도시화 발전 수준이 대기질 개선에 미치는 영향에 관한 연구: 중국 31개 성·직할시(省·直轄市)를 대상으로

리멍잉(Mengying Li),정주철(Juchul Jung) 한국환경정책학회 2021 環境政策 Vol.29 No.3

Assessing the Blood Supply Status of the Focal Ground-Glass Opacity in Lungs Using Spectral Computed Tomography

Guanfu Liu,Mengying Li,Guosheng Li,Zhiyong Li,Ailian Liu,Renwang Pu,Huizhi Cao,Yijun Liu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.1

Objective: To exploit material decomposition analysis in dual-energy spectral computed tomography (CT) to assess the blood supply status of the ground-glass opacity (GGO) in lungs. Materials and Methods: This retrospective study included 48 patients with lung adenocarcinoma, who underwent a contrast-enhanced dual-energy spectral CT scan before treatment (53 GGOs in total). The iodine concentration (IC) and water content (WC) of the GGO, the contralateral and ipsilateral normal lung tissues were measured in the arterial phase (AP) and their differences were analyzed. IC, normalized IC (NIC), and WC values were compared between the pure ground-glass opacity (pGGO) and the mixed ground-glass opacity (mGGO), and between the group of preinvasive lesions and the minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA) groups. Results: The values of pGGO (IC = 20.9 ± 6.2 mg/mL and WC = 345.1 ± 87.1 mg/mL) and mGGO (IC = 23.8 ± 8.3 mg/mL and WC = 606.8 ± 124.5 mg/mL) in the AP were significantly higher than those of the contralateral normal lung tissues (IC = 15.0 ± 4.9 mg/mL and WC = 156.4 ± 36.8 mg/mL; IC = 16.2 ± 5.7 mg/mL and WC = 169.4 ± 41.0 mg/mL) and ipsilateral normal lung tissues (IC = 15.1 ± 6.2 mg/mL and WC = 156.3 ± 38.8 mg/mL; IC = 15.9 ± 6.0 mg/mL and WC = 174.7 ± 39.2 mg/mL; all p < 0.001). After normalizing the data according to the values of the artery, pGGO (NIC = 0.1 and WC = 345.1 ± 87.1 mg/mL) and mGGO (NIC = 0.2 and WC = 606.8 ± 124.5 mg/mL) were statistically different (p = 0.049 and p < 0.001, respectively), but not for the IC value (p = 0.161). The WC values of the group with preinvasive lesions and MIA (345.4 ± 96.1 mg/mL) and IA (550.1 ± 158.2 mg/mL) were statistically different (p < 0.001). Conclusion: Using dual-energy spectral CT and material decomposition analysis, the IC in GGO can be quantitatively measured which can be an indicator of the blood supply status in the GGO.

Ethylene increases accumulation of compatible solutes and decreases oxidative stress to improve plant tolerance to water stress in Arabidopsis

Mengying Cui,Yingchao Lin,YUANGANG ZU,Thomas Efferth,Dewen Li,Zhonghua Tang 한국식물학회 2015 Journal of Plant Biology Vol.58 No.3

Ethylene (ET) plays an important role as signal transducer in plants in response to environmental stimuli. Under water deficient conditions, fine adjustment of osmosis and redox states through phytohormones is vital for plant resistance to drought. Here, physiological and cellular responses of ET insensitive mutants (ein2-5 and ein3-1) were analyzed under water deficiency stimulated by polyethylene glycol 6000 (PEG-6000), and compared with wild type plants (Col-0) as controls. The accumulation of compatible solutes was higher in Col-0 than in ein2-5 and ein3-1. In Col-0 plants, water stress also increased transcription of P5CS1, which encoded a key rate-limiting enzyme in proline biosynthesis. These results suggested that ET signaling is involved in increasing the up-regulation of soluble sugar and proline accumulation to adjust to osmotic stress. In addition, oxidative stress was higher in ET defective mutants than in Col-0 wild-type plants. Meanwhile, increased activities of the reactive oxygen species (ROS)-scavenging enzymes superoxide dismutase (SOD) and peroxidase (POD) were observed in ET insensitive mutants, indicating aggravated oxidative stress in ET-defective plants under drought. In conclusion, ET signaling is involved in modulating plant oxidative stress under drought conditions.

TFPI inhibits breast cancer progression by suppressing ERK/p38 MAPK signaling pathway

Xing Mengying,Yang Ying,Huang Jiaxue,Fang Yaqun,Jin Yucui,Li Lingyun,Chen Xiang,Zhu Xiaoxia,Ma Changyan 한국유전학회 2022 Genes & Genomics Vol.44 No.7

Background: Tissue factor pathway inhibitor-1 (TFPI) is a serine protease inhibitor, which is responsible for inactivating TF-induced coagulation. Recently, increasing studies revealed that TFPI was lowly expressed in tumor cells and exhibited the antitumor activity. Objective: The aim of this study was to explore the role and underlying molecular mechanisms of TFPI in breast cancer. Methods: The expression and prognostic value of TFPI were analyzed using UALCAN and Kaplan-Meier plotter website. The expression level of TFPI in breast cancer tissues and cells was examined by immunohistochemistry (IHC) and western blot analysis, respectively. Cellular proliferation was evaluated by CCK-8 and colony formation assays. Cell migration and invasion were determined by transwell assay. The methylation level of TFPI promoter was determined by methylation-specific PCR. Results: TFPI expression was significantly lower in breast cancer tissues and cells compared to normal breast tissues and normal breast cells. Patients with low TFPI levels showed worse overall survival (OS). Furthermore, overexpression of TFPI significantly inhibited the proliferation, migration and invasion of breast cancer cells. Conversely, knockdown of TFPI promoted the proliferation, migration and invasion of breast cancer cells. Mechanistically, TFPI inhibited the ERK/p38 MAPK signaling pathway in breast cancer. Moreover, DNA hypermethylation of TFPI promoter was responsible for the downregulation of TFPI in breast cancer cells. Conclusion: TFPI inhibited breast cancer cell proliferation, migration and invasion through inhibition of the ERK/p38 MAPK signaling pathway, suggesting that TFPI may serve as a novel prognostic biomarker and therapeutic target for breast cancer.

Preparation and Microstructure Control of PMDA/ODA Polyimide Hollow Fibers

Meifeng Xiao,Jianhua Li,Huanyu Lei,Mengying Zhang,Hongqing Niu,Dezhen Wu,Xiaodong Wang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.5

Poly(4,4'-oxydiphenylene pyromellitimide) (PMDA/ODA) hollow fiber membranes with regular morphologieshave been successfully prepared through a two-step dry-jet wet spinning method. The morphologies of polyimide (PI) hollowfibers were regulated via adjusting the major spinning parameters, including dope/bore flow rate ratio, bore fluidcomposition, coagulation bath temperature and air gap distance. SEM results show that the morphologies of PI hollow fibersstrongly depended on the spinning conditions, and fibers with regular asymmetric structures were finally obtained. The fiberwall thickened with the increase of dope/bore flow rate ratio, and the fibers could well self-support when the dope/bore flowrate ratio ranged from 3:1 to 4:1. While higher DMAc content in the bore fluid was conducive to the formation of finger-likevoids, reduced amount of DMAc would result in smaller finger-like voids and thereby lower overall porosities as well asbetter mechanical properties. Moreover, the finger-like voids and surface defects could be effectively prevented by loweringthe coagulation bath temperature or extending the air gap distance. Gas separation and mechanical properties of the hollowfibers were found closely related to these morphological changes. On such basis, regular PI hollow fibers with differentmicrostructures and Young’s modulus up to 1040 MPa were successfully fabricated. The prepared polyimide hollow fibersare promising candidates for fine separation under high temperature and high pressure or can be employed as the support ofcomposite membranes.

An Improved Multi-Objective Optimization Algorithm Based on NPGA for Cloud Task Scheduling

Peng Yue,Xue Shengjun,Li Mengying 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.4

As a commercial distributed computing mode, cloud computing needs to meet the quality of service (QoS) requirement of users, which is its top priority. However, cloud computing service providers also need to consider how to reduce the overhead of data center, and keep load balancing is one of the key points to maximize the use of the resource in the data center. In this paper, we propose an improved multi-objective niched Pareto genetic algorithm (NPGA) to take load balancing into consideration without affecting performance of time consumption and financial cost of handling the user’s cloud computing tasks by presenting the load balancing shift mutation operator. The simulation results and analysis show that the proposed algorithm performs better than NPGA in maintaining the diversity and the distribution of the Pareto-optimal solutions in the cloud tasks scheduling under the same population size and evolution generation.

The Multi-objective VM Resource Scheduling by Using an Improved PSO Algorithm in the Cloud Data Center

Shengjun Xue,Jingyi Chen,Mengying Li 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

With the exponential increase of the cloud business volume, Data center occurs load imbalance caused by some physical machine inefficiency due to the diversity of users requirements. Therefore the cloud datacenter need an appropriate algorithm to balance the PMs load and ensure the resource utilization in the cloud datacenter. The paper defines and formulates the problem parameters and proposes a Multi-objective Discrete Particle Swarm Optimization (MDPSO) to schedule the resources to the VMs requests according to the requirements. The simulation shows that the MDPSO algorithm not only guarantees the resource utilization, but also insures the PMs Load balance.

Effect of Gas Sensing Properties by Sn-Rh Codoped ZnO Nanosheets

Ziwei Chen,Zhidong Lin,Mengying Xu,Yuyuan Hong,Na Li,Ping Fu,Ze Chen 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.3

The hierarchically porous Sn-Rh codoped ZnO, Sn-doped ZnO and pureZnO nanosheets have been successfully synthesized through a simplehydrothermal reaction process without any surfactant or template at 180°C. The morphology and composition were carefully characterized by X-raydiffraction, energy dispersive X-ray spectrometer, field emission scanningelectronic microscopy and BET. The gas-sensing testing results indicatedthat the Sn-Rh codoped ZnO nanosheets, with the specific surface area was26.9 m2/g, exhibited enhanced gas-sensing performance compared withthat of pure ZnO and Sn-doped ZnO. The high sensitivity of the sensorbased on Sn-Rh codoped ZnO was 149.38 to 100 ppm ethanol and thedetection limit was less than 5 ppm (5.8). The response and recovery timeswere measured to be ~3 s and ~10 s when exposed to 100 ppm ethanol atthe test temperature of 300°C. The good sensing performance of the Sn-Rhcodoped ZnO sensor indicated that hierarchically porous Sn-Rh codopedZnO could be a promising candidate for highly sensitive gas sensors.

Diversity and Antiaflatoxigenic Activities of Culturable Filamentous Fungi from Deep-Sea Sediments of the South Atlantic Ocean

( Ying Zhou ),( Xiujun Gao ),( Cuijuan Shi ),( Mengying Li ),( Wenwen Jia ),( Zongze Shao ),( Peisheng Yan ) 한국균학회 2021 Mycobiology Vol.49 No.2

Despite recent studies, relatively few are known about the diversity of fungal communities in the deep Atlantic Ocean. In this study, we investigated the diversity of fungal communities in 15 different deep-sea sediments from the South Atlantic Ocean with a culturedependent approach followed by phylogenetic analysis of ITS sequences. A total of 29 fungal strains were isolated from the 15 deep-sea sediments. These strains belong to four fungal genera, including Aspergillus, Cladosporium, Penicillium, and Alternaria. Penicillium, accounting for 44.8% of the total fungal isolates, was a dominant genus. The antiaflatoxigenic activity of these deep-sea fungal isolates was studied. Surprisingly, most of the strains showed moderate to strong antiaflatoxigenic activity. Four isolates, belonging to species of Penicillium polonicum, Penicillium chrysogenum, Aspergillus versicolor, and Cladosporium cladosporioides, could completely inhibit not only the mycelial growth of Aspergillus parasiticus mutant strain NFRI-95, but also the aflatoxin production. To our knowledge, this is the first report to investigate the antiaflatoxigenic activity of culturable deep-sea fungi. Our results provide new insights into the community composition of fungi in the deep South Atlantic Ocean. The high proportion of strains that displayed antiaflatoxigenic activity demonstrates that deep-sea fungi from the Atlantic Ocean are valuable resources for mining bioactive compounds.

Effective interfacially polymerized polyarylester solvent resistant nanofiltration membrane from liquefied walnut shell

Ayang Zhou,Ying Wang,Dandan Cheng,Mengying Li,Lei Wang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.6

Walnut shell, an agricultural waste, has not been efficiently utilized so far. In this paper, walnut shell wasliquefied first, followed by characterization of XPS and ATR-FTIR. It is shown that syringylphenol and guaiacylphenolare contained in the walnut shell. A novel organic solvent resistant nanofiltration (OSN) membrane was prepared byliquefied walnut shell (LWP) and trimethyl chloride (TMC) on the crosslinked polyetherimide substrate via interfacialpolymerization method. The results showed that LWP and TMC formed polyarylester toplayer. The NF-2LWP membranemaintained stable N,N-Dimethylformamide (DMF) permeance of 2.2 L m2 h1 MPa1 and rejection of 98% forcrystal violet (CV, 407.98 g mol1) in 36 hours continuous separation process. Furthermore, guaiacol (GA), a componentof LWP, was used to prepare an OSN membrane, Compared with NF-LWP membrane, NF-GA membrane showsgood performance in the separation of tetrahydrofuran (THF) with the rejection of 96% for rose bengal (RB, 1,017.64 gmol1) and the permeance of 76 L m2 h1 MPa1. This study not only provides a good way for the efficient recycling ofwalnut shell, but also provides a new component for the preparation of polyarylester OSN membrane.