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Controlled electroplating and electromigration in nickel electrodes for nanogap formation
Los Santos Valladares, Luis De,Leon Felix, Lizbet,Bustamante Dominguez, Angel,Mitrelias, Thanos,Sfigakis, Francois,Khondaker, Saiful I,Barnes, Crispin H W,Majima, Yutaka IOP Pub 2010 Nanotechnology Vol.21 No.44
<P>We report the fabrication of nickel nanospaced electrodes by electroplating and electromigration for nanoelectronic devices. Using a conventional electrochemical cell, nanogaps can be obtained by controlling the plating time alone and after a careful optimization of electrodeposition parameters such as electrolyte bath, applied potential, cleaning, etc. During the process, the gap width decreases exponentially with time until the electrode gaps are completely bridged. Once the bridge is formed, the <I>ex situ</I> electromigration technique can reopen the nanogap. When the gap is ∼ 1 nm, tunneling current–voltage characterization shows asymmetry which can be corrected by an external magnetic field. This suggests that charge transfer in the nickel electrodes depends on the orientation of magnetic moments. </P>
Increase of YBa2Cu3O7 critical currents by Mo substitution and high-pressure oxygen annealing
Los A.,Dabrowski B.,Rogacki K. 한국물리학회 2021 Current Applied Physics Vol.27 No.-
We have previously shown for powders that Mo substitution into the CuO chains of YBa2Cu3O7 can create effective pinning centres which significantly increase the critical current density (jc) in 7 T field by a factor of 4 and 10 at 50 and 60 K, respectively (Rogacki et al., 2006) [1]. The present work reports on the influence of the Mo substitution and high-pressure oxygen annealing on the pinning properties and critical currents of YBa2Cu3- xMoxO7-d by comparing pure (x = 0, d > 0) and substituted (x = 0.03, d < 0) single crystals. Pinning properties have been investigated by measurements of magnetization loops and calculations of jc in the ab-plane, in the temperature range from 2 to 90 K and in fields up to 14 T. Depending on the Mo substitution and the oxygen treatment, several types of pinning centres increasing jc have been revealed and analysed in the frame of Dew- Hughes’ and Kramer’s models.
Attaching Thiolated Superconductor Grains on Gold Surfaces for Nanoelectronics Applications
De Los Santos Valladares, Luis,Bustamante Dominguez, Angel,Llandro, Justin,Suzuki, Seiichi,Mitrelias, Thanos,Bellido Quispe, Richard,Barnes, Crispin H. W.,Majima, Yutaka IOP Publishing 2010 Japanese journal of applied physics Vol.49 No.r9
de los Reyes, Benildo G,Mohanty, Bijayalaxmi,Yun, Song Joong,Park, Myoung-Ryoul,Lee, Dong-Yup Springer US 2015 Rice Vol.8 No.-
<P>Dissecting the upstream regulatory architecture of rice genes and their cognate regulator proteins is at the core of network biology and its applications to comparative functional genomics. With the rapidly advancing comparative genomics resources in the genus <I>Oryza</I>, a reference genome annotation that defines the various cis-elements and trans-acting factors that interface each gene locus with various intrinsic and extrinsic signals for growth, development, reproduction and adaptation must be established to facilitate the understanding of phenotypic variation in the context of regulatory networks. Such information is also important to establish the foundation for mining non-coding sequence variation that defines novel alleles and epialleles across the enormous phenotypic diversity represented in rice germplasm. This review presents a synthesis of the state of knowledge and consensus trends regarding the various cis-acting and trans-acting components that define spatio-temporal regulation of rice genes based on representative examples from both foundational studies in other model and non-model plants, and more recent studies in rice. The goal is to summarize the baseline for systematic upstream sequence annotation of the rapidly advancing genome sequence resources in <I>Oryza</I> in preparation for genus-wide functional genomics. Perspectives on the potential applications of such information for gene discovery, network engineering and genomics-enabled rice breeding are also discussed.</P>
de los Angeles Rivera-Juarez, Maria,Rosas-Murrieta, Nora Hilda,Mendieta-Carmona, Victoriano,Hernandez-Pacheco, Raquel Esneidy,Zamora-Ginez, Irma,Rodea-Avila, Carlos,Apresa-Garcia, Teresa,Garay-Villar, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Sialyltransferase gene expression is altered in several cancers, including examples in the cervix. Transcriptional regulation of the responsible genes depends on different promoters. We aimed to determine the association of single-nucleotide polymorphisms in the B3 promoter of the ST3GAL4 gene and the P1 promoter of the ST6GAL1 gene with cervical premalignant lesions or cervical cancer. A blood sample and/or cervical scrapes were obtained from 104 women with normal cytology, 154 with premalignant lesions and 100 with cervical cancer. We also included 119 blood samples of random donors. The polymorphisms were identified by sequencing from PCR products. For the B3 promoter, a fragment of 506 bp (from nucleotide -408 to +98) was analyzed, and for the P1 promoter a 490 bp (-326 to +164) fragment. The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions (OR=2.89; 95%CI 1.72-4.85) and cervical cancer (OR=2.23; 95%CI 1.27-3.91). We detected only one allele of each polymorphism in the ST6GAL1 P1 promoter. We did not detect any genetic variability in the P1 promoter region in our study population. Our results suggest that the rs10893506 polymorphism -22C/T may increase susceptibility to premalignant and malignant lesions of the cervix.
Marıa de los Angeles Fortis-Barrera,Francisco Javier Alarcon-Aguilar,Araceli Becerril-Garcıa,Jose Luis Eduardo Flores-Saenz,Julio Cesar Almanza-Perez,Mario Garcıa-Lorenzana,Roberto Carlos Lazzarini-Le 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.7
In Central and South American traditional medicine, people use Cecropia obtusifolia Bertol (Cecropiaceae) for the treatment of diabetes mellitus. However, its hypoglycemic action mechanism at pancreatic and liver level has been poorly explored. The present research aimed to establish the influence of the aqueous extract of C. obtusifolia, standardized in its content of chlorogenic acid, on insulin secretion in RINm5F cells and over the liver carbohydrates and lipids metabolism, and to determine concomitantly its hepatoprotective effect on mice with streptozotocin-induced diabetes. In RINm5F cells, concentrations 5, 50, 100, and 200 μg/mL of aqueous extract of C. obtusifolia were used to determine [Ca2+]i and insulin secretion. In an acute study, the extract was administered at doses of 500 mg/kg. In another test (subacute), the extract was daily administrated to diabetic mice (200 mg/kg/day) for 30 days. Blood glucose levels and other biochemical parameters were determined, and a liver histological analysis was performed. In RINm5F cells, C. obtusifolia increased [Ca2+]i and insulin secretion, whereas in diabetic mice exhibited acute and subacute hypoglycemic effects. Daily administration of C. obtusifolia to diabetic mice also increased liver glycogen storage and glycogen synthase levels, without apparent changes in gluconeogenesis. Besides, it increased peroxisome proliferator-activated receptor-α (PPAR-α) and long-chain-fatty-acid-CoA ligase 1 (ACSL-1) expression and reduced triglycerides, transaminases (alanine aminotransferase and aspartate aminotransferase), and collagen fibers, modifying anti-inflammatory (adiponectin and interleukin-10) and inflammatory (tumor necrosis factor-α) cytokines in serum. Therefore, the hypoglycemic effect of C. obtusifolia implicates a dual action, promoting insulin secretion, liver glycogen accumulation, and hepatoprotection by decreasing collagen fibers and inflammatory markers, whereas it improves lipid metabolism, due in part to PPAR-α.
A Girl with 15q Overgrowth Syndrome and dup(15)(q24q26.3) that Included Telomeric Sequences
María de los Ángeles Gutiérrez-Franco,María de la Luz Madariaga-Campos,Ana I. Vásquez-Velásquez,Esmeralda Matute,Roberto Guevara-Yáñez,Horacio Rivera 대한진단검사의학회 2010 Annals of Laboratory Medicine Vol.30 No.3
Distal 15q trisomy or tetrasomy is associated with a characteristic phenotype that includes mild to moderate intellectual disability, abnormal behavior, speech impairment, overgrowth, hyperlaxity, long face, prominent nose, puffy cheeks, pointed chin, small ears, and hand anomalies (mainly arachno- and camptodactyly). We present the case of a 13-yr-old girl with the main clinical features of 15q overgrowth syndrome and a 46,XX,dup(15)(q24q26.3)[117]/46,XX[3].ish dup(15)(q24q26.3) (SNPRN+,PML+,subtel++,tel++) de novo karyotype. The findings in this case are consistent with those in the previous distal 15q trisomy cases that presented with overgrowth and mental retardation. Further, the rearranged chromosome had a double set of directly oriented telomeric and subtelomeric sequences. (Korean J Lab Med 2010;30:318-24)