Part 1. Trade And Industrial Development : 1. Trade of Northeast Asia in a Global Perspective

( Wang Hui Jiong ) 연세대학교 동서문제연구원 1996 East and West Studies Series Vol.40 No.-

Part 2. Foreign Direct Investment : 7. Foreign Direct Investment in China: In Implication to the Northeast Asia Regional Cooperation

( Wang Hui Jiong ) 연세대학교 동서문제연구원 1996 East and West Studies Series Vol.40 No.-

Influence of high temperature on mechanical properties of concrete containing recycled fine aggregate

Jiong-Feng Liang,En Wang,Qiao-Li Le 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.1

This paper presents the results of an experimental study to investigate the influences of high temperatures on the mechanical properties of concrete containing recycled fine aggregate. A total of 150 concrete prisms (100x100x100 mm) are cast and heated under five different temperatures (20oC, 200oC, 400oC, 600oC, 800oC ) for test. The results show that the mass loss, compressive strength, elastic modulus, splitting tensile strength of concrete specimens containing recycled fine aggregate decline significantly as the temperature rise. At the same temperature, the compressive strength, splitting tensile strength, elastic modulus of concrete specimens containing recycled coarse aggregate and recycled fine aggregate (RHC) is lower than that of concrete specimens containing natural coarse aggregate and recycled fine aggregate (RFC). The shape of stress–strain curves of concrete specimens at different temperatures is different, and the shape of that become flatter as the temperature rises. Normal concrete has better energy absorption capacity than concrete containing recycled fine aggregate.

Serum Tumor Marker Levels might have Little Significance in Evaluating Neoadjuvant Treatment Response in Locally Advanced Breast Cancer

Wang, Yu-Jie,Huang, Xiao-Yan,Mo, Miao,Li, Jian-Wei,Jia, Xiao-Qing,Shao, Zhi-Min,Shen, Zhen-Zhou,Wu, Jiong,Liu, Guang-Yu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Background: To determine the potential value of serum tumor markers in predicting pCR (pathological complete response) during neoadjuvant chemotherapy. Materials and Methods: We retrospectively monitored the pro-, mid-, and post-neoadjuvant treatment serum tumor marker concentrations in patients with locally advanced breast cancer (stage II-III) who accepted pre-surgical chemotherapy or chemotherapy in combination with targeted therapy at Fudan University Shanghai Cancer Center between September 2011 and January 2014 and investigated the association of serum tumor marker levels with therapeutic effect. Core needle biopsy samples were assessed using immunohistochemistry (IHC) prior to neoadjuvant treatment to determine hormone receptor, human epidermal growth factor receptor 2(HER2), and proliferation index Ki67 values. In our study, therapeutic response was evaluated by pCR, defined as the disappearance of all invasive cancer cells from excised tissue (including primary lesion and axillary lymph nodes) after completion of chemotherapy. Analysis of variance of repeated measures and receiver operating characteristic (ROC) curves were employed for statistical analysis of the data. Results: A total of 348 patients were recruited in our study after excluding patients with incomplete clinical information. Of these, 106 patients were observed to have acquired pCR status after treatment completion, accounting for approximately 30.5% of study individuals. In addition, 147patients were determined to be Her-2 positive, among whom the pCR rate was 45.6% (69 patients). General linear model analysis (repeated measures analysis of variance) showed that the concentration of cancer antigen (CA) 15-3 increased after neoadjuvant chemotherapy in both pCR and non-pCR groups, and that there were significant differences between the two groups (P=0.008). The areas under the ROC curves (AUCs) of pre-, mid-, and post-treatment CA15-3 concentrations demonstrated low-level predictive value (AUC=0.594, 0.644, 0.621, respectively). No significant differences in carcinoembryonic antigen (CEA) or CA12-5 serum levels were observed between the pCR and non-pCR groups (P=0.196 and 0.693, respectively). No efficient AUC of CEA or CA12-5 concentrations were observed to predict patient response toward neoadjuvant treatment (both less than 0.7), nor were differences between the two groups observed at different time points. We then analyzed the Her-2 positive subset of our cohort. Significant differences in CEA concentrations were identified between the pCR and non-pCR groups (P=0.039), but not in CA15-3 or CA12-5 levels (p=0.092 and 0.89, respectively). None of the ROC curves showed underlying prognostic value, as the AUCs of these three markers were less than 0.7. The ROC-AUCs for the CA12-5 concentrations of inter-and post-neoadjuvant chemotherapy in the estrogen receptor negative HER2 positive subgroup were 0.735 and 0.767, respectively. However, the specificity and sensitivity values were at odds with each other which meant that improving either the sensitivity or specificity would impair the efficiency of the other. Conclusions: Serum tumor markers CA15-3, CA12-5, and CEA might have little clinical significance in predicting neoadjuvant treatment response in locally advanced breast cancer.

Elevated PIVKA-II is Associated with Early Recurrence and Poor Prognosis in BCLC 0-A Hepatocellular Carcinomas

Wang, Bei-Li,Tan, Qi-Wen,Gao, Xing-Hui,Wu, Jiong,Guo, Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: To investigate the prognostic value of serum PIVKA-II (prothrombin induced by the absence of vitamin K or antagonist-II) in BCLC (Barcelona Clinic Liver Cancer) 0-A hepatocellular carcinoma (HCC) patients after curative resection. Materials and Methods: Preoperative sera were collected from 140 patients with BCLC 0-A HCCs undergoing curative resection during 2011-2012 in Zhongshan Hospital. Follow-up ended on November 2013. ELISA was used to detect the serum concentrations of preoperative PIVKA-II. The prognostic value of PIVKA-II and other clinicopathological factors was analyzed by the Kaplan-Meier method and the multivariate Cox proportional hazards model. Results: During follow-up, 39 of 140 patients suffered recurrence and the 1-year recurrence rate was 27.9%. The high-PIVKA-II expression group had lower 1-year time to progression (TTP) compared with the low-expression group (54.8% vs 20.2%, p<0.001). Patients with high preoperative PIVKA-II expression showed a relatively higher risk of developing postoperative recurrence than those with low expression in the low-recurrence-risk subgroups, including ${\alpha}$-fetoprotein ${\leq}400ng/mL$ (45.4% vs 16.7%; p=0.006), tumor size ${\leq}5cm$ (54.2% vs 18.1%; p<0.001), single tumor (56.0% vs 19.1%; p<0.001), absence of satellite lesions (53.3% vs 19.8%; p=0.001), absence of vascular invasion (52.6% vs 14.9%; p=0.002), and Edmondson stage I/II (60.9% vs 20.3%; p<0.001). PIVKA-II was the strongest independent prognostic factor for TTP (hazard ratio, 2.877; 95% CI 1.524-5.429; p=0.001). Conclusions: Elevated PIVKA-II is associated with early recurrence of BCLC 0-A HCC after curative resection and can be considered a novel prognostic predictor.

Mechanical behavior of recycled fine aggregate concrete after high temperature

Jiong-Feng Liang,En Wang,Chun-Feng He,Peng Hu 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.65 No.3

This paper reports mechanical behavior of recycled fine aggregate concretes after high temperatures. It is found that compressive strength of recycled fine aggregate concretes decline significantly as the temperature rises. The elastic modulus of recycled fine aggregate concretes decreases with the increase in temperature, and the decrease is much quicker than the decrease in compressive strength. The split tensile strength of recycled fine aggregate concrete decrease as the temperature rises. Through the regression analysis, the relationship of the mechanical behavior with temperature are proposed, including the compressive behavior, elastic modulus and split tensile strength, which are fitting the test data.

Mechanical properties of recycled fine glass aggregate concrete under uniaxial loading

Jiong-Feng Liang,Ze-Ping Yang,Ping-Hua Yi,Jian-Bao Wang 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.2

This paper reports the results of an experimental study on the compressive strength and the stress-strain curve (SSC) of recycled fine glass aggregate concrete with different replacement percentages of recycled fine glass aggregate. The results show that the recycled fine glass aggregate contents have significant impact on the workability, compressive strength, the elastic modulus, the peak and the ultimate strains of recycled fine glass aggregate concrete. Analytical expressions for the stress–strain relationship of recycled fine glass aggregate concrete are given, which can satisfactorily describe the effect of the recycled fine glass aggregate on the SSC.

Micromechanical investigation of thermal stresses of a finite plane containing multiple elliptical inclusions based on the equivalent inclusion method and distributed dislocation method

Jiong Zhang,Yunhai Huang,Weidong Liu,Liankun Wang,Chao Yang,Lin Zuo 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.1

This paper presents a micromechanical method to analyze the thermal stresses in a finite plane containing multiple elliptical inclusions. Firstly, the Eshelby’s equivalent inclusion method is employed to solve the elastic fields of a two-dimensional infinite plane containing multiple elliptical inclusions under a uniform temperature change. Both the interior Eshelby’s tensor and the exterior Eshelby’s tensor are employed. Then the boundary of the plane is modeled by continuous distributions of dislocation densities. By combining the two steps, a system of singular integral equations is formulated based on the traction-free boundary condition. Then the thermal stresses of the plane can be obtained by the superposition of the stresses obtained by the Eshelby’s equivalent inclusion method and distributed dislocation method. Additionally, some examples are given to show the effects of the presented method. The effects of the material constants, geometric parameters and fiber packing arrangement on the thermal stresses are also studied.

Sex Differences in Early and Late Recurrence after Liver Resection of Hepatocellular Carcinoma (A Multicenter Study from China)

( Jiong-jie Yu ),( Ju-dong Li ),( Xin-fei Xu ),( Zhen-li Li ),( Jun Han ),( Hao Xing ),( Han Wu ),( Jian-hong Zhong ),( Yi-sheng Huang ),( Ya- Hao Zhou ),( Ting-hao Chen ),( Hong Wang ),( Wei-min Gu ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: There is a striking sex difference in the incidence of hepatocellular carcinoma (HCC), with a strong predominance for males. However, the impact of sex on the incidence of recurrence after curative resection of HCC remains controversial. Herein, we assess sex differences in the risks of recurrence and mortality for patients undergone curative resection of HCC. Methods: Data from 1,435 HCC patients undergone curative resection (1,228 males and 207 females) between 2004 and 2014 at five institutions in China were retrospectively analyzed. Patients’ baseline characteristics, operative variables, and rates of early recurrence (≤ 2 years after resection), late recurrence (> 2 years) and cancer-specific mortality (CSM) were evaluated and compared. Multivariable competing-risks regression analyses were performed to identify predictors associated with CSM, early and late recurrence. Results: The early recurrence rates between males and females were similar (43.3% vs. 42.0%, P=0.728), but the late recurrence and CSM rates in males were higher when compared to females (17.2% vs. 11.2%, P=0.044; 42.8% vs. 34.3%, P=0.022). Multivariable competing-risks regression analyses revealed no sex difference in early recurrence; however, males had significantly higher late recurrence rate [hazard ratio (HR), 1.752; 95% CI, 1.145-2.682; P=0.010] and CSM rate (HR, 1.307; 95% CI, 1.015-1.683; P=0.038) than females. Conclusions: Males had significantly higher late recurrence and CSM rates after curative resection of HCC than females. This suggests postoperative surveillance for HCC recurrence be varied by sex, especially for patients without recurrence at 2 years after resection.

Adaptive Preshuffling in Hadoop Clusters

Jiong Xie,FanJun Meng,HaiLong Wang,JinHong Cheng,Hongfang Pan,Xiao Qin 보안공학연구지원센터(IJGDC) 2013 International Journal of Grid and Distributed Comp Vol.6 No.2