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Jung Kyeongmin,Yoon Joohyun,Ahn Yeeun,Kim Soyeon,Shim Injeong,Ko Hyunwoong,Jung Sang-Hyuk,Kim Jaeyoung,Kim Hyejin,Lee Dong June,Cha Soojin,Lee Hyewon,Kim Beomsu,Cho Min Young,Cho Hyunbin,Kim Dan Say,K 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between irritability and various traits, including psychiatric disorders; and 3) identify additional and shared genetic variants for irritability and psychiatric disorders. We conducted a genome-wide association study (GWAS) using 379,506 European samples (105,975 cases and 273,531 controls) from the UK Biobank. We utilized various post-GWAS analyses, including linkage disequilibrium score regression, the bivariate causal mixture model (MiXeR), and conditional and conjunctional false discovery rate approaches. This GWAS identified 15 independent loci associated with irritability; the total SNP heritability estimate was 4.19%. Genetic correlations with psychiatric disorders were most pronounced for major depressive disorder (MDD) and bipolar II disorder (BD II). MiXeR analysis revealed polygenic overlap with schizophrenia (SCZ), bipolar I disorder (BD I), and MDD. Conditional false discovery rate analyses identified additional loci associated with SCZ (number [n] of additional SNPs = 105), BD I (n = 54), MDD (n = 107), and irritability (n = 157). Conjunctional false discovery rate analyses identified 85, 41, and 198 shared loci between irritability and SCZ, BD I, and MDD, respectively. Multiple genetic loci were associated with irritability and three main psychiatric disorders. Given that irritability is a cross-disorder trait, these findings may help to elucidate the genomics of psychiatric disorders.
Kim, Beomsue,Lee, Jee-Hyung,Yang, Myung-Soon,Jou, Ilo,Joe, Eun-Hye Wiley Subscription Services, Inc., A Wiley Company 2008 JOURNAL OF NEUROSCIENCE RESEARCH - Vol.86 No.6
<P>Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in two phases, specifically, an initial increase at about 12 hr after stimulation followed by a decrease, and another increase at about 48–72 hr. However, PGE<SUB>2</SUB> and 15d-PGJ<SUB>2</SUB> were detected at about 12 hr, and the levels continuously increased thereafter. Interestingly, all-trans retinoic acid (ATRA) suppressed the expression of early-phase COX-2 but augmented late-phase COX-2 and inhibited iNOS in the whole time sequence. ATRA enhanced PGE<SUB>2</SUB> production but had little effect on 15d-PGJ<SUB>2</SUB>. Moreover, ATRA selectively up-regulated the expression of a PGE<SUB>2</SUB> synthase, mPGES-1, but had little effect on the PGD<SUB>2</SUB> synthase, H-PGDS. The results collectively suggest that ATRA modulates microglial responses to inflammatory stimulators, particularly at the late phase, via enhancement of COX-2 expression and PGE<SUB>2</SUB> production. © 2008 Wiley-Liss, Inc.</P>
Kim, Beomsu Shin-Il,Jin, Young-Jae,Sakaguchi, Toshikazu,Lee, Wang-Eun,Kwak, Giseop American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.24
<P>This paper reports a unique fluorescence (FL) response and diverse applications of conjugated polyelectrolyte (CPE) through nonelectrostatic interaction with appropriate (bio)surfactants in an immiscible two-phase system. A sulfonated microporous conjugated polymer (SMCP) with a conformation-variable intramolecular stacked structure was used as the CPE film. Despite the extremely high hydrophilicity, the SMCP film responded significantly to the hydrophobic circumstances, either physicochemically or electronically, in the presence of water-in-oil (w/o)-type nonionic surfactants with appropriate hydrophile–lipophile balance (HLB) values. The polymer film became fully wet with hydrophobic solvents due to the addition of small amounts of (bio)surfactant to reveal remarkable FL emission enhancement and chromism. Microcontact and inkjet printing using the SMCP film (or SMCP-adsorbed paper) and the surfactant solution as substrate and ink, respectively, provided high-resolution FL images due to the distinctive surfactant-induced FL change (SIFC) characteristic. Moreover, the additional electrostatic interaction of SMCP film with oppositely charged surfactants further enhanced the FL emission. Our findings will help comprehensive understanding of the nonelectrostatic SIFC mechanism of CPEs and development of novel SIFC-active materials.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-24/acsami.5b03717/production/images/medium/am-2015-037176_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5b03717'>ACS Electronic Supporting Info</A></P>
Shape Control Systems for Sendzimir Cold-rolling Steel Mills with Actuator Saturation
Beomsu Kim,Soohee Han 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
This paper deals with the shape control methodology for Sendzimir cold-rolling steel mills. Due to the several problems which come from the Sendzimir mills’ complicate structure, designing automatic shape control system for these mills was one of the main control issues in cold rolling industries. The multi-variable problem and model uncertainty were regarded as main cause which make designing shape control difficult, but we found the actuator saturation problem is also severe. Since most conventional controllers for Sendzimir mill shape control systems do not have the consideration of actuator saturation problem, manual control by operators is still needed in the steel industries. The paper compares some typical shape controllers with various perspectives, and shows how much the actuator saturation affects the shape control performance. At the end of the paper, we’ll choose one most effective controller which can handle the actuator saturation problem and demonstrate the shape control result by simulation.
A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2
Kim, Jong-Jin,Lee, Yong-An,Su, Dongdong,Lee, Jungyeol,Park, Sung-Jin,Kim, Beomsue,Jane Lee, Jia Hui,Liu, Xiao,Kim, Seong Soon,Bae, Myung Ae,Lee, Jun-Seok,Hong, Seong Cheol,Wang, Lu,Samanta, Animesh,Kw American Chemical Society 2019 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.141 No.37
<P>Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to the use of antibodies for in vivo imaging or treatment of TIC. In this study, we discovered heme oxygenase 2 (HMOX2) as a novel biomarker for TIC and developed a selective small molecule probe TiNIR (tumor initiating cell probe with near infrared). TiNIR detects and enriches the functionally active TIC in human lung tumors, and through the photoacoustic property, TiNIR also visualizes lung TIC in the patient-derived xenograft (PDX) model. Furthermore, we demonstrate that TiNIR inhibits tumor growth by blocking the function of HMOX2, resulting in significantly increased survival rates of the cancer model mice. The novel therapeutic target HMOX2 and its fluorescent ligand TiNIR will open a new path for the molecular level of lung TIC diagnosis and treatment.</P> [FIG OMISSION]</BR>
Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review
Kim Beomsu,Park Byeongmin,You Seungju,Jung Suk Han,Lee Soobok,Lim Kangseok,Choi Yeo Jin,Kim Jong-Ho,이상민 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.4
Background Drug delivery to the brain is difficult, owing of the presence of a unique structure called the blood–brain barrier (BBB). Thus, strategies that facilitate drug delivery to the brain lesion sites via BBB penetration must be developed to optimally treat brain diseases, and cell membrane-camouflaged nanoparticles (CMCN) have been cited as potential candidates to overcome challenges related to BBB penetration. Area covered This review covers strategies that may facilitate drug delivery to the lesions of brain diseases beyond BBB, specifically focusing on utilization of cell membranes in nanoparticles. We summarized the possible benefits of utilizing cell membranes for delivering nanoparticles and also investigated the differences between cell membrane camouflaged nanoparticles and exosomes. Expert opinion CMCNs possess promising features that can serve as potential candidates for drug delivery vehicles to adequately deliver therapeutic agents to the brain as part of brain disease management. CMCN demonstrates remarkable biocompatibility, as they are designed using biologically derived materials. Moreover, these particles can potentially evade the immune system and prolong circulation time by using cell membrane proteins. The most prominent advantage of CMCN involves mimicking characteristics of cells that can penetrate into the brain. We believe that further research on CMCN will help develop a novel drug delivery platform that can improve brain disease management in the near future.