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이규찬(Kyuchang Lee),김철용(Chul Yong Kim),최명선(Myung Sun Choi) 대한방사선종양학회 1994 Radiation Oncology Journal Vol.12 No.3
Purpose : In supraglottic cancer, radiation therapy is used to preserve the laryngeal function but combined surgery and radiation therapy is required in advanced stage. The authors present the results of radiation therapy alone and combined surgery plus postoperative radiation therapy for supraglottic cancer. Methods and Materials : A retrospective analysis was done for 43 patients with squamous cell carcinoma of the supraglottic larynx who were treated from Feburary 1982 to December 1991, in the Department of Radiation Oncology. Korea Universiry Hospital. Patient distribution according to the AJCC staging system was as foolows; Ⅰ, 3(7.0%); Ⅱ, 7(16.3%); Ⅲ, 17(39.5%); Ⅳ, 16(37.2%). Patients age ranged from 30 to 72 year (median 62). Follow up durations were from 21 to 137 months(median 27). Seventeen patients(39.5%) were treated by radiation therapy alone with radiation dose of 6840 7380 cGy and 26 patients(60.5%) were treated with surgery plus postoperative irradiation with doses of 5820-6660 cGy. Results : Overall five-year survival rate for all stage was 51.8%, with 100% for Stage Ⅰ and Ⅱ, 47.3% for Stage Ⅲ and 29.2% for Stage Ⅳ. The difference of the survival rate by stage was statistically significant(p=0.0152). Five-year survival rate were 100% for locally confined tumor in the supraglottic larynx, 37.5% for transglottic extension, 26.7% for hypopharynx extension, and only two of 5 patients with both transglottic and hypopharynx extension were alive(p=0.0033), Five-year survival rate by neck node status were as follows; 55.0% for NO. 64.3$ for N1, 50.0% for N2, and all 2 of N3 were died of disease. Overall survival rate for radiation therapy alone group was 42.8% and it was 56.7% for surgery plus postoperative radiation therapy group with no statistically significant difference(p=0.5215). In Stage Ⅰ and Ⅱ, all patients survived. In Stage Ⅲ and Ⅳ, 5-year survival rate for radiation therapy alone group was 28.5% and 43.4% for surgery plus postoperative irradiation group(p=0.5103). Local control rate was 58.8%(10/17) for radiation therapy alone group and 73.1%(19/26) for surgery plus postoperative irradiation group. Three patients form surgery plus postoperative radiation therapy group developed distant metastasis in lungs. Conclusion : Treatment results of radiation therapy alone was excellent in early stage supraglottic cancer. In advanced stage even the difference was statistically not significant the result of postoperative radiation therapy group was superior compared with radiation therapy alone group. Since 1992, concomitant chemoradiotherapy with hyperfractionated radiotherapy is being used to improve the result of the treatment and preserve the laryngeal function in advanced stage supraglottic cancer.
유니티 환경에서 PC 기반 노트 처리형 리듬 게임 구현
김대현(Kim Dae Hyun),남윤희(Nam Yun Hee),류준용(Ryu Jun Yong),권정현(Kwon Jeong-Hyun),강규창(Kyuchang Kang) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2
본 구현은 PC 기반 리듬 게임에 관한 것으로 Unity를 사용하여 개발되었고 4개의 라인의 상단으로부터 내려오는 노트 블록이 라인 하단의 판정선에 도달했을 때 해당하는 버튼을 누르는 방식으로 구성되는 게임이다. 최근 언택트 사회를 맞이해 실외활동이 제한되어 실내에서 활동하는 경우가 많아졌고 이로 인해 실내에서 즐길 수 있는 여가활동의 필요성이 대두되었다. 본 구현에서는 이러한 요구를 만족하는 여가활동 중 하나인 게임을 구현하였다.
S-424 Association between critical shear stress and vascular complications in type 2 diabetes
( Junho Lee ),( Hojin Kim ),( Ilrae Park ),( Choonghee Kim ),( Junsung Moon ),( Jisung Yoon ),( Kyuchang Won ),( Hyoungwoo Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
The critical shear stress (CSS) is defined as a minimum shear-stress required to disperse RBC aggregates. Increased RBC aggregation is associated with the pathogenesis of vascular disease. The objective of this study was to clarify the association CSS and diabetic microangiopathy. We conducted a cross-sectional study with 234 patients with T2DM who visited Yeungnam university hospital. Patients with end stage renal disease, malignancy and who were diagnosed diabetic ketoacidosis were excluded. CSS was measured with a Rheoscan-D (Rheo-Meditech, Seoul, Korea), a microfluidic hemorheometer. We divided the CSS into quartile (Q1,Q2,Q3, and Q4 from lowest to highest CSS). 209 patients (mean age 59.27±12.64 years, M:F=122:87) were finally included. Patients with microvascular complications had lower CSS compared with patients without any complications (CSS 287 vs. 345, p=0.002). Of them, patients with retinopathy had lower CSS compared with patients without retinopathy (CSS 281 vs. 385, p=0.00), whereas patients with nephropathy and neuropathy had no significant difference in CSS. After adjustment for age, sex, HbA1C, duration of diabetes, hemoglobin, hypertension, smoking, alcohol and lipids, higher CSS remained significantly associated with the prevalence of diabetic nephropathy (Odds ratio for Q1 compared with Q4, 12.329; 95% confidence interval, 1.882-80.775). In patients with T2DM, there were significant relationship between CSS and diabeticnephropathy. These results suggest that CSS could be a novel marker for predicting diabetic nephropathy.