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Calsenilin regulates presenilin 1/γ‐secretase‐mediated N‐cadherin ∊‐cleavage and β‐catenin signaling
Jang, Changhwan,Choi, Jin‐,Kyu,Na, Yeo‐,Jung,Jang, Byungki,Wasco, Wilma,Buxbaum, Joseph D.,Kim, Yong‐,Sun,Choi, Eun‐,Kyoung Federation of American Society for Experimental Bi 2011 The FASEB Journal Vol.25 No.12
<P>Presenilin 1 (PS1) is a component of the γ-secretase complex that cleaves a variety of type I membrane proteins, including the β-amyloid precursor protein (β-APP), Notch, and neuronal (N)- and epithelial (E)-cadherins. N-cadherin is an essential adhesion molecule that forms a complex with, and is cleaved by, PS1/γ-secretase and β-catenin in the plasma membrane. The purpose of this study was to determine whether calsenilin, a presenilin-interacting protein, has a functional role in PS1/γ-secretase-mediated N-cadherin ε-cleavage using Western blot analysis, RT-PCR, immunoprecipitation, subcellular fractionation, biotinylation, and a luciferase reporter assay in SH-SY5Y neuroblastoma cells. Here, we demonstrate that the expression of calsenilin leads to a disruption of PS1/γ-secretase-mediated ε-cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1 (Ncad/CTF1), the reduction of cytoplasmic Ncad/CTF2 release, and a deceleration of PS1-CTF delivery to the cell surface. Interestingly, we also found that the expression of calsenilin is associated with the redistribution of β-catenin from the cell surface to a cytoplasmic pool, as well as with the negative regulation of genes that are targets of T-cell factor/β-catenin nuclear signaling. Taken together, our findings suggest that calsenilin is a novel negative regulator of N-cadherin processing that plays an important role in β-catenin signaling.</P>
Jang, JunPil,Na, MinKyun,Thuong, Phuong Thien,Njamen, Dieudonné,Mbafor, Joseph Tanyi,Fomum, Zacharias Tanee,Woo, Eun-Rhan,Oh, Won Keun The Pharmaceutical Society of Japan 2008 Chemical & pharmaceutical bulletin Vol.56 No.1
<P>Phytochemical study on an EtOAc-soluble extract of the root bark of <I>Erythrina mildbraedii</I> resulted in the isolation of six prenylated flavonoids 1—6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-<I>O</I>-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3<I>R</I>)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2‴,2‴-dimethylpyrano[5‴,6‴ :4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity <I>in vitro</I> with IC<SUB>50</SUB> values ranging from 5.3 to 42.6 μ<SMALL>M</SMALL>. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.</P>
Lycorine의 사람 구강 암 세포주에서 survivin 단백질 분해 증진으로 세포자멸사
Joseph H. Jeong,Nam-Pyo Cho,Boonsil Jang 대한구강악안면병리학회 2017 대한구강악안면병리학회지 Vol.41 No.1
Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, was reported to various physiological and pharmacological effects including anti-cancer activity. Nevertheless, there is no report of the anticancer effect of lycorine in oral cancer cells. The effects of lycorine on cell proliferation and apoptosis were examined through trypan blue exclusion assay, 4’-6-diamidino-2-phenylindole (DAPI) stain, Live/Dead assay, Western blot analysis and RT-PCR. Lycorine suppressed cell viability and induced apoptosis in MC3 and HSC-3 cell lines. Lycorine decreased survivin protein but did not affect its mRNA. It regulated survivin through accelerating protein degradation in a time-dependent manner although neither proteasome nor lysosome was not associated with lycorine-mediated protein degradation. Collectively, our results suggest that lycorine may be a potential therapeutic anti-cancer drug candidate for the treatment of human oral cancer.
Joseph, Dickson,Bü,sselmann, Julian,Harms, Corinna,Henkensmeier, Dirk,Larsen, Mikkel Juul,Dyck, Alexander,Jang, Jong Hyun,Kim, Hyoung-Juhn,Nam, Suk Woo Elsevier 2016 Journal of membrane science Vol.520 No.-
<P><B>Abstract</B></P> <P>By varying the amount of porogene (<I>ortho</I>-dichlorobenzene, ODB), and optimization of the dispersion process, two types of solvent cast Nafion membranes with an equivalent weight of 1100g/mol sulfonic acid can be obtained reproducibly. One type is a dense membrane with a porous layer on one surface. The other membrane type shows a novel structure, consisting of small closed pores throughout the membrane and a single layer of large open pores on one side. In addition, some membranes showed a structural morphology between these two types, a membrane with a dense part and a porous part on top of each other. The latter membrane structure was not fully reproducible yet, but probably could be by carefully adjusting the formulation of the casting solution. Also the effect of the casting temperature on the morphology is shown. Fully porous membranes were characterized for their water permeability, ion conductivity, mechanical properties, their performance in the fuel cell and the hydrogen crossover. While the fully porous membranes are not expected to be part of a real fuel cell, we expect that the new morphologies will inspire applied research, e.g. in which the pores are filled with electrolyte or material or a catalyst is blended into the polymer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nafion membranes with three different morphologies were prepared. </LI> <LI> a) dense Nafion membranes with a porous surface, based on EW 1100. </LI> <LI> b) mixed dense/porous membranes. </LI> <LI> c) fully porous membranes with closed pores and larger open pores on the surface. </LI> <LI> Membranes were prepared in a single step (solution casting). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Removal of contaminants of emerging concern by metal-organic framework nanoadsorbents: A review
Joseph, Lesley,Jun, Byung-Moon,Jang, Min,Park, Chang Min,Muñ,oz-Senmache, Juan C.,Herná,ndez-Maldonado, Arturo J.,Heyden, Andreas,Yu, Miao,Yoon, Yeomin Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.369 No.-
<P><B>Abstract</B></P> <P>Over the last two decades, various contaminants of emerging concern (CECs), such as endocrine disrupting compounds, along with pharmaceuticals and personal care products (PPCPs), have been of interest to the water industry because of their incomplete removal during the typical water and wastewater treatment processes. Recently, the potential environmental applications of metal-organic frameworks (MOFs) and MOF-based nanoadsorbents (MOF-NAs) have been widely studied. In particular, the use of these nanoadsorbents for CECs in water and wastewater treatment processes has been a rapidly growing area of interest in the recent literature due to their unique physicochemical properties. Therefore, it is necessary to understand the adsorption phenomena of various CECs by MOF-NAs, particularly because the physicochemical properties of various CECs create unique challenges for the removal of these compounds from water. In addition, the adsorption of CECs on MOF-NAs is significantly influenced by the physicochemical properties of the MOF-NAs and the water quality conditions. Therefore, this review provides a comprehensive assessment of recent studies on the removal of various CECs (<I>e.g</I>., analgesics, antibiotics, antiepileptics, antiseptics, and etc.) with different physicochemical properties by various MOF-NAs under various water quality conditions (<I>e.g</I>., pH, background ions/ionic strength, natural organic matter, and temperature). In addition, this review briefly discusses the recent literature on the synthesis of MOF-NAs, regeneration of MOF-NAs, and removal of CECs during water and wastewater treatment processes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Removal of contaminants of emerging concern by MOF nanoadsorbents was comprehensively reviewed. </LI> <LI> Comprehensively information was provided for applications of MOF nanoadsorbents in water industry. </LI> <LI> Areas of future research for the removal of various contaminants in MOF nanoadsorbents were suggested. </LI> </UL> </P>