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Shujun Sun,Xinliang Pan,Limin Zhao,Jianming Zhou,Hongzeng Wang,Yonghong Sun 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.3
Objectives. We sought to identify the expression of CD68-tumor-associated macrophages (TAMs) and CD34-microvascular density (MVD) in laryngeal squamous cell carcinoma (LSCC), to study the relationship with clinical pathological parameters and to determine whether their expression is predictive of disease. Methods. Pathologically confirmed 45 LSCC tissue and 20 peritumoral non-tumor tissue were examined. Immunohistochemical studies were used to detect the expression of CD68-TAMs and CD34-MVD. Results. The positive expression rate of CD68 in LSCC tissue was 82% (37/45), which was higher than the 10% (2/20) expression rate of the peritumoral tissue (P<0.05). The CD34-MVD positive expression rate in the LSCC tissue was 26.5±6.4, which obviously higher than 12.2±4.0 expression rate of the peritumoral tissue (P<0.05). The positive expression rates of both CD68 and CD34-MVD were higher in the lymph node metastasis (LNM) positive group than in the LNM negative group. The expression of CD68 had positive correlation with CD34-MVD. The 5-year disease-free survival rate in the group with the low CD68 expression was significantly higher than that in the group with high CD68 expression (76% vs. 42%, respectively). Conclusion. The high expression of CD68-TAMs in LSCC and its positive correlation with CD34-MVD illustrates that both play an important role in promoting the metastasis and angiogenesis of this cancer. Their expression was also positively correlated with the prognoses of these patients, suggesting that they could be used as important prognostic markers for LSCC.
Jianming Miao,Xingyu Sun,Kankan Deng,Xi Gong,Chao Peng,Tao Liu,Haosu Zhang 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3
This paper proposes a novel UDE-based nonlinear path-following (PF) control scheme for the underactuated autonomous underwater vehicle (AUV) with multiple uncertainties and input saturation. Firstly, to overcomethe drawback of dependence on the accurate mathematical model, the unknown time-varying sideslip angular speedin the error dynamic model is treated as kinematic uncertainty, and the linear superposition of parameter uncertainties, environmental perturbations, and other unmodeled dynamics is regarded as lumped dynamic uncertainty. Bothkinematic and dynamic uncertainties are estimated and compensated by the designed uncertainty and disturbanceestimators (UDEs). Secondly, a novel augmented backstepping controller based on the estimates generated by UDEsis proposed to achieve PF control of the underactuated AUV. The nonlinear tracking differentiator (NTD) is adoptedto prevent the “explosion of complexity” inherent in the traditional back-stepping method, and the auxiliary dynamical system is utilized to solve the issue of input saturation. Lastly, the stability analysis of the entire enclosed-loopframework is presented. Simulations and comparative analyses are presented to demonstrate the effectiveness androbustness of the presented strategy
Jianming Xu,Mingxuan Sun,Li Yu 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.2
This paper addresses the synthesis of an iterative learning controller for a class of linear systems with norm-bounded parameter uncertainties. We take into account an iterative learning algorithm with current cycle feedback in order to achieve both robust convergence and robust stability. The synthesis problem of the developed iterative learning control (ILC) system is reformulated as the γ-suboptimal H∞ control problem via the linear fractional transformation (LFT). A sufficient convergence condition of the ILC system is presented in terms of linear matrix inequalities (LMIs). Furthermore, the ILC system with fast convergence rate is constructed using a convex optimization technique with LMI constraints. The simulation results demonstrate the effectiveness of the proposed method.
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
Zhang, Jianming,Adriá,n, Francisco J.,Jahnke, Wolfgang,Cowan-Jacob, Sandra W.,Li, Allen G.,Iacob, Roxana E.,Sim, Taebo,Powers, John,Dierks, Christine,Sun, Fangxian,Guo, Gui-Rong,Ding, Qiang,Okra Macmillan Publishers Limited. All rights reserved 2010 Nature Vol.463 No.7280
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr–Abl, we recently reported the discovery of GNF-2, a selective allosteric Bcr–Abl inhibitor. Here, using solution NMR, X-ray crystallography, mutagenesis and hydrogen exchange mass spectrometry, we show that GNF-2 binds to the myristate-binding site of Abl, leading to changes in the structural dynamics of the ATP-binding site. GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, when used in combination with the ATP-competitive inhibitors imatinib or nilotinib, suppressed the emergence of resistance mutations in vitro, displayed additive inhibitory activity in biochemical and cellular assays against T315I mutant human Bcr–Abl and displayed in vivo efficacy against this recalcitrant mutant in a murine bone-marrow transplantation model. These results show that therapeutically relevant inhibition of Bcr–Abl activity can be achieved with inhibitors that bind to the myristate-binding site and that combining allosteric and ATP-competitive inhibitors can overcome resistance to either agent alone.
Ping Yu,Qilong Sun,Jianfeng Li,Zhenjiang Tan,Jianming Pan,Yongsheng Yan 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.4
Magnetic molecularly imprinted microspheres (MMIS) were successfully prepared by suspension polymerization,and then as-prepared MMIS were used as adsorbents for selective recognition of 2,4,6-trichlorophenol (2,4,6-TCP) from aqueous solutions. The results composites were characterized by Fourier transform infrared (FT-IR), X-raydiffraction (XRD), thermo gravimetric analysis (TGA), scanning electron microscope (SEM) and vibrating samplemagnetometer (VSM). The results demonstrated that MMIS possesses porous spherical morphology, and exhibits goodthermal stability and magnetic property (Ms=10.14 emu g−1). Then batch mode of binding experiments was used todetermine the equilibrium, kinetics and selectivity recognition. The Langmuir isotherm model fitted the equilibriumdata better than did the Freundlich model, and the maximum adsorption capacity on MMIS was about 1.7 times higherthan that of MNIS. Kinetics behaviors of MMIS were well described by the pseudo-second-order model. MMIS possessedoutstanding selectivity recognition for 2,4,6-TCP in the presence of other competitive phenols (such as sesamol,3-CP, thymol, 2,4-DCP). Furthermore, the reusability performance of MMIS showed about 17.53% loss after five repeatedcycles. Finally, the MMIS were successfully applied to the selective extraction of 2,4,6-TCP from the vegetablesamples.
Yanhua Cui,Minjia Meng,Dongshu Sun,Yan Liu,Jianming Pan,Xiaohui Dai,Yongsheng Yan 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.3
We developed a simple phase inversion technique to prepare molecularly imprinted membrane (MIM) at room temperature for membrane selective adsorption and separation of methyl p-hydroxybenzoate (M4HB). The prepared SMIP-MIM was characterized by SEM, FT-IR, TGA. Compared with non-imprinted membrane (NIM1-5) adsorbent, SMIP-MIM1-5 adsorbent with high specific surface area and showed higher binding capacity, faster kinetic and better selectively adsorption capacity for M4HB. The maximum isotherm adsorption capacity for M4HB of SMIPMIM4 was 3.519mg·g−1, and the experimental data was well fitted to the slips model by multiple analysis. The maximum kinetic adsorption capacity and equilibrium adsorption time for SMIP-MIM4 were 1.335mg·g−1 and 160 min, respectively. The mechanism for dynamic adsorption of M4HB onto SMIP-MIM4 was found to follow pseudo-firstorder model and pseudo-second-order model. Additionally, the permeability separation factor of SMIP-MIM4 for M4HB compared to a structural analogues methyl 2-hydroxybenzoate (M2HB) could reach 2.847. The adsorption capacity of SMIP-MIM4 for M4HB and M2HB was 0.549mg·cm−2 and 1.563mg·cm−2, respectively. The adsorption behavior of M4HB through SMIP-MIM4 followed the retarded permeation mechanism.