http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice
Go, Jun,Park, Tae-Shin,Han, Geun-Hee,Park, Hye-Yeon,Ryu, Young-Kyoung,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Noh, Jung-Ran,Hwang, Dae Youn,Kim, Sanghee,Oh, Won Keun,Lee, Chul-Ho,Kim, Kyoung-Sh D.A. Spandidos 2018 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.42 No.4
<P>Piperlongumine (PL), a biologically active compound from the <I>Piper</I> species, has been shown to exert various pharmacological effects in a number of conditions, including tumours, diabetes, pain, psychiatric disorders and neurodegenerative disease. In this study, we evaluated the therapeutic effects of PL on hippocampal function and cognition decline in aged mice. PL (50 mg/kg/day) was intragastrically administrated to 23-month-old female C57BL/6J mice for 8 weeks. Novel object recognition and nest building behaviour tests were used to assess cognitive and social functions. Additionally, immunohistochemistry and western blot analysis were performed to examine the effects of PL on the hippocampus. We found that the oral administration of PL significantly improved novel object recognition and nest building behaviour in aged mice. Although neither the percentage area occupied by astrocytes and microglia nor the level of 4-hydroxynonenal protein, a specific marker of lipid peroxidation, were altered by PL treatment, the phosphorylation levels of <I>N</I>-methyl-D-aspartate receptor subtype 2B (NR2B), calmodulin-dependent protein kinase II alpha (CaMKIIα) and extracellular signal-regulated kinase 1/2 (ERK1/2) were markedly increased in the hippocampus of aged mice following the administration of PL. We also found that PL treatment resulted in a CA3-specific increase in the phosphorylation level of cyclic AMP response element binding protein, which is recognized as a potent marker of neuronal plasticity, learning and memory. Moreover, the number of doublecortin-positive cells, a specific marker of neurogenesis, was significantly increased following PL treatment in the dentate gyrus of the hippocampus. On the whole, these data demonstrate that PL treatment may be a potential novel approach in the treatment of age-related cognitive impairment and hippocampal changes.</P>
Recent activity of mouse metabolic phenotyping service at Korea Mouse Phenotyping Center (KMPC)
Hye Sun Go,Ji Min Choi,Seul Gi Yoon,Su In Jang,Soo Jin Son,Da In On,Hyun A Noh,Mi Young Kim,Il Yong Kim,Je Kyung Seong 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
To understand the function of individual genes is also a key information in developing new treatment techniques. Even though a couple of genetically engineered mouse (GEM) models has been generated, still precising determination of mouse phenotype is not easy. Precising mouse phenotyping is one of the effective way leading to discovery gene function. International Mouse Phenotyping Consortium (IMPC) has established mega database of mouse phenotyping data from different institutes across the world based on generalized platform. However more precised mouse phenotyping is still needed. In order to meet the need for more detailed phenoyping in mouse, Korea Mouse Phenotyping Center (KMPC), nation-wide program for mouse production and phenotyping in Korea has been establishing several pipelines for disease-specific mouse phenotyping to support the mouse research. Here we introduce mouse metabolic and exercise phenotyping services, as well as the other services of mouse research such as providing genetically engineered mouse information, producing selling genetically engineered mice, and managing resource quality so that researchers can easily utilize the research infrastructure. Metabolic characterization in mouse is one of key factors for understanding the pathogenesis of obesity, type 2 diabetes and insulin resistance. KMPC has been providing mouse metabolic phenotyping including high fat diet, exercise and cold challenges. Multiple parameter including energy expenditure (EE), O2/CO2 consumption (RER), heat generation and activity has been provided with histology service and body composition. Also temperature can be measured during metabolic chamber with telemetric system. Here we summarized mouse metabolic phenotyping services at KMPC.
Go, Jun,Ha, Thi-Kim-Quy,Seo, Ji Yeon,Park, Tae-Shin,Ryu, Young-Kyoung,Park, Hye-Yeon,Noh, Jung-Ran,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Hwang, Dae Youn,Kim, Sanghee,Lee, Chul-Ho,Oh, Won Keun Elsevier 2018 Journal of Functional Foods Vol.43 No.-
<P><B>Abstract</B></P> <P>Sirtuin1 (Sirt1) is an unusual target for aging and aging-associated diseases. During the screening for Sirt1 activators from natural compounds, piperlongumine (PL), one of the major constituents of <I>Piper longum</I>, potently activated the deacetylase ability of Sirt1 <I>in vitro</I>. Treatment with PL, which regulated the gene transcription of antioxidant response element in hippocampal neurons, attenuated the cytotoxicity induced by intraneuronal Aβ<SUB>1-42</SUB> expression. The oral administration of PL, at a dose of 50 mg/kg/day for 2.5 months, significantly reduced the occupied area of beta-amyloid in parietal cortex of APP/PS1 mice. Novel object recognition and working memory impairment also markedly improved. Moreover, activated microglia and astrocytes in the cortex notably decreased, indicating the anti-inflammatory activity of PL. Finally, vesicular glutamate transporter 1 significantly increased in the hippocampus of APP/PS1 mice following PL treatment. These results suggested the beneficial effects PL and its therapeutic potential to ameliorate AD-like pathology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Piperlongumine (PL) activates the deacetylase ability of Sirt1 <I>in vitro</I>. </LI> <LI> PL improves cognitive deficits in APP/PS1 mice. </LI> <LI> PL reduces amyloid deposition and neuro-inflammation in the brain of APP/PS1 mice. </LI> <LI> PL increases VGLUT1 level in the hippocampus of APP/PS1 mice. </LI> </UL> </P>
Kim, Young-eun,Im, Hyo Been,Jung, Un Ho,Park, Ji Chan,Youn, Min Hye,Jeong, Heon-Do,Lee, Dong-Wook,Rhim, Geun Bae,Chun, Dong Hyun,Lee, Ki Bong,Koo, Kee Young Elsevier 2019 Fuel Vol.256 No.-
<P><B>Abstract</B></P> <P>The linear α-olefin 1-octene was produced via the dehydration of 1-octanol over Al<SUB>2</SUB>O<SUB>3</SUB> catalysts. The effect of calcination temperature on the characteristics of an Al<SUB>2</SUB>O<SUB>3</SUB> catalyst and its activity in the dehydration of 1-octanol to 1-octene was investigated. Al<SUB>2</SUB>O<SUB>3</SUB> catalysts calcined at various temperatures (250, 500, 750, 1000 °C) were evaluated at 300–400 °C with a liquid hourly space velocity (LHSV) of 7–56 h<SUP>−1</SUP>. XRD, BET, <SUP>27</SUP>Al-NMR, Py-FTIR, and NH<SUB>3</SUB>-TPD analyses indicated that the calcination temperature affected the crystal phase, surface area, occupancy of the coordinated Al<SUP>3+</SUP> ion, and acidic properties of Al<SUB>2</SUB>O<SUB>3</SUB> catalysts. Upon calcination at temperatures >750 °C, the surface area of Al<SUB>2</SUB>O<SUB>3</SUB> catalysts reduced due to γ-Al<SUB>2</SUB>O<SUB>3</SUB> to θ-Al<SUB>2</SUB>O<SUB>3</SUB> phase transition. The changes in the crystal phase decreased the surface area, which correlated to the acidity of the Al<SUB>2</SUB>O<SUB>3</SUB> catalyst. The distribution of unsaturated Al<SUP>3+</SUP> ions acting as LAS on the catalyst surface increased with increasing calcination temperature, but decreased above 750 °C calcination temperature due to the diminishing surface area. The Al<SUB>2</SUB>O<SUB>3</SUB> catalyst calcined at 500 °C showed the highest 1-octanol conversion in the dehydration of 1-octanol. High 1-octene selectivity was maintained while the isomer ratio decreased at a high LHSV of 56 h<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Linear α-olefin 1-octene produced via dehydration of 1-octanol over Al<SUB>2</SUB>O<SUB>3</SUB> catalyst. </LI> <LI> Changes in crystal phase affected the strong LAS and catalytic activity of Al<SUB>2</SUB>O<SUB>3</SUB>. </LI> <LI> Increased strong LAS improved 1-octanol conversion and 1-octene yield. </LI> <LI> Octene isomers decreased while DOE increased at higher LHSV. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hye-Won Jang,Seongman Bae,Youngmin Ko,Seong Jun Lim,Hye Eun Kwon,Joo Hee Jung,Hae yon Cho,Heounjeong Go,Hyun Wook Kwon,Young Hoon Kim,Sung-Han Kim,Sung Shin 대한이식학회 2021 Korean Journal of Transplantation Vol.35 No.4
The impact of the coronavirus disease 2019 (COVID-19) vaccination on humoral and cellular immunity in transplant recipients remains unknown. We report the case of a 78-year-old kidney transplant recipient who experienced acute T cell-mediated rejection after receiving the second dose of the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). She had no history of acute rejection throughout the 13 years after deceased donor kidney transplantation. Fifteen days after receiving the second dose of the BNT162b2 vaccine, the recipient visited our center with a mild headache and fever. Her serum creatinine level had increased from 0.61 to 4.95 mg/dL. Kidney allograft biopsy indicated acute T cell-mediated rejection (grade IB) with no pathologic evidence of antibody-mediated rejection. Anti-severe acute respiratory syndrome coronavirus 2 spike-immunoglobulin G and -immunoglobulin M measurements were weak positive and negative, respectively. Careful monitoring of kidney allograft function is vital for transplant recipients undergoing COVID-19 vaccination.
Go, Min-Jin,Hwang, Joo-Yeon,Kim, Dong-Joon,Lee, Hye-Ja,Jang, Han-Byul,Park, Kyung-Hee,Song, Ji-Hyun,Lee, Jong-Young Korea Genome Organization 2012 Genomics & informatics Vol.10 No.2
Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between childhood obesity and CVD risk, it would be worthwhile to evaluate whether previously identified lipid-related variants in adult subjects are associated with lipid variations in a childhood obesity study (n = 482). In an association analysis for 16 genome-wide association study (GWAS)-based candidate loci, we confirmed significant associations of a genetic predisposition to lipoprotein concentrations in a childhood obesity study. Having two loci (rs10503669 at LPL and rs16940212 at LIPC) that showed the strongest association with blood levels of TG and HDL-C, we calculated a genetic risk score (GRS), representing the sum of the risk alleles. It has been observed that increasing GRS is significantly associated with decreased HDL-C (effect size, $-1.13{\pm}0.07$) compared to single nucleotide polymorphism combinations without two risk variants. In addition, a positive correlation was observed between allelic dosage score and risk allele (rs10503669 at LPL) on high TG levels (effect size, $10.89{\pm}0.84$). These two loci yielded consistent associations in our previous meta-analysis. Taken together, our findings demonstrate that the genetic architecture of circulating lipid levels (TG and HDL-C) overlap to a large extent in childhood as well as in adulthood. Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.