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Jinkwon Kim,Junsik Mun,Youngdo Kim,Bongju Kim,Jeong Rae Kim,Lingfei Wang,Miyoung Kim,Changyoung Kim,Jason W. A. Robinson,Yoshiteru Maeno,Tae Won Noh 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
Ruddlesden-Popper (RP) phase oxides (An+1BnO3n+1, n = 1, 2, ...) have been spotlighted with versatile physical properties such as high-temperature superconductivity, colossal magnetoresistance. These emergent phenomena provide a platform for novel oxide-based electronic devices including spintronics application. However, high-quality RP-phase thin film growth has been disturbed by extended structural defects, such as out-of-phase boundaries (OPBs). OPB is a translational boundary between neighboring unit cells, shifted in a specific crystallographic direction. For instance, if RP-phase thin films grown on ABO₃ perovskite substrates, the structural mismatch between film and substrates induces a crystallographic shift in the c-axis direction, thus OPBs form at the film-substrate interface. Since OPB formation hampers the physical properties of RP-phase thin films, the suppression of the structural defects is highly required to carry out the high-performance RP-phase based functional devices. In this study, we suppressed OPB suppression in RP-phase oxide thin films by atomic-scale interface engineering. As model systems, the unconventional superconductor Sr₂RuO₄ (bulk Tc ~ 1.5 K) and La2-xSrxCuO₄ (bulk Tc ~ 39 K) thin films were employed. Despite the structural similarities between films and substrates, Sr2RuO4 and La2-xSrxCuO₄ films exhibited huge OPB formations. By controlling the atomic-scale interface engineering, the OPBs were significantly suppressed in the film structure. Notably, these OPB-free Sr₂RuO₄ and La2-xSrxCuO₄ thin films exhibited highly enhanced superconductivity than the film with huge OPB formation. Our study suggests a comprehensive method to suppress OPB formation in RP thin films, enabling superconducting spintronics devices based on the unconventional superconductivity.
Jinkwon Kim,Youngdo Kim,Junsik Mun,Jeong Rae Kim,Miyoung Kim,Changyoung Kim,Tae Won Noh 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1
Over the past decades, Ruddlesden-Popper (RP) phase oxides (A<sub>n+1</sub>B<sub>n</sub>O<sub>3n+1</sub>, n = 1, 2, ...) have been spotlighted with advantageous physical properties such as high-temperature superconductivity, giant magnetoresistance. <sup>[1-2]</sup> These emergent phenomena provide a platform for novel oxide-based electronic devices including spintronics application. However, high-quality RP-phase thin film growth has been disturbed by extended structural defects, so-called out-of-phase boundaries (OPBs).<sup>[3]</sup> OPB is a translational boundary between neighboring unit cells, shifted in a specific crystallographic direction. For instance, if RP-phase thin films grown on ABO<sub>3</sub> perovskite substrates, the structural mismatch between film and substrates induces a crystallographic shift in the c-axis direction, thus OPBs form at the film-substrate interface. Since OPB formation hampers the physical properties of RP-phase thin films, the suppression of the structural defects is highly required to carry out the high-performance RP-phase based functional devices.<sup>[4-5]</sup> In this study, we suppressed OPB suppression in RP-phase oxide thin films by using single-terminated LaSrAlO4 substrate (n = 1 RP phase, a = b= 3.756 Å and c =12.636 Å). As a model system, the high-T<sub>c</sub> cup rates superconductor La<sub>1.85</sub>Sr<sub>0.15</sub>CuO4 thin film (n = 1 RP phase, a = b= 3.777 Å and c =13.226 Å) was employed. Despite the structural similarities between films and substrates, the La<sub>2-x</sub>Sr<sub>x</sub>CuO<sub>4</sub> films exhibited huge OPB formations when deposited on mixed-terminated LaSrAlO4 substrate. In contrast, when the La<sub>2-x</sub>Sr<sub>x</sub>CuO<sub>4</sub> films were deposited on single-terminated LaSrAlO4 substrates, the OPBs were significantly suppressed in the film structure. Notably, these OPB-free La<sub>2-x</sub>Sr<sub>x</sub>CuO<sub>4</sub> films exhibited highly enhanced superconductivity (T<sub>c</sub><sup>zero</sup> ~ 30 K) than the film with huge OPB formation (T<sub>c</sub><sup>zero</sup> ~ 5 K) under the same thickness (~ 6.5 nm). Our study suggests a comprehensive method to suppress OPB formation in RP thin films, enabling superconducting spintronics devices based on RP-phase high-T<sub>c</sub> superconductors.[5-6]
The Effect of Pulsatility Index on Infarct Volume in Acute Lacunar Stroke
Kim, Yoon,Lee, Hanbin,An, Se-A,Yim, Byeongsoo,Kim, Jonguk,Kim, Ok Joon,Kim, Won Chan,Kim, Hyun Sook,Oh, Seung Hun,Kim, Jinkwon Yonsei University College of Medicine 2016 Yonsei medical journal Vol.57 No.4
<P><B>Purpose</B></P><P>Lacunar stroke, in the context of small vessel disease, is a type of cerebral infarction caused by occlusion of a penetrating artery. Pulsatility index (PI) is an easily measurable parameter in Transcranial Doppler ultrasound (TCD) study. PI reflects distal cerebral vascular resistance and has been interpreted as a surrogate marker of small vessel disease. We hypothesized that an increased PI, a marker of small vessel disease, might be associated with a larger infarct volume in acute lacunar stroke.</P><P><B>Materials and Methods</B></P><P>This study included 64 patients with acute lacunar stroke who underwent TCD and brain MRI. We evaluated the association between the mean PI value of bilateral middle cerebral arteries and infarct volume on diffusion-weighted MRI using univariate and multivariate linear regression.</P><P><B>Results</B></P><P>The mean infarct volume and PI were 482.18±406.40 mm<SUP>3</SUP> and 0.86±0.18, respectively. On univariate linear regression, there was a significant positive association between PI and infarct volume (<I>p</I>=0.001). In the multivariate model, a single standard deviation increase of PI (per 0.18) was associated with an increase of 139.05 mm<SUP>3</SUP> in infarct volume (95% confidence interval, 21.25 to 256.85; <I>p</I>=0.022).</P><P><B>Conclusion</B></P><P>We demonstrated that PI was an independent determinant of infarct volume in acute lacunar stroke. The PI value measured in acute stroke may be a surrogate marker of the extent of ischemic injury.</P>
Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke
Kim, Jinkwon,Song, Tae-Jin,Song, Dongbeom,Lee, Ki Jeong,Kim, Eun Hye,Lee, Hye Sun,Nam, Chung Mo,Nam, Hyo Suk,Kim, Young Dae,Heo, Ji Hoe American Heart Association, Inc. 2014 Hypertension Vol.64 No.2
<P>Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its predictive value for mortality in patients with acute stroke is unknown. We evaluated the prognostic value of baPWV in 1765 patients who had been admitted for acute ischemic stroke and had completed measurement of baPWV during admission. Primary outcomes were all-cause mortality and vascular mortality (death because of heart diseases, cerebrovascular diseases, or diseases of arteries, arterioles, and capillaries, determined according to the <I>International Classification of Diseases</I>) after stroke. During a mean follow-up period of 3.33±1.57 years, there were 228 all-cause deaths, including 143 vascular deaths. In multivariate Cox hazard regression, patients in the highest tertile of baPWV (>22.63 m/s) were at an increased risk for both all-cause death (adjusted hazard ratio, 1.97; 95% confidence interval, 1.25–3.08) and vascular death (adjusted hazard ratio, 2.39; 95% confidence interval, 1.33–4.29) compared with the lowest tertile (<17.79 m/s). This study suggested that measurement of baPWV during the acute phase of stroke might be useful in identifying patients at a higher risk for mortality.</P>
Plasma osteoprotegerin levels increase with the severity of cerebral artery atherosclerosis
Kim, Jinkwon,Song, Tae-Jin,Yang, Seung-Hee,Lee, Ok-Hee,Nam, Hyo Suk,Kim, Young Dae,Kim, Eun Hee,Lee, Hye Sun,Nam, Chung Mo,Heo, Ji Hoe Elsevier 2013 Clinical biochemistry Vol.46 No.12
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of cerebral atherosclerosis.</P> <P><B>Design and methods</B></P> <P>We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with cerebral atherosclerosis (≥50% stenosis).</P> <P><B>Results</B></P> <P>Of 107 patients, 73 (68.2%) had cerebral atherosclerosis. OPG levels were increased in patients with cerebral atherosclerosis (374.69±206.48 vs 261.17±166.91pg/mL, p=0.006). OPG levels showed positive correlation with the number of cerebral arteries with atherosclerosis (Spearman's <I>rho</I> =0.342, p<0.001). After adjustment for vascular risk factors, OPG>229.9pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57–13.55, p=0.005, binary logistic regression] of cerebral atherosclerosis and number [OR 3.20, 95% CI 1.26–8.12, p=0.014, ordinal logistic regression] of arteries with cerebral atherosclerosis.</P> <P><B>Conclusions</B></P> <P>Plasma OPG levels were significantly associated with the presence and severity of cerebral atherosclerosis. This finding suggests that plasma OPG might have a role in cerebral atherosclerosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Elevated OPG levels have been reported in patients with atherosclerotic diseases. </LI> <LI> The relationship between OPG and cerebral atherosclerosis is not well known. </LI> <LI> OPG levels were associated with presence and severity of cerebral atherosclerosis. </LI> </UL> </P>
Brachial-Ankle Pulse Wave Velocity for Predicting Functional Outcome in Acute Stroke
Kim, Jinkwon,Song, Tae-Jin,Kim, Eun Hye,Lee, Ki Jeong,Lee, Hye Sun,Nam, Chung Mo,Song, Dongbeom,Nam, Hyo Suk,Kim, Young Dae,Heo, Ji Hoe American Heart Association, Inc. 2014 Stroke Vol.45 No.8
<P><B>Background and Purpose—</B></P><P>We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction and whether the prognostic value differs between stroke subtypes.</P><P><B>Methods—</B></P><P>We included 1091 consecutive patients with first-ever acute cerebral infarction who underwent baPWV measurements. Stroke subtypes were classified using the Trial of Org 10172 in Acute Stroke Treatment classification. Poor functional outcomes were defined as modified Rankin Scale score >2 at 3 months after stroke onset.</P><P><B>Results—</B></P><P>We noted that 181 (16.59%) patients had a poor functional outcome. In multivariate logistic regression, patients in the highest tertile of baPWV (>22.25 m/s) were found to be at increased risk for poor functional outcome (adjusted odds ratio, 1.88; 95% confidence interval, 1.06–3.40) compared with those in the lowest tertile (<17.55 m/s). No significant interaction between baPWV and stroke subtype was noted. Receiver operating characteristic curve analysis indicated that the addition of baPWV to the prediction model significantly improved the discrimination ability for poor functional outcome.</P><P><B>Conclusions—</B></P><P>baPWV has an independent prognostic value for predicting functional outcome after acute cerebral infarction. The prognostic value did not differ according to the stroke subtype.</P>
28-day inhalation toxicity of graphene nanoplatelets in Sparague-Dawley rats
Jinkwon Kim(김진권),Jaehoon Shin(신재훈),Miseong Jo(조미성),Younghoon Kim(김영훈),Eungyeong Son(손은경),Hyeseon Park(박혜선),Byeonghak Moon(문병학),Jongseong Lee(이종성),Jinee Baek(백진이),Boowook Kim(김부욱),Jinsik Kim(김진식),Kangh 환경독성보건학회 2016 한국독성학회 심포지움 및 학술발표회 Vol.2016 No.10
Thrombus Volume as a Predictor of Nonrecanalization After Intravenous Thrombolysis in Acute Stroke
Yoo, Joonsang,Baek, Jang-Hyun,Park, Hyungjong,Song, Dongbeom,Kim, Kyoungsub,Hwang, In Gun,Kim, Young Dae,Kim, Seo Hyun,Lee, Hye Sun,Ahn, Seong Hwan,Cho, Han-Jin,Kim, Gyu Sik,Kim, Jinkwon,Lee, Kyung-Yu Ovid Technologies Wolters Kluwer -American Heart A 2018 Stroke Vol.49 No.9
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Kim Kwangho,Ryu Tae Young,Jung Eunsun,Han Tae-Su,Lee Jinkwon,Kim Seon-Kyu,Roh Yu Na,Lee Moo-Seung,Jung Cho-Rok,Lim Jung Hwa,Hamamoto Ryuji,Lee Hye Won,Hur Keun,Son Mi-Young,Kim Dae-Soo,Cho Hyun-Soo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regulates metastasis has not been fully elucidated. Here, we found that the histone methyltransferase SMYD2 is overexpressed in lung cancer and that knockdown of SMYD2 could reduce the rates of cell migration and invasion in lung cancer cell lines via direct downregulation of SMAD3 via SMYD2-mediated epigenetic regulation. Furthermore, using an in vitro epithelial-mesenchymal transition (EMT) system with a Transwell system, we generated highly invasive H1299 (In-H1299) cell lines and observed the suppression of metastatic features by SMYD2 knockdown. Finally, two types of in vivo studies revealed that the formation of metastatic tumors by shSMYD2 was significantly suppressed. Thus, we suggest that SMYD2 is a potential metastasis regulator and that the development of SMYD2-specific inhibitors may help to increase the efficacy of lung cancer treatment.
Crystal structure and magnetic properties of dicarboxylate-bridged Iinear chain Mn(Ⅱ) complexes
Kim, Jinkwon,Lim, Jin Mook,Suh, Man Cheol,Yun, Hoseop 공주대학교 자원재활용 신소재 연구센터 2002 센터사업 성과집 Vol.- No.1
Two managanese(Ⅱ) complexes, [Mn(mtm)(CH_3OH)_2(H_2O)]_n (1) and [Mn_2(mtm)_2(2,2'-bipy)_2]_n (2) bipy=bipyridine, mtm=[bis(methylthio)methylene]malonate) were synthesized and characterized by X-ray crystallography. Structure of 1 consists of octahedral manganese(Ⅱ) species which are extended by carboxylate bridges in syn-anti fashion along the c-axis. Chains of 1 are associated by hydrogen bonding among coordinating water and methanol molecules and carboxylate oxygen atoms, forming two-dimensional structures. The crystallographic asymmetric unit of 2 comprises two [Mn(2,2'-bipy)mtm)] units in which Mn(Ⅱ) atoms are bridged by μ_2-oxygens from carbosylate to form Mn_2O_2 rhombus. The dimeric units are linked doubly by second carboxylates in syn-anti fashion, resulting in a chain structure. The antiferromagnetic coupling of Mn(μ) ions in 1 (-0.2cm^-1) and 2(- 1.57 cm^-1) was determined from variable-temperature magnetic susceptibility data in the temperature range of 2-300 K.