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차정권(Jungkwon Cha),정상진(Sangjin Jung),조명수(Myungsoo Cho),최인혁(Inhyuk Choi) 한국자동차공학회 2016 한국자동차공학회 학술대회 및 전시회 Vol.2016 No.11
Reduction of planetary gear noise for the automatic transmission was investigated using dynamic stiffness strengthening of the transmission case and the mounting bracket. Dynamic stiffness of case was improved by the reinforcing rib and shape change, through the FRF test, and 1’st mode frequency was also improved by the shape change of vehicle mounting bracket. After that, noise reduction was confirmed by the comparing before and after vibration and noise level of automatic transmission at the anechoic chamber and vehicle. Test results show that gear noise of transmission was improved 10dB at anechoic chamber and 8dB reduced in vehicle noise respectively.
A Web-Based Decision Aid for Informed Prostate Cancer Screening: Development and Pilot Evaluation
Jung Wonyoung,Cho In Young,Jeon Keun Hye,Yeo Yohwan,Jun Jae Kwan,Suh Mina,Jeong Ansuk,Lee Jungkwon,Shin Dong Wook 대한의학회 2023 Journal of Korean medical science Vol.38 No.46
Background: Prostate-specific antigen-based routine screening is not recommended for the general population due to conflicting results with mortality reduction. We aimed to develop a web-based decision aid (DA) for informed decision making for prostate cancer screening. Methods: Using the International Patient Decision Aid Standards (IPDAS) development process model, we developed our DA based on patient and clinician interviews and multidisciplinary expert discussions. The prototype consisted of predicting individual prostate cancer risk and informed decision-making, including knowledge, risk and benefit, cost, personal value, and decision making. We conducted a pilot study on 101 healthy men, evaluating the effectiveness of DA by measuring knowledge, attitude, and intention to screen before and after using the DA, as well as decisional conflict and usefulness after using the DA. Results: Of the 101 participants (median age 60 [50–69] years), 84% had not undergone screening for prostate cancer in the past two years. After using the DA, knowledge on prostate cancer screening increased (mean score [of 10] before versus after: 6.85 ± 1.03 versus 7.57 ± 1.25; P < 0.001), and intention to not screen increased from 27.7% to 51.5% (P < 0.001), but attitude toward screening did not change (P = 0.564). After use of the DA, 79 participants reported no decisional conflict, and the usefulness score was high (mean score [of 100] 77.35 ± 7.69), with 85% of participants reporting that the DA helped with decision making. Conclusion: Our web-based DA yielded increased knowledge, decreased screening intention, and high perceived usefulness. These findings indicate potential clinical relevance, especially among younger individuals.
Kang, Donghyun,Shin, Jungkwon,Cho, Yongsik,Kim, Hyeon-Seop,Gu, Young-Ran,Kim, Haedong,You, Kwon Tae,Chang, Moon Jong,Chang, Chong Bum,Kang, Seung-Baik,Kim, Jong-Seo,Kim, V. Narry,Kim, Jin-Hong American Association for the Advancement of Scienc 2019 Science translational medicine Vol.11 No.486
<P>A progressive loss of cartilage matrix leads to the development of osteoarthritis (OA). Matrix homeostasis is disturbed in OA cartilage as the result of reduced production of cartilage-specific matrix and increased secretion of catabolic mediators by chondrocytes. Chondrocyte senescence is a crucial cellular event contributing to such imbalance in matrix metabolism during OA development. Here, we identify miR-204 as a markedly up-regulated microRNA in OA cartilage. miR-204 is induced by transcription factors GATA4 and NF-κB in response to senescence signals. Up-regulated miR-204 simultaneously targets multiple components of the sulfated proteoglycan (PG) biosynthesis pathway, effectively shutting down PG anabolism. Ectopic expression of miR-204 in joints triggers spontaneous cartilage loss and OA development, whereas miR-204 inhibition ameliorates experimental OA, with concomitant recovery of PG synthesis and suppression of inflammatory senescence-associated secretory phenotype (SASP) factors in cartilage. Collectively, we unravel a stress-activated senescence pathway that underlies disrupted matrix homeostasis in OA cartilage.</P>