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Kang, Byeong-Teck,Park, Chul,Jung, Dong-In,Yoo, Jong-Hyun,Kim, Ju-Won,Gu, Su-Hyun,Jeon, Hyo-Won,Kim, Jung-Hyun,Woo, Eung-Je,Park, Hee-Myung The Korean Society of Veterinary Science 2007 大韓獸醫學會誌 Vol.47 No.2
A 14-month-old, neutered female Miniature Pinscher was referred due to severe renal failure. The dog was treated with hysterotomy and followed by ovariohysterectomy (OHE) 6 days before the presentation. Excretory urographic and ultrasonographic studies revealed bilateral hydroureter and hydronephrosis. Postmortem necropsy revealed that ligatures were placed around the caudal portion of bilateral ureters in front of entrance into the bladder. This case shows that identifying and protecting the ureters are important during hysterotomy with OHE as well as OHE.
Kang, Kyoung Ah,Piao, Mei Jing,Hyun, Yu Jae,Zhen, Ao Xuan,Cho, Suk Ju,Ahn, Mee Jung,Yi, Joo Mi,Hyun, Jin Won Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.4
<▼1><P>Luteolin, a dietary flavone, modulates various signaling pathways involved in carcinogenesis. In this study, we investigated the molecular mechanism that underlies the apoptotic effects of luteolin mediated by DNA demethylation of the nuclear factor erythroid 2-related factor 2 (Nrf2) promoter and the interaction of Nrf2 and p53, a tumor suppressor, in human colon cancer cells. Luteolin increased the expression of apoptosis-related proteins and antioxidant enzymes. In DNA methylation, luteolin inhibited the expression of DNA methyltransferases, a transcription repressor, and increased the expression and activity of ten-eleven translocation (TET) DNA demethylases, a transcription activator. Methyl-specific polymerase chain reaction and bisulfite genomic sequencing indicated that luteolin decreased the methylation of the Nrf2 promoter region, which corresponded to the increased mRNA expression of Nrf2. In addition, luteolin increased TET1 binding to the Nrf2 promoter, as determined using a chromatin immunoprecipitation (ChIP) assay. TET1 knockdown decreased the percentages of luteolin-treated cells in sub-G<SUB>1</SUB> phase and cells with fragmented nuclei. Furthermore, complex formation between p53 and Nrf2 was involved in the apoptotic effects of luteolin. These results provide insight into the mechanism that underlies the anticancer effects of luteolin on colon cancer, which involve the upregulation of Nrf2 and its interaction with the tumor suppressor.</P></▼1><▼2><P><B>Cancer: Cell-killing plant compound exerts antioxidant effects</B></P><P>A molecule found in fruits, vegetables and herbs helps kill colon cancer cells by activating a master regulator of detoxifying enzymes. Jin Won Hyun from Jeju National University School of Medicine in South Korea and colleagues treated human colon cancer cells with luteolin, a molecule that occurs naturally in many food plants. They showed that luteolin increased the levels of proteins involved in cell death and antioxidant responses by causing DNA-modifying enzymes to strip suppressive chemical markers off the gene encoding Nrf2, a protein that regulates antioxidant effects. Nrf2 levels subsequently increased and the protein interacted with the tumor suppressor p53 to facilitate destruction of the colon cancer cells. The findings offer a mechanistic basis for using luteolin to help prevent and treat cancer.</P></▼2>
Kang, Nae-Won,Kim, Min-Hwan,Sohn, Seo-Yeon,Kim, Ki-Taek,Park, Ju-Hwan,Lee, Sun-Young,Lee, Jae-Young,Kim, Dae-Duk Elsevier 2018 Biomaterials Vol.182 No.-
<P><B>Abstract</B></P> <P>Cellulose nanofiber (CNF) is an attractive biomaterial given its film-forming properties, excellent mechanical properties and biocompatibility. Herein, CNF film was prepared as a topical drug delivery system by hybridizing curcumin (Cur)-loaded nanostructured lipid carriers (NLCs). NLCs with a mean diameter of ≈500 nm were fabricated by using a solvent diffusion method. The lipid composition of the NLCs was optimized based on the efficiency of Cur delivery to the artificial skin and mechanical strength of the developed films, where a composition containing shea butter and Capmul MCM EP exhibited the highest values of 233.2 ± 96.6 μg/cm<SUP>2</SUP>/mg and 4.86 ± 0.14 MPa, respectively. The Cur-loaded lipid-hybridized CNF (lipid@CNF) films with a smooth rather than particle-embedded surface were obtained by vacuum filtration of the NLCs and CNF mixture, which were confirmed by TEM, SEM, AFM, XPS, and FTIR analyses. The Cur-loaded lipid@CNF films exhibited more than 2.0-fold increases in Cur deposition to the epidermis of imiquimod (IMQ)-induced psoriatic mouse compared with the films without lipids, which potentially resulted from the amorphous state of Cur observed in the DSC and PXRD analyses and the permeation-enhancing effect of lipids. The <I>in vivo</I> anti-psoriatic efficacy test revealed that the Cur-loaded lipid@CNF films ameliorated the psoriatic skin symptoms in IMQ-induced mice, reducing the pro-inflammatory cytokine levels in the skin almost comparable to a commercially available topical corticosteroid cream. These results could be attributed to the enhanced Cur deposition along with the skin hydration effect of the films. These findings suggest that the developed CNF films can be used as a promising topical drug delivery system for psoriasis therapy.</P>
Kang, Dong Oh,Park, Yoonjee,Seo, Ji Hoon,Jeong, Myung Ho,Chae, Shung Chull,Ahn, Tae Hoon,Jang, Won Young,Kim, Woohyeun,Park, Eun Jin,Choi, Byoung Geol,Na, Jin Oh,Choi, Cheol Ung,Kim, Eung Ju,Rha, Seun Elsevier 2019 Journal of cardiology Vol.74 No.1
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Elevated high sensitivity C-reactive protein (hs-CRP) in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI) has prognostic value for future cardiovascular events. This study aimed to ascertain a valid prognostic time-period for predicting cardiovascular outcome based on baseline hs-CRP in AMI patients undergoing successful PCI on statin therapy.</P> <P><B>Methods</B></P> <P>Overall, 4410 AMI patients were enrolled from the Korea Acute Myocardial Infarction-National Institutes of Health (KAMIR-NIH) registry. Participants were divided into groups according to cut-off values of baseline hs-CRP (1.0, 3.0, and 10.0mg/L) and statin therapy intensity. The primary outcome was 36-month major adverse cardiovascular events (MACE), a composite of all-cause mortality, any myocardial infarction, and repeat revascularization. The secondary outcome was MACE developed 0–6, 6–12, and 12–36 months after AMI.</P> <P><B>Results</B></P> <P>The overall incidence of 36-month MACE was significantly higher as baseline hs-CRP increased (by groups: 8.8% vs. 8.6% vs. 10.7% vs. 15.4%, log-rank <I>p</I> <0.001). The prognostic effect of baseline hs-CRP was mostly confined to the first 6 months after AMI (0–6 months MACE by groups: 1.6% vs. 2.3% vs. 4.3% vs. 6.1%, log-rank <I>p</I> <0.001) and attenuated in high-intensity statin users. Six months after AMI, this prognostic effect of baseline hs-CRP was remarkably reduced (6–12 month MACE by groups: 2.4% vs. 2.1% vs. 2.8% vs. 4.0%, log-rank <I>p</I> =0.111, 12–36 month MACE by groups: 4.7% vs. 4.1% vs. 4.0% vs. 6.2%, log-rank <I>p</I> =0.218); however, high-intensity statin treatment showed a consistent improvement in outcome. The observed time-dependent prognostic effects remained consistent following multivariate analysis.</P> <P><B>Conclusions</B></P> <P>The prognostic impact of elevated hs-CRP at baseline was most evident during the first 6 months after AMI; however, the use of high-intensity statin persistently improved the clinical outcome even after the resolution of inflammatory reactions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The prognostic impact of baseline high sensitivity C-reactive protein (hs-CRP) was mostly confined to the first 6 months. </LI> <LI> High-intensity statin attenuated the prognostic impact of baseline hs-CRP elevation. </LI> <LI> Dose-dependent anti-inflammatory effect of statin is dominant over the first 6 months. </LI> <LI> High-intensity statin persistently improved outcome after first 6 months of acute myocardial infarction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P> <B>Time-dependent prognostic effect of baseline hs-CRP and high-intensity statin therapy after AMI.</B> </P> <P>The prognostic impact of elevated hs-CRP at baseline was mostly confined to the first 6 months after AMI, and high-intensity statin therapy persistently improved the clinical outcome over the extended follow-up period. The observed beneficial effect of high-intensity statin therapy was attributed to both the anti-inflammatory and cholesterol-lowering effects during the early 6 months; and predominantly to cholesterol-lowering effects in the later periods.</P> <P>AMI, acute myocardial infarction; hs-CRP, high sensitivity C-reactive protein; MACE, major adverse cardiovascular events.▪</P>
Kang, Min Su,Joh, Hyungmok,Kim, Haneun,Yun, Hye-Won,Kim, Donggyu,Woo, Ho Kun,Lee, Woo Seok,Hong, Sung-Hoon,Oh, Soong Ju The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.38
<P>In this work, we introduce a low cost, room-temperature and atmospheric pressure based chemical method to produce highly transparent, conductive, and flexible nano-mesh structured electrodes using Ag nanocrystals (NCs). Sequential treatments of ligand exchange and reduction processes were developed to engineer the optoelectronic properties of Ag NC thin films. Combinatorial analysis indicates that the origin of the relatively low conductivity comes from the non-metallic compounds that are introduced during ligand exchange. The reduction process successfully removed these non-metallic compounds, yielding structurally uniform, optically more transparent, dispersive, and electrically more conductive thin films. We optimized the design of Ag NC thin film mesh structures, and achieved low sheet resistance (9.12 Ω □<SUP>−1</SUP>), high optical transmittance (94.7%), and the highest figure of merit (FOM) of 6.37 × 10<SUP>−2</SUP>. Solution processed flexible transparent heaters, touch pads, and wearable sensors are demonstrated, emphasizing the potential applications of Ag NC transparent electrodes in multifunctional sensors and devices.</P>