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Elahi, Elahe,Kumm, Jochen,Ronaghi, Mostafa Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.1
The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to be most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.
Elahi, Elahe,Kumm, Jochen,Ronaghi, Mostafa 한국생화학분자생물학회 2004 BMB Reports Vol.37 No.1
The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to he most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.
Final report on force key comparison CCM.F-K2.a and CCM.F-K2.b (50 kN and 100 kN)
Vincke, William,Zhimin, Zhang,Pusa, Aimo,Averlant, Philippe,Kumme, Rolf,Germak, Alessandro,Ueda, Kazunaga,Park, Yon-Kyu,Torres, Jorge,Burke, Ben,Langmead, Fredrik,Fank, Sinan,Knott, Andy,Bartel, Tom Springer-Verlag 2012 METROLOGIA -BERLIN- Vol.49 No.-
<P>This report describes CIPM key comparison CCM.F-K2, a comparison between the deadweight force standard machines of fourteen National Measurement Institutes, at generated forces of 50 kN and 100 kN, in the period from 2004 to 2007. Two different measurement schemes were employed, one for machines capable of generating both 50 kN and 100 kN and the other using the single force of 50 kN, for machines of a lower maximum capacity than 100 kN. Multiple transducers were used and the force–time profile was strictly controlled, to minimize effects of creep. Analysis of the results took careful account of the drift of the transducers' sensitivities throughout the comparison period, as this was one of the major uncertainty contributions. The final results suggest that the nominal 50 kN forces generated at four of the fourteen laboratories (and the 100 kN forces at two of them) may be statistically significantly different from the same nominal forces generated at the other laboratories.</P><P>Main text.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.</P><P>The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</P>