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Kyeong Seop Kim,Tae Ha Kim,Mi Ae Kim,Jae Won Kim,Han Kyu Lim,Jung Sick Lee,Young Chang Sohn 한국발생생물학회 2017 한국발생생물학회 학술발표대회 Vol.2017 No.8
Gonadotropin-releasing hormone (GnRH) is a key neuropeptide regulating reproduction in humans and other vertebrates. Here, we evaluated the reproductive control system mediated by GnRH in the Pacific abalone Haliotis discus hannai. We cloned a prepro-GnRH cDNA (Hdh-GnRH) from the pleural-pedal ganglion (PPG) in H. discus hannai, and analyzed its spatiotemporal gene expression pattern. The open reading frame of Hdh-GnRH encodes a protein of 101 amino acids, consisting of a signal peptide, a GnRH dodecapeptide, a cleavage site, and a GnRH-associated peptide. This structure and sequence are highly similar to GnRH-like peptides reported for mollusks and other invertebrates. Quantitative polymerase chain reaction demonstrated that Hdh-GnRH mRNA was more strongly expressed in the ganglions (PPG and cerebral ganglion [CG]) than in other tissues (gonads, gills, intestine, hemocytes, muscle, and mantle) in both sexes. In females, the expression levels of Hdh-GnRH mRNA in the PPG and branchial ganglion (BG) were significantly higher at the ripe and partial spent stages than at the early and late active stages. In males, Hdh-GnRH mRNA levels in the BG showed a significant increase in the partial spent stage. Unexpectedly, Hdh-GnRH levels in the CG were not significantly different among the examined stages in both sexes. These results suggest that Hdh-GnRH mRNA expression profiles in the BG and possibly the PPG are tightly correlated with abalone reproductive activities.
Vitamin D status and associated metabolic factors in North Korea refugees in South Korea
( Kyeong Jin Kim ),( Nam Hoon Kim ),( Sin Gun Kim ),( Hee Young Kim ),( Yoon Jung Kim ),( Dong Seop. Choi ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
Background/Aims: Vitamin D deficiency defined as serum 25(OH)D level less than 20 ng/ml has been a major health problem in modern society regardless of age, sex, ethnicity, and region especially for immigrant populations. The purpose of this study is to investigate the vitamin D status and the prevalence of vitamin D insufficiency in North Korea Refugees living in South Korea, and also identify the associated factors of vitamin D insufficiency, and the relationship between metabolic syndrome and vitamin D insufficiency in this group. Methods: This study is based on the data from NORNS (North Korea refugee health iN South Korea). A total of 647 NKRs voluntarily took part in the survey and data was collected from October 2008 to November 2011 once a month at the Korea University Anam Hospital in Seoul. They were initially interviewed about general demographic information and a medical check-up consisting of anthropometric and various biochemical measurement was conducted. Among the 647 subjects, only 386 subjects were measured serum 25(OH)D level. Results: Among a total of 386 subjects, vitamin D insufficiency was found in 76.8% of male and 89.8% in females, whereas there is no one who have serum 25(OH)D level higher than 30 ng/ml in both sexes. The associated risk factors of vitamin D insufficiency were female, winter, smoking history and high systolic blood pressure. We found out the relationship between BMI and serum 25(OH)D level, underweight subjects with BMI below 20 kg/m2 had significantly lower serum 25(OH)D level compared with normal BMI (20 to 23 kg/m2) subjects. Controlling for age, sex, season, length of residence in South Korea, physical activities, the odd ratio of metabolic syndrome in subjects of serum 25(OH)D level below 10 ng/mL was 7.6 times higher compared with those of above 20 ng/ml (OR=7.6; 95% CI=1.63-35.8). Conclusions: The prevalence of vitamin D insufficiency is significantly high in North Korea refugees. The associated factors of vitamin D insufficiency are female, winter, smoking history. Vitamin D insufficiency is not related with obesity like previous studies but seem to be related with metabolic syndrome.
Assessment of Premature Ventricular Contraction Arrhythmia by K-means Clustering Algorithm
Kyeong-Seop Kim(김경섭) 한국컴퓨터정보학회 2017 韓國컴퓨터情報學會論文誌 Vol.22 No.5
Premature Ventricular Contraction(PVC) arrhythmia is most common abnormal-heart rhythm that may increase mortal risk of a cardiac patient. Thus, it is very important issue to identify the specular portraits of PVC pattern especially from the patient. In this paper, we propose a new method to extract the characteristics of PVC pattern by applying K-means machine learning algorithm on Heart Rate Variability depicted in Poinecare plot. For the quantitative analysis to distinguish the trend of cluster patterns between normal sinus rhythm and PVC beat, the Euclidean distance measure was sought between the clusters. Experimental simulations on MIT-BIH arrhythmia database draw the fact that the distance measure on the cluster is valid for differentiating the pattern-traits of PVC beats. Therefore, we proposed a method that can offer the simple remedy to identify the attributes of PVC beats in terms of K-means clusters especially in the long-period Electrocardiogram(ECG).
Kim, Tae Ha,Kim, Mi Ae,Kim, Kyeong Seop,Kim, Jae Won,Lim, Han Kyu,Lee, Jung Sick,Sohn, Young Chang Elsevier 2017 Comparative biochemistry and physiology. Part A, M Vol.209 No.-
<P><B>Abstract</B></P> <P>Gonadotropin-releasing hormone (GnRH) is a key neuropeptide regulating reproduction in humans and other vertebrates. Recently, GnRH-like cDNAs and peptides were reported in marine mollusks, implying that GnRH-mediated reproduction is an ancient neuroendocrine system that arose prior to the divergence of protostomes and deuterostomes. Here, we evaluated the reproductive control system mediated by GnRH in the Pacific abalone <I>Haliotis discus hannai</I>. We cloned a prepro-GnRH cDNA (<I>Hdh-GnRH</I>) from the pleural-pedal ganglion (PPG) in <I>H. discus hannai</I>, and analyzed its spatiotemporal gene expression pattern. The open reading frame of <I>Hdh-GnRH</I> encodes a protein of 101 amino acids, consisting of a signal peptide, a GnRH dodecapeptide, a cleavage site, and a GnRH-associated peptide. This structure and sequence are highly similar to GnRH-like peptides reported for mollusks and other invertebrates. Quantitative polymerase chain reaction demonstrated that <I>Hdh-GnRH</I> mRNA was more strongly expressed in the ganglions (PPG and cerebral ganglion [CG]) than in other tissues (gonads, gills, intestine, hemocytes, muscle, and mantle) in both sexes. In females, the expression levels of <I>Hdh-GnRH</I> mRNA in the PPG and branchial ganglion (BG) were significantly higher at the ripe and partial spent stages than at the early and late active stages. In males, <I>Hdh-GnRH</I> mRNA levels in the BG showed a significant increase in the partial spent stage. Unexpectedly, <I>Hdh-GnRH</I> levels in the CG were not significantly different among the examined stages in both sexes. These results suggest that <I>Hdh-GnRH</I> mRNA expression profiles in the BG and possibly the PPG are tightly correlated with abalone reproductive activities.</P>
Kim, Kyeong Seop,Kim, Tae Ha,Kim, Mi Ae,Lee, Jung Sick,Sohn, Young Chang Elsevier 2018 Comparative biochemistry and physiology. Part A, M Vol.222 No.-
<P><B>Abstract</B></P> <P>Neuropeptides in the central nervous system regulate reproductive activities in vertebrates. Ala-Pro-Gly-Trp-NH<SUB>2</SUB> (APGWamide), a neuromediator expressed in the neural ganglia of mollusks, controls sexual maturation and reproduction. To clarify the role of APGWamide in sexual behavior regulation and gamete cell maturation in mollusks, we cloned the cDNA of APGWamide precursor (<B> <I>Hdh</I> </B>-<B> <I>APGWamide</I> </B>) and examined the spatiotemporal expression of the transcript in the Pacific abalone <I>Haliotis discus hannai</I>. The 222-amino acid sequence of the precursor deduced from the cDNA sequence showed typical features of gastropod APGWamide precursors. Phylogenetic analysis revealed that Hdh-APGWamide is classified with other gastropod APGWamide precursors, which form a separate branch from those of the bivalves. <I>Hdh</I>-<I>APGWamide</I> mRNA was highly expressed in the neural ganglia in both sexes. In females, the three ganglia (pleuro-pedal ganglion, PPG; branchial ganglion, and cerebral ganglion) showed similar expression in immature and mature animals, whereas in males, the level in the PPG only was higher at maturity (P < 0.05). In vivo injection of APGWamide or 5-hydroxytryptamine (10<SUP>−3</SUP> M) increased the frequency of spawning and the number of released sperm cells by mature males (P < 0.05), while concentrations above 10<SUP>−7</SUP> M enhanced germinal vesicle breakdown in fully developed cultured oocytes (P < 0.05). Thus, the phylogenetic branch of the APGWamide precursor gene in Haliotidae was separate from the other branches under the phylum Mollusca, and this gene exhibited ganglion-specific expression, indicating that it may induce final maturation and spawning in both sexes of <I>Haliotis</I> spp.</P>