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Park, Sang Min,Kim, HyeMi,Song, Kwang Hoon,Eom, Seongsu,Park, HyoungJun,Doh, Junsang,Kim, Dong Sung Elsevier 2018 Biomaterials Vol.169 No.-
<P><B>Abstract</B></P> <P>Leukocyte infiltration plays critical roles in tissue inflammation for pathogen clearance and tumor eradication. This process is regulated by complex microenvironments in blood vessels, including inflamed endothelium, blood flow, and perivascular components. The role of perivascular components in leukocyte infiltration has not been systematically investigated until recently mostly due to lack of technology. In this work, we developed a three-dimensional multi-layered blood vessel/tissue model with a nanofiber membrane, enabling real-time visualization of dynamic leukocyte infiltration and subsequent interaction with perivascular macrophages. We directly fabricated a highly aligned, free-standing nanofiber membrane with an ultra-thin thickness of ∼1 μm in microfluidic systems. Coating the nanofiber membrane with matrigel showed synergetic topographical and biochemical effects on the reconstitution of a well-aligned endothelial monolayer on the membrane. Our 3D multi-layered blood vessel/tissue model will offer a powerful and versatile tool for investigating the mechanism of leukocyte tissue infiltration and subsequent immune responses.</P>
Transition of Corporate Designers' Perception for Social Impact Management
Park, Junsang,Nam, Wonsuk The International Promotion Agency of Culture Tech 2020 International Journal of Advanced Culture Technolo Vol.8 No.3
This is an era in which companies should realize sustainable management through business models that propose social values beyond financial benefits and solve social problems. Accordingly, the role of corporate designers should be extended to social value propositions and materializations, including corporate profit-seeking. Among the members and organizations of the company, design organization and designers have strengths in terms of humanities and creativity compared to other organizations and members. We should actively seek opportunities for corporate designers to find the context of connecting businesses and society on their own, actively seek opportunities to integrate them with corporate design, expand the role of corporate designers through creative ideas, and actively pursue sustainable and wide social career development that encompasses both inside and outside of the company. To this end, we suggested three transitions of thougths to change the perception of fixed and straight-line forms of enterprise organization, enterprise design approach and product development process so far to present useful insights through case studies, how enterprise designers can accommodate social impact through new communication and access.
Park, Junsang,Nam, Wonsuk The International Promotion Agency of Culture Tech 2020 International Journal of Advanced Culture Technolo Vol.8 No.3
Our overall society circulates in line with the economical situations characterized by production and consumption and companies play the role of providing products and services, thus taking very significant responsibilities for the socioeconomical and cultural aspects in society. Therefore, when designers attempt to think of a way to enable companies and society to share their values and propose specific concepts and visualize outcomes, it is very critical to be able to understand economical philosophy and management strategies that interconnect companies with society and seek out proper design approaches. Recently, the world's enterprise and management culture tend to connect products and services provided by companies through chains of social values. Based on the abovementioned shift in the management paradigm, the researcher investigates and analyzes actual cases of attempts by Samsung Electronics to achieve its social impacts and studies actual roles and approaches of in-house designers with creativity and insights of humanity with regard to these attempts. Each case is selected from various fields such as the company's products and service development, business systems, culture, and external strategies and the ultimate goal is to learn about actual insights and approaches of designers to make contributions to the company's management with social impacts. Especially, humanity and creative thinking of many designers working in the manufacturing industry can have significant contributions to achieving its management with social impacts and effects of sustainable management.
Negative role of inducible PD-1 on survival of activated dendritic cells
Park, Seong Jeong,Namkoong, Hong,Doh, Junsang,Choi, Jong-Cheol,Yang, Bo-Gie,Park, Yunji,Chul Sung, Young Society for Leukocyte Biology 2014 Journal of Leukocyte Biology Vol.95 No.4
<P>PD-1 expressed on activated DCs suppresses T cell activation via decreasing DC survival.</P>
Junsang Park,Sang Mook Kang,Yu Deok Won,Myung-Hoon Han,Jin Hwan Cheong,Byeong-Jin Ha,Je Il Ryu 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.6
Objective : Anterior cervical spine surgery (ACSS) is a common surgical procedure used to treat cervical spinal degenerative diseases. One of the complications associated with ACSS is prevertebral soft tissue swelling (PSTS), which can result in airway obstruction, dysphagia, and other adverse outcomes. This study aims to investigate the correlation between various cervical sagittal parameters and PSTS following single-level ACSS, as well as to identify independent risk factors for PSTS. Methods : A retrospective study conducted at a single institution. The study population included all patients who underwent single-level ACSS between January 2014 and December 2022. Patients with a history of cervical spine surgery or trauma were excluded from the study. The presence and severity of PSTS was assessed by reviewing pre- and postoperative imaging studies. The potential risk factors for PSTS that were examined include patient age, sex, body mass index, tobacco use, comorbidities, serum albumin levels, operative time, implant type, implanted level, and various cervical spine sagittal parameters. Multivariate linear regression analysis was performed to identify the independent risk factors for PSTS. Results : A total of 62 consecutive patients who underwent single-level ACSS over a 8-year period at a single institution were enrolled in this study. Only preoperative segmental angle showed positive correlation with PSTS among various cervical spine sagittal parameters (r=0.36, p=0.005). Artificial disc replacement showed a negative correlation with PSTS (β=-0.38, p=0.002), whereas the use of demineralized bone matrix (DBM) had a positive impact on PSTS (β=0.33, p=0.009). We found that male sex, lower preoperative serum albumin, and implantation of upper cervical level (above C5) were independent predictors for PSTS after single-level ACSS (β=1.21; 95% confidence interval [CI], 0.27 to 2.15; p=0.012; β=-1.63; 95% CI, -2.91 to -0.34; p=0.014; β=1.44; 95% CI, 0.38 to 2.49; p=0.008, respectively). Conclusion : Our study identified male sex, lower preoperative serum albumin levels, and upper cervical level involvement as independent risk factors for PSTS after single-level ACSS. These findings can help clinicians monitor high-risk patients and take preventive measures to reduce complications. Further research with larger sample sizes and prospective designs is needed to validate these findings.