The effect of drug holiday before tooth extraction on the development of medication-related osteonecrosis of the jaw in cancer patients receiving intravenous bisphosphonates

Çiğdem Karaca(Çiğdem Karaca ),Göknur Topaloğlu-Yasan(Göknur Topaloğlu-Yasan ),Selen Adiloğlu(Selen Adiloğlu ),Ecem Usman(Ecem Usman ) 대한구강악안면외과학회 2023 대한구강악안면외과학회지 Vol.49 No.2

Objectives: Drug holidays are suggested to reduce the formation of osteonecrosis in patients under intravenous (IV) bisphosphonates (BPs) therapy. The objectives of this study are to evaluate the incidence of medication-related osteonecrosis of the jaw (MRONJ) following tooth extraction in cancer patients using IV BP, and to assess the effect of drug holiday on the development of MRONJ. Patients and Methods: A manuel search of the patient folders of Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hacettepe University was undertaken to identify cancer patients who used IV BPs and had at least one tooth extraction between 2012 and 2022. Patents’ age, sex, systemic condition, the type of BP used, duration of BP used, number of tooth extraction, duration of drug holiday, localization of tooth extraction and incidence of MRONJ were recorded. Results: One hundred nine teeth were removed from 57 jaws in 51 patients. All tooth extractions were performed under perioperative antibiotic prophylaxis and with primary wound closure. The incidence of MRONJ was 5.3%. Stage 1 MRONJ developed in 3 patients (only one had a drug holiday). The median duration of drug holiday was 2 months. No significant difference between the patients with and without a drug holiday and MRONJ development was found (P=0.315). The mean age of patients developed MRONJ was 40.33±8.08 years. A statistically significant difference was found between age and MRONJ development (P=0.002). Conclusion: The effect of a short-term drug holiday on the development of MRONJ may be limited because BPs remain in bone tissue for a long time. Drug holidays should be applied with the approval of an oncologist with other preventive measurements.

Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function

Mehmet Karaca,Nazente Atceken,Şefayet Karaca,Ersoy Civelek,Bülent E. Şekerel,Renato Polimanti 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.5

Purpose: Respiratory diseases have a highly multifactorial etiology where different mechanisms contribute to the individual's susceptibility. We conducted a deep characterization of loci associated with asthma and lung function by previous genome-wide association studies (GWAS). Methods: Sixteen variants were selected from previous GWAS of childhood/adult asthma and pulmonary function tests. We conducted a phenome-wide association study of these loci in 4,083 traits assessed in the UK Biobank (n = 361,194 participants). Data from the Genotype-Tissue Expression (GTEx) project were used to conduct a transcriptomic analysis with respect to tissues relevant for asthma pathogenesis. A pediatric cohort assessed with the International Study of Asthma and Allergies in Children (ISAAC) Phase II tools was used to further explore the association of these variants with 116 traits related to asthma comorbidities. Results: Our phenome-wide association studies (PheWAS) identified 206 phenotypic associations with respect to the 16 variants identified. In addition to the replication of the phenotypes tested in the discovery GWAS, we observed novel associations related to blood levels of immune cells (eosinophils, neutrophils, monocytes, and lymphocytes) for the asthma-related variants. Conversely, the lung-function variants were associated with phenotypes related to body fat mass. In the ISAAC-assessed cohort, we observed that risk alleles associated with increased fat mass can exacerbate allergic reactions in individuals affected by allergic respiratory diseases. The GTEx-based analysis showed that the variants tested affect the transcriptomic regulation of multiple surrounding genes across several tissues. Conclusions: This study generated novel data regarding the genetics of respiratory diseases and their comorbidities, providing a deep characterization of loci associated with asthma and lung function.

Comparison of Limberg flap and excision and primary closure of pilonidal sinus disease, in terms of quality of life and complications

Ahmet Serdar Karaca,Rıdvan Ali,Muzaffer Capar,Sezar Karaca 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.5

Purpose: The aim of this study was to compare two different treatment methods for pilonidal sinus with respect to complications, recurrence, and patient quality of life. Methods: Five hundred forty-nine patients who underwent surgery for pilonidal sinus between January 2007 and August 2012 were included in this study. The patients were classified into group I (excision and primary closure) and group II (Limberg flap). Results: There was no significant difference in the mean age and gender of the patients between groups I and II (P = 0.512 and P = 0.472). The duration of surgical operation was lower in group I (P < 0.001). There was no significant difference in hospitalization time after surgery, minor complications, and recurrence between the groups (P = 0.674, P = 1.000, and P = 1.000, respectively). The time required for pain-free walking, urinating, and returning to work was significantly lower in group II (P < 0.001, P < 0.001, and P < 0.001, respectively). The patients in group I stated that they were more satisfied in terms of aesthetics (P < 0.001). Conclusion: According to the results of this study, Limberg flap method has better outcomes compared with excision and primary closure. Therefore, we recommend Limberg flap for treatment of pilonidal sinus disease.

Positive Effects of Oral β-Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX-4 Combination Chemotherapy

Karaca, Halit,Bozkurt, Oktay,Ozaslan, Ersin,Baldane, Suleyman,Berk, Veli,Inanc, Mevlude,Duran, Ayse Ocak,Dikilitas, Mustafa,Er, Ozlem,Ozkan, Metin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

The present study aimed to determine the effect of oral ${\beta}$-glucan on mucositis and leukopenia in 62 consecutive patients with colorectal cancer treated with an adjuvant FOLFOX-4 regimen. The patients were retrospectively evaluated in 2 groups: one group received ${\beta}$-glucan and the other did not (control group). Leucocytes, neutrophils, and platelets were evaluated before and 1 week after chemotherapy and oral mucositis and diarrhea were noted. Leucocyte and neutrophil counts after chemotherapy in the ${\beta}$-glucan group were $7,300/mm^3$ and $3,800/mm^3$, respectively, and the reductions, as compared to baseline, were not significant (p=0.673 and 0.784). The median platelet count was $264,000/mm^3$ after chemotherapy in the ${\beta}$-glucan group and the reduction, as compared to baseline, was borderline significant (p=0.048). In the control group, reduction in leucocyte, neutrophil, and platelet counts was statistically significant. Oral mucositis and diarrhea were less common in the ${\beta}$-glucan group. We conclude that ${\beta}$-glucan can be used to reduce the adverse effects of chemotherapy.

Mathematical Models for the Biofilm Formation of Geobacillus and Anoxybacillus on Stainless Steel Surface in Whole Milk

Karaca, Basar,Buzrul, Sencer,Cihan, Arzu Coleri Korean Society for Food Science of Animal Resource 2021 한국축산식품학회지 Vol.41 No.2

Biofilm formation of Geobacillus thermodenitrificans, Geobacillus thermoglucosidans and Anoxybacillus flavithermus in milk on stainless steel were monitored at 55℃, 60℃, and 65℃ for various incubation times. Although species of Geobacillus showed a rapid response and produced biofilm within 4 h on stainless steel, a delay (lag time) was observed for Anoxybacillus. A hyperbolic equation and a hyperbolic equation with lag could be used to describe the biofilm formation of Geobacillus and Anoxybacillus, respectively. The highest biofilm formation amount was obtained at 60℃ for both Geobacillus and Anoxybacillus. However, the biofilm formation rates indicated that the lowest rates of formation were obtained at 60℃ for Geobacillus. Moreover, biofilm formation rates of G. thermodenitrificans (1.2-1.6 Log10CFU/mL∙h) were higher than G. thermoglucosidans (0.4-0.7 Log10CFU/mL∙h). Although A. flavithermus had the highest formation rate values (2.7-3.6 Log10CFU/mL∙h), this was attained after the lag period (4 or 5 h). This study revealed that modeling could be used to describe the biofilm formation of thermophilic bacilli in milk.

The slenderness effect on wind response of industrial reinforced concrete chimneys

Karaca, Zeki,Turkeli, Erdem Techno-Press 2014 Wind and Structures, An International Journal (WAS Vol.18 No.3

There are several parameters affecting the response of industrial reinforced concrete (RC) chimneys, i.e., the severity of wind and earthquake loads acting to the structure, structural properties such as height and cross section of the chimney, the slenderness property of the structure etc. One of the most important parameter that should be considered while understanding the wind response of industrial RC chimneys is slenderness property. Although there is no certain definition for slenderness effect on these structures, some standards like ASCE-7 define slenderness from different aspects of the structural properties. In the first part of this study, general information about the definition of slenderness in the well-known standards and ten selected industrial RC chimneys are given. In the second part of the study, brief information about wind load standards that are used for calculating wind loads namely ACI 307/98, CICIND 2001, DIN 1056, TS 498 and Eurocode 1 is given. In the third part of the study, calculated wind loads for selected chimneys are represented. In the fourth part of this study, the internal forces obtained from load combinations that are applied to chimneys and some graphs presenting the effect of slenderness on chimneys are given. In the last part of the study, a conclusion and discussion part is taking place.

Association of Human Epidermal Growth Factor Receptor-2 Expression and Clinicopathological Findings in Patients with Colorectal Cancer

Karaca, Halit,Deniz, Kemal,Berk, Veli,Inanc, Mevlude,Ozkan, Metin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: To determine the frequency of HER-2 overexpression in colorectal cancer (CRC) patients, and to explore the relationship between clinicopathological prognostic factors and their effects on survival, based on immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) analysis. Materials and Methods: The study included 80 patients with a histologically proven diagnosis of CRC that received adjuvant FOLFOX-4 chemotherapy at our department between March 2006 and September 2010. Patient data were analyzed retrospectively. Results: The median follow-up period and age of the patients were 24 months and 59 years, respectively. In immunohistochemical staining, 3+ staining was found in 2 patients (2.5%) while 2+ was in 13 (16%). FISH for HER-2 was performed for all of these 15 patients; samples which were 3+ showed positivity but the ones with 2+ were negative. There was no significant correlation between HER-2 expression and age, gender, tumor localization, histological subtype, grade, lymphovascular and perineural invasion, or pTN stage (P>0.05), even when the patients with HER-2 overexpression were analyzed separately. There was also no significant relationship between progression-free survival (PFS) and overall survival (OS), and HER-2 expression, gender, tumor localization, obstruction-perforation, bleeding, histological type, grade, lymphovascular and perineural invasion, or pT staging (P>0.05); however, there was a significant relationship between lymph node involvement, and PFS and OS (P<0.05). Conclusions: Evaluation of HER-2 overexpression in a more comprehensive, multi-center, prospective trial with standardized methods will be an appropriate approach.

Re: Byung-Do Lee, Wan Lee, Kyung-Hwan Kwon, Moon-Ki Choi, Eun-Joo Choi and Jung-Hoon Yoon. Glandular odontogenic cyst mimicking ameloblastoma in a 78-year-old female: A case report. Imaging Science in Dentistry 2014; 44(3): 249-52

Karaca, Inci Rana,Ozturk, Dilara Nur,Uluturk, Hacer Korean Academy of Oral and Maxillofacial Radiology 2015 Imaging Science in Dentistry Vol.45 No.2

The slenderness effect on wind response of industrial reinforced concrete chimneys

Zeki Karaca,Erdem Türkeli 한국풍공학회 2014 한국풍공학회지 Vol.18 No.3

There are several parameters affecting the response of industrial reinforced concrete (RC)chimneys, i.e., the severity of wind and earthquake loads acting to the structure, structural properties such asheight and cross section of the chimney, the slenderness property of the structure etc. One of the mostimportant parameter that should be considered while understanding the wind response of industrial RCchimneys is slenderness property. Although there is no certain definition for slenderness effect on thesestructures, some standards like ASCE-7 define slenderness from different aspects of the structural properties. In the first part of this study, general information about the definition of slenderness in the well-knownstandards and ten selected industrial RC chimneys are given. In the second part of the study, briefinformation about wind load standards that are used for calculating wind loads namely ACI 307/98, CICIND2001, DIN 1056, TS 498 and Eurocode 1 is given. In the third part of the study, calculated wind loads forselected chimneys are represented. In the fourth part of this study, the internal forces obtained from loadcombinations that are applied to chimneys and some graphs presenting the effect of slenderness on chimneysare given. In the last part of the study, a conclusion and discussion part is taking place.

Seismic assessment of historical masonry structures: The case of Amasya Taşhan

Zeki Karaca,Erdem Türkeli,Şenol Pergel 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.20 No.4

Turkey owns a very important cultural and historical heritage that bears the traces of thousands of years of culture and civilization. It is an inevitable duty to carry these treasuries to the future generations. In this paper, structural safety assessment and strengthening stages of one of these important historical heritages namely Amasya Taşhan was investigated in details as a case study. For this purpose, the detailed architectural projects of the structure with the information of all load carrying and structural elements were prepared. Then, the structural dynamic analyses were performed by using SAP2000. The internal forces obtained from the dynamic analyses determined the weak regions. By obtaining the information from dynamic analyses, the method of state of the art technique of application of the structure that needs structural strengthening was selected. The last step is the application of these precautions to the whole structure. At the end of this study, this study not also contains several strengthening techniques that is used in one masonry structure together but also provides a useful reference to the practicing engineers.