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홍춘실,오경옥,이선영,차규정,김선애 충남대학교 간호과학연구소 2002 충남대 간호학술지 Vol.5 No.1
The purpose of the study was to examine the performance level of and the cognitive factors of health-promoting lifestyle in high school girls. This study was designed to provide basic data for development of nursing plan and effective intervention program for health promotion. The results were; (1) The mean score of health-promoting lifestyle profile was 2.61 (possible range 1-4) (2) Performance level of each subscale was scored as follows, interpersonal support(3.01), nutrition(2.74), self-actua!ization(2.68), stress management(2.55), health responsibility(2.35), and exercise(2.11). (3) The mean scores of the study variables (possible range 1-5) were relatively high in this sample, the mean of self-efficacy was 3.24; health locus of control was 2.97; perceived health status was 3.03. (4) The health-promoting lifestyle profile had a significant positive correlation with self-efficacy (r=.521, p<.001), health locus of control (r=.236, p<001), and perceived health status(r=.156, p<.01). The study showed the needs to intervene to improve the performance of health-promoting lifestyle of high school girls. Further study is recommended to develop and apply health improvement program especially for less performed dimensions such as exercise and health responsibility. Also, it is recommended to examine other cognitive-perceptual factors influencing health-promoting lifestyle.
Kyong Sil Park,Seon Young Hwang,Bo Youl Choi,June Kim,Sang Il Kim,Woo-Joo Kim,Chun Kang 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: As HIV/AIDS is becoming a chronic disease, the risk of developing cardiovascular disease (CVD) among people living with HIV/AIDS is rising. Anxiety and depression, which are common among people living with HIV/AIDS, have been linked with CVD. This study investigated the risk of CVD in people living with HIV/AIDS and explored the effects of depression and anxiety on CVD risk. METHODS: Data were collected for 457 people enrolled in the Korea Cohort HIV/AIDS study after 2010. Framingham risk scores were calculated to quantify the 10-year risk of developing CVD. Depression and anxiety variables were re-coded as a single combined variable. Multivariable logistic regression analysis was performed, adjusting for age, body mass index, low-density lipoprotein (LDL) cholesterol, triglycerides (TG), duration of human immunodeficiency virus (HIV) positivity after entry into the cohort, and depression/anxiety. RESULTS: Participants with both depression and anxiety were 2.28 times more likely than those with neither depression nor anxiety to have moderate/high-risk CVD risk. The 10-year risk of developing CVD was affected by LDL cholesterol, TG, age, and duration of HIV infection. LDL cholesterol and TG levels change according to the duration of HIV infection, and metabolic disorders affect the risk of CVD. Thus, a longer duration of HIV infection is associated with a higher risk of developing CVD. CONCLUSIONS: Screenings for depression and anxiety need to be provided regularly to assess the severity of those symptoms. To help decrease their risk of developing CVD, people living with HIV/AIDS should be offered behavioral modification interventions aimed at developing healthy lifestyle habits.
Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells
Kim, Min Joo,Choi, Ok Kyong,Chae, Kyung Sil,Kim, Min Kyeong,Kim, Jung Hee,Komatsu, Masaaki,Tanaka, Keiji,Lee, Hakmo,Chung, Sung Soo,Kwak, Soo Heon,Cho, Young Min,Park, Kyong Soo,Jung, Hye Seung Korean Endocrine Society 2015 Endocrinology and metabolism Vol.30 No.1
<P><B>Background</B></P><P>Damaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and the expression of mitochondrial complexes in autophagy-related 7 (<I>Atg7</I>)-deficient β-cells.</P><P><B>Methods</B></P><P>To evaluate the effect of autophagy deficiency on mitochondrial function in pancreatic β-cells, we isolated islets from <I>Atg7</I><SUP>F/F</SUP>:RIP-<I>Cre</I>+ mice and wild-type littermates. Oxygen consumption rate and intracellular adenosine 5'-triphosphate (ATP) content were measured. The expression of mitochondrial complex genes in <I>Atg7</I>-deficient islets and in β-TC6 cells transfected with si<I>Atg7</I> was measured by quantitative real-time polymerase chain reaction.</P><P><B>Results</B></P><P>Baseline oxygen consumption rate of <I>Atg7</I>-deficient islets was significantly lower than that of control islets (<I>P</I><0.05). Intracellular ATP content of <I>Atg7</I>-deficient islets during glucose stimulation was also significantly lower than that of control islets (<I>P</I><0.05). By Oxygraph-2k analysis, mitochondrial respiration in <I>Atg7</I>-deficient islets was significantly decreased overall, although state 3 respiration and responses to antimycin A were unaffected. The mRNA levels of mitochondrial complexes I, II, III, and V in <I>Atg7</I>-deficient islets were significantly lower than in control islets (<I>P</I><0.05). Down-regulation of <I>Atg7</I> in β-TC6 cells also reduced the expression of complexes I and II, with marginal significance (<I>P</I><0.1).</P><P><B>Conclusion</B></P><P>Impairment of autophagy in pancreatic β-cells suppressed the expression of some mitochondrial respiratory complexes, and may contribute to mitochondrial dysfunction. Among the complexes, I and II seem to be most vulnerable to autophagy deficiency.</P>
( Hwi Young Kim ),( Dong-ryeol Ryu ),( Tae Hun Kim ),( Kwon Yoo ),( Jin Sil Kim ),( Jeong Kyong Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Although chronic kidney disease (CKD) may develop as an extrahepatic manifestation in patients with nonalcoholic fatty liver disease (NAFLD), little is known about the clinical characteristics of NAFLD in patients with CKD. We aimed to investigate the prevalence and disease severity of NAFLD using noninvasive serum markers in patients with CKD. Methods: In this in-hospital retrospective cohort study, a total of 290 consecutive patients with CKD were enrolled between January 2015 and December 2016. Diagnostic performance of serum markers was evaluated in terms of the prediction of NAFLD on imaging studies, and disease severity was assessed using noninvasive fibrosis markers. Results: Median age was 65 years, and 186 patients were male (64.1%). Mean body mass index of all patients was 25.1 kg/m2. Median eGFR was 35.6 ml/min. Patients were categorized according to their eGFR as follows: G3a (45-59 ml/min), 79 (27.2%); G3b (30-44 ml/min), 94 (32.4%), G4 (15 - 29 ml/min), 69 (23.8%); G5 (<15 ml/min), 48 (16.6%). NAFLD was diagnosed in 54 patients (18.6%). Predictors for the presence of NAFLD from multivariate logistic regression analysis included higher BMI (odds ratio (OR), 1.120 (95% confidence interval (CI), 1.010 - 1.243; P=0.032), and higher levels of hemoglobin (OR, 1.558 (95% CI, 1.282 - 1.894); P<0.001), serum ALT level (OR, 1.029 (95% CI, 1.004 - 1.055); P=0.024), and triglycerides and glucose (TyG) index (OR, 3.134 (95% CI, 1.733 - 5.667; P<0.001). A prediction model for the presence of NAFLD was derived based on these variable; (-20.682 + 1.164 * TyG + 0.429 * hemoglobin +0.923 *Log (ALT) + 0.942 * BMI category (1 if BMI ≥25; 0 if BMI < 25), showing AUC of 0.853. In patients with NAFLD, the only predictor of higher BARD score ( >2) was TyG index (OR, 3.289 (95% CI, 1.229 - 8.801); P=0.018). Conclusions: Prevalence of NAFLD in patients with CKD was comparable to that of general population. Our model using BMI, TyG, ALT and hemoglobin accurately predicted the presence of NAFL, which requires further validation.
( Hwi Young Kim ),( Dong-ryeol Ryu ),( Hye Ah Lee ),( Jin Sil Kim ),( Jeong Kyong Lee ),( Tae Hun Kim ),( Kwon Yoo ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Data on the clinical characteristics of nonalcoholic fatty liver disease (NAFLD) in patients with chronic kidney disease (CKD) are scarce. We aimed to investigate clinical features and risk factors of NAFLD using noninvasive serum markers in patients with CKD, and attempted temporal validation. Methods: In this in-hospital retrospective cohort study, a total of 819 consecutive patients with CKD were enrolled between January 2011 and December 2016. Diagnostic performance of serum markers was evaluated in terms of the prediction of the presence of NAFLD on ultrasound, and disease severity was assessed using noninvasive fibrosis markers in the training cohort (2011-2014, n=567). Performance of noninvasive prediction for NAFLD was further assessed in the validation cohort (2015- 2016, n=252). Results: In the training cohort, NAFLD was observed in 89 patients (15.7%). Mean body mass index (BMI) was 24.6 kg/m2, and median eGFR was 28.0 ml/min. Patients were categorized according to their eGFR as follows: G3a (45-59 ml/min), 102 (18.0%); G3b (30-44 ml/min), 165 (29.1%), G4 (15-29 ml/ min), 139 (24.5%); G5 (<15 ml/min), 161 (28.4%). Predictors for the presence of NAFLD from multivariate logistic regression analysis included higher values of BMI (odds ratio (OR), 3.247; 95% confidence interval (CI), 1.849-5.703), hemoglobin (OR, 1.247; 95% CI, 1.084-1.434), serum ALT (OR, 1.644; 95% CI, 1.034-2.616), eGFR (OR, 3.538; 95% CI, 1.801-6.948), and triglycerides and glucose (TyG) index (OR, 4.903; 95% CI, 3.046-7.893).(all P<0.05) A prediction model for the presence of NAFLD was derived based on these variable; (-21.0935 + 0.2204 * hemoglobin + 1.590 * TyG + 0.4974 * Log (ALT) + 1.263 * eGFR category (3.1=1; 3.2, 4, 5 =0) + 1.1779 * BMI category (1 if BMI≥25; 0 if BMI< 25). Using the cut-off value of 0.146, AUC for the prediction of NAFLD was 0.850 (95% CI, 0.803-0.897). In patients with NAFLD, the only predictor of higher BARD score ( >2) was TyG index (OR, 3.289 (95% CI, 1.229 - 8.801); P=0.018). In the validation cohort, NAFLD was observed in 51 patients (20.2%). mean BMI was 25.4 kg/m2, and median eGFR was 36.0 ml/min. Patients were categorized according to their eGFR as follows: G3a, 70 (27.8%); G3b, 89 (35.3%), G4, 62 (24.6%); G5, 31 (12.3%). Using the same prediction model and the cut-off value, AUC=0.842. For all CKD patients with NAFLD (n=140), significant risk factors for disease severity included higher ALT (OR, 4.620; 95% CI, 2.117-10.084; P=0.001) and bilirubin (OR, 2.801; 95% CI, 1.040-7.538; P=0.042) for APRI, and higher bilirubin (OR, 2.747; 95% CI, 1.189-6.347; P=0.018) for FIB-4, respectively. Conclusions: Prevalence of NAFLD in patients with CKD was comparable to that of general population, which increased over time in our temporal validation. Our model using BMI, renal function, TyG, ALT and hemoglobin accurately predicted the presence of NAFLD, which requires further validation.