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Choi, Ji-Yeon,Seo, Jeong Yeon,Yoon, Young-So,Lee, Ye-Ji,Kim, Hee-Sun,Kang, Jihee Lee AAAS 2015 Science signaling Vol.8 No.365
<P><B>Resolving inflammation with Mer</B></P><P>Unchecked inflammatory responses in the body can do more harm than good; thus, the body has mechanisms for resolving inflammation and restoring normal tissue function. Choi <I>et al</I>. found that mice with impaired signaling by the receptor tyrosine kinase Mer had exacerbated inflammation in response to acute sterile tissue damage, as well as decreased abundance of liver X receptor (LXR) transcription factors (which are implicated in inhibiting macrophage responses) in their macrophages, spleens, and lungs. Conversely, treating macrophages in culture with an agonist of Mer increased LXR abundance and activity. Furthermore, an LXR agonist reduced inflammation in mice even in the context of reduced Mer signaling. The finding that Mer-dependent increases in LXR abundance lead to the resolution of inflammation might be exploited therapeutically.</P><P>The receptor tyrosine kinase Mer plays a central role in inhibiting the inflammatory response of immune cells to pathogens. We aimed to understand the function of Mer signaling in the resolution of sterile inflammation in experiments with a Mer-neutralizing antibody or with Mer-deficient (<I>Mer</I><SUP>−/−</SUP>) mice in a model of sterile, zymosan-induced acute inflammation. We found that inhibition or deficiency of Mer enhanced local and systemic inflammatory responses. The exacerbated inflammatory responses induced by the lack of Mer signaling were associated with reduced abundance of the transcription factors liver X receptor α (LXRα) and LXRβ and decreased expression of their target genes in peritoneal macrophages, spleens, and lungs. Similarly, treatment of mice with a Mer/Fc fusion protein, which prevents the Mer ligand Gas6 (growth arrest–specific protein 6) from binding to Mer, exacerbated the inflammatory response and decreased the abundance of LXR. Coadministration of the LXR agonist T0901317 with the Mer-neutralizing antibody inhibited the aggravating effects of the antibody on inflammation in mice. In vitro exposure of RAW264.7 cells or primary peritoneal macrophages to Gas6 increased LXR abundance in an Akt-dependent manner. Thus, we have elucidated a previously uncharacterized pathway involved in the resolution of acute sterile inflammation: Enhanced Mer signaling during the recovery phase increases the abundance and activity of LXR to inactivate the inflammatory response in macrophages.</P>
Jihee Choi,Jeonghoon Kim,KyooSang Kim 환경독성보건학회 2019 환경독성보건학회지 Vol.34 No.2
The purpose of this study was to evaluate the relationship between the use of certain household products (HPs) at home and atopic dermatitis (AD) in adults. The study was conducted on 1,500 households in Seoul, South Korea. We obtained information on general characteristics, the use of HPs, and AD through an online panel survey in July 2018. HPs were selected as 23 kinds of products with associated risks that are management targets of the Ministry of Environment. The international study of asthma and allergies in childhood was used for the AD questionnaires. Logistic regression analysis was used to identify AD affected by the use of HPs. Average number of used HPs was 13.44 out of 23, and average usage frequency of HPs was 3.52 times a month at home in Seoul for the last 1 year. Compared with subjects with a low number of HPs used (reference), subjects with a high number of used HPs (4th quartile) were more likely to have lifetime diagnosis of AD (odds ratio (OR) = 1.77, 95% confidence interval (CI); 1.23-2.54), symptoms of AD in the last 12 months (OR = 2.66, 95% CI; 1.92-3.70), and treatment of AD in the last 12 months (OR = 2.37, 95% CI; 1.48-3.80). Compared with subjects with a low HPs usage frequency (reference), subjects with a high HPs usage frequency (4th quartile) were more likely to have lifetime diagnosis of AD (OR = 1.88, 95% CI; 1.31-2.70), symptoms of AD in the last 12 months (OR = 2.14, 95% CI; 1.54-2.96), and treatment of AD in the last 12 months (OR = 2.23, 95% CI; 1.39-3.60). Therefore, the use of HPs was significantly associated with AD. The findings of this study might be useful as basic data for managing allergic diseases and establishing preventive measures.
Choi, Ji-Yeon,Park, Hyun-Jung,Lee, Ye-Ji,Byun, Jiyeon,Youn, Young-So,Choi, Ji Ha,Woo, So-Youn,Kang, Jihee Lee Williams Wilkins 2013 The Journal of pharmacology and experimental thera Vol.344 No.2
<P>Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Toll-like receptor activation. Previously, we found that lung Mer protein expression decreased after lipopolysaccharide (LPS) treatment due to enhanced Mer cleavage. The purpose of the present study was to examine whether pharmacologically restored membrane-bound Mer expression upregulates the Mer signaling pathways and suppresses lung inflammatory responses. Pretreatment with the ADAM17 (a disintegrin and metalloproteinase-17) inhibitor TAPI-0 (tumor necrosis factor alpha protease inhibitor-0) reduced LPS-induced production of soluble Mer protein in bronchoalveolar lavage (BAL) fluid, restored membrane-bound Mer expression, and increased Mer activation in alveolar macrophages and lungs after LPS treatment. TAPI-0 also enhanced Mer downstream signaling, including phosphorylation of protein kinase b, focal adhesion kinase, and signal transducer and activator of transcription 1. As expected from enhanced Mer signaling, TAPI-0 also augmented suppressor of cytokine signaling-1 and -3 mRNA and protein levels and inhibited nuclear factor κB activation at 4 and 24 hours after LPS treatment. TAPI-0 suppressed LPS-induced inflammatory cell accumulation, total protein level elevation in BAL fluid, and production of inflammatory mediators, including tumor necrosis factor-α, interleukin-1β, and macrophage inflammatory protein-2. Additionally, the effects of TAPI-0 on the activation of Mer signaling and the production of inflammatory responses could be reversed by cotreatment with specific Mer-neutralizing antibody. Restored Mer protein expression by treatment with TAPI-0 efficiently prevents the inflammatory cascade during acute lung injury.</P>
Assessment of relationship between farmer’s syndrome and neurotoxic symptoms in farming couples
Jihee Choi,Sun-In Moon,Sangchul Roh 환경독성보건학회 2020 환경독성보건학회지 Vol.35 No.3
The purpose of this study was to evaluate the relationship between farmer’s syndrome and neurotoxic symptoms in farming couples. The study was conducted on 348 farmers (174 couples) in Chungnam Province of South Korea. We obtained information on general and agricultural characteristics, farmer’s syndrome, and neurotoxic symptoms through face-to-face surveys from 2014 to 2019. The Korean version of the diagnostic standard scale was used for farmer’s syndrome, and the Swedish Q16 questionnaire was used for neurotoxic symptoms. Logistic regression analysis was used to identify neurotoxic symptoms affected by farmer’s syndrome. The prevalence of ‘positive’ neurotoxic symptoms was higher in wives (72.4%) than in husbands (56.9%). Compared with husbands with ‘negative and probable’ farmer’s syndrome (reference), husbands with ‘positive’ farmer’s syndrome were more likely to have ‘positive’ neurotoxic symptoms (odds ratio [OR] = 5.37, 95% confidence interval [CI] = 2.01-14.30). Compared with wives with ‘negative and probable’ farmer’s syndrome (reference), wives with ‘positive’ farmer’s syndrome were more likely to have ‘positive’ neurotoxic symptoms (OR = 7.07, 95% CI = 2.58-19.38). Therefore, neurotoxic symptoms in both husbands and wives were significantly associated with farmer’s syndrome. However, wives had a higher risk of neurotoxic symptoms than husbands. The findings of this study might be useful as important data for establishing and training agricultural safety and health policy.
초등학생의 식습관과 요 중 프탈레이트 대사체 농도와의 관계
최지희(Jihee Choi),김정훈(Jeonghoon Kim),최길용(Gilyoung Choi),김규상(KyooSang Kim) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.5
Objectives: The purpose of this study was to examine the relationship between dietary habits and concentrations of urinary phthalate metabolite in elementary school children. Methods: This study was conducted in Seoul, South Korea. We collected urine samples from 156 children from a single school in September 2016. Information on dietary habits was obtained from the parents of the children. Five types of urinary phthalate metabolites were analyzed using a high-performance liquid chromatography tandem mass spectrometer. Multiple linear regression analysis was used to determine the factors affecting the concentrations of urinary phthalate metabolite. Results: Girls had a significantly lower concentration of urinary mono-n-butyl phthalate (MnBP) (p=0.006) than did boys. When the consumption of bean processed food and wrapped delivery food were more than once a week, urinary MnBP (p=0.021) and monobenzyl phthalate (MBzP) (p=0.032) concentrations were the highest, respectively. Conclusion: Several urinary phthalate metabolite concentrations were associated with demographic and dietary habits. Particularly, urinary MnBP and MBzP were associated with several processed foods. The findings of this study might be useful as basic data for establishing and educating on environmental health policy.