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Genetic structure and variability of the working dog inferred from microsatellite marker analysis
Kwon, Yun-Jeong,Choi, Bong-Hwan,Eo, Jungwoo,Kim, Choongrak,Jung, Yi-Deun,Lee, Ja-Rang,Choi, Yuri,Gim, Jeong-An,Lee, Dong-Hoon,Ha, Ji-Hong,Kim, Dae-Soo,Huh, Jae-Won,Kim, Tae-Hun,Seong, Hwan-Hoo,Kim, He Springer-Verlag 2014 Genes & Genomics Vol.36 No.2
Working dogs serve as military watch dogs, search dogs, rescue dogs, and guide dogs with un-come-at-able character. They are drafted by in-training examination including concentration, capacity for locomotion, boldness and earthly desires. In this study, genetic diversity and relationships among two groups of working dogs (pass and fail group in-training examination) were assessed based on 15 microsatellite markers in 25 individuals of working dogs (military watch dogs and Korean search dogs). For the 15 microsatellite markers, the values of allelic richness (A (R) ) ranged from 2.21 (pass group) to 1.60 (fail group) in military watch dogs, while A (R) ranged from 2.79 (pass group) to 2.72 (fail group) in Korean search dogs. Among 52 different alleles of military watch dogs, 22 alleles were detected in pass group only, while 8 alleles in fail group only. In case of Korean search dogs, 3 alleles were observed in pass group only, while 13 alleles in fail group only. These group-specific unique alleles reflect good biomarker for selecting working dogs (military watch dogs and Korean search dogs), indicating that those group specific microsatellite alleles could separate working dogs to be pass or fail group in out-training dog population. Taken together, this study demonstrates the feasibility of microsatellite analyses for the selection of superior working dogs objectively. Furthermore, this approach could be used for the proper selection of working dogs in combination with in-training examination.
Transduced PEP-1-Grb7 Fusion Protein Suppressed LPS-induced COX-2 Expression
An, Jae-Jin,Kim, So-Young,Lee, Sun-Hwa,Kim, Dae-Won,Ryu, Hea-Jin,Yeo, Seung-Il,Jang, Sang-Ho,Kwon, Hyung-Joo,Kim, Tae-Yoon,Lee, Sang-Chul,Poo, Ha-Ryoung,Cho, Sung-Woo,Lee, Kil-Soo,Park, Jin-Seu,Eum, W Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.2
Although the incidence and severity of atopic dermatitis (AD) is steadily increasing at an alarming rate, its pathogenic mechanisms remain poorly understood yet. Recently, we found that the expression of Grb7 protein was markedly decreased in AD patients using proteomic analysis. In the present study, human Grb7 gene was fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-Grb7 fusion protein. The expressed and purified PEP-1-Grb7 fusion proteins transduced efficiently into skin cells in a time- and dose-dependent manner when added exogenously in culture media. Once inside the cells, the transduced PEP-1-Grb7 protein was stable for 48 h. In addition, transduced PEP-1-Grb7 fusion protein markedly increased cell viability in macrophage RAW 264.7 cells treated with LPS by inhibition of the COX-2 expression level. These results suggest that the PEP-1-Grb7 fusion protein can be used in protein therapy for inflammatory skin disorders, including AD.
Gestational Diabetes Affects the Growth and Functions of Perivascular Stem Cells
An, Borim,Kim, Eunbi,Song, Haengseok,Ha, Kwon-Soo,Han, Eun-Taek,Park, Won Sun,Ahn, Tae Gyu,Yang, Se-Ran,Na, Sunghun,Hong, Seok-Ho Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.6
Gestational diabetes mellitus (GDM), one of the common metabolic disorders of pregnancy, leads to functional alterations in various cells including stem cells as well as some abnormalities in fetal development. Perivascular stem cells (PVCs) have gained more attention in recent years, for the treatment of various diseases. However, the effect of GDM on PVC function has not been investigated. In our study, we isolated PVCs from umbilical cord of normal pregnant women and GDM patients and compared their phenotypes and function. There is no significant difference in phenotypic expression, response to bFGF exposure and adipogenic differentiation capacity between normal (N)-PVCs and GDM-PVCs. However, when compared with N-PVCs, early passage GDM-PVCs displayed decreased initial rates of cell yield and proliferation as well as a reduced ability to promote wound closure. These results suggest that maternal metabolic dysregulation during gestation can alter the function of endogenous multipotent stem cells, which may impact their therapeutic effectiveness.
An, Jun-Won,Kim, Nam,Lee, Kwon-Yeon,Gil, Sang-Keun Optical Society of Korea 2002 Journal of the optical society of Korea Vol.6 No.4
A 42 channel demultiplexer for dense wavelength division multiplexing(WDM) using photopoly-mer volumetric diffraction grating that has excellent optical properties and low cost capability, has been designed and optically demonstrated. From the experimental results, we have obtained the 3 dB bandwidth of 0.18 nm, crosstalk suppression of 20 dB and channel uniformity of 1.6 dB for 50 GHB channel spacing.
Performance Optimization Study of FinFETs Considering Parasitic Capacitance and Resistance
An, TaeYoon,Choe, KyeongKeun,Kwon, Kee-Won,Kim, SoYoung The Institute of Electronics and Information Engin 2014 Journal of semiconductor technology and science Vol.14 No.5
Recently, the first generation of mass production of FinFET-based microprocessors has begun, and scaling of FinFET transistors is ongoing. Traditional capacitance and resistance models cannot be applied to nonplanar-gate transistors like FinFETs. Although scaling of nanoscale FinFETs may alleviate electrostatic limitations, parasitic capacitances and resistances increase owing to the increasing proximity of the source/drain (S/D) region and metal contact. In this paper, we develop analytical models of parasitic components of FinFETs that employ the raised source/drain structure and metal contact. The accuracy of the proposed model is verified with the results of a 3-D field solver, Raphael. We also investigate the effects of layout changes on the parasitic components and the current-gain cutoff frequency ($f_T$). The optimal FinFET layout design for RF performance is predicted using the proposed analytical models. The proposed analytical model can be implemented as a compact model for accurate circuit simulations.
An, Jae jin,Lee, Yeom pyo,Kim, So young,Lee, Sun hwa,Kim, Dae won,Lee, Min jung,Jeong, Min seop,Jang, Sang ho,Kang, Jung hoon,Kwon, Hyeok yil,Kang, Tae cheon,Won, Moo ho,Cho, Sung woo,Kwon, Oh shin,Le Korean Society for Molecular Biology 2008 Molecules and cells Vol.25 No.1
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the selective death of motor neurons. Mutations in the SOD1 gene are responsible for a familial form of ALS (FALS). Although many studies suggest that mutant SOD1 proteins are cytotoxic, the mechanism is not fully understood. To investigate the role of mutant SOD1 in FALS, human SOD1 genes were fused with a PEP-1 peptide in a bacterial expression vector to produce in-frame PEP-1-SOD fusion proteins (wild type and mutants). The expressed and purified PEP-1-SOD fusion proteins were efficiently transduced into neuronal cells. Neurones harboring the A4V, G93A, G85R, and D90A mutants of PEP-1-SOD were more vulnerable to oxidative stress induced by paraquat than those harboring wild-type proteins. Moreover, neurones harboring the mutant SOD proteins had lower heat shock protein (Hsp) expression levels than those harboring wild-type SOD. The effects of the transduced SOD1 fusion proteins may provide an explanation for the association of SOD1 with FALS, and Hsps could be candidate agents for the treatment of ALS.