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Poster Session : PS 0310 ; Hematology : Anemia in Elderly Over Age 80: How Much is Enough?
( Joo Kyoung Cha ),( Yun Jin Jeong ),( Hyun Jung Lee ),( Seok Lae Chae ),( Hee Jin Huh ),( Jae Woo Chung ),( Do Yeun Kim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Anemia is commonly observed in elderly population, and the prevalence of anemia increases with advanced age. Anemia is a sign of poor health state and increase adverse outcomes in the elderly. Therefore, assessment of anemia is important in elderly patients. Objectives: The aim of this study was to classify the type of anemia and to assess the current state of anemia evaluation in the elderly population. Methods: Medical records-based retrospective study was performed for patients who were more than 80 years (>80) old and visited Dongguk University Ilsan Hospital from April 2005 to February 2014. Results: Total 548 patients who had anemia according to WHO criteria were identifi ed. The median age was 85 years old (range, 82-99) and median hemoglobin level was 11g/dL (range, 2. 7-12. 9). Twenty eight, 468, and 52 patients were classifi ed as microcytic anemia, nomocytic anemia, and macrocytic anemia, respectively. Among them, 397 patients (72. 4%) did not underwent proper the evaluation for the cause anemia. In detail: 8 (28. 5%) of microcytic anemia, 361 (77. 1%) of normocytic anemia, and the 28 (53. 84%) of 52 macrocytic anemia patients. The remaining 151 patients (27. 6%) had completed the evaluation, and 24 patients (15. 9%) were diagnosed as solid or hematologic malignancies. Conclusions: This fi nding showed physicians often neglected anemia in elderly over age 80. Though the patients have limited life expectancy, physicians need to discriminate the sub-population who will be benefi t from adequate evaluation and treatment.
Long-term study of the association of adipokines and glucose variability with diabetic complications
( Jin Joo Cha ),( Hye Sook Min ),( Kitae Kim ),( Mi Jin Lee ),( Mi Hwa Lee ),( Jung Eun Kim ),( Hye Kyoung Song ),( Dae Ryong Cha ),( Young Sun Kang ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.2
Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical rele-vance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit-to-visit glucose variability were measured in diabetic patients. Associations among adipokines and variable metabolic parameters and microvascular, and macrovascular complications were evaluated. Results: Plasma adiponectin and glypican-4 levels were significantly increased in patients with renal insufficiency. These adipokines were negatively associated with estimated glomerular filtration rate and positively associated with urinary albumin excretion. The relative risk of renal progression to dialysis increased independently with increasing level of adiponectin. Glypican-4 and visfatin were not predictive of any microvascular or macrovascular complications. Glucose variability increased the risk of diabetic nephropathy and cerebrovascular complications. Conclusions: Adiponectin and glypican-4 were associated with renal function and might be able to predict renal progression. Glucose variability was a predictable factor for diabetic nephropathy and cerebrovascular complications.
Joo Wan Cha,Hae Jung Koo,Bu Yo Kim,Belorid Miloslav,Min Hoo Kim,Hyun Jun Hwang,Dong Ho Park,Hyun-Kyoung Lee,Ki Ho Chag,Chulkyu Lee 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10
A DSD (Drop Size Distribution) of rainfall observed in 2010 and 2011 using parsivel (Particle Size Velocity disdrometer) in Korea"s mountainous regions. The cloud microphysical processes for precipitation generation was estimated by the conceptual model of the cloud microphysical process using the DSD parameters. This study tried to find out the differences in the main cloud microphysical processes in different climate region by comparing the data of this study with those of previous studies at each site in East Asia and analyzed the most dominant cloud microphysical processes by rainfall intensity at each site in previous studies. For defining climate at each site in East Asia, this study used the Köppen-Geiger climate classification. As the defining climate at each site in East Asia, the main cloud microphysical processes were “VD” (Vapor Deposition) below light rain rate and “Mixed WC (Weak Convection)+ CC (Collision and Coalescence) +ICWRG (ICe-based and Warm Rain Growth)” above moderate rain rate in humid subtropical climate region. The most dominant cloud microphysical processes were “WC”, “CC”, “ICWRG” and the mixed microphysical processes of them in tropical rainforest climate region, “VD” and “ICWRG” in subarctic climate in high altitude region and mega cities of hot summer continental climate, “Mixed ICG and ICWRG” in warm summer continental climate region, and “ICWRG” in dry winter humid subtropical climate region.
Silencing of MUC8 by siRNA increases P2Y<sub>2</sub>-induced airway inflammation
Cha, Hee-Jae,Jung, Min-Su,Ahn, Do Whan,Choi, Jang-Kyu,Ock, Mee Sun,Kim, Kyung Soo,Yoon, Joo-Heon,Song, Eun Ju,Song, Kyoung Seob American Physiological Society 2015 American Journal of Physiology: Lung cellular and Vol.308 No.6
<P>Mucin hypersecretion and overproduction are frequent manifestations of respiratory disease. Determining the physiological function of airway mucin is presently considered more important than identifying the relevant signaling pathways. The lack of a full-length human mucin 8 (MUC8) cDNA sequence has hindered the generation of a Muc8 knockout mouse line. Thus, the precise physiological functions of MUC8 are unclear. Herein, we investigated the function of MUC8 using a small-interfering RNA (siRNA)-mediated genetic silencing approach in human airway epithelial cells. Herein, intracellular IL-1α production was stimulated by an ATP/P2Y<SUB>2</SUB> complex. While ATP/P2Y<SUB>2</SUB> increased IL-1α secretion in a time-dependent manner, treatment with P2Y<SUB>2</SUB>-specific siRNA significantly decreased IL-1α secretion. Moreover, ATP increased P2Y<SUB>2</SUB>-mediated upregulation of <I>MUC8</I> expression; however, IL-1α significantly decreased the extent to which ATP/P2Y<SUB>2</SUB> upregulated <I>MUC8</I> expression. Interestingly, treatment with MUC8-specific siRNA decreased the production of anti-inflammatory cytokines (TGF-β and IL-1 receptor antagonist) and increased the production of inflammatory cytokines (IL-1α and IL-6) in our system. In addition, siRNA-mediated knockdown of MUC8 expression dramatically increased the secretion of inflammatory chemokines and resulted in an approximately threefold decrease in cell chemotaxis. We propose that MUC8 may function as an anti-inflammatory mucin that participates in inflammatory response by attracting immune cells/cytokines to the site of inflammation. Our results provide new insight into the physiological function of MUC8 and enhance our understanding of mucin overproduction during airway inflammation.</P>
Cha, Yu-Jung,Lim, Kyoung Soo,Park, Min-Kyu,Schneider, Stephen,Bray, Brian,Kang, Myung-Chol,Chung, Jae-Yong,Yoon, Seo Hyun,Cho, Joo-Youn,Yu, Kyung-Sang Dove Medical Press 2014 Drug design, development and therapy Vol.8 No.-
<P><B>Background</B></P><P>KM-023 is a new second-generation nonnucleoside reverse-transcriptase inhibitor that is under development for the treatment of human immunodeficiency virus (HIV) type 1 infection.</P><P><B>Objective</B></P><P>This study determined KM-023 tolerability and pharmacokinetic characteristics in healthy subjects.</P><P><B>Materials and methods</B></P><P>A randomized, double-blinded, placebo-controlled, dose-escalation study was conducted in 80 healthy South Korean male volunteers. The subjects were allocated to single- or multiple-dose (once daily for 7 days) groups that received 75, 150, 300, or 600 mg drug or placebo in a 4:1 ratio. Safety and pharmacokinetic assessments were performed during the study. Plasma and urine concentrations were quantified using liquid chromatography–tandem mass spectrometry.</P><P><B>Results</B></P><P>The average maximum concentration (C<SUB>max</SUB>) and area under the concentration–time curve from time 0 to infinity (AUC<SUB>∞</SUB>) values of KM-023 for the 75–600 mg doses in the single-dose study ranged from 440.2 ng/mL to 1,245.4 ng/mL and 11,142.4 ng · h/mL to 33,705.6 ng · h/mL, respectively. Values of the mean C<SUB>max</SUB> at a steady state and AUC within the dosing interval ranged from 385.1 ng/mL to 1,096.7 ng/mL and 3,698.9 ng · h/mL to 10,232.6 ng · h/mL, respectively, following 75–600 mg doses in the multiple-dose study. Dose proportionality was not observed for KM-023. KM-023 showed a 0.6-fold accumulation after multiple doses in the 600 mg dose group. The mean half-life values ranged between 20.7 and 31.2 hours. KM-023 was generally well tolerated without serious adverse events.</P><P><B>Conclusion</B></P><P>KM-023 demonstrated dose- and time-dependent nonlinear pharmacokinetic characteristics after single or multiple doses over a dose range (75–600 mg) in healthy subjects. KM-023 showed favorable tolerability in this study. This Phase I clinical trial information can be used to design further clinical studies appropriately to evaluate KM-023 in patients with HIV-1 infection.</P>
Therapeutic outcomes of methotrexate injection in unruptured interstitial pregnancy
( Myung Joo Kim ),( Jae-ho Cha ),( Hyo Sook Bae ),( Mi Kyoung Kim ),( Mi-la Kim ),( Bo Sung Yun ),( You Shin Kim ),( Seok Ju Seong ),( Yong Wook Jung ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.6
Objective To examine the therapeutic outcomes of methotrexate (MTX) in the treatment of unruptured interstitial pregnancy. Methods We reviewed the medical records of patients who were diagnosed with interstitial pregnancy and received MTX as first-line treatment between January 2003 and July 2014 at CHA Gangnam Medical Center. The treatment success rates and subsequent pregnancy outcomes were examined. Results Ninety-seven patients were diagnosed with interstitial pregnancy between January 2003 and July 2014. Of them, 38 initially received MTX treatment. The diagnosis was made at a median of 6<sup>+3</sup> weeks (5<sup>+0</sup> to 11<sup>+3</sup> weeks). Thirty patients received a systemic MTX injection, while the other 8 received a local MTX injection. Systemic treatment composed of an 8-day alternating MTX regimen, single-dose regimen, or high-dose regimen (100 mg/m<sup>2</sup> + 200 mg/m<sup>2</sup> intravenously over 12 hours). The local injection consisted of a direct MTX injection into the gestational sac with or without systemic MTX injection. Twenty-one patients (55.3%) were successfully treated with MTX. However, MTX therapy failed in 17 patients (44.7%), who required surgery. Mode of MTX treatment was the only predictive variable of MTX treatment success (P=0.039). Treatment success was seen in 7 of 8 patients (87.5%) in the local MTX group vs. 14 of 30 patients (46.7%) in the systemic MTX group. After treatment, 13 patients attempted a successive pregnancy; of them, 10 patients had a confirmed clinical pregnancy and healthy live birth. Conclusion Combined MTX treatment including a local injection might be an initial approach to the treatment of interstitial pregnancy.