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SINGLET OXYGEN-MEDIATED PHOTOOXIDATION OF METHYL 11-HYDRO-13-(METHYLOXY)CARBONYLARTEMISINATE
Lee, Jung-Kul,Han, Jae-Hong,Kim, Jeong-Han,Lim, Yoong-Ho,Kim, Soo-Un Korean Society of Photoscience 1994 Journal of Photosciences Vol.1 No.2
Singlet oxygen-mediated photooxidation and subsequent triplet oxygen insertion of 11-hydro-13-(methyloxy)carbonylartemisinate (4) yielded a diketo compound 5 as the major product instead of the expected 11-hydro-13-(methyloxy)carbonylartemisinin (6). The formation of the unexpected product was in part consistent with the mechanism proposed by Acton and Roth and is the first isolation of the diketo compound from the photooxidation of artemisinate.
( Jung Wan Choe ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Young Kul Jung ),( Ja Seol Koo ),( Hyung Joon Yim ),( Sang Woo Lee ) 대한간학회 2017 Gut and Liver Vol.11 No.6
Background/Aims: Various clinical scoring systems, including the Glasgow-Blatchford score (GBS), Rockall risk score (RS), and AIMS65 score (AIMS65), have been validated to predict the clinical outcomes in patients with upper gastrointestinal bleeding (UGIB). We compared the performance of these three scoring systems in predicting clinical outcomes in patients with UGIB in Korea. Methods: We retrospectively evaluated 286 patients with UGIB who visited emergency department. The primary outcome was the need for clinical intervention (endoscopic, radiologic, or surgical) and blood transfusion. Results: The causes of UGIB were esophageal/gastric varices in 64 patients, peptic ulcer in 168, Mallory-Weiss tear in 32, malignancy of UGI tract in eight, and unknown in 14. One hundred seventy-four (61%) patients required blood transfusion, 166 (58%) required endoscopic intervention, and 10 (3.5%) required surgical intervention. The GBS outperformed the RS and AIMS65 in predicting the need for endoscopic intervention. Conclusions: The GBS and RS were more accurate than AIMS65 in predicting the need for clinical interventions and transfusion patients with UGIB, regardless of variceal or nonvariceal bleeding. The AIMS65 may not be optimal for predicting clinical outcomes of UGIB in Korea. (Gut Liver 2017;11:813-820)
Immunological Activities of Cationic Methylan Derivatives
Lee, Jung-Kul,Kim, In-Won,Kim, Tae-Su,Choi, Joon-Ho,Kim, Jung-Hoe,Park, Si-Hyung The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.3
Methylan polysaccharide was aminated to add dialkylaminoethyl and free amino groups at hydroxyl sites in the methylan backbone, and these derivatives were quaternized to produce pH-independent cationic polyelectrolytes. The immunological activities of the resulting methylan derivatives were investigated. Diethylaminoethyl (DEAE)-methylan derivatives inhibited the classical pathway of the complement system in a dose-dependent way. Quaternized DEAE-methylan exhibited the highest anticomplementary activities among the all derivatives. Anticomplementary activities increased significantly as the cationic charge of the methylan derivatives increased via aminoderivatization followed by quaternization, indicating that there is an electrostatic interaction between the methylan derivatives and the negatively charged functional residues on the cell.
( Jung Wan Choe ),( Hyung Joon Yim ),( Seung Hwa Lee ),( Hwan Hoon Chung ),( Sang Jun Suh ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Young Kul Jung ),( Ja Seol Koo ),( Ji Hoon Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: No single effective method has yet been established for the prophylactic treatment of gastric varices. So, we aimed to compare two prophylactic treatment methods, including EVO and BRTO for gastric varices. Methods: We retrospectively analyzed patients with gastric varices, who had undergone either EVO or BRTO as a prophylactic treatment. The end points were eradication rate of gastric varices and gastric variceal bleeding rate during the follow-up period. Results: Total 84 patients were consisted of 55 patients in EVO group and 29 patients in BRTO group. No difference was observed in the clinical profiles of patients, including age, gender, Child-Pugh score, etiology of liver cirrhosis, and presence of hepatocellular carcinoma, between the EVO and BRTO groups. There was also no difference with respect to endoscopic features of gastric varices including F-component and location. As primary end points, the gastric varices were disappeared partially or completely in 50 patients in EVO group, and 27 patients in BRTO group. (90.9% vs 93.1%, p= 0.542). At the complete eradication rate, there was also no difference between two groups. (49.1% vs 65.5%, p=-0.150) However, 12 patients in EVO group bled from gastric varices after treatment during the median follow-up of 28 months, compared to only one case in BRTO group. (21.8% vs 3.4%, p=0.027) In addition, there were no differences in worsening in the endoscopic classification of esophageal varices or amounts of ascites. All-cause mortalities were similar in both. Conclusions: EVO and BRTO are equally effective for eradication of gastric varices with similar frequencies of complications and mortalities. However, BRTO proved more effective in preventing bleeding from gastric varices in the long run.
Lee, Young-Sun,Kim, Hyun Jung,Kim, Ji Hoon,Yoo, Yang Jae,Kim, Tae Suk,Kang, Seong Hee,Suh, Sang Jun,Joo, Moon Kyung,Jung, Young Kul,Lee, Beom Jae,Seo, Yeon Seok,Yim, Hyung Joon,Yeon, Jong Eun,Kim, Jae RAVEN PRESS PUBLISHERS 2017 JOURNAL OF CLINICAL GASTROENTEROLOGY Vol.51 No.4
<P>Background and Aims: Although both corticosteroids and pentoxifylline are currently recommended drugs for the treatment of patients with severe alcoholic hepatitis, their effectiveness in reducing mortality remains unclear. In this systematic review, we aimed to evaluate the therapeutic and adverse effects of corticosteroids, pentoxifylline, and combination by using Cochrane methodology and therefore determine optimal treatment for severe alcoholic hepatitis. Methods: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from their inauguration until October 2015. Combinations of the following keywords and controlled vocabularies were searched: alcoholic hepatitis, corticosteroid, and pentoxifylline. Results: A total of 2639 patients from 25 studies were included. The treatment groups did not differ significantly in terms of overall mortality. Analysis of 1-month mortality revealed corticosteroid monotherapy reduced mortality compared with placebo (OR= 0.58; 95% CI, 0.34-0.98; P= 0.04), but pentoxifylline monotherapy did not. The mortality with dual therapy was similar to corticosteroid monotherapy (OR=0.91; 95% CI, 0.62-1.34; P= 0.63). However, dual therapy decreased the incidences of hepatorenal syndrome or acute kidney injury (OR= 0.47; 95% CI, 0.26-0.86; P= 0.01) and the infection risk (OR= 0.63; 95% CI, 0.41-0.97; P= 0.04) significantly more than corticosteroid monotherapy did. None of the treatments conferred any medium-term or long-term survival benefits in the present study. Conclusions: Dual therapy was not inferior to corticosteroid monotherapy and could reduce the incidence of hepatorenal syndrome or acute kidney injury and risk of infection. Therefore, dual therapy might be considered in treatment of patients with severe alcoholic hepatitis.</P>