Ultimate strength behavior of steel-concrete-steel sandwich beams with ultra-lightweight cement composite, Part 2: Finite element analysis

Jia-Bao Yan,J.Y. Richard Liew,Min-Hong Zhang 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.4

Ultra-lightweight cement composite (ULCC) with a compressive strength of 60 MPa and density of 1,450 kg/㎥ has been developed and used in the steel-concrete-steel (SCS) sandwich structures. This paper investigates the structural performances of SCS sandwich composite beams with ULCC as filled material. Overlapped headed shear studs were used to provide shear and tensile bond between the face plate and the lightweight core. Three-dimensional nonlinear finite element (FE) model was developed for the ultimate strength analysis of such SCS sandwich composite beams. The accuracy of the FE analysis was established by comparing the predicted results with the quasi-static tests on the SCS sandwich beams. The FE model was also applied to the nonlinear analysis on curved SCS sandwich beam and shells and the SCS sandwich beams with J-hook connectors and different concrete core including ULCC, lightweight concrete (LWC) and normal weight concrete (NWC). Validations were also carried out to check the accuracy of the FE analysis on the SCS sandwich beams with J-hook connectors and curved SCS sandwich structure. Finally, recommended FE analysis procedures were given.

Evaluation of Elastic In-plane Flexural Rigidity of Unstiffened Multiplanar CHS X-joints

L. J. Jia,Y. Y. Chen 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.1

Tubular structures have been widely applied in offshore structures and civil buildings in past decades. Some research has beencarried out on rigidity of unstiffened circular hollow section (CHS) joints with various types, e.g. T-, Y-, K- and X-joints byformer researchers. However, limited investigations on the in-plane flexural rigidity of multiplanar CHS X-joints which arecommonly used in single-layered latticed structures are found in available literatures. In this paper, first a finite element modelwas calibrated through comparison with test results, and then a numerical parametric study on elastic axial rigidity ofmultiplanar unstiffened CHS X-joints was carried out using the calibrated models with package ABAQUS. Based on theparametric results, an in-plane flexural rigidity formula for the joints was fitted. Finally, a comparison among the differentformulae in predicting joint rigidity of unstiffened CHS X-joints was carried out, which indicated a good reliability of theproposed formula.

A Phase 3 Evaluation of Daclatasvir plus Asunaprevir in Treatment-Naive Patients with Chronic HCV Genotype 1b Infection

( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.

Melting and Casting Processes : EFFECT OF FLUID FLOW ON EUTECTIC CARBIDE OF STEEL HK40

Y . S . Yang,Q . M . Liu,H . R . Guan,Y . N . Jiao,W . Q . Zhang,Z . Q . Hu,J . S . Zhang,G . L . Jia,G . Z . Zhang,Y . Y . Gao 대한금속재료학회 ( 구 대한금속학회 ) 1995 Advanced Material and Processing Vol.1 No.-

Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt

Jia, Y.,Wu, C.,Kim, J.,Kim, B.,Lee, S.J. Butterworths ; Elsevier Science Ltd 2016 The Journal of nutritional biochemistry Vol.28 No.-

<P>We have previously reported that astaxanthin (AX), a dietary carotenoid, directly interacts with peroxisome proliferator-activated receptors PPAR alpha and PPAR gamma, activating PPAR alpha while inhibiting PPAR gamma, and thus reduces lipid accumulation in hepatocytes in vitro. To investigate the effects of AX in vivo, high-fat diet (HFD)-fed C57BL/6J mice were orally administered AX (6 or 30 mg/kg body weight) or vehicle for 8 weeks. AX significantly reduced the levels of triglyceride both in plasma and in liver compared with the control HFD mice. AX significantly improved liver histology and thus reduced both steatosis and inflammation scores of livers with hematoxylin and eosin staining. The number of inflammatory macrophages and Kupffer cells were reduced in livers by AX administration assessed with F4/80 staining. Hepatic PPAR alpha-responsive genes involved in fatty acid uptake and beta-oxidation were upregulated, whereas inflammatory genes were downregulated by AX administration. In vitro radiolabeled assays revealed that hepatic fatty acid oxidation was induced by AX administration, whereas fatty acid synthesis was not changed in hepatocytes. In mechanism studies, AX inhibited Akt activity and thus decreased SREBP1 phosphorylation and induced Insig-2a expression, both of which delayed nuclear translocation of SREBP1 and subsequent hepatic lipogenesis. Additionally, inhibition of the Akt-mTORC1 signaling axis by AX stimulated hepatic autophagy that could promote degradation of lipid droplets. These suggest that AX lowers hepatic lipid accumulation in HFD-fed mice via multiple mechanisms. In addition to the previously reported differential regulation of PPAR alpha and PPAR gamma, inhibition of Akt activity and activation of hepatic autophagy reduced hepatic steatosis in mouse livers. (C) 2015 Elsevier Inc. All rights reserved.</P>

Study of optical and electrical properties of TiO2/Ag/TiO2 multilayers

J. H. Jia,L. Y. Chen,H. Xie,H. Y. You,J. Li,P. Zhou 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.32

Optical and electrical properties of TiO2/Ag/TiO2 multilms prepared by a multi-target sputtering method were investigated. The transmittance spectra and the sheet resistance as a function of layer thickness were carefully measured and analyzed. By properly adjusting the thickness of the metal and dielectric lms, a low sheet resistance of 30 Ohms/sq. and a high transmittance of over 90 % in the 500-700 nm wavelength region were achieved. It was found that a Ag layer played a significant role in determining the optical and electrical properties of the film structure.

Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase

Kim, Y.J.,Hwang, S.H.,Jia, Y.,Seo, W.D.,Lee, S.J. Published on behalf of the Canadian Institute of F 2017 Food Research International Vol.101 No.-

<P>Chronic alcohol consumption leads to hepatic lipid accumulation and alcoholic fatty liver disease. Previously, we demonstrated that barley sprout extract, which contains saponarin as an active compound, reduces hepatic steatosis. In this study, we investigated the effect of barley sprout extracts (BSE) on hepatic lipid accumulation in a mouse model of alcoholic fatty liver disease. Seven-week-old C57BL/6 mice were fed an alcohol-containing diet (5% ethanol) and a low or high dose of BSE (100 or 200 mg/kg body weight, respectively) for 10 days. The high dose of BSE significantly decreased hepatic lipid accumulation compared with the ethanol-only control group. In the second animal study, mice were fed an alcohol-containing diet for 10 days, followed by a 45% high fat diet with oral administration of BSE (100 or 200 mg/day/kg body weight) for 4 weeks. Mice in both BSE-fed groups showed reduced hepatic steatosis. In the livers of mice fed BSE, phosphorylation of AMP-activated protein kinase (AMPK) was increased, and expression of hepatic autophagy markers was elevated. In cultured hepatocytes, BSE (200 (mu g/mL) increased the rate of fatty acid oxidation and reduced that of fatty acid synthesis. Taken together, these findings suggest that BSE promotes degradation of lipid droplets and subsequent activation of fat oxidation by activating AMPK in the liver, thus protecting against development of hepatic steatosis in alcohol-fed mice. Saponarin, a major flavonoid in BSE and an activator of AMPK, increased the activity of microsomal triglyceride transfer protein, which suggests that the reduction in hepatic triglyceride levels was mediated by this component of BSE. In conclusion, BSE ameliorated hepatic steatosis in a mouse model of ethanol-induced fatty liver by activating AMPK, an effect possibly mediated by the saponarin component.</P>

Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice

Lee, J.H.,Jia, Y.,Thach, T.T.,Han, Y.,Kim, B.,Wu, C.,Kim, Y.,Seo, W.D.,Lee, S.J. Pergamon Press 2017 Nutrition research Vol.43 No.-

<P>Policosanols have hypocholesterolemic activity; however, the molecular mechanism of the policosanol effects is currently poorly characterized. We hypothesized that hexacosanol, a policosanol compound derived from barley sprout, may decrease cellular and plasma cholesterol levels; we thus investigated the hypocholesterolemic activity and mechanism of hexacosanol on both hepatocytes and high-fat-induced obese C57BL/6J mice. The reduction of total cholesterol, free cholesterol, and cholesteryl ester concentrations was confirmed in hexacosanol-stimulated hepatocytes (-38%, -33%, and -53%, respectively). Plasma, hepatic cholesterol concentrations, and hepatic steatosis were significantly reduced in high-fat-fed mice orally administered with hexacosanol (0.7 mg/kg body weight a day) for 8 weeks compared with those of vehicle-fed control mice (-15% and -40%, respectively). Hexacosanol in fact bound to the allosteric regulation site of AMP-activated protein kinase (AMPK)-beta subunit and thus activated AMPK that inhibited the activity of 3-hydroxy-3methyl-glutaryl-coenzyme A reductase by inhibitory phosphorylation. In addition, activation of AMPK by hexacosanol induced hepatic autophagy activity, which could further reduce hepatic lipid accumulation. Alternatively, hexacosanol suppressed the nuclear translocation and activation of sterol regulatory element-binding protein-2 (SREBP-2), a key transcription factor in cholesterol biosynthesis. These results collectively suggest that hexacosanol is a major hypocholesterolemic compound in barley sprouts with regulation of AMPK activation and SREBP-2 suppression. These suppress 3-hydroxy-3-methyl-glutarylcoenzyme A reductase at both mRNA expression and protein activity levels. In conclusion, hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. (C) 2017 Published by Elsevier Inc.</P>

Targeting neddylation pathway with MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis in renal cell carcinoma

Wang, J.,Wang, S.,Zhang, W.,Wang, X.,Liu, X.,Liu, L.,Li, L.,Liang, Y.,Yu, J.,Jeong, L.S.,Jia, L.,Zhao, H.,Zhang, Y. Academic Press 2017 Biochemical and biophysical research communication Vol. No.

Inhibition of protein neddylation pathway has emerged an attractive anticancer strategy in preclinical studies by using Nedd8-activating enzyme (NAE) inhibitor MLN4924 (Pevonedistat). Previous studies have reported the antitumor activity of MLN4924 mediated by its efficacy on apoptosis, autophagy and senescence. However, whether MLN4924 has any effect on renal carcinoma cells (RCC) remains unexplored. Here we reported that MLN4924 specifically inhibited protein neddylation pathway, leading to statistically significantly suppress the proliferation, survival and migration of RCC cells by inducing G<SUB>2</SUB> cell-cycle arrest, followed by apoptosis in a MLN4924 dose-dependent manner. Further mechanistic study revealed that MLN4924-induced apoptosis was mediated by substantial up-regulation of pro-apoptotic NOXA. These findings highlighted the anticancer effects of the neddylation inhibitors (e.g. MLN4924) for the treatment of RCC.

First-principles study of the crystal structures and physical properties of H₁₈-BN and Rh6-BN

Ren, X.Y.,Zhao, C.X.,Niu, C.Y.,Wang, J.Q.,Jia, Y.,Cho, J.H. North-Holland 2016 Physics letters. Section A. Vol.380 No.46

<P>As the analog of carbon allotropes, new three-dimensional (3D) boron nitride (BN) allotropes have attracted much attention of researchers due to their great importance in fundamental sciences and wide practical applications. Here, based on first-principles density-functional theory calculations, we predict two new stable BN allotropes: One is H-18-BN with the P (6) over bar m2 (D-3h(1)) symmetry containing eighteen atoms in the hexagonal unit cell and the other is Rh6-BN with the R (3) over barm (C-3v(5)) symmetry containing six atoms in the rhombohedral primitive unit cell. The dynamic stabilities of the two structures are examined through the phonon spectrum analysis as well as molecular dynamics simulations, whereas the mechanical properties are analyzed by elastic constants, bulk modulus and shear modulus. From the analysis of the enthalpy evolution with respect to pressure, we find that h-BN can be transformed into either H-18-BN or RH6-BN structure under a higher pressure of similar to 15 GPa. We also find that both the H-18-BN and Rh6-BN allotropes are brittle materials with indirect band gaps of 2.31 and 4.48 eV, respectively. The simulated XRD spectra provide detailed structural information of H-18-BN and Rh6-BN for future experimental examinations. Our findings not only greatly enrich the existing structural family of 3D-BN materials but also stimulate further experiments. (C) 2016 Elsevier B.V. All rights reserved.</P>