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김윤정 ( Kim Yunjeong ) 국제비교한국학회 2017 비교한국학 Comparative Korean Studies Vol.25 No.3
무의미시론에 의하면 김춘수의 무의미시는 비단 의미의 해체와 대상 부재의 이미지를 실험하는 데서 그치는 것이 아니라 ‘리듬’의 양상으로 현상하는 것이다. 이는 김춘수의 무의미시를 파동의 일 현상으로서 보게 하는 근거가 된다. 음악의 본질이 파동이라는 점 때문에 이를 이용해 정신의 강박 구조를 치료하는 음악치료학이라는 분야도 생겨났거니와, 김춘수의 무의미시가 ‘리듬’을 추구한다는 점은 그것이 소리로서 각인되게 됨에 따라 인체에 직접적으로 영향을 미치는 파동에너지에 해당한다는 사실을 말해준다. 실제로 노래의 구조로 이루어진 김춘수의 무의미시의 파동의 형태를 측정해본다면 대체로 완만한 싸인(sin)파를 형성하고 있음을 확인할 수 있게 되는데, 이러한 파형은 인체에 안정적으로 작용하는 좋은 소리이자 좋은 에너지가 된다. 김춘수는 사력을 다해 무의미시가 노래의 구조가 되도록 하였음을 짐작할 수 있다. ‘리듬’으로서의 무의미시는 김춘수에게 주문이나 염불의 차원으로까지 나아갈 수 있는 성질의 것이었다. 그것은 김춘수가 「하늘수박」을 통해 주문을 실험하였던 점에서도 확인될 수 있는바, 노래 구조의 시에서 단순성과 음악성을 더욱 강조함으로써 김춘수는 주문으로서의 시를 시도하였다. 언어의 비의미성을 확대함에 따라 생겨난 주문으로서의 시는 김춘수에게 선(禪)의 세계에서 말하는 교외별전, 불립문자와 같은 차원에 놓이는 것이었다. 이는 무의미시가 지닌 초월성을 암시하는 것이다. 또한 이점은 김춘수가 언어를 분해함으로써 상징으로서의 언어를 해체하고 소리로서의 언어를 구현하고자 하였던 시도와도 관련된다. 훈민정음이 그러했듯 무의미시는 소리라는 성질에 의해 우주의 일부가 될 수 있게 된 것이다. ‘리듬’을 주장함에 따라 파동역학1의 관점에서 고찰하는 것이 가능한 무의미시는 인체 에너지장에 영향을 미치는 물리력을 지닐 뿐만 아니라 소리라는 성질에 의해 우주와 합일하는 계기 또한 된다. 이는 무의미시가 지니는 초월성을 가리키는 것으로, 김춘수는 무의미시를 통해 자신의 강박적 정신의 치유는 물론이고 언어의 순수성을 꾀함으로써 언어의 대사회적 기능 또한 회복하고자 하였음을 알 수 있다. In terms of the Meaningless-poetics, Kim Chunsu’s Meaningless-poetry is not just about experimenting with meaning-deconstruct and non-objects image, but developing rhythmic patterns. This is the basis for seeing Kim Chunsu’s meaningless-poetry as a work of wave-mechanics. As the music-therapy treats the compulsive structure of the mind by using the wave-energy of music, Kim Chunsu’s poetry of the rhythmic patterns affects the human body by the wave-energy of rhythm. Actually, the wave of the Kim Chunsu’s song-structure poetry is a stable sound and a good energy for human body. Kim Chunsu’s Meaningless-poetry of the rhythmic patterns can be developed to the level of a spell or a mantra. By strengthening simplicity and musicality in the poem of the song-structure, Kim Chunsu tried poetry as a spell. The poem as a spell is placed in the dimension of the ‘non-sound letters’ in the Buddhism. This means the transcendence of the Meaningless-poetry. And this is related to the attempt that Kim Chunsu tried to implement the language as sound by deconstructing the language as a symbol. The Meaningless-poetry as a wave-mechanics not only has the physical force that affects the energy-field of human body, but also the opportunity to unite with the cosmos. This indicates the transcendence of the Meaningless-poetry. Kim Chunsu has tried to restore the social function of language with pure language as well as heal his obsessive mind.
Kim, Tae-Eun,Ha, Na,Kim, Yunjeong,Kim, Hyunsook,Lee, Jae Wook,Jeon, Ji-Young,Kim, Min-Gul Dove Medical Press 2017 Drug design, development and therapy Vol.11 No.-
<P>Previous in vitro studies have demonstrated the inhibitory effect of green tea on drug transporters. Because rosuvastatin, a lipid-lowering drug widely used for the prevention of cardiovascular events, is a substrate for many drug transporters, there is a possibility that there is interaction between green tea and rosuvastatin. The aim of this study was to investigate the effect of green tea on the pharmacokinetics of rosuvastatin in healthy volunteers. An open-label, three-treatment, fixed-sequence study was conducted. On Day 1, 20 mg of rosuvastatin was given to all subjects. After a 3-day washout period, the subjects received 20 mg of rosuvastatin plus 300 mg of epigallocatechin-3-gallate (EGCG), a major ingredient of green tea (Day 4). After a 10-day pretreatment of EGCG up to Day 14, they received rosuvastatin (20 mg) plus EGCG (300 mg) once again (Day 15). Blood samples for the pharmacokinetic assessments were collected up to 8 hours after each dose of rosuvastatin. A total of 13 healthy volunteers were enrolled. Compared with the administration of rosuvastatin alone, the concomitant use at Day 4 significantly reduced the area under the concentration–time curve from time 0 to the last measurable time (AUC<SUB>last</SUB>) by 19% (geometric mean ratio 0.81, 90% confidence interval [CI] 0.67–0.97) and the peak plasma concentration (<I>C</I><SUB>max</SUB>) by 15% (geometric mean ratio 0.85, 90% CI 0.70–1.04). AUC<SUB>last</SUB> or <I>C</I><SUB>max</SUB> of rosuvastatin on Day 15 was not significantly different from that on Day 1. This study demonstrated that co-administration of EGCG reduces the systemic exposure of rosuvastatin by 19%, and pretreatment of EGCG can eliminate that effect of co-administration of EGCG.</P>
Kim, Jung Soo,Kim, Yunjeong,Han, Song-Hee,Jeon, Ji-Young,Hwang, Minho,Im, Yong-Jin,Kim, Jung Hyun,Lee, Sun Young,Chae, Soo-Wan,Kim, Min-Gul The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.1
A rapid, sensitive and selective analytical method was developed and validated for the determination of compound K, a major intestinal bacterial metabolite of ginsenosides in human plasma. Liquid-liquid extraction was used for sample preparation and analysis, followed by liquid chromatography tandem spectrometric analysis and an electrospray-ionization interface. Compound K was analyzed on a Phenomenex Luna C18 column ($100{\times}2.00$ mm, 3 ${\mu}m$) with the mobile phase run isocratically with 10 mM ammonium acetate-methanol-acetonitrile (5:47.5:47.5, v/v/v) at a flow rate of 0.5 mL/min. The method was validated for accuracy (relative error <12.63%), precision (coefficient of variation <9.14%), linearity, and recovery. The assay was linear over the entire range of calibration standards i.e., a concentration range of 1 ng/mL to 1,000 ng/mL ($r^2$ >0.9968). The recoveries of compound K after liquid-liquid extraction at 1, 2, 400, and 800 ng/mL were $106.00{\pm}0.08%$, $103.50{\pm}0.19%$, $111.45{\pm}5.21%$, and $89.62{\pm}34.46%$ for intra-day and $85.40{\pm}0.08%$, $94.50{\pm}0.09%$, $112.50{\pm}5.21%$, and $95.87{\pm}34.46%$ for inter-day, respectively. The lower limit of quantification of the analytical method of compound K was 1 ng/mL in human plasma. The developed method was successfully applied to a pharmacokinetic study of compound K after oral administration in ten of healthy human subjects.
( Yunjeong Jo ),( Sang Uk Han ),( Yoon Jae Kim ),( Ju Hyeon Kim ),( Shin Tae Kim ),( Seong-jin Kim ),( Ki-baik Hahm ) 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.1
Background/Aims: Loss of transforming growth factor β1 (TGF-β1) exhibits a similar pathology to that seen in a subset of individuals infected with Helicobacter pylori, including propagated gastric inflammation, oxidative stress, and autoimmune features. We thus hypothesized that gastric mucosal TGF-β1 levels could be used to determine the outcome after H. pylori infection. Methods: Northern blot for the TGF-β1 transcript, staining of TGF-β1 expression, luciferase reporter assay, and enzyme-linked immunosorbent assay for TGF-β1 levels were performed at different times after H. pylori infection. Results: The TGF-β1 level was markedly lower in patients with H. pylori-induced gastritis than in patients with a similar degree of gastritis induced by nonsteroidal anti-inflammatory drugs. There was a significant negative correlation between the severity of inflammation and gastric mucosal TGF-β1 levels. SNU-16 cells showing intact TGF-β signaling exhibited a marked decrease in TGF-β1 expression, whereas SNU-638 cells defective in TGF-β signaling exhibited no such decrease after H. pylori infection. The decreased expressions of TGF-β1 in SNU-16 cells recovered to normal after 24 hr of H. pylori infection, but lasted very spatial times, suggesting that attenuated expression of TGF-β1 is a host defense mechanism to avoid attachment of H. pylori. Conclusions: H. pylori infection was associated with depressed gastric mucosal TGF-β1 for up to 24 hr, but this apparent strategy for rescuing cells from H. pylori attachment exacerbated the gastric inflammation. (Gut Liver 2010;4:43-53)
문학과 종교의 유사성에 관한 언어적 고찰 - 오장환, 한용운, 김소월 시를 중심으로
김윤정(Kim Yunjeong) 한국언어문학회 2008 한국언어문학 Vol.66 No.-
This paper studies the religious features in poetry. As poetry results from rite at first, poetic language has many similarities to religion. The most representative feature is ‘symbol’ and ‘paradox’. ‘Symbol’ and ‘paradox’ are not only rhetoric. They are aimed to the world above. Poem can seek after transcendental world by ‘symbol’ and ‘paradox’. In that point, ‘symbol’ and ‘paradox’ are resemblant to religion structurally.<BR> To study the feature of ‘symbol’, this paper analyzed the poem of Oh Jang Whan. Oh Jang Whan emphasized the importance of ‘symbol’ and orthodoxy ‘symbolism’ in Jo-sun. This paper confirmed transcendental and religious feature in Oh Jang Whan’s poem. Especially Oh Jang Whan wanted to find symbol in woman image and mother’s world.<BR> And to study the feature of ‘paradox’, this paper analyzed the poem of Han Yong Woon. In poem of Han Yong Woon, the paradoxical language is the most remarkable feature. Especially, the atitude to ‘Nim’ can compare with the atitude to God in religion. Han Yong Woon showed transcendant feature by ‘paradox’.<BR> The last religious feature in poetry is related to the fact that poem involves ritual feature. That is from the fact that poem is pointed to spiritual world. The various emotion like sadness, sobbness and grief in Kim So Weol’s poem express the state of spirit. Kim So Weol is remarkable poet in the point that he seeks after opening the spiritual world.
Antioxidant and Neuroprotective effects of Gochujang Supplemented with Functional Ingredients
Sunghee Kim,Yunjeong Gwon,Jungeun Kim,Seungmin Park,Siyul Byeon,Janice Nullan Averilla,Ji Sun Lim,Chan Ho Jang,Jisun Oh,Myeong Hui Choi,Jun Young Kim,Jong-Sang Kim 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10
Development of a novel high throughput selection method for proteins with improved solubility
Chakhee KIM,Jonghyeok SHIN,Myungseo PARK,Yunjeong PARK,Hooyeon KIM,Hye Rin KIM,Joon-Bum PARK,Byoungjae KONG,Young-Hun JUNG,Choongjin BAN,Seokoh MOON,Yuna KIM,Seok-Hyeon YU,Sora CHO,Won-Ki MIN,Dae-Hyuk 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.4