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Huan, Le Cong,Tran, Phuong-Thao,Phuong, Cao Viet,Duc, Phan Huy,Anh, Duong Tien,Hai, Pham The,Huong, Le Thi Thu,Thuan, Nguyen Thi,Lee, Hye Jin,Park, Eun Jae,Kang, Jong Soon,Linh, Nguyen Phuong,Hieu, Tr Elsevier 2019 Bioorganic chemistry Vol.92 No.-
<P><B>Abstract</B></P> <P>In search for novel small molecules with antitumor cytotoxicity via activating procaspase-3, we have designed and synthesized three series of novel (E)-<I>N</I>′-benzylidene-4-oxoquinazolin-3(4<I>H</I>)-yl)acetohydrazides (<B>5a-j, 6a-h,</B> and <B>7a-h)</B>. On the phenyl ring ò the benzylidene part, three different substituents, including 2-OH-4-OCH<SUB>3</SUB>, 4-OCH<SUB>3</SUB>, and 4-N(CH<SUB>3</SUB>)<SUB>2</SUB>, were introduced, respectively. Biological evaluation showed that the acetohydrazides in series <B>5a-j</B>, in which the phenyl ring of the benzylidene part was substituted by 2-OH-4-OCH<SUB>3</SUB> substituent, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung). Most of the compounds, in this series, especially compounds <B>5c, 5b</B> and <B>5h,</B> also significantly activated caspase-3 activity. Among these, compound <B>5c</B> displayed 1.61-fold more potent than PAC-1 as caspase-3 activator. Cell cycle analysis showed that compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> significantly arrested the cell cycle in G1 phase. Further apoptotic studies also demonstrated compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> as strong apoptotic cell death inducers. The docking simulation studies showed that these compounds could activate procaspase <I>via</I> chelating Zn<SUP>2+</SUP> ion bound to the allosteric site of the zymogen.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel (<I>E</I>)-<I>N</I>′-benzylidene-2-(4-oxoquinazolin-<I>3(4H)-yl</I>)acetohydrazides were synthesized. </LI> <LI> The acetohydrazides <B>5a-i</B> exhibited potent cytotoxicity against three human cancer cell lines. </LI> <LI> A number of cytotoxic compounds exhibited good caspase activation activity. </LI> <LI> The cytotoxic compounds were shown to arrest cells at G1 phase. </LI> <LI> The cytotoxic compounds were shown as strong apoptotic inducers. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
MAI, Thi Cam Tu,NGUYEN, Hong Son,PHAN, Nguyen Ngoc Diem,LE, Minh Hang,LUU, Phuong Khanh,NGUYEN, Thi Thu Thao,NGUYEN, Thi Thu Trang Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.6
This study examines the impact of CSR and its authenticity on customer loyalty through the brand image in the chain coffee shop industry. Using qualitative and quantitative methods, 601 survey questionnaires were distributed, of which 491 were analyzed. The results show that CSR has a positive impact on brand image and customer loyalty. In addition, authenticity does not moderate the impact of CSR on brand image and loyalty, as it is difficult for customers to verify the authenticity of CSR action programs. This study emphasizes the importance of CSR action programs and authenticity for businesses to sustainably enhance their distinctive brand image and customer loyalty. Therefore, for sustainable development in the future, managers of coffee shop chains need to focus on the following issues. First, the most important thing is the right awareness of businesses regarding CSR and CSR authenticity. Third, businesses should strengthen the transparency of CSR action programs in various media so that consumers can easily verify authenticity, to increase brand image and improve customer loyalty.
Factors Affecting the Work Motivation of the Construction Project Manager
PHAN, Phuong Thanh,PHAM, Cuong Phu,TRAN, Nhu Thi Quynh,LE, Hang Thi Thu,NGUYEN, Hanh Thi Hong,NGUYEN, Quyen Le Hoang Thuy To Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12
Project manager plays a very important role in the success of any project. The primary duty of the project manager is to combine the outcomes or results of the various processes and activities of project management into a systematic project management strategy or plan for the project. In the construction industry, a lack of motivation is an urgent problem for many project managers in construction and engineering projects. Lack of motivation affects the quality and productivity of jobs, reducing profits and growth for companies, businesses, contractors or organizations that rely on human resources. The reasons for this lack of motivation are diverse ranging from salary to culture to life and working environment, among others. Through surveys and data analysis using Cronbach's Alpha reliability and EFA (Exploratory Factor Analysis), our research scaled the factors affecting work motivation of project managers in the construction industry in Vietnam. The research results identified six major groups of relevant factors including (i) salary and benefits, (ii) work environment, (iii) promotion opportunities, (iv) organizational culture, (v) interest in the job, and (vi) relationship with the organization. From there, this paper contributed useful information as well as measures for businesses, companies, contractors or organizations in the construction industry.
Relaxor Behaviors in xBaTiO₃–(1-x)CoFe₂O₄ Materials
Cao Thi My Dung,Nhu Hoa Tran Thi,Kieu Hanh Thi Ta,Vinh Cao Tran,Bao Thu Le Nguyen,Van Hieu Le,Phuong Anh Do,Anh Tuan Dang,Heongkyu Ju,Bach Thang Phan 한국자기학회 2015 Journal of Magnetics Vol.20 No.4
Dielectric properties of xBaTiO₃–(1-x)CoFe₂O₄ composite materials have been investigated. Dielectric properties of BaTiO₃, CoFe₂O₄ and 0.5BaTiO₃–0.5CoFe₂O₄ samples show frequency dependence, which is classified as relaxor behavior with different relaxing degree. The relaxor behaviors were described using the modified Curier-Weiss and Vogel–Fulcher laws. Among three above samples, the BaTiO₃ sample has highest relaxing degree. Photoluminescence spectral indicated defects, which might in turn control relaxing degree.
Loc My Thi Nguyen,Tien-Trung Nguyen,Thanh Thi Nghiem,Hien Thu Thi Le,Thao Phuong Thi Trinh,Thuan Van Pham,Thanh Chi Nguyen,Linh Khanh Hoang,Trung Tran 한국과학학술지편집인협의회 2020 Science Editing Vol.7 No.1
In the context of the need to ensure appropriate signalling of the publication of high-quality, international-calibre publications in Vietnam, as well as new policies to improve the quality and effectiveness of scientific research in Vietnam, it is practical to investigate the possibility of developing a national open access database (NOAD). This study aims to answer the question of whether it is necessary to establish a NOAD in Vietnam. We used document analysis to evaluate issues related to NOADs. The results of this study show the complexity, lack of consistency, and difficulty in obtaining practical statistics and assessing research and scientific records in Vietnam today. Furthermore, the findings of this study imply that it is necessary to establish a NOAD of scientific research in Vietnam. The information in this report can be used to develop a NOAD for Vietnam in particular, and for any country that lacks one in general.
Trung Tran,Loc Thi My Nguyen,Thanh Thi Nghiem,Hien Thi Thu Le,Cuong Huu Nguyen,Thuy Phuong La,Trung Tien Nguyen,Hang Thi-Thu Nguyen 한국과학학술지편집인협의회 2019 Science Editing Vol.6 No.2
This study aimed at elucidating the present situation of scholarly journals published in Vietnam according to the minimum criteria to be indexed in the ASEAN Citation Index (ACI) and Scopus, with the goal of suggesting development strategies for scholarly journals in Vietnam. From the 387 journals accredited by the Vietnamese State Council for Professorship, 13 education journals were arbitrarily selected, and their compliance with the five minimum criteria for the ACI (peer review, timeliness, abstracts in English, references in Roman script, and a website in English) and the six minimum criteria for Scopus (peer review, timeline, abstracts in English, references in Roman characters, Electronic International Standard Serial Number [ISSN], and publication ethics) were assessed. Two of the 13 journals were eligible to be indexed in the ACI, while none fulfilled the minimum criteria to be indexed in Scopus. An urgent task for the editors of those journals is to establish an informative journal homepage in English that provides basic information on the journal. Then, an Electronic ISSN can be obtained from the ISSN International Center. Furthermore, the following steps are suggested for journal promotion: establishment of appropriate editorial policies and publication ethics procedures, improvement of research integrity, enhancement of the journals’ reputation in the international scientific community, and improvement of the online publishing system by adopting a journal manuscript management system. To achieve those goals, financial support from the Vietnamese government will be invaluable.
Factors Influencing on Consumer's Decision on Vegetarian Diets in Vietnam
NGO, Vu Quynh Thi,VO, Thi Anh Dao,NGO, Anh Phung,NGUYEN, Do Mai Anh,LE, Minh Thu,TO, Thi Phuong Loan,NGUYEN, Thi Thuy Phi Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
Recently, vegetarian diets have experienced a dramatic increase in popularity. The aim of the study is to explore and test the relationship between the factors influencing consumers' dietary decisions in Ho Chi Minh City, Vietnam. The questionnaire applied a five-point Likert scale to investigate factors that affect Ho Chi Minh City's citizens when they have a vegetarian diet. 497 respondents (68% female; 61.2% aged 18-22; 82.7% had regular vegetarian diets) living in Ho Chi Minh City took part in both online and offline surveys. The results were processed by SPSS 22.0 software. The reliability was checked by Cronbach Alpha and Exploratory factor analysis (EFA) to identify the underlying relationships between measured variables. The Correlation analysis was implemented to show how strong and degree of two variables are related to each other before the multivariate regression equation was analyzed. The result showed the Five factors that were motivating people in Ho Chi Minh City to decide on plant-based diets, such as Animal Welfare, Health, Religion, Mood, and Reference groups. The mood is the most influential variable that significantly influences people's food choices. Attitudes toward vegetarian diets are changing. Therefore, recognizing the trends in food consumption might help companies take advantage of investment opportunities and build their marketing strategies.
LE, Hoang Ba Huyen,NGO, Chi Thanh,TRINH, Thi Thu Huyen,NGUYEN, Thi Thu Phuong Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.2
The article aims to identify the main factors affecting customers' decision to use mobile banking service in Vietnam, a case study in Thanh Hoa province. Based on theoretical frameworks of the Technology Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology (UTAUT), the study has been conducted with 370 questionnaires to consumers who have not yet used and are currently using mobile banking in Thanh Hoa province. The research results indicates that several factors have been evaluated to be more important than others, of which, the social influence is the strongest, the second is the compatibility and some others factors such as perceived ease of use, perceived trust, etc., all affecting the intention to use mobile banking in Thanh Hoa. Based on these important results, the article propose a number of recommendations: (i) Exploiting the advantages of social influence on the increase of intention to use; (ii) Increasing compatibility and minimizing costs for customers when they use Mobile Banking; (iii) Developing a strategy to increase the users' perceived ease of using banking services; (iv) Issuing a policy on increasing the security of Mobile Banking system to meet customers' needs; and (v) Developing an individual customer management system to improve service quality.
Social Capital and Migration: A Case Study of Rural Vietnam
Hong Thu NGUYEN,My Kim LE,Thi Thuy Dung NGUYEN,Vu Phuong Linh DAO,Ngoc Tien NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.1
To investigate the short-run effects of social capital on migration decisions of individuals in the rural areas of Vietnam, we conducted dataset mining and performed regression model analysis in the form of panel data. As control variables, we employed the variable of social capital, which is measured by an individual’s network, as well as demographic characteristics of individuals and households. We discovered that when a household is in financial distress, social networks such as linkages or asking for aid from others often enhance individual capacity. Individuals with a large social network outside of their immediate area are more inclined to relocate to the location where their connectors live. Individual participation and degree of participation in the organizational community, on the other hand, have little bearing on the likelihood of migration. In addition, this research examines theories and empirical research on the relationship between social capital and migration. Based on our research findings, we have recommended some measures to boost the efficiency of social capital and migration in rural areas of Vietnam through local government solutions.