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A case of serotonin syndrome caused by linezolid
( Won Jong Choi ),( Young Hee Nam ),( Soo Keol Lee ),( Dong Sub Jeon ),( Hye Won Lee ),( Hee Joo Nam ),( So Hee Lee ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
Serotonin yndrome (SS) is a potentially life-threatening drug reaction characterized by mental status changes, increased neuromuscular tone, and autonomic instability. Linezolid, an oxazolidinone antibacterial agent, is widely used in general hospitals, however, which interacts some serotonin agonists and may cause SS. We report a case of SS caused by linezolid without the concomitant use of serotonin agonist. A 72-year-old patient was admitted for recurrent wound infection on his left ankle. He developed fever, skin rash and renal function deterioration, and blood eosinophil and liver enzymes increased after administration of vancomycin. Antibiotic therapy was changed to linezolid for methicillin-resistant Staphylococcus aureus. Four days later, he developed agitation, fever (38.6℃), hypertension (200/100 mm Hg) and tachycardia (130 beats/minute). There were no abnormal findings on laboratory and image tests including brain and chest computed tomography as causes for his symptoms. He had not taken any serotonin agonists including serotonin uptake inhibitor and monoamineoxidase-inhibiting antidepressants. The administration of linezolid was stopped. His symptoms improved within 24 hour, and had fully recovered within 2 days without additional treatment.Serotonin syndrome (SS) is a potentially life-threatening drug reaction characterized by mental status changes, increased neuromuscular tone, and autonomic instability. Linezolid, an oxazolidinone antibacterial agent, is widely used in general hospitals, however, which interacts some serotonin agonists and may cause SS. We report a case of SS caused by linezolid without the concomitant use of serotonin agonist. A 72-year-old patient was admitted for recurrent wound infection on his left ankle. He developed fever, skin rash and renal function deterioration, and blood eosinophil and liver enzymes increased after administration of vancomycin. Antibiotic therapy was changed to linezolid for methicillin-resistant Staphylococcus aureus. Four days later, he developed agitation, fever (38.6℃), hypertension (200/100 mm Hg) and tachycardia (130 beats/minute). There were no abnormal findings on laboratory and image tests including brain and chest computed tomography as causes for his symptoms. He had not taken any serotonin agonists including serotonin uptake inhibitor and monoamineoxidase-inhibiting antidepressants. The administration of linezolid was stopped. His symptoms improved within 24 hour, and had fully recovered within 2 days without additional treatment.
Joo, Young-Hoon,Park, Sung-won,Jung, Seung-Hyun,Lee, Yeon-Soo,Nam, In-Chul,Cho, Kwang-Jae,Park, Jun-Ook,Chung, Yeun-Jun,Kim, Min-Sik Informa Healthcare 2013 Acta oto-laryngologica Vol.133 No.9
<P><I>Conclusion:</I> Our findings show that copy number loss of <I>FHIT</I> is associated with lymph node metastasis (LNM) and suggest that the down-regulation of Fhit indicates poor prognosis in early oral squamous cell carcinoma (OSCC). <I>Objectives:</I> The purpose of this study was to identify alterations in genetic markers related to LNM in early OSCC. <I>Methods:</I> Genome-wide copy number alterations were analyzed in 14 early OSCCs with (<I>n</I> = 7) or without (<I>n</I> = 7) cervical LNM using 180K array-comparative genomic hybridization. To explore the prognostic implications of the most significantly associated genetic alteration with cervical LNM, immunohistochemical analysis was conducted in 30 OSCCs. <I>Results:</I> A total of 11 recurrently altered regions (RARs) were identified in the 14 OSCC cases. Six RARs on chromosomes 3p26-3p14, 5q22, and 9p21 were found to be significantly more common in early OSCC with LNM (<I>p</I> < 0.05). Among these, loss of 3p14.2 (where the <I>FHIT</I> gene is located) was the most frequent (five of seven patients with LNM, and none of seven without LNM), and most significantly associated with cervical LNM (<I>p</I> = 0.005). Fhit immunohistochemical staining of 30 OSCCs showed that Fhit negativity was associated with cervical LNM (<I>p</I> = 0.032) and poor disease-specific survival (<I>p</I> = 0.045).</P>
Diarylheptanoids from the Seeds of <i>Alpinia katsumadai</i> as Heat Shock Factor 1 Inducers
Nam, Joo-Won,Kang, Ga-Young,Han, Ah-Reum,Lee, Dongho,Lee, Yun-Sil,Seo, Eun-Kyoung American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.10
<P>Seven new diarylheptanoids, (−)-(<I>R</I>)-4″-hydroxyyashabushiketol (<B>1</B>), (3<I>S</I>,5<I>S</I>)-alpinikatin (<B>2</B>), katsumain C (<B>3</B>), 7-<I>epi</I>-katsumain C (<B>4</B>), <I>ent</I>-alpinnanin B (<B>5</B>), <I>ent</I>-alpinnanin A (<B>6</B>), and <I>ent</I>-calyxin H (<B>8</B>), were isolated from the EtOAc extract of the seeds of <I>Alpinia katsumadai</I> together with three known compounds, alpinnanin B (<B>7</B>), epicalyxin H (<B>9</B>), and calyxin H (<B>10</B>). Each isomer mixture of <B>3</B> and <B>4</B>, <B>5</B>–<B>7</B>, and <B>8</B>–<B>10</B> was separated successfully by preparative HPLC using a chiral column. The three isomer mixtures (<B>3</B> and <B>4</B>, <B>5</B>–<B>7</B>, <B>8</B>–<B>10</B>) at 1 μM increased expression of heat shock factor 1 (HSF1) with fold increases of 1.438, 1.190, and 1.316, respectively, which was accompanied with increased expression of heat shock protein (HSP) 27 (1.403-, 1.250-, and 1.270-fold, respectively) and HSP70 (1.373-, 1.313-, and 1.229-fold, respectively) without cellular cytotoxicity, suggesting a possible application of these compounds as HSP inducers. Celastrol was used as a positive control of HSP induction, producing fold increases of 1.066 (HSF1), 1.216 (HSP27), and 1.371 (HSP70) at 1 μM. Compounds <B>1</B> and <B>2</B> did not affect the induction of HSF1 protein.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-10/np200355n/production/images/medium/np-2011-00355n_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200355n'>ACS Electronic Supporting Info</A></P>
Nam, Hyun,Kim, Ji-Hye,Kim, Jae-Won,Seo, Byoung-Moo,Park, Joo-Cheol,Kim, Jung-Wook,Lee, Gene Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.7
Human Hertwig's epithelial root sheath/epithelial rests of Malassez (HERS/ERM) cells are epithelial remnants of teeth residing in the periodontium. Although the functional roles of HERS/ERM cells have yet to be elucidated, they are a unique epithelial cell population in adult teeth and are reported to have stem cell characteristics. Therefore, HERS/ERM cells might play a role as an epithelial component for the repair or regeneration of dental hard tissues; however, they are very rare population in periodontium and the primary isolation of them is considered to be difficult. To overcome these problems, we immortalized primary HERS/ERM cells isolated from human periodontium using SV40 large T antigen (SV40 LT) and performed a characterization of the immortalized cell line. Primary HERS/ERM cells could not be maintained for more than 6 passages; however, immortalized HERS/ERM cells were maintained for more than 20 passages. There were no differences in the morphological and immunophenotypic characteristics of HERS/ERM cells and immortalized HERS/ERM cells. The expression of epithelial stem cell and embryonic stem cell markers was maintained in immortalized HERS/ERM cells. Moreover, immortalized HERS/ERM cells could acquire mesenchymal phenotypes through the epithelial-mesenchymal transition via TGF-${\beta}1$. In conclusion, we established an immortalized human HERS/ERM cell line with SV40 LT and expect this cell line to contribute to the understanding of the functional roles of HERS/ERM cells and the tissue engineering of teeth.
Nam-Su Lee,Hee-Sook Park,Jong-Ho Won,Dae-Sik Hong,Su-Taek Uh,이상재,Joo-Hang Kim,Se-Kyu Kim,Myung-Ju Ahn,최정혜,Suk-Chul Yang,Jung-Ae Lee,Keun-Seok Lee,Chang-Yeol Yim,Yong-Chul Lee,Chul-Soo Kim,Moon-Hee Lee 대한암학회 2005 Cancer Research and Treatment Vol.37 No.6
Purpose: We prospectively conducted a multi-center,open-label, randomized phase II trial to compare the efficacy and safety of docetaxel plus cisplatin (DC) and etoposideplus cisplatin (EC) for treating advanced stage non-small cell lung cancer (NSCLC).Materials and Methods: Seventy-eight previously untreated patients with locally advanced, recurrent or metastatic NSCLC were enrolled in this study. The patientsreceived cisplatin 75 mg/m2 on day 1 and either docetaxel 75 mg/m2 on day 1 or etoposide 100 mg/m2 on days 1 to 3 in the DC or EC arm, respectively, every 3 weeks.Results: The objective response rate was 39.4% (15/38) and 18.4% (7/38) (p=0.023) in the DC and EC arms, respectively. The median time to progression (TTP) was5.9 and 2.7 months (p=0.119), and the overall survival was 12.1 and 8.7 months (p=0.168) in the DC and EC arms, respectively. The prognostic factors for longer survival were an earlier disease stage (stage III, p=0.0095), the responders to DC (p=0.0174) and the adenocarcinoma histology (p=0.0454). The grades 3 and 4 toxicities were similar in both arms, with more febrile neutropenia (7.9% vs. 0%) and fatigue (7.9% vs. 0%) being noted in the DC arm.Conclusion: DC offered a superior overall response rate than does EC, along with tolerable toxicity profiles, although the DC drug combination did not show significantlyimproved survival and TTP.
Nam, Yuran,Kim, Hyun Jong,Kim, Young-Mi,Chin, Young-Won,Kim, Yung Kyu,Bae, Hyo Sang,Nam, Joo Hyun,Kim, Woo Kyung The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3
Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes such as thermal sensation, skin barrier formation, and wound healing. TRPV3 was initially proposed as a warm temperature sensor. It is activated by synthetic small-molecule chemicals and plant-derived natural compounds such as camphor and eugenol. Schisandra chinensis (Turcz.) Baill (SC) has diverse pharmacological properties including antiallergic, anti-inflammatory, and wound healing activities. It is extensively used as an oriental herbal medicine for the treatment of various diseases. In this study, we investigated whether SC fruit extracts and seed oil, as well as four compounds isolated from the fruit can activate the TRPV3 channel. By performing whole-cell patch clamp recording in HEK293T cells overexpressing TRPV3, we found that the methanolic extract of SC fruit has an agonistic effect on the TRPV3 channel. Furthermore, electrophysiological analysis revealed that ${\gamma}$-schisandrin, one of the isolated compounds, activated TRPV3 at a concentration of $30{\mu}M$. In addition, ${\gamma}$-schisandrin (${\sim}100{\mu}M$) increased cytoplasmic $Ca^{2+}$ concentrations by approximately 20% in response to TRPV3 activation. This is the first report to indicate that SC extract and ${\gamma}$-schisandrin can modulate the TRPV3 channel. This report also suggests a mechanism by which ${\gamma}$-schisandrin acts as a therapeutic agent against TRPV3-related diseases.