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CNS Cholinergic Innervation to the Hippocampus in the Rat Using pseudorabies Virus as a Neurotracer
Ko, Mihee,Oh, Moonyou,Noh, Haesook,Cho, Moonjae,Lee, Youngjae,Lee, Bonghee 제주대학교 기초과학연구소 2002 基礎科學硏究 Vol.15 No.1
The hippocampus is a central area of the memory-related neural system. Combined irnmunohistochemistry against choline acetyl transferase and retrograde transneuronal labelling of the pseudorabies virus were used to identify cholinergic neurons in the central nervous system projecting to the hippocampal formation of the rat. Five to ten μL of Bartha strain of pseudorabies virus were injected into the dentate gyrus, CA1 and CA3 of the hippocampus of 20 Sprague Dawley rats using stereotaxic instrument. Forty eight to 96 hr after the injection, the brains were removed and the tissue sections were processed for double immunofluorescence procedure using polyclonal antibodies against pseudorabies virus or choline acetyl transferase. The double labelled neurons were distributed at several different nuclei and the labelling patterns of three different areas of the hippocampus were similar. These data suggests that the cholinergic innervation to the hippocampus were distributed in a transsynaptic manner throughout the whole brain area.
Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus
( Mihee Hong ),( Hee Yeon Kim ),( Hannah Seok ),( Chang Dong Yeo ),( Young Soo Kim ),( Jae Yen Song ),( Young Bok Lee ),( Dong-hee Lee ),( Jae-im Lee ),( Tae-kyu Lee ),( Hyo-suk Ahn ),( Yoon Ho Ko ),( 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.5
Background/Aims: This study examined prevalence and risk factors of periodontitis in representative samples of Korean adults, with and without diabetes mellitus (DM). Methods: Data from the 2012 Korean National Health and Nutritional Examination Survey were analyzed. A total of 4,477 adults (≥ 30 years old) were selected from 8,057 individuals who completed a nutrition survey, a self-reported general health behavior questionnaire, an oral examination, an oral hygiene behaviors survey, and laboratory tests. DM was defined as a fasting plasma glucose ≥ 126 mg/dL, or self-reported diagnosed diabetes, or current use of oral hypoglycemic agents and/or insulin. The community periodontal index was used to assess periodontitis status and comparisons between the periodontitis and the non-periodontitis group, were performed, according to the presence of DM. Risk factors for periodontitis in adults with DM and without DM were evaluated by multiple logistic regression analysis. Results: The prevalence of periodontitis was significantly higher in adults with DM (43.7%) than in those without DM (25%, p < 0.001). In adults without DM, risk factors for periodontitis were older age, male, urban habitation, waist circumference, smoking, oral pain, and less frequent tooth brushing. Significant risk factors for periodontitis in adults with DM were the smoking, oral pain, and not-using an oral hygiene product. Conclusions: Adults with DM have an increased risk of periodontitis than those without DM. Current smoking and oral pain increase this risk. Using an oral hygiene product can reduce risk of periodontal disease in adults with DM.
Kyoung Sik Yang,Woonchul Ko,MIhee Ko,Doseung Lee,Jong chul Lee,Yoonji Lee,Yong-Hwan Jung 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
두점박이사슴벌레(Prosopocoilus astacoides blanchardi)는 딱정벌레목(Coleoptera) 사슴벌레과(Lucanidae)에 속하는 종으로 국내에서는 제주도에만 분포하며, 2012년 5월 31일에 멸종위기 야생생물 Ⅱ급 보호종으로 지정되었다. 본 연구는 2014년 5월부터 2018년 8월까지 두점박이사슴벌레가 번식 및 개체군이 유지되는 기주목 12그루를 대상으로 번식지의 특성을 연구하였다. 기주목은 상수리나무(Quercus acutissima) 11그루, 떡갈나무(Q.dentata) 1그루로 분포 해발고도는 150m~355m이며, 기주목의 수고와 흉고는 각 4.5m~10m, 17cm~34cm였다. 특히, 기주목에는 두점박이사슴벌레가 은신할 수 있는 보리밥나무(Elaeagnus macrophylla), 송악(Hedera rhombea), 담쟁이덩굴(Parthenocissus tricuspidata), 마삭줄(Trachelospermum asiaticum), 청미래덩굴(Smilax china), 밀나물(S. riparia), 칡(Pueraria lobata), 으아리(Clematis mandshurica), 사위질빵(C. apiifolia), 며느리밑씻개(Polygonum senticosum), 줄사철나무(Euonymus fortunei), 남오미자(Kadsura japonica) 등의 덩굴성 식물이 기주목의 줄기를 잠식해 있었고, 잠식률은 5%~80%까지 다양했다. 하지만 덩굴성 식물의 줄기잠식률이 낮으면, 기주목에 갈라진 틈이 있거나 군락을 이루고 있어 은신처가 있었고, 단독으로 기주목이 있는 곳은 줄기잠식률이 40%~80% 매우 높았다. 본 연구를 통해 두점박이사슴벌레는 번식 및 개체군 유지를 위해 포식자를 피하고 먹이를 구하기 위해 덩굴성 식물이 줄기를 잠식하고 있는 참나무속(Quercus)의 기주목에 주로 서식하는 것으로 판단된다.
A survey on the distribution of dung beetles in cattle pasture and horse pasture in Jeju, Korea
Kyoung Sik Yang,Woonchul Ko,MIhee Ko,Doseung Lee,Jong chul Lee,Yoonji Lee,Yong-Hwan Jung 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
제주도내 소 방목지와 말 방목지에서 소똥구리류의 분포를 조사하였다. 본 조사는 2018년 5월부터 9월까지 소 방목지와 인접한 말 방목지 각 3곳(조천읍, 제1 산록도로, 안덕면)을 대상으로 월 3회 실시하였으며, 각 지역마다 함정덫(Pit-fall Trap)을 5m 간격으로 5개씩 설치하여 닭내장으로 유인하였다. 조사결과 소 방목지는 뿔소똥구리(Copris ochus) 21개체, 멸종위기Ⅱ급 보호종인 애기뿔소똥구리(C. tripartitus) 64개체, 렌지소똥풍뎅이(Onthophagus lenzii) 778개체, 모가슴소똥풍뎅이(O. fodiens) 31개체, 창뿔소똥구리(Liatongus phanaeoides) 2개체로 총 5종 896개체가 조사되었고, 종풍부도(Richness Index, RI)에서 다수종(Abundant)은 렌지소똥풍뎅이 1종 이었고, 나머지 종은 희소종(Rare)으로 나타내었다. 종다양도(H’)는 조천읍(0.29), 제 1산록도로(1.06), 안덕면(0.72)로 나타났다. 말 방목지는 각 14개체, 42개체, 205개체, 51개체, 1개체로 총 5종 313개체가 조사되었고, 다수종은 렌지소똥풍뎅이 1종, 보통종(Common)은 애기뿔소똥구리, 모가슴소똥풍뎅이 2종이었고, 나머지 종은 희소종(Rare)으로 나타내었다. 종다양도(H’)는 조천읍(0.76), 제 1산록도로(1.22), 안덕면(1.03)로 나타났다. 본 조사결과 소똥구리류의 종다양도는 말 방목지가 높았지만 조사기간 동안 안덕면에서는 4개체가 잡히면서 종다양도가 높았고, 소 방목지는 렌지소똥풍뎅이의 개체수가 대부분을 차지하면서 종다양도는 낮았지만, 소똥구리류는 소 방목지에 주로 서식하는 것으로 판단된다.
Park, Sung Soo,Kim, Seung Hoon,Kim, Mihee,Kim, Jong Wook,Ko, Yoo Mi,Kim, Sung-Kyoung,Kim, So Hyang,Kim, Chi Hong The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Although influenza A (H1N1) virus leads to self-limiting illness, co-infection with bacteria may result in cases of severe respiratory failure due to inflammation and necrosis of intra-airway, as pseudomembranous tracheobronchitis. Pseudomembranous tracheobronchitis is usually developed in immunocompromised patients, but it can also occur in immunocompetent patients on a very rare basis. We report a case of pseudomembranous tracheobronchitis complicated by co-infection of inflenaza A and Staphylococcus aureus, causing acute respiratory failure in immunocompetent patients.
( Sung Soo Park ),( Seung Hoon Kim ),( Mihee Kim ),( Jong Wook Kim ),( Yoo Mi Ko ),( Sung Kyoung Kim ),( So Hyang Kim ),( Chi Hong Kim ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Although influenza A (H1N1) virus leads to self-limiting illness, co-infection with bacteria may result in cases of severe respiratory failure due to inflammation and necrosis of intra-airway, as pseudomembranous tracheobronchitis. Pseudomembranous tracheobronchitis is usually developed in immunocompromised patients, but it can also occur in immunocompetent patients on a very rare basis. We report a case of pseudomembranous tracheobronchitis complicated by co-infection of inflenaza A and Staphylococcus aureus, causing acute respiratory failure in immunocompetent patients.
Choi, Miyeon,Lee, Seung Hoon,Wang, Sung Eun,Ko, Seung Yeon,Song, Mihee,Choi, June-Seek,Kim, Yong-Seok,Duman, Ronald S.,Son, Hyeon National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.51
<P><B>Significance</B></P><P>The rapid antidepressant response is produced by ketamine administration. However, the molecular mechanisms underlying the antidepressant-like action of ketamine remain incomplete. Here we show for the first time to our knowledge that ketamine stimulates the phosphorylation (Ser259/Ser498) and nuclear export of histone deacetylase 5 (HDAC5). As a consequence, myocyte enhancer factor 2 (MEF2) transcriptional activity is enhanced and results in the induction of MEF2 target gene expression. We further show that ketamine down-regulates and, at the same time, phosphorylates HDAC5 to attenuate its repressive influence on transcription in the hippocampus. These studies unveil a previously unidentified role of HDAC5 in regulating neuronal function in response to ketamine, and thus provide the foundation for new approaches for the treatment of major depression.</P><P>Ketamine produces rapid antidepressant-like effects in animal assays for depression, although the molecular mechanisms underlying these behavioral actions remain incomplete. Here, we demonstrate that ketamine rapidly stimulates histone deacetylase 5 (HDAC5) phosphorylation and nuclear export in rat hippocampal neurons through calcium/calmodulin kinase II- and protein kinase D-dependent pathways. Consequently, ketamine enhanced the transcriptional activity of myocyte enhancer factor 2 (MEF2), which leads to regulation of MEF2 target genes. Transfection of a HDAC5 phosphorylation-defective mutant (Ser259/Ser498 replaced by Ala259/Ala498, HDAC5-S/A), resulted in resistance to ketamine-induced nuclear export, suppression of ketamine-mediated MEF2 transcriptional activity, and decreased expression of MEF2 target genes. Behaviorally, viral-mediated hippocampal knockdown of HDAC5 blocked or occluded the antidepressant effects of ketamine both in unstressed and stressed animals. Taken together, our results reveal a novel role of HDAC5 in the actions of ketamine and suggest that HDAC5 could be a potential mechanism contributing to the therapeutic actions of ketamine.</P>