Hydrophilic Functionalization of Self-Assembled Monolayers by using UV-O₃ treatment

Kyo Keun Im,Byoung Hoon Lee,Won SamHwang,Myung Mo Sung 한국진공학회 2006 한국진공학회 학술발표회초록집 Vol.15 No.1

베타-카로틴의 면역생물학적 연구

안영근(Young Keun Ahn),구자돈(Ja Don Koo),김정훈(Joung Hoon Kim),김봉희(Bong Hee Kim),조필형(Phil Hyoung Cho),구교임(Kyo Im Koo) 대한약학회 1992 약학회지 Vol.36 No.5

Effects of beta-carotene on the immunobiological responses were studied in ICR mice. ICR male mice were divided into 8 groups (10 mice/group), and beta-carotene at doses of 4, 20 and 100mg/kg were orally administered to ICR mice once daily for 28 consecutive days. Cyclophosphamide (CY) was injected intraperitoneally (i.p.) to ICR mice with a single dose of 5mg/kg body weight at 2 days before secondary immunization. Mice were sensitized and challenged with sheep red blood cells (S-RBC). Immune responses were evaluated by humoral immunity, cellular immunity and non-specific immunity. The results of this study were summarized as follows; (1) Beta-carotene significantly increased the weight ratios of liver, spleen and thymus to body weight depending on dose, and significantly increased the increasing rate of body weight and the number of circulating leukocyte. (2) Beta-carotene dose-dependently increased hemagglutination titer, Arthus reaction and hemolytic plaque forming cell related to humoral immunity. (3) Beta-carotene significantly increased delayed-type hypersensitivity reaction and rosette forming cell related to cellular immunity. (4) Beta-carotene dose-dependently increased phagocytic activity, and significantly increased natural killer (NK) cell activity. (5) Beta-carotene dose-dependently inhibited reductions in humoral immunity, cellular immunity, NK cell activity and phagocytic activity by treatment with CY.

굴절교정수술 전후의 망막 이상과 술 전 시행한 망막 레이저 치료 빈도

김민교(Min Kyo Kim),이 훈(Hoon Lee),이형근(Hyung Keun Lee),서경률(Kyoung Yul Seo),김응권(Eung Kweon Kim),김태임(Tae Im Kim) 대한안과학회 2015 대한안과학회지 Vol.56 No.11

목적: 근시교정을 위해 다양한 각막굴절교정수술 혹은 유수정체 안내렌즈 삽입술을 시행한 환자에서 수술 전 발견한 망막 이상과 술 전 시행한 예방적 레이저 광응고술 여부, 그리고 수술 후 발생한 망막 질환의 빈도를 알아보고자 하였다. 대상과 방법: 본원에서 2005년 1월부터 2013년 6월까지 시행한 굴절교정수술 환자를 대상으로 술 전 검사에서 발견한 망막 이상의 종류와 빈도 및 이에 대해 예방적 레이저 광응고술을 시행한 비율을 조사하였으며, 수술 이후 새로이 발생한 망막 질환의 종류와 빈도를 후향적 의무기록 조사를 통해 분석하였다. 결과: 총 466명 894안(라식군 117명 225안, 라섹 및 엑시머군 231명 450안, 유수정체 안내렌즈 삽입술군 121명 219안) 중 268안 (29.98%)에서 술 전 망막 이상이 발견되었고, 이 중 144안(16.11%)에서 예방적 레이저 광응고술을 시행하였으며, 추적 관찰 기간 중 8안(라섹 및 엑시머 군 5안, 유수정체 안내렌즈 삽입술군 3안)에서 술 전에 관찰되지 않았던 망막 이상이 새로 발견되었다. 수술 전 구면렌즈 대응치와 망막 이상의 유무 간의 유의한 상관관계가 관찰되었다. 결론: 굴절교정술 환자의 대부분을 차지하는 근시 환자에서 망막 이상의 빈도는 정상안보다 높으며 수술 전 망막 레이저 치료가 필요 한 경우가 많았다. 뿐만 아니라 수술 후 추적기간 중에도 망막 이상이 발생하는 경우가 있어 이에 대한 술자와 환자 모두의 주의가 요구된다. Purpose: We investigated the incidence of retinal lesions before and after surgery and the percentage of preoperative prophy-lactic laser treatment in patients who underwent corneal refractive surgery or phakic intraocular lens implantation (pIOLi). Methods: The medical records of patients who underwent refractive surgery from January 2005 to June 2013 were reviewed retrospectively. We investigated the incidence and type of retinal lesions identified during the preoperative examination. Additionally, the percentage of preoperative prophylactic laser treatment and the incidence of postoperative newly developed retinal lesions were analyzed. Results: A total of 894 eyes of 466 subjects (laser in situ keratomileusis [LASIK] 225 eyes, 117 subjects; laser-assisted sub-epithelial keratectomy [LASEK] or photorefractive keratectomy [PRK] 450 eyes, 231 subjects; pIOLi 219 eyes, 121 subjects) were enrolled in the present study. Retinal lesions were found in 268 eyes (29.98%) and of those, 144 eyes (16.11%) received prophylactic laser treatment. Postoperative newly developed retinal lesions were detected in 8 cases (LASEK or PRK, 5 cases; pIOLi, 3 cases) during the follow-up period. There was a significant correlation between preoperative spherical equivalent and the presence of retinal lesions. Conclusions: The patient population of refractive surgery is largely myopic and thus particularly vulnerable to retinal lesions. Additionally, a considerable number of patients required preoperative prophylactic laser treatment. Therefore, both surgeons and patients should be aware of the risks of developing postoperative retinal lesions.

베타-카로틴의 면역생물학적 연구

안영근,구자돈,김정훈,김봉희,조필형,구교임 원광대학교 식품약품안전성연구소 1993 食品藥品安全性硏究 Vol.6 No.-

Effects of beta-carotene on the immunobiological responses were studied in ICR mice. ICR male mice were divided into 8 groups (10 mice/group), and beta-carotene at doses of 4, 20 and 100 ㎎/㎏ were orally administered to ICR mice once daily for 28 consecutive days. Cyclophosphamide (CY) was injected intraperitoneally (i.p.) to ICR mice with a single dose of 5 ㎎/㎏ body weight at 2 days before secondary immunization. Mice were sensitized and challenged with sheep red blood cells (S-RBC). Immune responses were evaluated by humoral immunity, cellular immunity and non-specific immunity. The results of this study were summarized as follows; (1) Beta-carotene significantly increased the weight ratios of liver, spleen and thymus to body weight depending on dose, and significantly increased the increasing rate of body weight and the number of circulating leukocyte. (2) Beta-carotene dose-dependently increased hemagglutination titer. Arthus reaction and hemolytic plaque forming cell related to humoral immunity. (3) Beta-carotene significantly increased delayed-type hypersensitivity reaction and rosette forming cell related to cellular immunity. (4) Beta-carotene dose-dependently increased phagocytic activity, and significantly increased natural killer (NK) cell activity. (5) Beta-carotene dose-dependently inhibited reductions in humoral immunity, cellular immunity, NK cell activity and phagocytic activity by treatment with CY.

베타-카로틴의 면역생물학적 연구

안영근,구자돈,김정훈,김봉희,조필형,구교임 충남대학교 약학대학 의약품개발연구소 1992 藥學論文集 Vol.8 No.-

Effects of beta-carotene on the immunobiological responses were studied in ICR mice. ICR male mice were divided into 8 groups (10 mice/group), and beta-carotene at doses of 4, 20 and 100 ㎎/㎏ were orally administered to ICR mice once daily for 28 consecutive days. Cyclophosphamide (CY) was injected intraperitoneally (i.p.) to ICR mice with a single dose of 5 ㎎/㎏ body weight at 2 days before secondary immunization. Mice were sensitized and challenged with sheep red blood cells (S-RBC). Immune responses were evaluated by humoral immunity, cellular immunity and non-specific immunity. The results of this study were summarized as follows; (1) Beta-carotene significantly increased the weight ratios of liver, spleen and thymus to body weight depending on dose, and significantly increased the increasing rate of body weight and the number of circulating leukocyte. (2) Beta-carotene dose-dependently increased hemagglutination titer, Arthus reaction and hemolytic plaque forming cell related to humoral immunity. (3)Beta-carotene significantly increased delayed-type hypersensitivity reaction and rosette forming cell relatted to cellular immunity. (4) Beta-carotene dose-dependently increased phagocytic activity, and significantly increased natural killer (NK) cell activity. (5) Beta-carotene dose-dependently inhibited reductions in humoral immunity, cellular immunity, NK cell activity and phagocytic activity by treatment with CY.

Fabrication of SAMs/TiO₂ Hybrid Thin Films by Using Molecular Layer Deposition as the New Method

Byoung Hoon Lee,Kyo Keun Im,Jae Kwon Hwang,Myung Mo Sung 한국진공학회 2006 한국진공학회 학술발표회초록집 Vol.15 No.1

치면열구전색재와 충전재료에 대한 우식유발 세균의 부착특성 비교

강재민(Jae-Min Kang),임상욱(Sang-Uk Im),조화영(Jae-Min Kang),마재경(Jae-Kyung Ma),김정숙(Jeong-Sook Kim),김교한(Kyo-Han Kim),송근배(Keun-Bae Song),최연희(Youn-Hee Choi) 대한치과재료학회 2015 대한치과재료학회지 Vol.42 No.3

Streptococcus mutans (S. mutans) is most commonly founded Mutans Streptococci group in human oral cavity. This study aimed to compare the adhesion ability of Xylitol-sensitive (Xs) and Xylitol-resistant (Xr) on three filling materials which are currently used by dentists. Hydroxyapatite (HA) disk (control group, n=36), sealant (n=36), resin (n=36), glass-ionomer (n=36) disks were made by mold (10.2 mm Ø, 3 mm hight). Xs and Xr of S. mutans KCTC3065 and S. mutans UA159 were formed and cultured in TYE media. After culture, 500 ㎕ of 0.01% crystal violet was added to the plate, dyeing was performing, and mixed 1 ㎖ solution of ethanol:acetone (4:1 w/w) for reaction termination. The absorbance of the extracted solution was measured by using ELISA reader and the extracted solution on disk was observed with SEM. The adhesion ability was calculated by ELISA reader. Adhesion ability of Xs and Xr from S. mutans of resin was higher than those of HA disk and the adhesion ability of sealant was lower compared to those of HA disk. Sealant had the lowest adhesion ability of dental caries-inducing bacteria among three filling materials when viewed in terms of relevance of the material and decay-inducing bacteria in oral cavity.

‘Hongju’: A Seedless Table Grape Cultivar

Roh, Jeong Ho,Hur, Youn Young,Jung, Sung Min,Park, Kyo Sun,Yun, Hae Keun,Nam, Jong Chul,Hwang, Hae Sung,Im, Dong Jun,Chung, Kyong Ho American Society for Horticultural Science 2018 HortScience Vol.53 No.12