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김진관(JinKwan Kim),신철(Chol Shin),이승관(SeungGwan Lee),이창규(ChangKyou Lee),김성욱(SuhngWook Kim),조경진(KyungJin Cho),김순기(SoonKi Kim) 고려대학교 보건과학연구소 2006 보건과학논집 Vol.32 No.1
Cytoglobin(Cygb) is a newly recognized globin type, which are almost ubiquitously present in human tissues. Cytoglobin is reported to function as an oxygen scavanging and distribution protein and induced by hypoxia. The physiological role of cytoglobin is not yet clearly understood. We investigated cytoglobin in human blood leukocyte from obstructive sleep apnea patients(n=5) and normal controls(n=5). Immunoreactivity to anticytoglobin in OSA patients were much higher than that in normal control. These results suggest that cytoglobins of leukocyte might be overexpressed in obstructive sleep apnea.
[CB-0004] Assembly of chromosome-level genome to accelerate octoploid strawberry breeding
Koeun Han(Koeun Han),Sun Yi Lee(Sun Yi Lee),Jinhee Kim(Jinhee Kim),Hye-Eun Lee(Hye-Eun Lee),Jinkwan Jo(Jinkwan Jo),Eun Su Lee(Eun Su Lee),Byoung-Cheorl Kang(Byoung-Cheorl Kang),Do-Sun Kim(Do-Sun Kim) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Increase in serum haptoglobin and apolipoprotein M in patients with obstructive sleep apnoea
KIM, JINKWAN,LEE, SEUNGGWAN,IN, KWANGHO,KIM, JEHYEONG,YOU, SEHWA,KANG, KYUNGHO,SIM, JAEJEONG,LEE, SANGYEUB,YOON, DAEWUI,LEE, JUNGBOK,SHIN, CHOL Blackwell Publishing Ltd 2009 Journal of sleep research Vol.18 No.3
<P>Summary</P><P>Obstructive sleep apnoea (OSA) is a common syndrome, which is associated with a number of medical problems that impact morbidity and mortality. Although the precise mechanisms that underlie these associations are not fully understood, previous studies have suggested that patients with OSA show elevations of several biomarkers that are associated with cardiovascular risk. This study was undertaken to identify serum proteins associated with OSA by using a proteomics technique and to examine changes in identified protein levels after continuous positive airway pressure treatment. The study participants consisted of 40 male patients (aged 40–49 years) with severe OSA and 34 male control subjects matched for age and body mass index. All subjects underwent polysomnography. Using a proteomics approach, we identified nine proteins that were differentially expressed in patients with severe OSA and controls. Three of these nine proteins, haptoglobin, paraoxonase-1 and apolipoprotein M, were quantified by using enzyme-linked immunosorbent assays, kinetic assays and by using Western blotting. Multiple regression analysis showed that haptoglobin and apolipoprotein M levels are independently related to apnoea–hypopnoea index (<I>P</I> < 0.01). A further study is required to determine the nature of associations between these identified proteins and OSA in a large population.</P>
수면 무호흡증 환자에서 Angiotensin converting enzyme, Angiotensinogen M235T의 유전적 다형성
김진관(JinKwan Kim),신철(Chol Shin),이승관(Seung-Gwan Lee),이창규(Chang-kyou Lee),김순기(SoonKee Kim) 고려대학교 보건과학연구소 2004 보건과학논집 Vol.30 No.1
Obstructive sleep apnea(OSA) occcurs when tissues in the upper airway collapse during sleep, and is accompanied by hypoxemia and EDS(excessive daytime sleepiness). Also OSA is related to hypertension and cardio-vascular disease. According to recent study, OSA possibility is estimated through partial gene"s predispoding factor. To study the correlation of OSA and angiotensin converting enzyme and angioten-sinogen genotype, this study examined genetic polymorphism of OSA patient and normal case using PCR and restriction enzyme digestion. We found significant differences between most sevene obstructive sleep apnea and normal control in the ACE genotypes. The freguency of genotypes in MSO was: DD : 15.5%, ID : 82.2%, Ⅱ : 2.2%(p<0.05) The freguency of genotypes in Normal group(NO) was: DD : 8.5%, ID : 71.8%, Ⅱ : 19.7%. But there were no significant differences between obstructive sleep group and normal control in the AGT(M235T) genotypes. The freguency of genotypes in MSO was : MM : 8.9%, MT : 13.3%, TT : 77.8%. In normal group was: MM : 5.6%, MT : 25.4% TT : 69.0%. Our data suggest some effect between ACE polymorphism and OSA but no effect between AGT polymorphism and OSA.
GM:S의 풍부한 API와 낮은 진입 장벽의 교육적 활용 방법
김진관 ( Jinkwan Kim ),이희준 ( Heejun Lee ) 한국컴퓨터교육학회 2017 한국컴퓨터교육학회 학술발표대회논문집 Vol.21 No.2
기존의 프로그래밍 교육용 프로그램(스크래치, 엔트리)들은 프로그래밍의 진입장벽을 낮춰 교육의 효율을 높일 수 있었다[1][2]. 하지만 그러한 접근 방식은 실용적인 프로그래밍에 대한 지표가 되기에는 좋지 않다. 우리는 교육용 프로그램으로 게임메이커 스튜디오(이하 GM:S)를 사용하는 것을 제안 하고, 기존 지표의 단 점을 풍부한 스크립팅 API와 네이티브 라이브러리 링크 등으로 극복한 GM:S를 교육적 목적으로 사용하는 방법에 대해 알아보고자 한다.
김진관 ( Jinkwan Kim ),표상신 ( Sang Shin Pyo ),윤대위 ( Dae Wui Yoon ) 대한임상검사과학회 2021 대한임상검사과학회지(KJCLS) Vol.53 No.4
수면은 필수적인 생리적 기능일 뿐만 아니라 인간의 성장, 성숙 및 전반적인 건강을 증진시키는 데 중요한 역할을 한다. 수면과 수면 장애가 대사성 질환에 미치는 영향에 대한 관심이 높아지고 있다. 폐쇄성 수면무호흡증은 일반적인 건강 문제이며, 지난 10년 동안 비만율의 증가로 인해 더 두드러진 대사 질환과 함께 폐쇄성 수면무호흡증의 유병률이 현저하게 증가했다. 폐쇄성 수면무호흡증에 의한 대사성 질환을 유발하는 근본적인 메커니즘은 다인성일 가능성이 높으며, 완전히 밝혀지지 않고 있지만, 염증과 산화 스트레스의 활성화와 식욕 조절 호르몬의 조절장애는 폐쇄성 수면무호흡증 환자에게 나타나는 대사 기능 장애와 비만의 중요한 병리 생리학적 성분으로 나타났다. 본 연구에서는 폐쇄성 수면무호흡증과 대사질환의 연관성에 대한 연구 현황과 폐쇄성 수면무호흡증이 이러한 질병을 유발하는 병리생리학적 메커니즘에 대해 검토하고자 한다. 이를 통해 폐쇄성 수면 무호흡증과 비만, 그리고 폐쇄성 수면무호흡증과 대사 기능 장애 사이의 잠재적인 상호작용을 이해할 수 있다. Sleep plays an important role in maintaining overall human health. There is increasing interest regarding the impact of sleep related disorders on metabolic diseases. Obstructive sleep apnea (OSA) is a common health problem, and in the last decade, the emergence of increasing obesity rates has further led to a remarkable increase in the prevalence of OSA, along with more prominent metabolic diseases. Obesity is the strongest risk factor for OSA. However, OSA is also known to cause obesity, suggesting an interaction between OSA and obesity. Although the underlying mechanisms leading to OSA-induced metabolic diseases are probably multi-factorial and are yet to be fully elucidated, the activation of inflammation and oxidative stress and the dysregulation of appetite-regulating hormones have emerged as important pathophysiological components of metabolic dysfunction and obesity observed in patients with OSA. Here, we will review the current state of research regarding the association of OSA with metabolic diseases and the possible pathophysiological mechanisms by which OSA could lead to such diseases. This will enhance our understanding of the potential interactions between OSA and obesity and between OSA and metabolic dysfunction.
플라스틱 ETC 하우징의 치수변형 해결 방법에 대한 연구
김보경(Bokyeong Kim),김진관(Jinkwan Kim),김경환(Kyunghwan Kim) 한국자동차공학회 2019 한국자동차공학회 학술대회 및 전시회 Vol.2019 No.11
As global environmental regulations for vehicles are intensifying, it is necessary to reduce the weight of a vehicle. This trend has led to the emergence of technology to replace metal parts with engineering plastics. Electronic throttle control valves that control the intake air volume of gasoline internal combustion engines are normally made of aluminum, but some use engineering plastics for additional weight reduction. However, in order to apply engineering plastics, problems such as poor dimensional stability than metal machining must be improved. This paper presents effects of changing injection molding conditions such as injection pressure, mold temperature, gate position, as a means to solve the above problem.