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An Sunho,Vo Tam Thuy Lu,Son Taekwon,Choi Hoon,Kim Jinyoung,Lee Juyeon,Kim Byung Hoon,Choe Misun,Ha Eunyoung,Surh Young-Joon,Kim Kyu-Won,Seo Ji Hae 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in various cancer types, their role in cancer is unclear. Here, we aimed to investigate the oncogenic role of SAMHD1 in human clear cell renal cell carcinoma (ccRCC), particularly as a core molecule promoting cancer cell migration. We found that SAMHD1 participated in endocytosis and lamellipodia formation. Mechanistically, SAMHD1 contributed to the formation of the endosomal complex by binding to cortactin. Thereafter, SAMHD1-stimulated endosomal focal adhesion kinase (FAK) signaling activated Rac1, which promoted lamellipodia formation on the plasma membrane and enhanced the motility of ccRCC cells. Finally, we observed a strong correlation between SAMHD1 expression and the activation of FAK and cortactin in tumor tissues obtained from patients with ccRCC. In brief, these findings reveal that SAMHD1 is an oncogene that plays a pivotal role in ccRCC cell migration through the endosomal FAK-Rac1 signaling pathway.
Kim, Sunho,Kim, Royoung,Nam, Hee-Jo,Kim, Ryeo-Gyeong,Ko, Enjin,Kim, Han-Su,Shin, Jihye,Cho, Daeun,Jin, Yurhee,Bae, Soyeon,Jo, Ye Won,Jeong, San Ah,Kim, Yena,Ahn, Seoyeon,Jang, Bomi,Seong, Jiheyon,Lee, Korea Genome Organization 2020 Genomics & informatics Vol.18 No.3
This paper describes a community effort to improve earlier versions of the full-text corpus of Genomics & Informatics by semi-automatically detecting and correcting PDF-to-text conversion errors and optical character recognition errors during the first hackathon of Genomics & Informatics Annotation Hackathon (GIAH) event. Extracting text from multi-column biomedical documents such as Genomics & Informatics is known to be notoriously difficult. The hackathon was piloted as part of a coding competition of the ELTEC College of Engineering at Ewha Womans University in order to enable researchers and students to create or annotate their own versions of the Genomics & Informatics corpus, to gain and create knowledge about corpus linguistics, and simultaneously to acquire tangible and transferable skills. The proposed projects during the hackathon harness an internal database containing different versions of the corpus and annotations.
Controlled extracellular topographical and chemical cues for acceleration of neuronal development
Park, Sunho,Choi, Kyoung Soon,Kim, Daun,Kim, Woochan,Lee, Dohyeon,Kim, Hong-Nam,Hyun, Hoon,Lim, Ki-Taek,Kim, Jin-Woo,Kim, Yang-Rae,Kim, Jangho Elsevier 2018 Journal of industrial and engineering chemistry Vol.61 No.-
<P><B>Abstract</B></P> <P>Physical and chemical cues, which have emerged as a promising strategy for regulating cellular behaviors, provide important signaling cues to living cells. Neurons are also exposed to distinguishing physical and chemical environments that can greatly influence their behaviors and functions. In this study, we proposed the laminin-coated matrix nanotopography platforms (LMNPs) that generate extracellular physical and chemical cues for neuronal development. Using our platforms, we showed that nanotopographical and biochemical cues could provide suitable environments for neuronal cultures. More importantly, we showed that a LMNPs could control the orientation of neuronal structures as well as accelerate neuronal development through synergistic effects of extracellular nanotopographical and chemical cues. Our study imparts new design principles on the role of nanotopographical and chemical cues in neuronal development for the fabrication of neuroprosthetic scaffolds.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Sunho Park ),( Sujin Kim ),( Yonghyun Gwan ),( Woochan Kim ),( Daun Kim ),( Sungmin Park ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.2
Graphene, one of carbon nanomaterials, has unique properties such as high electrical conductivity, surface area, and carrier mobility, which is currently regarded as emerging engineering platforms in various fields including agriculture and biological applications. Here, we present graphene oxide (GO) that can provide a positive influence on plant growth. To this end, we approached two methods with indirect and direct stimulation to provide unique structural, mechanical, chemical cues of graphene to plants including Arabidopsis thaliana and watermelon. The GO injected Arabidopsis thaliana showed the enhanced growth such as increased root length, leaf number, leaf area, and flower number. In addition, it was confirmed that the GO injected watermelon showed the enhanced sugar concentration. Our findings suggest that graphene with suitable concentration may provide positive effects on the plant growth as a new tool for rational design of plant growth-assisted agents for future agriculture.
Engineering Eggshell Membranes for Manipulation of Nanotopographically-defined Functional Platforms
( Sunho Park ),( Daun Kim ),( Woochan Kim ),( Dohyeon Lee ),( Sungmin Park ),( Sujin Kim ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Eggshell membrane (ESM), one of the agricultural bioresources, is being recognized as emerging engineering platforms in various fields including agriculture and biological engineering. Eggshell membrane is the protein-rich membrane between the eggshell and egg white, having interesting characteristics such as structural, chemical, and physical properties. However, the raw ESM has many limitations (e.g., low electric capability and mechanical property), which raised some problems for its wide use as commercial engineering platforms. Here, we present new ESM-based engineering platforms based on nanotechnology. To develop the nanotopographically-enhanced ESM platforms, we used graphene, one of the carbon-based nanomaterials, that provides unique nanotopographically-defined cues to the raw ESM. The graphene-ESM hybrid platforms showed hierarchically micro- and nanoscale structures (i.g., microfibers from ESM and nanosheets from graphene). It is also found that the graphene-ESM hybrid platforms could enhance the electrical and mechanical property compared to the raw ESM. Our approach can enable the design and manipulation of ESM-based functional engineering platforms for various applications such as agricultural, biological, environmental, and biomedical platforms (e.g., biomaterials, electric devices, sensors, air purification systems).
Engineered Nanomaterials as an Enabling Bionic Strategy for Acceleration of Plant Growth
( Sunho Park ),( Woochan Kim ),( Daun Kim ),( Dohyeon Lee ),( Sungmin Park ),( Sujin Kim ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
It is an important challenge to control and accelerate growth of plants in the world. In this work, we propose a novel bionic strategy for controlling and accelerating plant growth using engineered nanomaterials. It is usually recognized that nanomaterials might influence toxicity in plant growth; however, we here demonstrated that engineered nanomaterials can be used as interesting tools for the acceleration of plant growth as well as biosensor platforms. As a model study, we treated engineered nanomaterials to the Arabidopsis thaliana in the agar plates. Interestingly, we showed that our engineered nanomaterials with various concentrations could affect the plant growth in terms of the length of roots, the area of leaves, and the number of leaves, and the formation of the flower buds. We believe that the engineered nanomaterials could provide positive effects as an enabling bionic strategy for the acceleration of plant growth.
Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing
Kim, Jangho,Bae, Won-Gyu,Kim, Yeon Ju,Seonwoo, Hoon,Choung, Han-Wool,Jang, Kyoung-Je,Park, Sunho,Kim, Bog Hee,Kim, Hong-Nam,Choi, Kyoung Soon,Kim, Myung-Sun,Choung, Pill-Hoon,Choung, Yun-Hoon,Chung, J Wiley (John WileySons) 2017 Advanced healthcare materials Vol.6 No.19
Kim, Sunho,Kim, Bongsung,Im, Inseob,Kim, Dongjae,Lee, Haeseong,Nam, Jaewook,Kyoon Chung, Ho,Lee, Hoo-Jeong,Min Cho, Sung IOP Pub 2017 Nanotechnology Vol.28 No.34
<P>This study proposes a simple method of Au coating on silver nanowires (Ag NWs) transparent conductive films as the anode of organic light emitting diodes (OLED) to increase the work function of the film and thus enhance hole transport. We carefully engineer the process conditions (pretreatment, solution concentrations, and coating number) of the coating using a diluted HAuCl<SUB>4</SUB> solution on the Ag NWs film to minimize etching damage on Ag NWs accompanying the galvanic replacement reaction. Ultraviolet photoelectron spectroscopy and Kelvin probe force microscopy show work function increase of Ag NWs upon Au coating. OLED devices based on Au-coated Ag NWs show a lower turn-on voltage and higher luminance, compared with pristine Ag NWs device. Although the Ag NWs device displays poor efficiencies in the low luminance range due to a high leakage, some of the Au-coated Ag NWs devices showed efficiencies higher than those of the ITO device in a high luminance.</P>
Engineering nanowrinkled microfibers composed of eggshell membrane and graphene
Park, Sunho,Choi, Kyoung Soon,Kim, Woochan,Lee, Dohyeon,Kim, Daun,Kim, Myung-Sun,Kim, Kyunghoon,Kim, Jangho Elsevier 2018 Materials letters Vol.229 No.-
<P><B>Abstract</B></P> <P>We present a facile method for designing and manipulating eggshell membrane-based nanowrinkled microfibers (EMNMs) using graphene and a spin-coating technique. Graphene is simply spin-coated on the eggshell membrane to form multiscale structures of nanowrinkled microfibers. We demonstrate that the EMNMs combine the unique properties of the raw eggshell membrane and graphene, such as micro- and nanoscale hierarchical morphologies, specific crystalline structures, and surface wettability. We also show that the properties of the EMNMs can be controlled by adjusting the concentration of graphene.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanowrinkled microfibers composed of eggshell membrane and graphene are fabricated. </LI> <LI> The properties of the prepared nanowrinkled microfibers are investigated. </LI> <LI> The microfiber properties can be controlled by adjusting the graphene concentration. </LI> </UL> </P>