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Experimental Study on the Electro-osmotic Treatment of Frost Boiling Damage of Cold-Region Subgrade
Deren Liu,Jiale Yang,Shuangyang Li,Xu Wang,Shuochang Xu 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.4
In cold regions, the pore water of subgrade surface soil rises sharply because ice lenses thaw in spring-thawing seasons and cannot drain out in a short time, which leads to a high water content in the thawed layer of the cold-region subgrade. Frost boiling damage of subgrade occurs frequently under repeated traffic loads and seriously affects the normal operation of the road. Based on the advantages of rapid and effective electro-osmotic drainage, a horizontal stage electro-osmotic drainage method (HSEDM) was designed to treat the frost boiling damage of cold-region subgrade. To test the engineering effectiveness of the HSEDM, a model test was carried out, in which many key indexes, such as the current intensity, effective potential, electrode corrosion, water content, shear strength and surface settlement, were closely monitored. Through the controlled trial, it indicates that the pore water was mainly driven to move from the anode to the cathode and further drained out from the slope by electric field force. At the same time, the shear strength of the frost boiling subgrade increases significantly after electro-osmotic consolidation. The experimental results provide a theoretical basis for the engineering application of the HSEDM in the treatment of frost boiling damage of cold-region subgrade.
Xiaoning Wu,Xiaoqian Xu,Jialing Zhou,Yameng Sun,Huiguo Ding,Wen Xie,Guofeng Chen,Anlin Ma,Hongxin Piao,Bingqiong Wang,Shuyan Chen,Tongtong Meng,Xiaojuan Ou,Hwai-I Yang,Jidong Jia,Yuanyuan Kong,Hong Yo 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Background/Aims: Existing hepatocellular carcinoma (HCC) prediction models are derived mainly from pretreatment or early on-treatment parameters. We reassessed the dynamic changes in the performance of 17 HCC models in patients with chronic hepatitis B (CHB) during long-term antiviral therapy (AVT). Methods: Among 987 CHB patients administered long-term entecavir therapy, 660 patients had 8 years of follow-up data. Model scores were calculated using on-treatment values at 2.5, 3, 3.5, 4, 4.5, and 5 years of AVT to predict threeyear HCC occurrence. Model performance was assessed with the area under the receiver operating curve (AUROC). The original model cutoffs to distinguish different levels of HCC risk were evaluated by the log-rank test. Results: The AUROCs of the 17 HCC models varied from 0.51 to 0.78 when using on-treatment scores from years 2.5 to 5. Models with a cirrhosis variable showed numerically higher AUROCs (pooled at 0.65–0.73 for treated, untreated, or mixed treatment models) than models without (treated or mixed models: 0.61–0.68; untreated models: 0.51–0.59). Stratification into low, intermediate, and high-risk levels using the original cutoff values could no longer reflect the true HCC incidence using scores after 3.5 years of AVT for models without cirrhosis and after 4 years of AVT for models with cirrhosis. Conclusions: The performance of existing HCC prediction models, especially models without the cirrhosis variable, decreased in CHB patients on long-term AVT. The optimization of existing models or the development of novel models for better HCC prediction during long-term AVT is warranted.
Yixiang Ai,Dereje Gobena Alemayehu,Genwen Mao,Yaping Liang,Ran Cao,Jiale Hu,Yimin Yang,Zhiwei Ren 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.6
Background: To evaluate the feasibility of treating odontoid fractures in the Chinese population with two cortical screws based on computed tomography (CT) scans and describe a new measurement strategy to guide screw insertion in treating these fractures. Methods: A retrospective review of cervical computed tomographic scans of 128 patients (aged 18–76 years; men, 55 [43.0%]) was performed. The minimum external transverse diameter (METD), minimum external anteroposterior diameter (MEAD), maximum screw length (MSL), and screw projection back angle (SPBA) of the odontoid process were measured on coronal and sagittal CT images. Results: The mean values of METD and MEAD were 10.0 ± 1.1 mm and 12.0 ± 1.0 mm, respectively, in men and 9.2 ± 1.0 mm and 11.0 ± 1.0 mm, respectively, in women. Both measurements were significantly higher in men (p < 0.001). In total, 87 individuals (68%) had METD > 9.0 mm that could accommodate two 3.5-mm cortical screws. The mean MSL value and SPBA range were 34.4 ± 2.9 mm and 13.5°–24.2°, respectively, with no statistically significant difference between men and women. Conclusions: The insertion of two 3.5-mm cortical screws was possible for anterior fixation of odontoid fractures in 87 patients (68%) in our study, and there was a statistically significant difference between men and women.
Decreased Brain Zinc Availability Reduces Hippocampal Neurogenesis in Mice and Rats
Suh, Sang Won,Won, Seok Joon,Hamby, Aaron M,Yoo, Byung Hoon,Fan, Yang,Sheline, Christian T,Tamano, Haruna,Takeda, Atsushi,Liu, Jialing SAGE Publications 2009 Journal of cerebral blood flow and metabolism Vol.29 No.9
<P> In the adult brain, neurogenesis occurs in the subgranular zone of the dentate gyrus (DG), where high levels of vesicular zinc are localized in the presynaptic terminals. To determine whether zinc has a role in modulating hippocampal neurogenesis under normal or pathologic conditions, we manipulated the level of vesicular zinc experimentally. To reduce hippocampal vesicular zinc, rats were either fed a zinc-deficient diet or treated with a zinc chelator, clioquinol (CQ). The number of progenitor cells and immature neurons was decreased significantly in the DG after 6 weeks of dietary zinc deprivation. Conversely, the number of progenitor cells and immature neurons was restored after a 2-week reversal to a normal zinc-containing diet. Similarly, a 1-week treatment with the zinc chelator, CQ, reduced the number of progenitor cells. The results of our previous study showed that hypoglycemia increased hippocampal neurogenesis. This study shows that zinc chelation reduced hypoglycemia-induced progenitor cell proliferation and neurogenesis. Finally, the role of vesicular zinc on neurogenesis was further assessed in zinc transporter 3 (ZnT3) gene deleted mice. Zinc transporter 3 knockout (KO) mice had significantly fewer proliferating progenitor cells and immature neurons after hypoglycemia. Our data provide converging evidence in support of the essential role zinc has in modulating hippocampal neurogenesis. </P>