold satisfying gradient ${\rho}$-Einstein soliton with convex Einstein potential possesses non-negative scalar curvature. We have also deduced a sufficient condition for a Riemannian manifold to be compact which satisfies almost ${\eta}$-Ricci soliton.