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JIANPING LIN,HUIQING LAN,WEIFENG ZHENG,FACHUN LAI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.6
Silver nanoparticles (NPs) ¯lms with di®erent nominal thicknesses were deposited on the anodic aluminum oxide (AAO) templates with pore diameter about 200 nm by thermal evaporation. These NPs ¯lms were used as the surface enhanced Raman scattering (SERS) active substrates. The microstructure and surface morphology of the ¯lms were studied by X-ray di®raction and scanning electron microscopy, respectively. The SERS activity of the ¯lms was investigated by Raman scattering of adsorbed rhodamine 6G (R6G) at di®erent concentrations. The results revealed that the average diameter of Ag NPs in di®erent samples is 58 nm, 75 nm, 93 nm and 108 nm, respectively. Ag NPs ¯lm on AAO template is very suitable as a SERS active substrate and can detect R6G molecules with a concentration of 10?8 M. The intensity of the SERS spectra is related to both the Ag NPs size and interparticle distance. The sample with an average particle diameter of 93 nm has the highest SERS enhancement factor (1:3 ? 106).
Yue Lin,Yuanyuan Zhang,Qiongtao Song,Tao Song,Xue Han,Ying Zhang,Xuan Zhang,Xi Chu,Fenghua Zhang,Li Chu,Jianping Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10
To explore the cardiovascular protective effectsof Magnesium isoglycyrrhizinate (MI), especially theunderlying cellular mechanisms related to L-type calciumchannels and myocardial contractility, and to examine theeffects of MI on hERG K? current expressed in HEK293cells. We used the whole-cell patch clamp technique,video-based edge detection and dual excitation fluorescencephotomultiplier systems to explore the effect of MIon L-type Ca2? currents (ICa-L) and cell contraction in ratcardiomyocytes. We also examined the rapidly activatingdelayed rectifier potassium current (IKr) expressed inHEK293 cells using a perforated patch clamp. MI inhibitedICa-L in a dose-dependent manner, with a half-maximalinhibitory concentration (IC50) of 0.22 mg/ml, and themaximal inhibitory effect was 61.10 ± 0.59%. MI at aconcentration of 0.3 mg/ml reduced cell shortening by24.12 ± 3.97% and the peak value of the Ca2? transient by36.54 ± 4.96%. MI had no significant influence on hERGK? channels expressed in HEK293 cells at all testpotentials. MI exerts protective effects on the heart via theinhibition of ICa-L and cell shortening in rat cardiomyocytes. However, MI had no significant influence on IKr;thus, MI may exert cardioprotective effects without causingdrug-induced long QT syndrome.
Study on the Constitutive Model of Boron Steel 22MnB5 with Different Phase Fractions
Fangfang Liao,Jianping Lin,Ming Wang Fu 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.10
The mechanical properties of boron steel 22MnB5 is determined by phase fractions. In order to obtain the mechanical properties and service performance of car component by simulation accurately, a microstructure based constitutive model needs to be developed. In this paper, different area fractions of martensite, bainite and ferrite in boron steel 22MnB5 were obtained via control of cooling rate and the different microstructures were determined quantitatively by metallographic image processing. A modified Katsuro Inoue’s constitutive model was then proposed, which is a function of effective plastic strain, strain rate and the phase fractions of martensite, bainite and ferrite. On the other hand, crash simulation of B-pillar with tailored mechanical properties was conducted as a case study to investigate the relationship between microstructure and property configuration by using the modified Katsuro Inoue’s model. The relationship among phase fraction, the height of tailored segment, and the internal energies absorbed by different segments, the maximum acceleration and displacement of B-pillar during the collision process was studied, and the empirical equations between microstructure and dynamic response of crash performance were also established and formulated.
Xua Zhinan,Fang Limei,Lin Jianping,Jiang Xiaoxia,Liu Ying,Cen Peilin The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.1
The asymmetric biosynthesis of ethyl (S)-4-chloro-3-hydrobutanoate from ethyl 4-chloro-3-oxobutanoate was investigated by using whole cells of Candida magnoliae JX120-3 without the addition of glucose dehydrogenase or $NADP^+/NADPH$. In a one-phase system, the bioconversion yield was seriously affected on the addition of 12.1 g/L ethyl 4-chloro-3-oxobutanoate. In order to reduce this substrate inhibition, a water/ n-butyl acetate two-phase system was developed, and the bioreduction conditions optimized with regard to the yield and product enantiometric excess value. The optimal conditions were as following: water to n-butyl acetate volume ratio of 1:1, 4.0 g DCW/L active cells, 50 g/L glucose and $35^{\circ}C$. By adopting a dropwise substrate feeding strategy, high concentration of ethyl 4-chloro-3-oxobutanoate (60 g/L) could be asymmetrically reduced to ethyl (S)-4-chloro-3-hydrobutanoate with high yield (93.8%) and high enantiometric excess value (92.7%).
Zhinan Xu,Limei Fang,Jianping Lin,Xiaoxia Jiang 한국생물공학회 2006 Biotechnology and Bioprocess Engineering Vol.11 No.1
The asymmetric biosynthesis of ethyl (S)-4-chloro-3-hydrobutanoate from ethyl 4-chloro-3-oxobutanoate was investigated by using whole cells of Candida magnoliae JX120-3 without the addition of glucose dehydrogenase or NADP+/NADPH. In a one-phase system, the bioconversion yield was seriously affected on the addition of 12.1 g/L ethyl 4-chloro-3-oxobutanoate. In order to reduce this substrate inhibition, a water/n-butyl acetate two-phase system was developed, and the bioreduction conditions optimized with regard to the yield and product enantiometric excess value. The optimal conditions were as following: water to n-butyl acetate volume ratio of 1:1, 4.0 g DCW/L active cells, 50 g/L glucose and 35°C. By adopting a dropwise substrate feeding strategy, high concentration of ethyl 4-chloro-3-oxobutanoate (60 g/L) could be asymmetrically reduced to ethyl (S)-4-chloro-3-hydrobutanoate with high yield (93.8%) and high enantiometric excess value (92.7%).
Jiong-feng Zhao,Tao-Wang,Jianping Lin,Lirong Yang,Mian-bin Wu 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.2
Early research on the nutritional value of 1,3- diacylglycerols (1,3-DAGs) has resulted in a significant interest in their synthesis. 1,3-DAGs can be produced chemically and biologically. In this work, a regioselective lipase from Rhizopus oryzae was efficiently immobilized on nanosized magnetite particles (NSM) in an oriented way, resulting in significant enhancement of activity. The specific hydrolytic and esterification activities of the immobilized enzyme were 1,660% and 260% of those of the free enzyme, respectively. The immobilized enzyme was then used to catalyze the esterification of oleic acid with glycerol in a solvent-free system for preparation of 1,3-DAG in a 1 L reactor. The catalytic process was studied in detail, the final concentration of 1,3-DAG reached >76% under the optimal condition when the molar ratio of oleic acid to glycerol was 2.8:1. The regioselectivities of free and immobilized enzyme were both >97%. The immobilized enzyme was reused for 55 cycles with only ~30% activity loss at 30ºC. The purity of 1,3-DAG was up to ~95% (w/w) after a simple purification step with the recovery ratio ~85%. This is the first report of efficient 1,3-DAG purification by neutralization without acyl migration.