Photoacoustic imaging platforms for multimodal imaging

Kim, Jeesu,Lee, Donghyun,Jung, Unsang,Kim, Chulhong 대한초음파의학회 2015 ULTRASONOGRAPHY Vol.34 No.2

<P>Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information. Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy. This article reviews techniques that integrate PA with the above imaging methods and describes their applications.</P>

High-Resolution Photoacoustic Imaging Techniques for Functional Analysis of Biological Tissue

Jeesu KIM 한국생물공학회 2024 한국생물공학회 학술대회 Vol.2024 No.4

한의치료와 ‘마음의 방 그리기’를 활용한 공황장애 치험 1례 보고

김지수 ( Jeesu Kim ),정문주 ( Moon Joo Cheong ),이가원 ( Ga-won Lee ),유영수 ( Yeoung-su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2020 동의신경정신과학회지 Vol.31 No.3

Objectives: The purpose of this study was to introduce the progress of treatment and improve clinical use after conducting Mentalizing the Rooms of Mind, the main technique of Mindfulness & Loving Beingness psychotherapy, for a patient with panic disorder. Methods: We conducted a Mentalizing the Rooms of Mind for 10 sessions on an age 23 female diagnosed with panic disorder based on the DSM-5 diagnostic criteria. After receiving consent from the subject, through chart review, the progress of treatment was observed focusing on the MMPI-2 and CSEI-s (The Core Seven Emotions Inventory-short form) conducted pre- and post-treatment. This study was approved by the Institutional Review Board of Wonkwang University Sanbon Hospital (WMCSB202007-55). Results: 1. The MMPI-2 clinical scales of an age 23 female with panic disorder showed a 7 (Pt)-1 (Hs)-3 (Hy) profile pre-treatment, but for post-treatment, the scale showed 1 (Hs)-3 (Hy) profile, and the 7 (Pt) scale showed significant decline. In the MMPI-2 reconstructed clinical scales, RC7 (Dysfunctional Negative Emotions) and RC8 (Aberrant Experiences) showed significant decline. 2. In the pre- and post-treatment MMPI-2 content scales, Anxiety, Fears, Obsessiveness, Social Discomfort, and Work Interference scores decreased, showing overall positive stability. On the MMPI-2 supplementary scales, the Anxiety and Post-Traumatic Stress Disorder scores decreased, and the Ego Strength increased, resulting in improved overall psychological adaptation. 3. Pre- and post-treatment of an age 23 female with panic disorder, CSEI-s showed significant decline of 恐, 驚, 悲, and 思. So it seems that the emotions caused by Chiljeongsang (七情傷) were more stable than before treatment. Conclusions: As shown above, the treatment of panic disorder through Mentalizing the Rooms of Mind, a major technique of Mindfulness & Loving Beingness psychotherapy, showed positive changes in MMPI-2 as well as improvement of the subjective symptoms. Thus, Mentalizing the Rooms of Mind has high clinical use, and it seems that it is necessary to create a manual for this in the future.

회사의 도산위기와 이사의 책임 - 도산개시신청의무를 중심으로 -

김지수 ( Kim Jeesu ) 연세대학교 법학연구원 2020 法學硏究 Vol.30 No.3

The aim of this article is to propose to take appropriate steps designed to protect the interests of the creditors where the company approaches, or has already reached, a situation of insolvency or financial distress. The author finds the solution in the need to preserve value for creditors and suggests, the duty and liability of directors for delayed filing for insolvency in our system to adopt. Accordingly, this article seeks to demonstrate that directors’ duties toward creditors should shift on the ground of three reasons: Firstly, the directors’ and shareholders’ opportunist behavior, Secondly, the need to preserve value for creditors, and Thirdly, the abuse of the corporation system. Under corporate law a board of directors of a solvent corporation only owes a fiduciary duty to its shareholders to maximize profit and shareholder worth. However, the principle of capital maintenance restrictions, which is notably on the prohibition of unlawful distributions to shareholders focused, is to linked to a state of factual insolvency. When the corporate enters the zone of insolvency, the fiduciary duties of the board shift to including of preserving the company’s assets for the benefit of creditors. Once the shareholders’ investment has been wiped out, the creditors replace the shareholders as the residual risk-takers. At this point directors should instigate some kind of organised response designed to protect the interests of the creditors. If the directors fail to take appropriate steps, the creditors, often unaware of the company’s precarious state of affairs, are likely to suffer harm from the continued trading of the company, while the chances that the company will ever regain solid financial ground will usually dwindle rapidly. Directors’ (personal) Liability for Conduct in the vicinity of Insolvency is therefore detrimental to creditor interests. So when the corporate becomes insolvent, the fiduciary duties of directors of corporations shift from profit maximization to protecting the assets of the estates for the benefit of creditors. The author submits a reform plan to introducing a directors’ duty for filing for insolvency and his liability for delayed filing into Korean law system.

Iterative Learning Control을 이용한 3-wheel Omni-directional Mobile Robot의 제어

김지수(Jeesu Kim),한경룡(Kyung L. Han),이진수(Jin S. Lee) 대한전자공학회 2010 대한전자공학회 학술대회 Vol.2010 No.6

Tumor vasodilation by N-Heterocyclic carbene-based nitric oxide delivery triggered by high-intensity focused ultrasound and enhanced drug homing to tumor sites for anti-cancer therapy

Kang, Youngnam,Kim, Jeesu,Park, Junbeom,Lee, Yeong Mi,Saravanakumar, Gurusamy,Park, Kyeng Min,Choi, Wonseok,Kim, Kimoon,Lee, Eunsung,Kim, Chulhong,Kim, Won Jong Elsevier 2019 Biomaterials Vol.217 No.-

<P><B>Abstract</B></P> <P>Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drug accumulation in tumors is accelerated by the enhanced permeability and retention effect, leading to an improvement in the anti-tumor effect. N-heterocyclic carbene-based NO donors (e.g., 1,3-bis-(2,4,6-trimethylphenyl)imidazolylidene nitric oxide (IMesNO) have been developed for stable NO storing in air and water, and NO release by thermolysis. Herein, we demonstrated on-demand NO release by high-intensity focused ultrasound (HIFU) as a stimulus, which generated high heat and exerted an ablation effect when treated <I>in vivo</I>. We demonstrated IMesNO to be a HIFU-responsive NO donor and its potential application <I>in vivo</I> using IMesNO-loaded micelles. Moreover, IMesNO-loaded micelles mixed with drug-loaded micelles (IMesNO/DOX@MCs) showed acceleration of drug accumulation in tumor sites and enhanced tumor growth inhibition. Thus, our findings suggest a potential clinical bioapplication of NO-releasing drug-loaded micelles owing to the therapeutic function of NO and HIFU treatment for anti-cancer therapy.</P>

Acute Respiratory Distress Syndrome after Rotavirus Infection in a C1q Nephropathy Patient: A Case Report

Hye Jin Kim,Jeesu Min,Ji Hyun Kim,Yu Hyeon Choi,Mi Seon Han,Il-Soo Ha,Hee Gyung Kang 대한소아신장학회 2021 Childhood kidney diseases Vol.25 No.2

C1q nephropathy is a rare glomerulopathy that typically presents with nephrotic syndrome in children. Treatment with immunosuppressive agents renders patients vulnerable to infection and its complications. Gastroenteritis is common in children, and rotavirus is a leading cause. Extraintestinal manifestations of rotavirus have recently been reported; however, there is a paucity of cases exploring the involvement of a rotavirus on the respiratory system. Acute respiratory distress syndrome (ARDS) is a rapid onset respiratory failure characterized by noncardiogenic pulmonary edema and hypoxemia. Causes of ARDS include sepsis, pneumonia, pancreatitis, aspiration, and trauma. In this paper, we report a case of ARDS after rotavirus infection in a child with C1q nephropathy who had been treated with immunosuppressive agents.

“Smart” gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification <i>via</i> pH-induced aggregation

Song, Jaejung,Kim, Jeesu,Hwang, Sekyu,Jeon, Mansik,Jeong, Sanghwa,Kim, Chulhong,Kim, Sungjee The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.53

<P>'Smart' gold nanoparticles can respond to mild acidic environments, rapidly form aggregates, and shift the absorption to red and near-infrared. They were used as a photoacoustic imaging agent responsive to the cancer microenvironment, and have demonstrated the cancer-specific accumulation at the cellular level and an amplified signal which is twice higher than the control in vivo.</P>

Multifunctional Nanodroplets Encapsulating Naphthalocyanine and Perfluorohexane for Bimodal Image-Guided Therapy

Choi, Hyunsik,Choi, Wonseok,Kim, Jeesu,Kong, Won Ho,Kim, Ki Su,Kim, Chulhong,Hahn, Sei Kwang American Chemical Society 2019 Biomacromolecules Vol.20 No.10

<P>Although nanocarriers containing perfluorocarbon (PFC) have been widely investigated as an ultrasound (US) imaging agent and a high intensity focused ultrasound (HIFU) agent, these carriers have suffered from low stability and biocompatibility limiting their further biomedical applications. Here, we developed surface cross-linked polymer nanodroplets as a HIFU therapeutic agent guided by bimodal photoacoustic (PA) and US imaging. Pluronic F127 was reacted with 4-nitrophenyl chloroformate (NPC) and mixed with naphthalocyanine (Nc) in dichloromethane, which was added into the aqueous solution of amine-functionalized six-arm-branched poly(ethylene glycol) (PEG) to form an oil-in-water emulsion for the cross-linking reaction between the terminal NPC of Pluronic F127 and the primary amine of six-arm PEG. The resulting solution was sonicated with liquid perfluorohexane (PFH) to prepare PEG cross-linked Pluronic F127 nanoparticles encapsulating Nc and PFH (Nc/PFH@PCPN). Nc/PFH@PCPN appeared to be stable without any coalescence or vaporization in the physiological condition. Upon the application of HIFU, Nc/PFH@PCPN was vaporized and showed increased US intensity for 180 min. The Nc dye in the nanodroplets enabled the stable encapsulation of PFH and the bimodal US/PA imaging. In vivo PA/US image-guided HIFU ablation therapy confirmed that the nanodroplets increased the cavitation effect, induced necrosis and apoptosis of tumor cells, and reduced tumor growth significantly for 12 days. Taken together, the multifunctional Nc/PFH@PCPN was successfully developed as a new platform for PA/US image-guided HIFU therapy.</P> [FIG OMISSION]</BR>

Real-time Triple-modal Photoacoustic, Ultrasound, and Magnetic Resonance Fusion Imaging of Humans

Park, Sara,Jongseong Jang,Jeesu Kim,Young Soo Kim,Chulhong Kim IEEE 2017 IEEE transactions on medical imaging Vol.36 No.9

<P>Imaging that fuses multiple modes has become a useful tool for diagnosis and therapeutic monitoring. As a next step, real-time fusion imaging has attracted interest as for a tool to guide surgery. One widespread fusion imaging technique in surgery combines real-time ultrasound (US) imaging and pre-acquired magnetic resonance (MR) imaging. However, US imaging visualizes only structural information with relatively low contrast. Here, we present a photoacoustic (PA), US, and MR fusion imaging system which integrates a clinical PA and US imaging system with an optical tracking-based navigation subsystem. Through co-registration of pre-acquired MR and real-time PA/US images, overlaid PA, US, and MR images can be concurrently displayed in real time. We successfully acquired fusion images from a phantom and a blood vessel in a human forearm. This fusion imaging can complementarily delineate the morphological and vascular structure of tissues with good contrast and sensitivity, has a well established user interface, and can be flexibly integrated with clinical environments. As a novel fusion imaging, the proposed triple-mode imaging can provide comprehensive image guidance in real time, and can potentially assist various surgeries.</P>