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      • SCOPUSKCI등재

        Progress in R&D of coated conductor in M-PACC project

        Izumi, T.,Ibi, A.,Nakaoka, K.,Taneda, T.,Yoshida, T.,Takagi, Y.,Nakamura, T.,Machi, T.,Katayama, K.,Sakai, N.,Yoshizumi, M.,Koizumi, T.,Kimura, K.,Kato, T.,Kiss, T.,Shiohara, Y. The Korea Institute of Applied Superconductivity a 2014 한국초전도저온공학회논문지 Vol.16 No.2

        The five-year national project in Japan for R&D of coated conductors and applications, named as the Materials and Power Applications of Coated Conductors (M-PACC) project, was finished at the end of FY2013. The project consists of four sub-themes as cable, transformer, SMES and coated conductors. In the theme of coated conductors, the fabrication process had been developed to satisfy the requirements from the applications such as in-field $I_c$ performance, low AC loss in the long tapes etc. Through the project, the remarkable progress was achieved as follows; a high in-field minimum $I_c$ value over 54A/cm-width under 3T at 77K was realized in a 200m long EuBCO tape with artificial pinning centers of $BaHfO_3$ by the pulsed laser deposition (PLD) technique on the IBAD template. On the other hand, the AC loss reduction was confirmed in the tapes fabricated by both PLD and the metal organic deposition (MOD) techniques by scribing 100m tapes into 10-filamments. Additionally, the mechanism of the delamination phenomenon was systematically investigated and the strength was improved by eliminating the origins of the weak points in the films. Through the development, all targeted goals were accomplished and the several results were appreciated as a world champion data.

      • SCIESCOPUSKCI등재

        Effect of Rumen Protected Methionine on Lactational Performance of Dairy Cows

        Izumi, K.,Kikuchi, C.,Okamoto, M. Asian Australasian Association of Animal Productio 2000 Animal Bioscience Vol.13 No.9

        Thirty-six Holstein dairy cows were used to evaluate the effect of a rumen protected methionine supplement (RPMet). The cows were divided into two groups of 18 each (control/experimental). The experimental group was given 15 g/d of RPMet (Mepron $^{(R)}$M85, Degussa) from the 4th to the 26th week postpartum. All cows were fed a similar amount of forage including alfalfa silage, corn silage and timothy silage. Concentrate mixture was offered in proportion to the milk yield of each cow. Sufficiency of major metabolizable AAs was checked. Milk yield and milk composition was monitored for each individual cow. A metabolic profile test (MPT) was carried out at the 7th, 11th and 21st week postpartum. Without supplement, both methionine and leucine fell short of the daily requirement. Supplementation with 15 g/d RPMet was calculated to be within a sufficient margin of safety. Milk yield tended to remain higher in the supplemented group than in the controls during supplementation with RPMet. The differences in weekly milk production at the 17th, 18th, 19th and 22nd weeks postpartum were significantly high in the RPMet group (p<0.05). The average 305-d milk yield and the percentages of milk fat, milk protein and solids-not-fat were not affected by the treatment. No differences were observed in either the somatic cell count in the milk or the reproductive status. Judging from MPT, all the cows were in good health during lactation.

      • SCOPUSKCI등재
      • SCIESCOPUSKCI등재

        Effects of Dietary Fat Sources on Occurrences of Conjugated Linoleic Acid and trans Fatty Acids in Rumen Contents

        An, B.K.,Kang, C.W.,Izumi, Y.,Kobayashi, Y.,Tanaka, K. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.2

        The effects of dietary sources of C18:2 n-6 or C18:3 n-3 fatty acids on the occurrence of conjugated linoleic acid (CLA) and time-dependent changes of free fatty acid fractions in rumen contents were investigated. Sheep (n=4) fitted with rumen fistula were used in a 44 Latin square design wxith each 14 d period. Sheep were fed one of four diets consisting of grass hay and concentrates in a ratio of 70:30. Dietary treatments were 100% concentrates (served as the control), and concentrates were replaced by safflower seed at 30% (SFS), safflower meal at 18% - safflower oil at 12% (SFO), and safflower meal at 18%-linseed oil at 12% (LNO). At the end of each experimental period, rumen contents from each sheep were collected before feeding and at 1, 3, 6 and 12 h after feeding. The levels of cis-9, trans-11 CLA in free fatty acid fraction were considerably increased in all treated groups relative to the control, but not significantly. The increase in cis-9, trans-11 CLA was slightly higher in SFS and SFO groups than group fed diet containing linseed oil. The level of cis-9, trans-11 CLA in free fatty acid fraction was reached to the maximum value at 1hr after feeding and, thereafter gradually decreased to near the value before feeding. The generation of trans-11 C18:1 was significantly higher in all treated groups than that of control. The level of trans-11 C18:1 was linearly increased after feeding of experimental diets, reaching the maximum value at 3 h. Feeding of diets containing polyunsaturated fats to sheep resulted in a marked increase in the levels of trans-11 C18:1 and a slight increase of CLA in free fatty acid fraction of rumen contents. Our results support that endogenous synthesis of CLA from trans-11 C18:1 may be involved the primary source of CLA in dairy product. (Asian-Aust.

      • SCOPUSKCI등재
      • KCI우수등재

        글리세린 근섬유의 소편화에 미치는 Ca2+ 과 pH 의 영향 및 알카리 강직근의 소편화 .

        성삼경,화천건차랑 ( S . K . Sung,K . Izumi ) 한국축산학회 1982 한국축산학회지 Vol.24 No.3

        Fragmentations of different rigor type muscles during postmortem storage were studied and glycerinated muscle fibers were employed in order to determine the factors influencing fragmentation. Degree of fragmentation was significantly different on different rigor types. Fragmentation of acid rigor proceed rapidly during postmortem aging while it was very slow in alkaline rigor. Similar results were obtained when glycerinated muscle fibers were incubated with sarcoplasm extracted from two types of rigor muscle. The protein compositions of sarcoplasm from two rigor types were not significantly different. But the fragmentation of the two rigor types changed according to the pH change. The same effects were also obtained by use of Ca^(2+) Under the conditions of acid rigor sarcoplasm, fragmentation was not suppressed by the addition of the lodoacetate, irreversible inhibitor of CAF. On the other hand, the fragmentation was not increased by the addition of Ca^(2+) alone under conditions alkaline rigor sarcoplasm. From these results it can be suggested that the fragmentation of different rigor types are influenced by different factors and Ca^(2+), CAF and proteases are involved with a complex relationship.

      • SCIESCOPUS

        Liver Cancer Working Group Report

        Kudo, M.,Han, K. H.,Kokudo, N.,Cheng, A.-L.,Choi, B. I.,Furuse, J.,Izumi, N.,Park, J.-W.,Poon, R. T.,Sakamoto, M. Oxford University Press 2010 Japanese journal of clinical oncology Vol.40 No.suppl1

        <P>Hepatocellular carcinoma is a highly prevalent disease in many Asian countries, accounting for 75-80% of victims worldwide. The incidence of hepatocellular carcinoma varies enormously across Asia, but tends to follow the incidences of hepatitis B infection and liver cirrhosis. The incidence and etiology of hepatocellular carcinoma in Japan are different from the rest of Asia, but similar to that in Western countries because hepatitis C infection is the main etiological factor in Japan. Hepatitis B virus vaccination programs are showing great success in reducing hepatitis B virus-related hepatocellular carcinoma. Screening program improves detection of early hepatocellular carcinoma and has some positive impact on survival, but the majority of hepatocellular carcinoma patients in Asia still present with advanced hepatocellular carcinoma. Long-term outcomes following treatment of even early/intermediate or advanced disease are often unsatisfactory because of a lack of effective adjuvant and systemic therapies. Various clinical practice guidelines for hepatocellular carcinoma have been established and are in use. Clinical diagnosis of hepatocellular carcinoma by imaging diagnosis is replacing diagnosis of hepatocellular carcinoma by pathological confirmation. New imaging and treatment techniques are continuously being developed and guidelines should be updated every 3 or 4 years, incorporating new evidence. New molecularly targeted therapies hold great promise. Sorafenib is the first systemic therapy to demonstrate prolonged survival vs. the placebo in patients with advanced hepatocellular carcinoma. Various other new molecularly targeted agents are currently under investigation.</P>

      • KCI등재

        A Meta-Analysis of the Effect on Myopia Progression Control for Children and Adolescents in Korea

        Hye-Won Park,Tae-Hun Kim 대한시과학회 2020 대한시과학회지 Vol.22 No.3

        목적 : 국내 소아 및 청소년의 근시 진행 억제에 대한 효과를 축적한 연구물을 종합하여 확인하고 비교 분석하 여 근시 진행 억제를 위한 임상적 의미를 제시하고자 하였다. 방법 : 국내 소아 및 청소년을 대상으로 근시 진행 억제를 위해 ‘아트로핀(atropine)’, ‘각막굴절교정렌즈(orthokeratology lens)’, ‘근시억제렌즈(myopia control lens)’를 수행한 연구를 수집하였다. 체계적으로 메타분석을 실시하기 위해 PICO 기준으로 검색하여 최종 11편을 선정하였다. RoBANS 도구를 사용하여 질 평가를 하였으며 개별 연구들의 효과크기를 산출하고 효과크기 차이를 검증하기 위해 메타ANOVA를 실시하였다. 결과 : 근시 진행 억제에 대한 메타분석을 실시한 결과 전체 효과 크기는 –0.41 D으로 나타났다. 근시 진행 억 제에 대한 하위 분석 효과 크기 결과 ‘각막굴절교정렌즈’ -0.50 D, ‘근시억제렌즈’ -0.37 D으로 유의한 차이를 보 여 근시 진행 억제를 확인할 수 있었으며, ‘아트로핀’ -0.32 D였으며 유의한 차이를 보이지 않았다. 근시 진행 억 제 방법에 대한 메타ANOVA 결과 방법들 간에 차이가 없는 것으로 나타났다. 결론 : 근시 진행을 억제하기 위해 방법들 간에 큰 차이는 없지만 부작용이 없고 장기간 지속할 수 있는 방법을 선택해야 할 것이다. Purpose : The purpose of this study was to provide a clinical implication for myopia progression control by synthesizing, comparing and analyzing the studies that have been accumulated effects on myopia progression control of children and adolescents in Korea. Methods : This study collected studies in which myopia progression control was investigated as interventions such as ‘atropine’, ‘orthokeratology lens’, and ‘myopia control lens’ for children and adolescents in Korea. For systematic meta-analysis, 11 studies were finally selected after literature search based on the PICO criteria. It was to be evaluated qualitatively using the tools RoBANS, and metaANOVA was performed to calculate effect size of individual studies and to verify the difference in effect size. Results : The meta-analysis showed that myopia progression control had an effect size, with a total effect size of –0.41 D. As a result of the sub-analysis effect size for myopia progression control, ‘orthokeratology lens’ -0.50 D and ‘myopia control lens’ -0.37 D were shown and significant differences between them were found. The control of myopia progression control was confirmed, which was ‘atropine’ -0.32 D, showing that no significant difference was found. MetaANOVA for myopia progression control showed no difference between the methods. Conclusion : There is no significant difference between the methods to control myopia progression, but it would be necessary to choose a method that has no side effects and to last for a long time.

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