Effects of gas flow on particulate deposition in EGR coolers

Xun Zhang,Jihui Li,Zhiqiang Han,Xunshun Wu,Wei Tian 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1

This paper presents the test approach to investigate the effects of gas flow rate on particulate deposition inside the exhaust gas recirculation (EGR) coolers. The tests were carried out on a diesel engine equipped with the EGR cooler that a given total gas flow rate passed through and that contained pluggable exchanger tubes to adjust the flow rate in the tubes. Test results show that under the given coolant temperature and EGR gas temperature, the lower flow rate in the exchanger tube is and the longer tubes are, the more particulate with D p > 50 nm deposit in the cooler. With the given total gas flow rate passing through the cooler, the lower flow rate in the exchanger tube is and the longer tubes are, the larger deposit mass is inside the cooler. In the cases of longer tubes, the effects of gas flow rate on the deposit mass are depends on the effects of gas velocity on the particulate deposition, rather than the effects of flow rate on the particulate number passing through the heat exchanger tube per minute.

The Nedd8‐activating enzyme inhibitor MLN 4924 ( TAK ‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma

Zhang, Wenjuan,Liang, Yupei,Li, Lihui,Wang, Xiaofang,Yan, Zi,Dong, Changsheng,Zeng, Mu‐,Sheng,Zhong, Qian,Liu, Xue‐,Kui,Yu, Jinha,Sun, Shuyang,Liu, Xiaojun,Kang, Jihui,Zhao, Hu,Jeong, Lak BLACKWELL SCIENTIFIC PUBLICATIONS 2019 CELL PROLIFERATION Vol.52 No.2

Postoperative circulating tumor DNA detection and CBLB mutations are prognostic biomarkers for gastric cancer

Zhou Hekai,Liu Houcong,Li Jun,Wang Jidong,Fu Xiaohong,Li Yingqiang,Mao Shaolong,Du Jihui 한국유전학회 2023 Genes & Genomics Vol.45 No.8

Background Several studies have demonstrated that circulating tumor DNA (ctDNA) can be used to predict the postoperative recurrence of several cancers. However, there are few studies on the use of ctDNA as a prognosis tool for gastric cancer (GC) patients. Objective This study aims to determine whether ctDNA could be used as a prognostic biomarker in GC patients through multigene-panel sequencing. Methods Using next-generation sequencing (NGS) Multigene Panels, the mutational signatures associated with the prognosis of GC patients were identified. We calculated the survival probability with Kaplan–Meier and used the Log-rank test to compare survival curves between ctDNA-positive and ctDNA-negative groups. Potential application of radiology combined with tumor plasma biomarker analysis of ctDNA in GC patients was carried out. Results Disease progression is more likely in ctDNA-positive patients as characterized clinically by a generally higher T stage and a poorer therapeutic response (P < 0.05). ctDNA-positive patients also had worse overall-survival (OS: P = 0.203) and progression-free survival (PFS: P = 0.037). The combined analysis of ctDNA, radiological, and serum biomarkers in four patients indicated that ctDNA monitoring can be a good complement to radiological and plasma tumor markers for GC patients. Kaplan–Meier analysis using a cohort of GC patients in the TCGA database showed that patients with CBLB mutations had shorter OS and PFS than wild-type patients (OS: P = 0.0036; PFS: P = 0.0027). Conclusions This study confirmed the utility and feasibility of ctDNA in the prognosis monitoring of gastric cancer.

Dual-channel separation system based on platanus fruit-like Ni@Ni(OH)2 hierarchical architecture for fast, efficient and continuous light/heavy oil–water separation

Atian Xie,Jiuyun Cui,Yangyang Chen,Jihui Lang,Chunxiang Li,Yongsheng Yan,Jiangdong Dai 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.74 No.-

Realization of fast, efficient and continuous oil–water separation is of great significance for solving theproblem of oil pollution. We present here a facile hydrothermal strategy to synthesize a superhydrophilicplatanus fruit-like Ni@Ni(OH)2 hierarchical architecture (SI-PFHA). Additionally, superhydrophobicplatanus fruit-like Ni@Ni(OH)2 hierarchical architecture (SO-PFHA) is obtained through stearic acidmodification of SI-PFHA. Dual-channel separation system is integrated based on two superwettingmembranes. Such separation system is competent for continuous light/heavy oil–water separation withhighflux and high separation efficiency. Importantly, outstanding durability and reusability make thisseparation system a promising strategy for practical application in remediation of oily wastewater.

Effects of ergothioneine-enriched mushroom extract on oxidative stability, volatile compounds and sensory quality of emulsified sausage

Tao, Ye,Xiao, Shan,Cai, Jiaming,Wang, Jihui,Li, Lin Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.10

Objective: The aim of this work was to assess the effect of ergothioneine (ESH)-enriched mushroom extract on oxidative stability, volatile compounds, and sensory quality of emulsified sausage. Methods: The ESH content was determined by high performance liquid chromatography. The antioxidant activity of Flammulina velutipes (F. velutipes) extract was determined through radical-scavenging activity of 1,1 diphenyl-2-picryl-hydrazyl, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals. Four different groups of emulsified sausage were manufactured: control, no antioxidants; BHA, 0.01% butylated hydroxyanisole; EEME, 0.8% ESH-enriched mushroom (F. velutipes) extract; AE, 0.012% authentic ESH, after storage for 14 days (at 4℃), the quality of sausage including oxidative stability (2-thiobarbituric acid reactive substances and protein carbonyls content), volatile compounds and sensory quality were studied. Results: It was demonstrated that adding ESH-enriched F. velutipes extract to sausage could effectively prevent lipid and protein oxidation, and its efficacy was equivalent with 0.01% BHA. During meat processing, the ESH mainly contributed to the antioxidative activity of F. velutipes extract. The flavor and sensory attributes of emulsified sausage were improved through adding ESH-enriched F. velutipes extract. Conclusion: Accordingly, the extract of F. velutipes contained high-level of ESH and could be a good antioxidant candidate for processed meat production.

Facile preparation of antifouling g-C3N4/Ag3PO4 nanocomposite photocatalytic polyvinylidene fluoride membranes for effective removal of rhodamine B

Yanhua Cui,Lili Yang,Minjia Meng,Qi Zhang,Binrong Li,Yilin Wu,Yunlei Zhang,Jihui Lang,Chunxiang Li 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.2

A simplified strategy for facilely fabricating antifouling graphite carbon nitride/silver phosphate (g-C3N4/ Ag3PO4) nanocomposite photocatalytic polyvinylidene fluoride (PVDF) porous membranes was developed for effective removal of rhodamine B (RhB). g-C3N4/Ag3PO4 heterojunction was strongly fixed to the interior of the PVDF membranes via phase inversion method. The membrane structure was analyzed by Fourier transform spectrophotometer (FT-IR). The morphology of the prepared membranes was investigated using scanning electron microscopy (SEM), EDX-mapping and atomic force microscopy (AFM), respectively. All prepared nanocomposite photocatalytic PVDF membranes exhibited a typically porous structure, and g-C3N4/Ag3PO4 nanocomposites were well dispersed inside the membranes. The obtained g-C3N4/Ag3PO4 heterojunction nanoparticle decorated PVDF membrane had a lower water contact angle of 79o and higher porosity of 85% than that of other two control membranes. The nanocomposite photocatalytic PVDF porous membranes had extremely high permeation flux over 1,083 L·m−2·h−1, and could be used for the removal of RhB. The removal efficiency of g-C3N4/Ag3PO4-PVDF membranes towards RhB solution under visible light irradiation reached 97%, higher than that of the pure PVDF membranes (41%) and g-C3N4-PVDF membranes (85%). Remarkably, the flux performance and flux recovery ratio (FRR) of membranes revealed that the g-C3N4/Ag3PO4- PVDF membranes could recover high flux after fouling, which presented better fouling resistance. Furthermore, the fabricated antifouling g-C3N4/Ag3PO4 nanocomposite photocatalytic PVDF porous membranes exhibited excellent recyclability. Therefore, it is expected that g-C3N4/Ag3PO4-PVDF membranes could provide an energy-saving strategy for effective removal of organic dyes wastewater and have a great potential for practical wastewater treatment in the future.

Identification of S-Nitrosylation of Proteins of Helicobacter pylori in Response to Nitric Oxide Stress

Wei Qu,Yabin Zhou,Yundong Sun,Ming Fang,Han Yu,Wenjuan Li,Zhifang Liu,Jiping Zeng,Chunyan Chen,Chengjiang Gao,Jihui Jia 한국미생물학회 2011 The journal of microbiology Vol.49 No.2

Innate and adaptive immune responses are activated in humans when Helicobacter pylori invades the gastric mucosa. Nitric oxide (NO) and reactive nitrogen species are important immune effectors, which can exert their functions through oxidation and S-nitrosylation of proteins. S-nitrosoglutathione and sodium nitroprusside were used as NO donors and H. pylori cells were incubated with these compounds to analyze the inhibitory effect of NO. The suppressing effect of NO on H. pylori has been shown in vitro. Furthermore,the proteins modified by S-nitrosylation in H. pylori were identified through the biotin switch method in association with matrix-assisted laser desorption ionization/time-of-flight tandem mass spectrometry (MALDITOF-MS/MS). Five S-nitrosylated proteins identified were a chaperone and heat-shock protein (GroEL),alkyl hydroperoxide reductase (TsaA), urease alpha subunit (UreA), HP0721, and HP0129. Importantly,S-nitrosylation of TsaA and UreA were confirmed using purified recombinant proteins. Considering the importance of these enzymes in antioxidant defenses, adherence, and colonization, NO may exert its antibacterial actions by targeting enzymes through S-nitrosylation. Identification of protein S-nitrosylation may contribute to an understanding of the antibacterial actions of NO. Our findings provide an insight into potential targets for the development of novel therapeutic agents against H. pylori infection.