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Single‐Molecule Four‐Color FRET
Lee ,, Jinwoo,Lee ,, Sanghwa,Ragunathan, Kaushik,Joo, Chirlmin,Ha, Taekjip,Hohng, Sungchul WILEY‐VCH Verlag 2010 Angewandte Chemie Vol.122 No.51
<P><B>Sechs FRET‐Interfluorophoreffizienzen</B> <I>E</I><SUB><I>ij</I></SUB> (siehe Schema) wurden in Echtzeit durch eine Einzelmolekül‐Vierfarben‐FRET‐Technik mittels konfokaler Mikroskopie sowie Fluoreszenzmikroskopie mit interner Totalreflexion bestimmt. Das Verfahren wurde verwendet, um die korrelierte Bewegung der vier Arme der Holliday‐Junction und die Korrelation von RecA‐vermittelten Strangaustauschereignissen an beiden Enden eines synaptischen Komplexes zu untersuchen.</P>
Krieger, Elmar,Joo, Keehyoung,Lee, Jinwoo,Lee, Jooyoung,Raman, Srivatsan,Thompson, James,Tyka, Mike,Baker, David,Karplus, Kevin Wiley Subscription Services, Inc., A Wiley Company 2009 Proteins Vol.77 No.suppl9
<P>A correct alignment is an essential requirement in homology modeling. Yet in order to bridge the structural gap between template and target, which may not only involve loop rearrangements, but also shifts of secondary structure elements and repacking of core residues, high-resolution refinement methods with full atomic details are needed. Here, we describe four approaches that address this 'last mile of the protein folding problem' and have performed well during CASP8, yielding physically realistic models: YASARA, which runs molecular dynamics simulations of models in explicit solvent, using a new partly knowledge-based all atom force field derived from Amber, whose parameters have been optimized to minimize the damage done to protein crystal structures. The LEE-SERVER, which makes extensive use of conformational space annealing to create alignments, to help Modeller build physically realistic models while satisfying input restraints from templates and CHARMM stereochemistry, and to remodel the side-chains. ROSETTA, whose high resolution refinement protocol combines a physically realistic all atom force field with Monte Carlo minimization to allow the large conformational space to be sampled quickly. And finally UNDERTAKER, which creates a pool of candidate models from various templates and then optimizes them with an adaptive genetic algorithm, using a primarily empirical cost function that does not include bond angle, bond length, or other physics-like terms.</P>
조리 방법에 따른 고구마줄기의 Phytochemical 함량과 항산화 활성 비교
양세희, 정혜진, 성예지, 이하나, 이세윤, 양진우, 이준수 忠北大學校 農業科學硏究所 2017 農業科學硏究 Vol.33 No.1
Vegetable consumption is associated with health benefits. Recently, the interest in these food groups has grown among due to the identification of new compound in their chemical composition. Most of the vegetables are cooked by blanching, boiling, steaming, microwaving before consumed. These cooking processes may change not only food physical characteristics but also chemical composition. The present study was undertaken to investigate the effect of different cooking methods on phytochemical content and antioxidant capacity in Ipomoea batatas (L.) Lam stem. The result of study, Total polyphenol of phytochemical in Ipomoea batatas (L.) Lam stem was 6.88-12.65 mg GAE/100 g and flavonoid was 3.16-10.46 mg CE/100 g. Compared with the raw of Ipomoea batatas (L.) Lam stem, all cooking methods were found to significant correlations between the antioxidant activity assessed by ABTS, DPPH and polyphenol(p<0.05). These results can be provide the basic data how to prevent lose of nutrition in Ipomoea batatas (L.) Lam stem when cooking.
Lee, Sung-Hyun,Kim, Hye-Rim,Lee, Taeseon,Lee, Haemin,Lee, Jinwoo,Lee, Jaegeun,Park, Junbeom,Lee, Kun-Hong Elsevier 2017 Carbon Vol.124 No.-
<P>Carbon nanotube (CNT) fibers were synthesized from ethylene, acetylene, or methane by separately injecting ferrocene and the carbon precursors during a direct spinning process. Ethylene and acetylene have low decomposition temperatures. It was difficult to synthesize CNT fibers from these precursors using the direct spinning method. CNT fibers were continuously synthesized by delaying the contact time between the catalyst particles and the carbon precursors, which provided sufficient time for catalyst growth. Changes in catalyst size from 2 nm to 20 nm were observed as a function of the catalyst formation step setting temperature (350-440 degrees C) and the carbon precursor injection tube length (8-310 mm), and the relationship between the catalyst size and the CNT diameter was characterized. The CNT fibers had higher I-G/I-D ratios when synthesized from acetylene (69.87) or ethylene (18.52) than from methane (3.61). The choice of the carbon precursor had a much larger effect on the I-G/I-D ratio of the synthesized CNT fibers than the other operating variables. (C) 2017 Elsevier Ltd. All rights reserved.</P>
Analysis of Fifty Hotspot Mutations of Lung Squamous Cell Carcinoma in Never-smokers
Lee, Ha Youn,Lee, Se-Hoon,Won, Jae-Kyung,Lee, Dong Soo,Kwon, Nak-Jung,Choi, Sun Mi,Lee, Jinwoo,Lee, Chang-Hoon,Lee, Sang-Min,Yim, Jae-Joon,Yoo, Chul-Gyu,Kim, Young Whan,Han, Sung Koo,Park, Young Sik KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.3
<P>Smoking is the major risk factor for lung squamous cell carcinoma (SCC), although a small number of lung SCCs occurs in never-smokers. The purpose of this study was to compare 50 hotspot mutations of lung SCCs between never-smokers and smokers. We retrospectively reviewed the medical records of patients newly diagnosed with lung SCC between January 1, 2011 and December 31, 2013 in the Seoul National University Hospital. Formalin-fixed, paraffin-embedded tumor samples were used for analysis of hotspot mutations. Fifty cancer-related genes in never-smokers were compared to those in ever-smokers. Of 379 lung SCC patients, 19 (5.0%) were never-smokers. The median age of these 19 patients was 67 years (interquartile range 57–73 years), and 10 of these patients were women (52.5%). The incidence rates of stage I, II, III, and IV disease in this group were 26.4%, 5.3%, 31.6%, and 36.8%, respectively, and sequencing was performed successfully in 14 cases. In the 26 lung SCC tumor samples (12 from never-smokers and 14 from ever-smokers) sequenced using personal genome machine, the most common mutations were in <I>TP53</I> (75.0%), <I>RAS</I> (66.7%), and <I>STK11</I> (33.3%), but mutations were also found in <I>EGFR</I>, <I>KIT</I>, and <I>PTEN</I>. The distribution of hotspot mutations in never-smokers was similar to that in ever-smokers. There was no significant difference in overall survival between the 2 groups. The 50 hotspot mutations of lung SCC in never-smokers were similar to those of ever-smokers.</P>
Jinwoo Lee,Hyuk Jong Bong,Daeyong Kim,Young‑Seon Lee,Yumi Choi,Myoung‑Gyu Lee 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.5
The feasibility of room-temperature (cold) forming of peak-aged 7075 high-strength aluminum alloy (7075-T6) sheets aftersolution heat treatment followed by water quenching was investigated. The anisotropic plastic properties of the heat-treatedaluminum sheet (7075-WT) were experimentally characterized by performing uniaxial tensile tests (along different loadingdirections) and a balanced biaxial tension test. Limit dome height (LDH) and cylindrical cup drawing experiments wereconducted to evaluate the formability at room temperature. With the obtained anisotropic mechanical properties, differentyield functions, including Yld2000-2d, Hill 1948, and von-Mises, were determined and implemented in the finite elementsimulations to numerically predict the formability at room temperature. The formability of the 7075-WT sheet at roomtemperature could be significantly enhanced owing to the prior heat treatment, and the finite element simulations performedusing the anisotropic yield functions and Voce hardening law were in good agreement with the measured LDH. The LDHof the 7075-WT sheet in the plane strain and biaxial stress modes and the earing in the circular cup drawing tests could bebetter predicted non-quadratic Yld2000-2d function than those by isotropic and Hill 1948 quadratic yield functions.
A Case of Acute Pulmonary Thromboembolism after Taking Tadalafil
Lee, Jinwoo,Kwon, Ji Hyun,Lee, Chang-Hoon,Lee, Sang-Min,Yim, Jae-Joon,Yoo, Chuy-Gyu,Kim, Young Whan,Han, Sung Koo,Park, Young Sik The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.73 No.4
Tadalafil is a phosphodiesterase-5 inhibitor (PDE5I), which is widely used to treat erectile dysfunction. Although PDE5Is have excellent safety profiles, and most of the side effects are mild, rare serious adverse events have been reported in association with PDE5Is. Thrombosis is one of those events, and a few previous reports have suggested the association of PDE5Is with thrombosis. We report the case of a 61-year-old male who developed pulmonary embolism combined with pulmonary infarction directly after taking tadalafil. Both the patient and the physician suspected tadalafil as the culprit drug, as the patient was in an otherwise healthy condition. However, after extensive evaluation, we noticed that factor VIII levels were elevated. Prior reports suggesting the association between thrombosis and PDEIs either lack complete information on coagulation factors, or show inconsistencies in their results. Physicians should operate caution prior to accepting the diagnosis of adverse drug reaction.
Lee, Jinwoo,Na, Hyon Bin,Kim, Byoung Chan,Lee, Jin Hyung,Lee, Byoungsoo,Kwak, Ja Hun,Hwang, Yosun,Park, Je-Geun,Gu, Man Bock,Kim, Jaeyun,Joo, Jin,Shin, Chae-Ho,Grate, Jay W.,Hyeon, Taeghwan,Kim, Jungb Royal Society of Chemistry 2009 Journal of materials chemistry Vol.19 No.42
<P>A magnetically-separable and highly-stable enzyme system was developed by adsorption of enzymes in superparamagnetic hierarchically ordered mesocellular mesoporous silica (M-HMMS) and subsequent enzyme crosslinking. Superparamagnetic nanoparticles were homogeneously incorporated into hierarchically-ordered mesocellular mesoporous silica (HMMS) by the decomposition of a preformed iron propionate complex. The size of the incorporated superparamagnetic nanoparticles was around 5 nm, generating a magnetically separable host with high pore volumes and large pores (M-HMMS). α-chymotrypsin (CT) was adsorbed into M-HMMS with high loading (∼30 wt%) in less than 30 minutes. Glutaraldehyde (GA) treatment of adsorbed CT resulted in nanometer scale crosslinked enzyme aggregates in M-HMMS (CLEA-M). The activity of these CT aggregates in M-HMMS (CLEA-M-CT) was 34 times than that of simply adsorbed CT in M-HMMS, due to an effective prevention of enzyme leaching during washing <I>via</I> a ship-in-a-bottle approach. CLEA-M-CT maintained the initial activity not only under shaking (250 rpm) for 30 days, but also under recycled uses of 35 times. The same approach was employed for the synthesis of CLEA-M of lipase (CLEA-M-LP), and proven to be effective in improving the loading, activity, and stability of enzyme when compared to those of adsorbed LP in M-HMMS.</P> <P>Graphic Abstract</P><P>Crosslinked enzyme aggregates in magnetitie-coated mesoporous silica, fabricated <I>via</I> a two-step procedure of enzyme adsorption and crosslinking, were highly active, highly stable, and easily recyclable using a magnet. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b909109b'> </P>
A Case of Acute Pulmonary Thromboembolism after Taking Tadalafil
( Jinwoo Lee ),( Ji Hyun Kwon ),( Chang Hoon Lee ),( Sang Min Lee ),( Jae Joon Yim ),( Chuy Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Young Sik Park ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.4
Tadalafil is a phosphodiesterase-5 inhibitor (PDE5I), which is widely used to treat erectile dysfunction. Although PDE5Is have excellent safety profiles, and most of the side effects are mild, rare serious adverse events have been reported in association with PDE5Is. Thrombosis is one of those events, and a few previous reports have suggested the association of PDE5Is with thrombosis. We report the case of a 61-year-old male who developed pulmonary embolism combined with pulmonary infarction directly after taking tadalafil. Both the patient and the physician suspected tadalafil as the culprit drug, as the patient was in an otherwise healthy condition. However, after extensive evaluation, we noticed that factor VIII levels were elevated. Prior reports suggesting the association between thrombosis and PDEIs either lack complete information on coagulation factors, or show inconsistencies in their results. Physicians should operate caution prior to accepting the diagnosis of adverse drug reaction.