1,3,5-Trichloro-2,4,6-Triazinetrion: A Versatile Heterocycle for the One-Pot Synthesis of 14-Aryl- or Alkyl -14H-Dibenzo[a,j]xanthene, 1,8-Dioxooctahydroxanthene and 12-Aryl-8,9,10,12-Tetrahydrobenzo[a]xanthene-11-one Derivatives under Solvent-Free Condi

Maleki, Behrooz,Gholizadeh, Mostafa,Sepehr, Zeinalabedin Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.5

A facile, green, efficient and environment-friendly protocol for the synthesis of 14-aryl- or alkyl-14Hdibenzo[a,j]xanthene, 1,8-dioxooctahydroxanthene and 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-one have been developed by one-pot condensation of various aldehydes with (i) ${\beta}$-naphthol (ii) cyclic 1,3-dicarbonyl compounds and (iii) ${\beta}$-naphthol and cyclic 1,3-dicarbonyl compounds, in the presence of 1,3,5-trichloro-2,4,6-triazinetrion (trichloroisocyanuric acid, TCCA) as catalyst under solvent-free conditions. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, easy purification, and economic availability of the catalyst.

Aromatization of 1,3,5-Trisubstituted of 4,5-Dihydro-1H-Pyrazoles by In-Situ Generation of I⁺ from Hydrogen Peroxide/Acids/Iodide Potassium or Sodium Systems

Maleki, Behrooz,Veisi, Hojat Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.12

A simple, green and cost-effective protocol was used for the aromatization of 1,3,5-trisubstituted-2-pyrazolines to the corresponding pyrazoles by in situ generation of iodine ($I^+$) from $H_2O_2$/AcOH or SSA or oxalic acid /KI or NaI system under thermal condition with moderate to good yields.

Screening of Rhizobacteria for Biological Control of Cucumber Root and Crown Rot Caused by Phytophthora drechsleri

Maleki, Mojdeh,Mokhtarnejad, Lachin,Mostafaee, Somayyeh The Korean Society of Plant Pathology 2011 Plant Pathology Journal Vol.27 No.1

Antagonistic rhizobacteria, more specifically fluorescent pseudomonads and certain species of Bacillus, are known as biocontrol agents of fungal root diseases of agronomic crops. In this study, 144 bacteria were isolated from cucumber rhizosphere and screened as potential biological control agents against Phytophthora drechsleri, the causal agent of cucumber root rot, in vitro condition. Non-volatile compounds of 23 isolates showed noticeable inhibition zone (> 30%) against P. drechsleri, whereas volatile compounds of 7 isolates could prevent more than 30% of the mycelial growth of the fungus. All promising isolates, except of Pseudomonas flourescens V69, promoted significantly plant growth under in vitro condition. P. flourescens CV69 and V11 exhibited the highest colonization on the root. Results of the greenhouse studies showed that a reduction in disease incidence by use of some strains, and particularly use of strains CV6 and V11 as a soil treatment, exhibited a reduction in disease incidence so that suppressed disease by 85.71 and 69.39% respectively. Pseudomonas flourescens CV6 significantly suppressed disease in comparison to Ridomil fungicide. The use of mixture bacterial strains in the soil inoculated by the fungus resulting in falling down the most of the plants which didn't show significant difference with infected control soils without bacteria.

Antinociceptive Properties of Extracts and Two Flavonoids Isolated from Leaves of Danae racemosa

Maleki-Dizaji, Nasrin,Fathiazad, Fatemeh,Garjani, Alireza 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

The antinociceptive properties of the hydro-methanolic extract (HME) and two flavonoids isolated from Danae racemosa have been investigated in several nociceptive rat models. The HME from D. racemosa $(100-400mgkg^{-1},\;i.p.)$ produced significant dose-related inhibition of acetic acid-induced abdominal constriction. In the same dose range, the HME produced dose-related inhibition in both phases of a formalin-test. Treatment of animals with naloxone $(5mgkg^{-1},\;i.p.)$ completely reversed the antinociceptive effect caused by morphine $(5mgkg^{-1},\;s.c.)$ and the HME $(200mgkg^{-1},\;i.p.)$ when assessed against the first phase of the formalin-test, but this effect was less significant for the HME in the second phase. Furthermore, when assessed via a hot-plate test, the HME $(100-400mgkg^{-1},\;i.p.)$ caused a significant increase in response latency. The HME, given daily for to 7 consecutive days, develop tolerance, but did not induce cross-tolerance to morphine. These data demonstrate that the HME elicites pronounced antinociception against several pain models. The actions of the HME involve, at least in part, an interaction with the opioid system, but does not seem to be related with non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action of D. racemosa is likely to be partially related to the presence of quercetin and kaempferol.

Epidemiology of Oral Cancer in Iran: a Systematic Review

Maleki, Davood,Ghojazadeh, Morteza,Mahmoudi, Seyed-Sajjad,Mahmoudi, Seed-Mostafa,Pournaghi-Azar, Fatemeh,Torab, Ali,Piri, Reza,Azami-Aghdash, Saber,Naghavi-Behzad, Mohammad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: Oral cancer stands among the 10 top causes of cancer death in the world. Considering the role of epidemiologic information on planning and effective interventions, the present study aimed to investigate the epidemiology of oral cancer in Iran. Materials and Methods: The required information for this systematic review study was obtained from PubMed, Google Scholar, CINAHL,SID, Medlib, Magiran and Iranmedex databases, using key words "cancer", "oral cancer", "squamous cell carcinoma", "oral cavity carcinoma" and their Persian equivalents in combination with keywords of epidemiology, prevalence, etiology, frequency, and Iran from 1990 to 2014. From 1,065 related studies found, finally 25 were included to the study. Results: The mean age of 8,248 patients in 25 studies was $54.0{\pm}15.1years$. The male/female ratio for oral cancer was 1.91. Tongue with average percentage of 29.9 was the most involved site. Regarding microscopic grade, 65.7% of cases were grade 1. SCCs, accounting for an average of 70.0%, was the most common among all types of oral cancer. In the majority of studies, smoking including cigarette, hookah, and tobacco consumption was found to be a risk factor. Conclusions: The epidemiological pattern of oral cancer in Iran is somewhat similar to that of other countries. Yet the information on hand in this field is limited and considering the role of epidemiological data we suggest conducting more accurate studies to catch data that is required for effective programs and interventions.

FUZZY NUMBER LINEAR PROGRAMMING: A PROBABILISTIC APPROACH (3)

Maleki, H.R.,Mashinchi, M. 한국전산응용수학회 2004 Journal of applied mathematics & informatics Vol.15 No.1

In the real world there are many linear programming problems where all decision parameters are fuzzy numbers. Several approaches exist which use different ranking functions for solving these problems. Unfortunately when there exist alternative optimal solutions, usually with different fuzzy value of the objective function for these solutions, these methods can not specify a clear approach for choosing a solution. In this paper we propose a method to remove the above shortcoming in solving fuzzy number linear programming problems using the concept of expectation and variance as ranking functions

Prevalence of Abnormal Papanicolaou Test Results and Related Factors among Women Living in Zanjan, Iran

Maleki, Azam,Ahmadnia, Elahe,Avazeh, Azar,Mazloomzadeh, Saeideh,Molaei, Behnaz,Jalilvand, Ahmad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

Background: Currently, a comprehensive program for screening and early detection of cervical cancer does not exist in Iran. This study aimed to determine the prevalence of abnormal Papanicolaou (Pap) smears and some related factors among women living in Zanjan, Iran. Materials and Methods: This cross-sectional study was conducted in 2012 in Zanjan on 4274 married women aged 20-65 years. The study participants were selected through two-stage cluster sampling. After obtaining written consent, demographic and fertility questionnaires were completed. Samples from cervix were obtained through a standard method using the Rover Cervex- Brush. Evaluation and interpretation of the samples were reported using the Bethesda 2001 method. Data were statistically analyzed using chi-square and logistic regression models. Results: Most inflammatory changes in the samples were mild (37.4%). Abnormal atypical changes in the epithelial cells were found in 4.04%. The highest percentage of abnormal changes in the epithelial cells was atypical squamous cells of undetermined significance (ASCUS) (1.9%). Abnormal results of Pap smear was significantly and independently associated with age, papillomavirus infection, and lack of awareness about Pap smear tests. Conclusions: Given the high prevalence of inflammatory and precancerous changes in this study, compared to other studies in Iran and other Muslim countries, and the effect of demographic variables and individual factors on abnormal results, increasing the awareness of women and their families regarding the risk factors for cervical cancer, preventive measures such as screening, and timely treatment seem necessary.

Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis

Maleki Azam,Bashirian Saeid,Soltanian Ali Reza,Jenabi Ensiyeh,Farhadinasab Abdollah 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.2

Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS).Purpose: Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD.Methods: Three main English databases were searched for articles published through December 2020. The NewcastleOttawa Scale was used to assess study quality. Study heterogeneity was determined using I2 statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model.Results: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27–1.57) and (RR, 1.43; 95% CI, 1.35–1.51), respectively. There was no heterogeneity among the included articles based on OR (I2=0.0%, P=0.588) and RR (I2=0.0%, P=0.878).Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.

Seismic Fragility Assessment of SMRFs with Drilled Flange Connections using Ground Motion Variability

Mehdi Maleki,Roohollah Ahmady Jazany,Mohammad Soheil Ghobadi 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.4

Seismic behavior of Steel Moment Resisting Frames (SMRFs) with Drilled Flange (DF) connections as well as Reduced Beam Section (RBS) and Welded Unreinforced Flange-Bolted web (WUF-B) as a Pre-Northridge connection have been compared analytically considering Far-field earthquake-induced. The backbone curves of RBS and WUF connections are extracted from available studies and the backbone curve of DF connection is presented in this study in order to simulating the buildings models. DF, RBS, WUF connections and Panel Zone (PZ) are numerically modeled based on the proposed models provided by the prior researches and these models are applied to analyze low- and high-rise buildings designed in accordance with the relevant standards. Incremental Dynamic Analysis (IDA) process is utilized to evaluate the effects of DF connection on structural seismic response of SMRFs. Afterwards, the structures’ performance in different response levels is probabilistically assessed by means of IDA and fragility curves. The results show that the seismic demand of SMRFs with DF and RBS connections are so similar, specifically for low-rise buildings. Likewise, SMRFs with DF connection provide up to 43% higher seismic demand in high-rise buildings compared to RBS connection. Eventually, DF connection can be used as an authentic option in SMRFs.

Probabilistic Seismic Assessment of SMFs with Drilled Flange Connections Subjected to Near-Field Ground Motions

M. Maleki,R. Ahmady Jazany,M. S. Ghobadi 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.1

This paper aims to probabilistically evaluate the infl uences of drilled fl ange (DF) connection on seismic performance of steel moment frames (SMFs) incorporating near-fi eld ground motions. Meanwhile, reduce beam section (RBS) connection as a prequalifi ed connection and pre-Northridge welded unreinforced fl ange (WUF) connection were compared with DF connection. To model accurately the components of RBS and WUF connections and panel zone in SMFs, the proposed models of former researches were utilized. However, to simulate all DF connections the hinge properties were extracted from experimentally validated fi nite element models. Two sample low- and high-rise buildings were designed based on valid codes and simulated by OpenSees platform in order to study the nonlinear performance of aforementioned connections. Incremental dynamic analysis process was carried out to assess comprehensively the eff ect of DF connection on structural response and probability of structural instability for various intensity of seismic loads. Then, the seismic risk for Collapse Prevention and immediate occupancy limit states were calculated by fragility analysis. Also, seismic demand hazard curves for the sample buildings were extracted. The results of this study indicated that DF connections provided acceptable seismic performance as well as RBS connections in low- and high-rise buildings.