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Kang, Dong Oh,Park, Yoonjee,Seo, Ji Hoon,Jeong, Myung Ho,Chae, Shung Chull,Ahn, Tae Hoon,Jang, Won Young,Kim, Woohyeun,Park, Eun Jin,Choi, Byoung Geol,Na, Jin Oh,Choi, Cheol Ung,Kim, Eung Ju,Rha, Seun Elsevier 2019 Journal of cardiology Vol.74 No.1
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Elevated high sensitivity C-reactive protein (hs-CRP) in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI) has prognostic value for future cardiovascular events. This study aimed to ascertain a valid prognostic time-period for predicting cardiovascular outcome based on baseline hs-CRP in AMI patients undergoing successful PCI on statin therapy.</P> <P><B>Methods</B></P> <P>Overall, 4410 AMI patients were enrolled from the Korea Acute Myocardial Infarction-National Institutes of Health (KAMIR-NIH) registry. Participants were divided into groups according to cut-off values of baseline hs-CRP (1.0, 3.0, and 10.0mg/L) and statin therapy intensity. The primary outcome was 36-month major adverse cardiovascular events (MACE), a composite of all-cause mortality, any myocardial infarction, and repeat revascularization. The secondary outcome was MACE developed 0–6, 6–12, and 12–36 months after AMI.</P> <P><B>Results</B></P> <P>The overall incidence of 36-month MACE was significantly higher as baseline hs-CRP increased (by groups: 8.8% vs. 8.6% vs. 10.7% vs. 15.4%, log-rank <I>p</I> <0.001). The prognostic effect of baseline hs-CRP was mostly confined to the first 6 months after AMI (0–6 months MACE by groups: 1.6% vs. 2.3% vs. 4.3% vs. 6.1%, log-rank <I>p</I> <0.001) and attenuated in high-intensity statin users. Six months after AMI, this prognostic effect of baseline hs-CRP was remarkably reduced (6–12 month MACE by groups: 2.4% vs. 2.1% vs. 2.8% vs. 4.0%, log-rank <I>p</I> =0.111, 12–36 month MACE by groups: 4.7% vs. 4.1% vs. 4.0% vs. 6.2%, log-rank <I>p</I> =0.218); however, high-intensity statin treatment showed a consistent improvement in outcome. The observed time-dependent prognostic effects remained consistent following multivariate analysis.</P> <P><B>Conclusions</B></P> <P>The prognostic impact of elevated hs-CRP at baseline was most evident during the first 6 months after AMI; however, the use of high-intensity statin persistently improved the clinical outcome even after the resolution of inflammatory reactions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The prognostic impact of baseline high sensitivity C-reactive protein (hs-CRP) was mostly confined to the first 6 months. </LI> <LI> High-intensity statin attenuated the prognostic impact of baseline hs-CRP elevation. </LI> <LI> Dose-dependent anti-inflammatory effect of statin is dominant over the first 6 months. </LI> <LI> High-intensity statin persistently improved outcome after first 6 months of acute myocardial infarction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P> <B>Time-dependent prognostic effect of baseline hs-CRP and high-intensity statin therapy after AMI.</B> </P> <P>The prognostic impact of elevated hs-CRP at baseline was mostly confined to the first 6 months after AMI, and high-intensity statin therapy persistently improved the clinical outcome over the extended follow-up period. The observed beneficial effect of high-intensity statin therapy was attributed to both the anti-inflammatory and cholesterol-lowering effects during the early 6 months; and predominantly to cholesterol-lowering effects in the later periods.</P> <P>AMI, acute myocardial infarction; hs-CRP, high sensitivity C-reactive protein; MACE, major adverse cardiovascular events.▪</P>
Kang, Mi-Jin,Kwon, Ji-Won,Kim, Byoung-Ju,Yu, Jinho,Choi, Won-Ah,Shin, Yee-Jin,Hong, Soo-Jong Springer-Verlag 2011 Journal of human genetics Vol.56 No.4
<P>Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronchoconstriction, recruitment of eosinophils, basophils and T-lymphocytes, and enhanced synthesis of leukotriene C4. We investigated whether polymorphisms of the leukotriene C4 synthase (LTC4S) -444A/C and PTGDR -441T/C were associated with clinical phenotypes and responsiveness to leukotriene receptor antagonist (LTRA) in Korean asthmatic children. We enrolled 270 normal and 870 asthmatic children. We prescribed montelukast (5 mg per day) to 100 of asthmatic children, and analyzed the responsiveness to LTRA by exercise challenge tests. Polymorphisms were genotyped by PCR-restriction fragment length polymorphism. As the number of minor alleles of the PTGDR -441T/C and LTC4S -444A/C polymorphisms increased, the log total eosinophil counts increased in atopic asthmatic children (P-value=0.03). We found a significant association between responsiveness to montelukast and the PTGDR polymorphism (P-value=0.038). However, the LTC4S -444A/C and PTGDR -441T/C were not associated with the susceptibility for asthma (LTC4S, AA versus AC+CC, adjusted odds ratio of 0.98 (95% confidence interval, 0.73-1.31); PTGDR, TT versus TC+CC, adjusted odds ratio of 0.90 (95% confidence interval, 0.68-1.19)) or clinical phenotypes (P-value>0.05). The effects of the PTGDR and LTC4S polymorphisms on the enhancement of eosinophil counts were additive in the Korean children with asthma. In addition, the PTGDR polymorphism seems to be associated with the responsiveness to LTRA. Therefore, therapies that target the PTGDR may be useful for modulating the responsiveness to LTRA.</P>
Simulation Study on a Prompt Gamma Detection System for Use in Proton Therapy
Byoung Hwi Kang,Jong Won Kim 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.3
In proton beam therapy, it is important to know the location of the distal dose falloff. The method we adopt is to detect prompt gammas emitted from nuclear reactions in the direction normal to incident protons. While we have successfully measured the falloff locations in the therapy energy range of 100 -- 200 MeV by using a scanning system, a stationary system is needed for practical applications. The new system we are developing consists of a micro-time projection chamber (TPC), which can track the Compton-scattered electrons, and a position-sensitive scintillation detector. The performance of such a system has been studied and optimized using the Monte Carlo simulation toolkits GEANT and GLECS. With coincidence information between the TPC and the scintillation camera, the prompt gammas can be reconstructed with high angular resolution to filter the normal direction. We present the simulation results for the planned system. In proton beam therapy, it is important to know the location of the distal dose falloff. The method we adopt is to detect prompt gammas emitted from nuclear reactions in the direction normal to incident protons. While we have successfully measured the falloff locations in the therapy energy range of 100 -- 200 MeV by using a scanning system, a stationary system is needed for practical applications. The new system we are developing consists of a micro-time projection chamber (TPC), which can track the Compton-scattered electrons, and a position-sensitive scintillation detector. The performance of such a system has been studied and optimized using the Monte Carlo simulation toolkits GEANT and GLECS. With coincidence information between the TPC and the scintillation camera, the prompt gammas can be reconstructed with high angular resolution to filter the normal direction. We present the simulation results for the planned system.
Kang, Kyoung Ah,Zhang, Rui,Piao, Mei Jing,Ko, Dong Ok,Wang, Zhi Hong,Lee, Kyung,Kim, Bum Joon,Shin, Taekyun,Park, Jae Woo,Lee, Nam Ho,Yoo, Byoung Sam,Hyun, Jin Won Taylor Francis 2008 Journal of toxicology and environmental health. Pa Vol.71 No.15
<P> Oxidative stress is known to generate reactive oxygen species (ROS) in cells, which subsequently induce the synthesis of matrix metalloproteinases (MMP) and an aging phenomenon. The protective effects of triphlorethol-A, derived from Ecklonia cava, were investigated against hydrogen peroxide (H2O2)-induced damage using human skin keratinocytes. Data showed that triphlorethol-A inhibited ROS formation, induced catalase expression, inhibited DNA damage, and increased cell viability in keratinocytes. Triphlorethol-A treatment significantly reduced MMP-1 expression and production, compared to H2O2-treated cells. In addition, triphlorethol-A abrogated the activation of extracellular signal regulated protein kinase (ERK), which originates upstream of MMP-1 expression, and was induced by H2O2 treatment. Moreover, triphlorethol-A inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of ERK. Data indicate that the antioxidative properties of triphlorethol-A involve the inhibition of MMP-1 via ERK and AP-1 inhibition.</P>
An Intelligent Control of Mobile Robot Based on Voice Command
Byoung-Kyun Shim,Kwang-wook Kang,Woo-Song Lee,Jong-Baem Won,Sung-Hyun Han 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
In general, it is possible to estimate the noise by using information on the robot’s own motions and postures, because a type of motion and gesture produces almost the same pattern of noise every time. In this paper, we describe an voice recognition control system for robot(VRCS) system which can robustly recognize voice by adults and children in noisy environments. We evaluate the VRCS system in a communication robot placed in a real noisy environment. Voice is captured using a wireless microphone. To suppress interference and noise and to attenuate reverberation, we implemented a multi-channel system consisting of an outlier-robust generalized side-lobe canceller technique and a feature-space noise suppression using MMSE criteria. Voice activity periods are detected using GMM-based end-point detection