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The Relationship between Serum Amyloid A and Lung Function in Retired Coal Miners
( Jae Hoon Shin ),( Jae Hoon Shin ),( Jinee Baek ),( Jong Seong Lee ),( Byung-soon Choi ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Occupational exposure to mineral dusts such as coal and crystalline silica may cause chronic lung diseases, including pneumoconiosis and chronic obstructive pulmonary disease (COPD). COPD is characterized by an abnormal inflammatory response in the lung, impaired lung function and associated with systemic inflammation. Individuals with impaired lung function have significantly raised levels of several circulating inflammatory markers such as serum amyloid A (SAA) indicating the presence of systemic inflammation. We investigated the SAA levels as the prospective biomarkers of COPD in retired coal workers. The study population contained 163 workers exposed to mineral dusts. We measured SAA and conducted pulmonary function test. The levels of SAA in workers, who had %FEV1 < 80% predicted, were significantly higher than those of workers who had %FEV1 ≥ 80% (p=0.049). %FEV1 predicted showed significant negative correlation with SAA (r=-0.247, p<0.01). In present study, there was significant relationship between SAA and impaired lung function. The serum levels of SAA, however, may be affected by the heart disease and acute inflammatory responses, further studies are needed to measure other acutephase proteins and inflammatory cytokines using lung specific specimen such as lung tissue and bronchoalveolar lavage fluid.
Kamut (Triticum turgidum spp.) 식빵 급여가 고지방식이 유도 비만 C57BL/6 마우스에 미치는 효과
정현기(Hyun Gi Jung),백지윤(Ji Yun Baek),최예정(Ye Jung Choi),강기성(Ki Sung Kang),김현영(Hyun Young Kim),김지현(Ji Hyun Kim),최진상(Jine Shang Choi) 한방비만학회 2021 한방비만학회지 Vol.21 No.2
Objectives: The purpose of this study was to investigate the effect of white pan bread added with Kamut (Triticum turgidum spp.) on high fat diet (HFD)-induced obese C57BL/6 mice. Methods: The white pan bread or white pan bread with Kamut (BK) were administered for 8 weeks in HFD-induced obese C57BL/6 mice. To evaluate the effect and its mechanisms of BK on obese mice, we measured body weight change, serum lipid profiles, histopathological analysis, and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) in the liver. Results: Administration of BK significantly decreased body weight in HFD-induced obese mice. In addition, BK-administered group significantly reduced serum total cholesterol, glucose, and high-density lipoprotein cholesterol levels compared with the HFD-induced control group. The HFD-induced mice had damaged liver tissue and increased the size of adipose tissue, but BK-administered group attenuated liver damage and decreased the size of adipocyte. Furthermore, administration of BK significantly down-regulated C/EBPα in the liver compared with HFD-fed mice. In particular, BK-administered group has higher inhibited body weight, serum lipid profiles, and C/EBPα expressions than white pan bread-administered group. Conclusions: This study demonstrated that administration of BK attenuated HFD-induced obesity by regulation of C/EBPα than consumption of white pan bread. Therefore, BK could be developed as a bread for prevention of obesity.
소변 중 디아민을 이용한 디이소시아네이트 노출 근로자의 생물학적 모니터링
이종성 ( Jong Seong Lee ),김부옥 ( Boowook Kim ),신정아 ( Jungah Shin ),백진이 ( Jinee Baek ),신재훈 ( Ae Hoon Shin ),김지혜 ( Ji-hye Kim ) 한국산업보건학회 (구 한국산업위생학회) 2016 한국산업보건학회지 Vol.26 No.2
Objectives: Diisocyanates are a potent inducer of diseases of the airways, especially asthma. In this study, toluenediamine(TDA)and methylenedianiline(MDA) in urine were evaluated as biomarkers of exposure to tolunenediisocyanate(TDI) and methylenediphenyl diisocyanate(MDI), respectively. Methods: Workers exposed to TDI and MDI, as well as non-occupationally exposed subjects, were studied and pre- and post-shift urine samples were collected from 8 control subjects and 8 workers from a factory which manufactures polyurethane products for reducing noise and vibration in automobiles. Airborne TDI and MDI(n=8) were sampled on solvent-free glass filters impregnated with n-butyl amine and detected by liquid chromatography atmospheric pressure ionization tandem mass spectrometry. Urinary TDA and MDA were detected as pentafluoropropionic acid an hydride(PFPA) derivatives by liquid chromatography electrosprayionization tandem mass spectrometry. Results: The median levels of urinary 2,6-TDA(p<0.001), 2,4-TDA(p=0.001), and MDA(p<0.001) of workers in post-shiftsamples were significantly higher than those of controls. The median levels of urinary 2,6-TDA(0.63 ㎍/gcreatinine vs 0.34 ㎍/gcreatinine, p=0.017) and MDA(4.21 ㎍/g creatinine vs 3.18 ㎍/g creatinine, p=0.017) of workers in post-shift samples were significantly higher than those of the pre-shift samples. There were significant correlations between the urinary 2,6-TDA,2,4-TDA, and MDA of workers in post-shift samples and the airborne 2,6-TDI(rho=0.952, p<0.001), 2,4-TDI(rho=0.833,p=0.001), and MDI(rho=0.952, p<0.001).Conclusions: These urinary diamines, metabolites of diisocyanates, in post-shift samples were useful biomarkers to assessoccupational exposure to diisocyanates
만성폐쇄성폐질환을 동반한 탄광부진폐증자의 혈청 중 LD 및 CRP 농도
이종성,신재훈,이유림,백진이,최병순,Lee, Jong Seong,Shin, Jae Hoon,Lee, YouLim,Baek, JinEe,Choi, Byung-Soon 대한임상검사과학회 2017 대한임상검사과학회지(KJCLS) Vol.49 No.3
Coal workers' pneumoconiosis (CWP) and chronic obstructive pulmonary disease (COPD) are characterized as chronic inflammation of the lung in miners exposed to coal mine dust. The aim of the present study was to compare the levels of serum lactate dehydrogenase (LD) and C-reactive protein (CRP) as the inflammatory indices between subjects with CWP and those with CWP and COPD (CWP+COPD), among a total of 97 subjects (27 control, 40 CWP, and 30 CWP+COPD patients). The mean levels of serum LD (165.7 vs 184.6 U/L, p=0.016) and CRP (0.08 vs 0.15 mg/dL, p=0.002) in subjects with CWP were higher than those of in subjects without CWP. The mean level of serum CRP (0.10 vs 0.19 mg/dL, p=0.008) in subjects with COPD was higher than that in subjects without COPD. In an analysis of covariance adjusted by age, the mean level of serum CRP showed statistical significance among the study groups, control, CWP, and CWP+COPD (0.07 vs 0.13 vs 0.19 mg/dL, p=0.005); the mean level of serum CRP in the CWP+COPD group was significantly higher than that of the control group (p=0.001). The results suggest that a high level of CRP in the serum may be associated with CWP and COPD in retired coal miners.
Pulmonary Toxicity in Rats After 5-Day Repeated Inhalation Exposure to Graphene Nanopowder
Jae Hoon Shin(신재훈),Sung Gu Han,Jin Kwon Jim,Boo Wook Kim,Joo Hwan hwang,Jong Seong Lee,Ji Hyun Lee,JinEe Baek,Tae Gyu Kim,KeunSoo Kim,Heon Sang Lee,Nam Woong Song,Kangho Ahn,Il Je Yu 대한직업환경의학회 2015 대한직업환경의학회 학술대회 논문집 Vol.2015 No.11
28-day inhalation toxicity of graphene nanoplatelets in Sparague-Dawley rats
Jinkwon Kim(김진권),Jaehoon Shin(신재훈),Miseong Jo(조미성),Younghoon Kim(김영훈),Eungyeong Son(손은경),Hyeseon Park(박혜선),Byeonghak Moon(문병학),Jongseong Lee(이종성),Jinee Baek(백진이),Boowook Kim(김부욱),Jinsik Kim(김진식),Kangh 환경독성보건학회 2016 한국독성학회 심포지움 및 학술발표회 Vol.2016 No.10