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      • KCI등재

        Influence of Blanching and Drying Air Temperature on Drying Kinetics of Banana Slices

        Kumar Ravi,Pandey Om Prakash,Dhiman Sushil Kumar,Kumar Prashant 한국농업기계학회 2021 바이오시스템공학 Vol.46 No.4

        Purpose Drying of agro products, analternative approach to truncate the post harvesting losses which is about 40%in case of banana as reported in literatures, is conducted for banana slicesusing tray dryer. The objective was to investigate the effect of blanching and dryingtemperature on drying kinetics of banana slices for which a comparative studyof the drying kinetics of the bananaslices under blanching and without blanching conditions was conducted. Methods The samples were made circularin shape with average diameter of 30mm and 2mm thickness. Drying was done atair velocity of 3ms-1 maintained at three different temperatures of60oC, 70oC and 80oC. Blanching of banana sliceswas done in an aqueous solution of citricacid for 1 minute. Results Comprison of blanching andwithout blancing samples was done based on drying kinetics, color, energy analysis, andcost analysis to optimize the drying conditions and reduce the process cost.Two thin layer drying models werefitted to the experimental data using nonlinear regression analysis and theresults were evaluated using statistical parameter. The significant effects ofdrying temperature, drying time and blanching on moisture content of bananaslices were analyzed by ANOVA (Analysis of Variance). Conclusions The blanchingtechnique was found as cost-effective dryingprocess as compared to the without blanching technique.

      • p16 Expression as a Surrogate Marker for HPV Infection in Esophageal Squamous Cell Carcinoma can Predict Response to Neo-Adjuvant Chemotherapy

        Kumar, Rajeev,Ghosh, Sankar Kumar,Verma, Akalesh Kumar,Talukdar, Anuradha,Deka, Monoj Kumar,Wagh, Mira,Bahar, H.M. Iqbal,Tapkire, Ritesh,Chakraborty, Kali Pankaj,Kannan, R. Ravi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

        Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. Materials and Methods: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry. All patients received neo-adjuvant chemotherapy. Response was assessed clinically and histopathologically with attention to p16 expression. Results: p16 was expressed in 22% of ESCC (22 out of 101) and was more prevalent in patients who were more than 45 years of age (P=0.048). p16 positive tumors appeared more commonly in the upper 2/3 of the thoracic esophagus (18 in 22). Nine of the 22 (41%) p16 positive tumors achieved pathologic complete response following neo-adjuvant chemotherapy (P=0.008). There was a trend towards reduced mortality in this group (P=0.048). Some 9 of the 20 (45%) patients who achieved pathologic complete response were p16 positive. Conclusions: Expression of p16 in ESCC correlates with higher rate of pathologic complete remission in patients undergoing neo adjuvant chemotherapy and could be a predictive marker for response assessment.

      • KCI등재

        Design, Synthesis, In Silico Screening, and Antiproliferative Activity of Novel 1,2,3-Triazole Tethered Dibenzosuberane Conjugates

        Ravi Kant,Keshav Kumar Saini,Ravindra Kumar Upadhyay,Yogender Singh,Y. Veera Manohara Reddy,Shishu Pal Singh,M. Abdul Kareem,K. R. Dasegowda,H. Prabhavati,Rakesh Kumar,박종필,Lalita S. Kumar 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.5

        To explore novel and potent compounds with anticancer activity, two series of 1H-1,2,3-triazole tethered dibenzosuberane conjugates (5a-i and 5j-n) were synthesized using a linear and convergent approach. The synthesized novel compounds were screened for their in vitro antiproliferative activity against HepG2 cell lines using the MTT assay to explore their binding interactions with the 5EQG protein. IC50 values revealed that the most active combination against HepG2 cell lines was triazole tethered with an ortho chloro-substituted aryl ring (5g) (IC50: 99.64 μg/mL). The other compounds in the series exhibited comparable cytotoxic activities against HepG2 cell lines. The results were substantiated by molecular docking studies. The majority of the compounds demonstrated high binding affinity for the active site of the targeted protein. In addition, in silico drug-likeness prediction by the ADMET method has been explored with these compounds. All synthesized novel derivatives were characterized by mass spectrometry, infrared spectroscopy, 1H-nuclear magnetic resonance (NMR) spectroscopy, and 13C-NMR spectroscopy.

      • KCI등재

        Blunt Trauma Pancreas in Children: Is Non-Operative Management Appropriate for All Grades?

        Ravi Kumar Garg,Jai Kumar Mahajan 대한소아소화기영양학회 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.4

        Purpose: Blunt trauma of pancreas in children is uncommon and its management varies from observational to early operative intervention. We analysed the feasibility and outcome of non-operative management in all grades of paedi-atric pancreatic injuries.Methods: A total of 15 patients of pancreatic trauma seen in a Paediatric Surgery Unit were retrospectively analyzed.Results: Age of the patients ranged from 3-11 years (mean, 7.7 years). The mode of injury was local trauma in 9 children. Only 3 patients had associated injuries and all were haemodynamically stable. Serum amylase levels were raised in 12 patients at admission which ranged from 400-1,000 IU. Computed tomography scan made a correct diagnosis in 14 patients. Grades of the injury varied from grade I-V (1, 3, 6, 4, 1 patients respectively). Fourteen patients were managed conservatively. One patient underwent laparotomy for suspected superior mesenteric hematoma. The aver-age duration of enteral feeds was 3.7 days and of hospital stay was 9.4 days. Six patients formed pancreatic pseudo-cysts; two were managed conservatively while the other four underwent cystogastrostomy. The patients were followed up for a period of 1-12 years. All remained asymptomatic and none had exocrine or endocrine deficiencies.Conclusion: Non-operative treatment for isolated blunt trauma of pancreas in children may be safely followed for all the grades of injury; if associated injuries requiring surgical intervention are ruled out with a good quality imaging and the patients are hemodynamically stable. It did not increase the hospital stay and morbidity and avoided operative intervention on acutely injured pancreas.

      • Promising wet chemical strategies to synthesize Cu nanowires for emerging electronic applications.

        Ravi Kumar, D V,Woo, Kyoohee,Moon, Jooho RSC Pub 2015 Nanoscale Vol.7 No.41

        <P>Copper nanowires (Cu NWs) are of particular interest for application as transparent and flexible conducting electrodes in 'see-through' and/or 'deformable' future electronics due to their excellent electrical, optical, and mechanical properties. It is necessary to develop reliable and facile methods to produce well-defined Cu NWs prior to their full exploitation. Among the wide variety of methods available to generate Cu NWs, solution-based synthesis routes are considered to be a promising strategy because of several advantages including fewer constraints on the selection of precursors, the solvent and reaction conditions, and the feasibility of large-scale low-cost production. Here, we provide a thorough review of various recently developed synthetic methodologies to obtain Cu NWs, with particular emphasis on wet chemical synthesis approaches including a hydrothermal route, reduction of metal precursors, and catalytic synthesis. The emerging applications of Cu NWs including transparent electrodes and flexible/stretchable electronics are also discussed, followed by brief comments on the remaining challenges and future research perspectives.</P>

      • Co-integration and Causality Analysis among Major Black gram Markets in Andhra Pradesh, India

        Kumar, K. Nirmal Ravi Korean Society of Food and Agricultural Informatio 2021 Agribusiness and Information Management Vol.12 No.2

        Market integration and prices in pulse crops like black gram play an important role in determining the production decisions of the farmers and diversification towards high value nutritious crops. In this context, the present study explores extent of market integration and price transmission in selected major black gram markets in Andhra Pradesh using Johansen co-integration, Vector Error Correction Model and Granger causality test. The study used monthly prices data of black gram (Rs/quintal) sourced from selected markets of Srikakulam, Krishna and Kurnool spanning January, 1990 to December, 2019. The results of the study strongly buttressed the existence of co-integration and interdependence of selected black gram markets in Andhra Pradesh. However, the speed of adjustment of the prices found to be moderate in Krishna market and quite weaker in Srikakulam market and thereby prices correct a small percentage of the disequilibrium in these markets with the greatest percentage by the external and internal forces. So, it necessitates the need for future research, to investigate the influence of external and internal factors such as market infrastructure, Government policy and self-sufficient production, product characteristics and utilization towards market integration. As there exists only unidirectional causality from Krishna to Kurnool and from Krishna to Srikakulam markets, it calls for strengthening the information technology for flow of market information regularly to help the farmers for increasing their income.

      • KCI등재

        Giant Duplication Cyst Presenting as a Discharging Umbilicus

        Ravi Kumar Garg,Monika Bawa,Katragadda Lakshmi Narasimha Rao 대한소아소화기영양학회 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.3

        Alimentary tract duplication cysts are rare congenital anomalies, most commonly located in the ileum, but may present anywhere from mouth to anus.Clinically, they may be asymptomatic, incidentally diagnosed or may present with ob-struction, volvulus, intussusception or gastrointestinal bleed. Here we report a case of a one year old male child present-ing in gasping state and shock. Despite the initial strong suspicion of Meckel’s diverticulum and tubercular abdomen, the final diagnosis remained elusive till exploratory laparotomy was performed which revealed a duplication cyst of ileum with perforation into the umbilicus. Duplication cyst should always be kept as a differential diagnosis so that early intervention can help in better management.

      • KCI등재

        Submental intubation: alternative short-term airway management in maxillofacial trauma

        Ravi Raja Kumar,Suresh Vyloppilli,Shermil Sayd,Annamala Thangavelu,Benny Joseph,Auswaf Ahsan 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.42 No.3

        Objectives: To assess submental route intubation as an alternative technique to a tracheostomy in the management of the airway in cranio-maxillofacial trauma, along with an assessment of its morbidity and complications. Materials and Methods: Submental intubation was performed in 17 patients who had maxillofacial panfacial trauma and management was done under general anesthesia during a period of one year from 2013 to 2014 at Departments of Oral and Maxillofacial Surgery and Dentistry, the Malankara Orthodox Syrian Church Medical College, Kochi, India. Results: In all 17 cases, the technique of submental intubation was found to be simple and reliable. Hypertrophic scars were noted in three cases, orocutaneous fistula and mucocele in one case each. All these complications were managed comfortably without significant morbidity to the patient. Conclusion: Submental intubation is a good technique that can be used regularly in the management of the airway in cranio-maxillofacial trauma, but with some manageable complications.

      • KCI등재

        FALLING FUZZY FILTERS IN BE-ALGEBRAS

        Ravi Kumar Bandaru,N. Rafi,Bijan Davvaz 충청수학회 2017 충청수학회지 Vol.30 No.2

        The notion of falling fuzzy filters of a BE-algebra is introduced based on the theory of falling shadows and fuzzy sets. Relation between fuzzy filters and falling fuzzy filters are presumed and characterized them interms of subsets of a sample space.

      • Opportunities for Agricultural Water Management Interventions in the Krishna Western Delta - A case from Andhra Pradesh, India

        Kumar, K. Nirmal Ravi Korean Society of Food and Agricultural Informatio 2017 Agribusiness and Information Management Vol.9 No.1

        Agricultural water management has gained enormous attention in the developing world to alleviate poverty, reduce hunger and conserve ecosystems in small-scale production systems of resource-poor farmers. The story of food security in the $21^{st}$ century in India is likely t o be closely linked to the story of water security. Today, the water resource is under severe threat. The past experiences in India in general and in Andhra Pradesh in particular, indicated inappropriate management of irrigation has led to severe problems like excessive water depletion, reduction in water quality, water logging, salinization, marked reduction in the annual discharge of some of the rivers, lowering of ground water tables due to pumping at unsustainable rates, intrusion of salt water in some coastal areas etc. Considering the importance of irrigation water resource efficiency, Krishna Western Delta (KWD) of Andhra Pradesh was purposively selected for this in depth study, as the farming community in this area are severely affected due to severe soil salinity and water logging problems and hence, adoption of different water saving crop production technologies deserve special mention. It is quite disappointing that, canals, tube wells and filter points and other wells could not contribute much to the irrigated area in KWD. Due to less contribution from these sources, the net area irrigated also showed declining growth at a rate of -6.15 per cent. Regarding paddy production, both SRI and semi-dry cultivation technologies involves less irrigation cost (Rs. 2475.21/ha and Rs. 3248.15/ha respectively) when compared to transplanted technology (Rs. 4321.58/ha). The share of irrigation cost in Total Operational Cost (TOC) was highest for transplanted technology of paddy (11.06%) followed by semi-dry technology (10.85%) and SRI technology (6.21%). The increased yield and declined cost of cultivation of paddy in SRI and semi-dry production technologies respectively were mainly responsible for the low cost of production of paddy in SRI (Rs. 495.22/qtl) and semi-dry (Rs. 532.81/qtl) technologies over transplanted technology (Rs. 574.93/qtl). This clearly indicates that, by less water usage, paddy returns can be boosted by adopting SRI and semi-dry production technologies. Both the system-level and field-level interventions should be addressed to solve the issues/problems of water management. The enabling environment, institutional roles and functions and management instruments are posing favourable picture for executing the water management interventions in the State of Andhra Pradesh in general and in KWD in particular. This facilitates the farming community to harvest good crop per unit of water resource used in the production programme. To achieve better results, the Farmers' Organizations, Water Users Associations, Department of Irrigation etc., will have to aim at improving productivity per unit of water drop used and this must be supported through system-wide enhancement of water delivery systems and decision support tools to assist farmers in optimizing the allocation of limited water among crops, selection of crops based on farming situations, and adoption of appropriate alternative crops in drought years.

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