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Flavonoids from the leaves of Litsea japonica and their anti-complement activity
Lee, Sun-Young,Min, Byung-Sun,Kim, Jung-Hee,Lee, Joongku,Kim, Tae-Jin,Kim, Chan-Soo,Kim, Young-Ho,Lee, Hyeong-Kyu John Wiley Sons, Ltd. 2005 Phytotherapy research Vol.19 No.4
<P>Four flavonoids, epicatechin (1), afzelin (2), quercitrin (3), and tiliroside (4), were isolated from the leaves of Litsea japonica (Thunb.) Jussieu (Lauraceae). The structures of compounds were identified by comparing their chemical and spectral data with those previously reported. The flavonoids (1–4) were tested for their anti-complement activity against classical pathway of complement system. Compounds 2–4 showed inhibitory activity against complement system with IC<SUB>50</SUB> values of 258, 440, and 101 µm, respectively, whereas 1 was inactive. For the evaluation of the structure-activity relationship of 5,7-dihydroxyflavones, myricitrin (5) from Juglans mandshurica also tested for it's anti-complement activity and is inactive in this assay system. Furthermore, compounds 2, 3, and 5 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (5a), and these were also tested for their activity. Of the three aglycones, 2a exhibited anti-complement activity with an IC<SUB>50</SUB> value of 730 µM, while 3a and 5a were inactive. The inhibitory potencies of 2, 2a, 3, 3a, 5, and 5a against complement activity increased in inverse proportion to number of free hydroxyls on B-ring of 5,7-dihydroxyflavone. Of the compounds tested, 4 showed the most potent inhibitory activity against the complement system. Copyright © 2005 John Wiley & Sons, Ltd.</P>
Lee, Hyeong-Kyu,Oh, Sei-Ryang,Kwon, Ok-Kyoung,Ahn, Kyoung-Seop,Lee, Joongku,Kim, Jin-Cheol,Min, Byung-Sun,Joung, Hyouk Heyden & Son 2007 Phytotherapy research Vol.21 No.5
<P>A new coumarin, hydroxylomatin (1), was isolated from the CHCl<SUB>3</SUB>-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3–5) including khellactone (3). The structure of hydroxylomatin (1) was determined to be 3′&bgr;,5′-dihydroxy-3′,4′-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia. This study also examined the antitumor activity of khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice. Copyright © 2007 John Wiley & Sons, Ltd.</P>
3T3-L1 Adipocyte와 C57BL/KsJ-db/db Mice에서 KOCAT-D1의 항당뇨 활성
양지희(Ji-Hee Yang),원혜진(Hye-Jin Won),박호영(Ho-Young Park),남미현(Mi-Hyun Nam),이현순(Hyun-Sun Lee),이중구(Joongku Lee),김종탁(Jong-Tak Kim),이광원(Kwang-Won Lee) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.5
본 연구는 중국 광동지방에서 민간에서 널리 사용되는 Kocat-D1의 항당뇨 효능을 확인하기 위하여 진행하였다. Kocat-D1의 포도당 흡수능 증가 활성을 지방구세포인 3T3-L1을 이용하여 측정해본 결과, 0.2 nM 인슐린(낮은 인슐린 농도)만 투여한 대조군보다 0.2 nM 인슐린과 100℃ 열수 추출물을 0.2 ㎎/㎖의 농도로 같이 처리하였을 때 대조군보다 포도당 흡수능이 165.0±0.7%로 증가하였다. 8주령의 C57BL /KsJ-db/db mice를 정상대조군(normal control, db/+ mice 비처리군), 당뇨대조군(DM control, db/db mice 비처리군) 및 Kocat-D1군(db/db mice에 Kocat-D1 100oC 열수 추출물을 350 ㎎/㎏/day로 투여한 군)으로 나누었다. 16주간의 처리 후 체중과 식이 섭취량은 Kocat-D1군이 당뇨대조군보다 감소하였다. Kocat-D1군의 혈당은 14.7±1.4 m㏖l/ℓ였으며 당뇨대조군(27.1±0.2 m㏖l/ℓ)보다 유의적 수준으로 감소 하였다. 인슐린 농도는 Kocat-D1 투여군이 0.17±0.02 ng/㎖로 당뇨대조군의 0.05±0.02 ng/㎖보다 증가하였다. 신장의 glomeruli 부분의 collagen 축적을 확인하기 위하여 periodic acid-shiff base(PAS)로 염색한 결과 Kocat-D1에서 PAS로 염색된 collagen 부분이 감소한 것을 확인하였다. This study investigated anti-diabetic activity of Kocat-D1, which is a currently used traditional medicine for treatment of diabetes in Shandong, China. Insulin sensitizing activity was observed in a cell-based glucose uptake assay using 3T3-L1 adipocytes. The treatment of 0.2 ㎎/㎖ of hot water extract of Kocat-D1 with 0.2 nM insulin was associated with a significant increasing in glucose uptake (165.0±0.7%) over the treatment of 0.2 nM insulin. C57BL/KsJ-db/db mice (8 weeks of age) were separated into 3 groups: normal control (control, db/+ mice untreated), diabetic control (DM control, db/db mice untreated), Kocat-D1 (db/db mice treated with Kocat-D1 extract 350 ㎎/㎏/day). After 16 weeks of treatment, body weight and total diet intake of Kocat-D1 group were significantly lower than DM control groups. Blood glucose levels of the Kocat-D1 group (14.7±1.4 m㏖/ℓ) were significantly lower compared to the DM control group (27.1±0.2 m㏖/ℓ). Furthermore, insulin level was significantly increased in the Kocat-D1 group (0.17±0.02 ng/㎖) compared with the DM control group (0.05±0.02 ng/㎖). The glomeruli in kidney was stained using periodic acid-shiff base (PAS) for confirming collagen accumulation. The glomeruli in kidney of Kocat-D1 group had significantly reduced PAS-positive compared with that of DM control.
李重求,李相泰 성균관대학교 기초과학연구소 1994 論文集 Vol.45 No.2
韓國産 잔대屬 植物중 北韓種과 未確認種을 除外한 分類群에 대해 그 동안 混同되었던 種의 限界를 분명히 하기 위하여 總 11種 17分類群의 外部形態學的 特徵을 調査하여 分類學的으로 整理하고 檢索表를 作成하였고, 本 硏究에서 긴당잔대(Adenophora stricta Miq. var. lacifolia Honda)가 未記錄種으로 追加되었다. 韓國産 잔대屬 植物을 Baranov(1963)의 分類體系에 따라 分類하면 다음과 같으며 Remotiflorae節은 Ponomarchuk(1971)이 昇格處理한 結果를 따랐다 : 1) 輪生葉과 가늘고 긴 圓筒形의 蜜盤을 갖는 Platyphyllae節(층층잔대, 털잔대, 좀층층잔대, 가는 층층잔대, 넓은잔대, 외대잔대, 잔대, 왕잔대); 2) 互生葉이며 葉柄이 길고 圓筒形 蜜盤을 갖는 Remotiflorae節(모시대, 그늘모시대, 흰모시대) ; 3) 互生葉이며 葉柄이 없으며, 짧은 圓筒形이 蜜盤을 갖는 Microdiscus節(당잔대, 긴당잔대, 진퍼리잔대, 가는잎잔대); 4) 葉柄이 없는 互生葉과 圓盤型 蜜盤을 갖는 Thyrsanthae節(둥근잔대, 두메잔대). All taxa of the Korean Adenphora except North Korean and dubious ones were morphologically investigated to delimit their taxonomic position. As for 11 species and 17 taxa, a taxonomic treatment and keys to the taxa were made. Adenophora stricta Miq. var. lancifolia Honda was reported as an unrecorded taxon to Korea. According to the Baranov's system (1963) the Korean Adenophora species except Sect. Remotiflorae (Ponomarchuk, 1971) which had been treated as a series in Sect. Microdiscus by Baranov, were classified as follows: Sect. 1. Platyphyllae with whorled leaves and long-thin tubular disc: A. verticiliata, var. abbreviata, var. angustifolia, and for. hirsuta, A. divaricata var. manshurica, A. racemosa, A. triphylla var. japonica, and A. tyosenensis. Sect. 2. Remotiflorae with alternate, long-petiolate leaves and tubular disc: A. remotiflora, var. hirticalyx, and for. leucantha. Sect. 3. Microdiscus with alternate, sessile leaves and short tubular disc: A. stricta, var. lancifolia, A. palustris, and A. liliifolia. And Sect. 4. Thyrsanthae with alternate, sessile leaves and cylindrical disc: A. cornopifolia and A. lamarckii.
Phytochemical Investigation of Tiarella polyphylla
Guanghai Shen,오세량,민병선,Joongku Lee,Kyung Seop Ahn,김영호,Hyeong-Kyu Lee 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3β-hydroxy- 20(29)lupen-27-oic acid (9), β-sitosterol-3-O-β-D-glucoside (10), stigmasterol-3-O-β-D–glucoside (11), β–sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis.