Effect of resistance training at different intensities on hippocampal neurotrophic factors and peripheral CCL11 levels in obese mice

Jinhee,Woo,Hee-Tae,Roh,Chan-Ho,Park,Byung-Kon,Yoon,Do-Yeon,Kim,Ki-Ok,Shin 한국응용과학기술학회 (구.한국유화학회) 2019 한국응용과학기술학회지 Vol.36 No.3

We investigated the effect of moderate- and high-intensity resistance training on hippocampal neurotrophic factors and peripheral CCL11 levels in high-fat diet (HFD)-induced obese mice. C57/black male mice received a 4 weeks diet of normal (control, CON; n = 9) or a high-fat diet (HF; n = 27) to induce obesity. Thereafter, the HF group was subdivided equally into the HF, HF + moderate-intensity exercise (HFME), and HF + high-intensity exercise (HFHE) groups ( n = 9, respectively), and mice were subjected to ladder-climbing exercise for 8 weeks. The hippocampal brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels were significantly lower in the HF group than in the CON group ( p < 0.05). In addition, in the HFME and HFHE groups were significantly higher than in the HF group ( p < 0.05). The peripheral CCL11 levels were significantly higher in the HF group than in the CON group ( p < 0.05). In addition, in the HFME and HFHE groups were significantly lower than in the HF group ( p < 0.05). However, there was no significant difference according to the exercise intensity among the groups. Collectively, these results suggest that obesity can induce down-regulation of neurotrophic factors and inhibition of neurogenesis. In contrast, regardless of exercise intensity, resistance training may have a positive effect on improving brain function by inducing increased expression of neurotrophic factors.

Both endurance- and resistance-type exercise prevents neurodegeneration and cognitive decline in mice with impaired glucose tolerance

Jinhee,Woo,Ki-Ok,Shin,Chan-Ho,Park,Byung-Kon,Yoon,Do-Yeon,Kim,Ju-Yong,Bae,Yul-Hyo,Lee,Kangeun,Ko,Hee-Tae,Roh 한국응용과학기술학회 (구.한국유화학회) 2019 한국응용과학기술학회지 Vol.36 No.3

The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). HOMA-IR was significantly higher in IGT group than CO group ( p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group ( p < 0.05), while beta-amyloid (Aβ) was significantly higher in IGT group than in CO group ( p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups ( p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.

Development of an Internet of things-based treatment adherence program among older adults with mild cognitive impairment using Intervention Mapping: A developmental study

Jinhee Shin,Eunhee Cho,Gwang Suk Kim,Heejung Kim,Byoung Seok Ye,Chang-Gi Park 한국노인간호학회 2023 노인간호학회지 Vol.25 No.3

보육교사의 자기장학이 교직전문성과 교수몰입에 미치는 영향

신진희(Shin, Jinhee),김정희(Kim, Junghee) 이화여자대학교 이화어린이연구원 2019 영유아교육: 이론과 실천 Vol.4 No.3

본 연구는 보육교사의 자기장학, 교직전문성, 교수몰입이 보육교사의 개인적 특성에 따라 차이가 있는지 알아보고, 보육교사의 자기장학이 교직전문성과 교수몰입에 미치는 영향을 살펴보는 데 목적이 있다. 이를 위해 서울과 경기 지역에 위치한 어린이집에 재직 중인 보육교사 333명을 대상으로 설문 조사를 하였고, 신뢰도 분석, 기술통계, ttest, 일원변량분석(one-way ANOVA), 다중회귀분석을 실시하였다. 연구결과, 보육교사의 일반적 배경에 따라 자기장학, 교직전문성, 교수몰입의 차이가 있었고, 자기장학이 교직전문성과 교수몰입에 영향을 미치는 것으로 나타났다. 본 연구의 결과는 보육교사의 교직전문성과 교수몰입에 자기장학이 중요한 역할을 한다고 것을 시사한다. 보육현장에서 교육의 질적 향상을 위해 자기장학의 구체적 방안의 마련과 사회적·국가적 지원이 더욱 요구되고 보육교사의 자기장학 발전에 많은 관심과 노력들이 기대된다. The purpose of the study is to examine the differences between child care teacher’s selfsupervision, teacher’s professionalism and teaching flow depending on child care teacher’personal background. It also aims to explore the effect of teacher’s self-supervision on their professionalism and teaching flow. A survey was conducted with 333 child care teachers in Seoul and Kyunggi areas. t -test, correlation analysis and multiple regression analysis, one-way ANOVA and Scheffé’s post hoc analysis were used for analysis. Consequently the study showed the differences between self-supervision, teacher’s professionalism and teaching flow depending on the personal background of child care teachers. It also revealed that the self supervision was the important factor markedly influencing on teacher’s professionalism and teaching flow. It implies that self-supervision plays a significant role in teacher’s professionalism and teaching flow. Therefore, it is necessary that the concrete methods of supporting the self-supervision based on social and national organization should be provided to the teachers in order to enhance the quality of education.

[우수논문] Variational Autoencoder를 이용한 ECG 데이터 증강 및 부정맥 분류 모델

곽진희(Jinhee Kwak),신준호(Junho Shin),신정수(Jungsoo Shin),정재희(Jaehee Jung) 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.12

한정된 자원 환경에서의 주문형 비디오 스트리밍 서비스를 위한 효율적인 인센티브 메커니즘

신규용(Kyuyong Shin),이종덕(Jongdeog Lee),신진희(Jinhee Shin),박찬진(Chanjin Park) 한국컴퓨터정보학회 2013 韓國컴퓨터情報學會論文誌 Vol.18 No.4

과거에는 단순한 파일 공유 어플리케이션들이 인터넷 트래픽의 가장 큰 비중을 차지하고 있었지만 현재는 실시간 스트리밍을 포함한 비디오 어플리케이션들이 그 자리를 대체하고 있다. 이에 따라 협조적 분산 환경을 지원하는 피투피 (P2P) 어플리케이션들의 패러다임도 비디오 스트리밍을 지원하는 방향으로변화하고 있다. 현재 비디오 스트리밍을 지원하는 피투피 방식들은 대부분 구협이 쉽고 스트리밍 어플리케이션으로의 전환이 용이한 비토렌트 (BitTorrent)를 기반하고 있다. 하지만 비토렌트 기반의 비디오 스트리밍방식들은 무임승차에 취약한 비토렌트의 특성을 그대로 반영하기 때문에 무임승차에 의해 시스템 자원이 부족한 상황에서는 제대로 동작하지 않는 단점이 있다. 따라서 본 논문에서는 비토렌트 기반의 비디오 스트리밍 방식들의 무임승차에 대한 취약성을 분석하고, 기존 방식들에 대한 대안으로 (협조적 분산 환경 하에서 협동을 강제하기 위해 개발되었던) T-Chain의 적용 가능성에 대해 검토한다. 시뮬레이션 결과 T-Chain을 기반으로 한 비디오 스트리밍 방식인 S-TChain의 경우 부족한 자원환경에서 비토렌트 기반의 다른 방법들에 비해 평균 60% 이상의 향상된 성능을 보였다. Recently the ratio of the Internet traffic generated by video streaming applications including video-on-demand (VOD) is getting higher and higher, while P2P-based naive content distribution has been the main source of the Internet traffic in the past. As a result, the paradigm of cooperatively distributed systems (e.g., P2P) is changing to support streaming applications. Most P2P assisted approaches for video streaming today are based on Bit Torrent thanks to its simplicity of implementation and easy adaptability. They, however, have immanent vulnerability to free-riding inherited from Bit Torrent, which inevitably hurts their performance under limited system resources with free-riding. This paper studies the weakness to free-riding of existing Bit Torrent-based video streaming applications and investigates the adaptability of T-Chain (which was originally designed to prevent free-riding in cooperatively distributed systems) to video streaming applications. Our experiment results show that the video streaming approach based on T-Chain outperforms most existing Bit Torrent-based ones by 60% on average under limited system resources with free-riding.

Data Augmentation과 Supervised Contrastive Learning을 이용한 불균형 혐오 표현 데이터셋 분류

신준호(Junho Shin),신정수(Jungsoo Shin),곽진희(Jinhee Kwak),정재희(Jaehee Jung) 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.12

Japan Y generation's Purchasing Decision Factors of Fashion Jeans

Jinhee Lee,Su-Jeong H. Shin,Yoshiko Odamaki 가정과삶의질학회 2011 한국가정관리학회 학술발표대회 자료집 Vol.2011 No.5

Schisandrae Fructus Reduces Symptoms of 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure in Mice

Shin, Dasom,Ha, Jinhee,Hong, Seong Bin,Kang, Geun-Hyung,Hwang, Deok-Sang,Bae, Hyunsu Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-

<P>Menopause is associated with a decrease in the level of sex hormones such as ovarian estradiol and progesterone and can cause various symptoms such as depression, hot flash, fatigue, heart palpitations, and headache. Furthermore, there is a risk of developing complications such as osteoporosis, cardiovascular diseases, Alzheimer's disease, and ovarian cancer. Schisandrae Fructus (SF) is widely used in Korean medicine as a cure for such complications. This study was conducted to evaluate the therapeutic effects of SF against menopause symptoms associated with follicle depletion caused by the industrial chemical 4-vinylcyclohexene diepoxide (VCD) in mice. VCD directly targets the preantral follicles. Mice were injected with VCD (160 mg/kg intraperitoneally) daily for 15 days and then with SF dosage 3 times/week for six weeks. To evaluate the effects of SF, body weight, tail skin temperature, uterine weight, lipid profile, and osteocalcin levels were measured. A decrease in body weight and tail skin temperature and an increase in uterine weight were observed upon SF treatment. Moreover, SF treatment significantly decreased total cholesterol, triglyceride, osteocalcin, and low-density lipoprotein levels and low-density/high-density lipoprotein ratio. These results suggest the potential use of SF in the treatment of menopausal symptoms in women.</P>

유산소 훈련 강도 차이가 비만 어린이의 산화적 조직 손상에 의한 심혈관질환 병태생리적 경로에 미치는 영향

Jinhee Woo(우진희),Ki Ok Shin(신기옥),Keun Soo Kim(김근수),Young Il Kim(김영일),Sunghwun Kang(강성훈) 한국생명과학회 2010 생명과학회지 Vol.20 No.9

본 연구는 12주 유산소 운동이 비만 어린이의 혈청지질성분, 항산화효소 활성 및 자율신경계 활동에 미치는 영향을 조사하였다. 피험자들은 16명의 비만어린이와 19명의 정상어린이를 대상으로 12주간 중강도 유산소 운동을 실시하였다. 측정 항목은 VO₂peak, 신체조성, 혈청지질, ox-LDL, 8-OHdG, SOD, GPx 활성, total mRNA, 그리고 자율신경계 활성을 측정하였다. 그 결과 체중은 OW그룹에서 시기간 차이가 나타나지 않았으나, 12주 운동 후 OR과 CO그룹에서 유의하게 증가하였다. WHR은 OR과 CO그룹에서 차이가 나타나지 않았으나, 12주 운동 후 OW그룹에서 유의하게 감소하였다. 비만 그룹에서 baseline TG는 대조군 보다 더 높게 나타났으며(p<0.05), 자율신경계 활성은 낮게 나타났다. 항산화효소 유전자 발현은 모든 그룹에서 시기간 유의한 차이가 나타났다. 결론적으로 비만어린이에서 산화적 손상과 항산화효소 활성은 정상어린이와 유사하게 나타났다. 그러나 정상어린이에 비해 비만어린이의 TG는 더 높게 나타났고 자율신경계 활성은 더 낮게 나타났다. 따라서 비만어린이에서 TG의 증가와 자율신경계 활성의 감소는 비만환자의 출발점이 어린시기에 시작될 수 있음을 시사한다. 또한 규칙적인 유산소성 운동은 어린시기에서 항산화효소 발현을 수정하여 줄 수 있다고 사료된다. The purpose of this study was to examine the effect of 12 wk of aerobic exercise on lipid profiles, antioxidant enzyme activities, oxidative products, and autonomic nervous activity (ANA) in children with obesity. We studied 16 children with obesity and 19 age-matched normal weight controls over a period of 12 wk, during which time moderate intense running exercise was performed. Measurements included peak oxygen uptake, body composition, blood lipid profiles, ox-LDL, 8-OHdG, SOD, GPx activities, total mRNA, and ANA. There were no differences in body weight between periods in the OW group, but body weight increased after 12 wk in OR and CO groups. There were no differences in WHR between periods in the OR and CO groups, but the WHR values decreased after 12 weeks in the OW group. In the obese group, the baseline TG was higher than in the controls (p<0.05), while the ANA level was lower. There were differences in antioxidant enzyme gene expressions between periods in all groups. In conclusion, oxidative damage and antioxidant enzyme activities in obese children were found to be similar to those of normal weight children. However, TG was higher and ANA was lower in obese children than in normal weight children. These results indicated that increased TG and decreased ANA levels begins in childhood in obese patients. Also, regular aerobic exercise may modify the antioxidant enzyme gene expression in early life.