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Yang, Jisu,Chatterjee, Nivedita,Kim, Youngho,Roh, Ji-Yeon,Kwon, Jung-Hwan,Park, Myung-Sook,Choi, Jinhee Elsevier 2018 CHEMOSPHERE - Vol.200 No.-
<P><B>Abstract</B></P> <P>As part of a study to explore the long-term effects of the Hebei Spirit oil spill accident, transgenerational toxicity and associated epigenetic changes were investigated in the nematode <I>Caenorhabditis elegans.</I> Under experimental conditions, worms were exposed to Iranian heavy crude oil (IHC) under three different scenarios: partial early-life exposure (PE), partial late-life exposure (PL), and whole-life exposure (WE). Growth, reproduction, and histone methylation were monitored in the exposed parental worms (P0) and in three consecutive unexposed offspring generations (F<SUB>1-3</SUB>). Reproductive potential in the exposed P0 generation in the WE treatment group was reduced; additionally, it was inhibited in the unexposed offspring generations of the P0 worms. This suggests that there was transgenerational inheritance of defective reproduction. Comparison of developmental periods of exposure showed that IHC-treated worms in the PL group had a greater reduction in reproductive capacity than those in the PE group. Decreased methylation of histone H3 (H3K9) was found in the IHC-exposed parental generation. A heritable reduction in reproductive capacity occurred in wildtype <I>N2</I> but was not found in a H3K9 histone methyltransferase (HMT) mutant, <I>met-2</I>(<I>n4256</I>), suggesting a potential role for HMT in transgenerational toxicity. Our results suggest that the reproductive toxicity after IHC exposure could be heritable and that histone methylation is associated with the transmission of the inherited phenotype.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Transgenerational toxicity of Iranian heavy crude oil (IHC) was investigated in the nematode <I>Caenorhabditis elegans</I> in the four consecutive generations under different exposure scenarios. </LI> <LI> <I>C. elegans</I> reproduction potential was inhibited by the IHC in the unexposed generations and in the exposed parental generation. </LI> <LI> Whole-life exposure condition exhibited transgenerational inheritance of defective reproduction. </LI> <LI> Decreased methylation of histone H3K9 was found in the exposed generation; however, a heritable diminution in reproduction did not occur in the H3K9 histone methyltransferase defective mutant. </LI> <LI> Reproductive toxicity caused by IHC exposure was found to be transmitted to subsequent unexposed generations, and methylation of histone H3K9 seems to be involved in it. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jisu Song,Seung Eun Lee,Woo-Jin Yang,Han-Jo Yang,Mi-Ryung Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Onion (Allium Cepa L) has been used as a medicinal plant in folk medicine as well as food. Onions contain a variety of bioactive compounds including quercetin. In this study, the lactic acid bacteria fermentation process was established for the development of functional materials using red onion. First, a mixture of red onion concentrate containing high amount quercetin and pumpkin was prepared and inoculated with 8 types of lactic acid bacteria. The number of viable cells, pH, acidity, and reducing sugar change were monitored for each fermentation period. In addition, polyphenol content, quercetin content, and antioxidant activity were evaluated. Lactobacillus parabuchneri (LPB) showed the highest fermentation ability and physiological activity during 5-day fermentation. The anticancer activity and the anti-inflammatory activity of LPB fermented product were confirmed by using SW480 cell and RAW264.7 cells. From the results of this experiment, the optimum conditions for lactic acid bacteria fermentation of the red onion containing high amount quercetin were set up and the possibility of functional materials using high quercetin red onion was suggested.
Physiological activity of elephant garlic fermented using lactic acid bacteria
Jisu Song,Seung Eun Lee,Woo-Jin Yang,Han-Jo Yang,Mi-Ryung Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Elephant garlic (Allium ampeloprasum var. ampeloprasum), also called giant garlic, is a perennial plant belonging to the genus Allium and has been used as a spice or medicinal plant for centuries. In this study, we tried to establish a lactic acid fermentation process for the development of functional materials using elephant garlic. In order to set the optimal conditions for lactic acid fermentation using the elephant garlic powder, a mixture of elephant garlic and pumpkin powder was prepared and inoculated with 8 kinds of lactic acid bacteria. The number of viable cells, pH, acidity, and reducing sugar changes were monitored and polyphenol contents and antioxidant activities of them were evaluated during the fermentation period. Lactobacillus satsumensis (LS) showed excellent fermentation ability, which had high physiological activity in 48 hours of fermentation. The anti-inflammatory activity of LS fermented product was evaluated using the inhibition degree (%) of LPS-induced NO production in RAW264.7 cells and the anticancer activity was confirmed by the determination of SW480 cell growth at each sample concentration.