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안리숙(Li Suk An),나종순(Jon Soon Na),김상우(Sang Woo Kim),전희경(Hee Kyung Chun),김병수(Byung Soo Kim),정재열(Jae Yeul Jung),오수혁(Soo Hyuk Oh),김재광(Jae Kwang Kim),정인식(In Sik Chung) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6
Gastrointestinal tract involvement with hepatocellular carcinoma is rarely reponed ei en in the A.,ia and the Africa v;here this carcinoma is one of the relatevely common malignancies. We preserit a case of a 48-year-old man with duodenal bulh metastasis of hepatocellular carcincma, who died because of rnassive hernaternesis, 2 months later. One case v,ith rapicl duoJenal neiastasis ot' hepatocellular carcinorna is reported with the relevant literatures are reviewecl. (Korean J Gastroenterol 1995;27: 888 - 892)
1996년도 제35차 대한소화기학회 추계학술대회 / 일반연제 : 위장관 ; 비궤양성소화불량환자에서 위배출시간지연과 자율신경기능실조의 임상적 의의
박수헌,김진일,나종순,채현석,김재광,한준열,최규용,정인식,정규원,선희식,박두호,손형선 ( Soo Heon Park,Jin Il Kim,Jon Soon Na,Hiun Suk Chae,Jae Kwang Kim,Jun Yul Han,Kyu Yong Choi,In Sik Chung,Kyu Won Chung,Hee Sik Sun,Doo Ho Park,Hyung Su 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
박수헌,김진일,정인식,김재광,정규원,한준열,선희식,손형선,방춘상,나종순 대한소화기학회 1998 대한소화기학회지 Vol.32 No.1
Background/Airns: Although patients with cirrhosis often complain the gastrointestinal symptoms such as indigestion, little attention has been paid to the possible effects of portal hypertension on gut function. Frequently, endoscopic feature of patients with cirrhosis included congestive gastropathy. However, it has not been shown that whether gastric emptying time is delayed in cirrhotic patients with congestive gastropathy. The aims of this study were to evaluate the gastric emptying in cirrhotic patients with congestive gastropathy and to understand the factors causing the delay of gastric emptying time in patients with cirrhosis. Methods: Between April 1996 and September 1996, 30 cirrhotic patients with congestive gastropathy, 27 cirrhotic patients without congestive gastropathy, and 15 controls were participated in this study at St, Mary Hospital. All patients were subjected to evaluation of gastrointestinal symptom score, endoscopy, Child-Pugh score, and gastric emptying time with solid meal. Results: The gastric emptying time was longer in cirrhotic patients with congestive gastropathy than in controls (105.6±9.58 vs 72.4±6.02 minutes), but there was no significant difference between cirrhotic patierits without congestive gastropathy and controls (93.7±7.93 vs 72.4±6.02 minutes). Among Factors influencing gastric emptying time in cirrhosis such as congestive gastropathy, ascites, gastric varix, AST, ALT, Child-Pugh score, prothrombin time, age, albumin level, esophageal varix, and bilirubin, only the congestive gastropathy was statistically significant (p$lt;0.05). Conclusions: The gastric emptying time was delayed in cirrhotic patients who had congestive gastropathy. Thus, congestive gastropathy may contribute to the pathogenesis of delayed gastric emptying in cirrhosis.
만성 C형 간염과 간 세포 암에서의 Proliferating Cell Nuclear Antigen ( PCNA ) 의 발현에 관한 면역조직화학적 관찰
정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),이창돈(Chang Don Lee),이영석(Young Suk Lee),최상욱(Sang wook Choi),양진모(Jin Mo Yang),이봉수(Bong Soo Lee),방충상(Choong Sang Bang),나종순(Jon Soon Na) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
N/A Backgrounds/Aims: It has been reparted that pmliferating cell nuclear antigen(PCNA) wouM be related to proliferating cells, and thus the PCNA labelling index may provide useful information about the hepatecjte ngeaeration of chronic hepatitis and the biologic behavior of hepatocellular carcinoma(HCC). Tbe aims of this study were to investigate any carrelation between the PCNA labellmg index and distribution pattern of proliferating cells in chronie hepatitis C and HCC in Korea. Methods: We obtained biopsy specimens in 31 patients with chronic hepatitis C and 49 patients with HCC. Results: PCNA expession rate and PCNA labelling index were 70,9 %(22/31cases), 3.1 +- 0.4 % in ehtonic hepatitis C, 72,2 %(26/36cases), 4.1> 1.7% in noncancerous tissue of HCC, 94,4 %(34/35cases), 21.2 +- 4.6% in cancer tissue of HCC, respectively. Bxpression rate af PCNA was significandy higher in HCC than that of chronic hepatitis C and noncancerous portion of HCC cases. 22 patients(70.9%) of 31 patients with chronic heaptitis C were positive in PCNA immunohistochemical staining. Incidence of distribution of PCNA positive hepatocytes in the lobule was 100% in periportal area, 68.1 % in mi*dxanal area, 13.6% in pericentral area and 22.7 % in bile ductules, respectively. And 72.7 % in periportal area and midzonal area,4.5% in periportal area and pericetnal area, 13.6% in panlobular area.In patients with HCC, many PCNA positive tumor cells were seen thmughout the neoplasms. Conclusians: These results suggest that the proliferating a4tivities such as PCNA labelling index and PCNA expression pattern may represent the chronicity of chranic hepatitis C. (Kereaa J Gastroenterol )907;29:651-658)