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( Min Um ),( Ji-woo Kim ),( Jae-won Lee ) 한국목재공학회 2020 목재공학 Vol.48 No.3
In this study, ultrasound-assisted extraction was performed to extract ascorbic acid from rugosa rose (Rosa rugosa Thunb.) fruit. The optimal conditions were investigated by response surface methodology, using two variable including reaction time (16-44 min) and temperature (16-44°C). The ascorbic acid extraction was sensitive to the reaction time rather than the reaction temperature, and the optimal conditions for ascorbic acid extraction were 25°C and 30 min. Ascorbic acid and gallic acid in the rugosa rose fruit extract were completely separated by HPLC, with a resolution factor of over 1.5 between the two. The correlation coefficient of the ascorbic acid was 0.999 in a linearity test for 50-150 μg/mL concentration of extract. The limit of detection and limit of quantification values were 0.16 μg/mL and 29.89 μg/mL, respectively. The relative standard deviations (RSD) for repeatability and reproducibility were determined, and each RSD showed good precision at less than 5% (N=6).
Yoo Ji-Min,Kim Sung-Min,Um Yoo-Hyun,Kim Tae-Won,서호준,홍승철,Jeong Jong-Hyun 대한우울조울병학회 2021 우울조울병 Vol.19 No.2
Background: This study aimed to assess the clinical characteristics of patients with major depressive disorder who were rehospitalized within 1 year and to determine whether the 1-year rehospitalization rate varied depending on the type of medication and treatment method. Methods: Clinical characteristics of 531 patients hospitalized for major depressive disorder were assessed. The use and type of antidepressants, antipsychotics, mood stabilizers, and hypnotics were also evaluated. Results: Of the 531 subjects, 68 (12.8%) were rehospitalized within a year. The number of past depressive episodes (1.56±2.67 vs. 0.90±1.18) (p=0.048) and the number of previous psychiatric hospitalizations (0.82±1.93 vs. 0.29±0.83 times) (p=0.029) were high in the 1-year rehospitalization group. The rate of family history of mood disorder (25.0% vs. 13.6%) (p=0.014) and the rate of comorbid personality disorder (16.2% vs. 8.6%) (p=0.049) were also high in the 1-year rehospitalization group. Multiple logistic regression analysis showed that the number of previous psychiatric hospitalizations affected the rate of 1-year rehospitalization (p=0.003). Conclusion: The number of previous psychiatric hospitalizations could be used to predict rehospitalizations of patients with major depressive disorder within 1 year. In addition, family history of mood disorders and comorbidity of personality disorders may affect rehospitalization of such patients
Parkin Directly Modulates 26S Proteasome Activity.
Um, Ji Won,Im, Eunju,Lee, Hyun Jung,Min, Boram,Yoo, Lang,Yoo, Jiho,Lü,bbert, Hermann,Stichel-Gunkel, Christine,Cho, Hyun-Soo,Yoon, Jong Bok,Chung, Kwang Chul The Society 2010 The Journal of neuroscience Vol.30 No.35
<P>Parkinson's disease (PD) is a common neurodegenerative disease that involves the deterioration of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains poorly understood, recent genetic, postmortem, and experimental evidence shows that abnormal protein accumulation and subsequent aggregate formation are prominent features of both sporadic and familial PD. While proteasome dysfunction is observed in PD, diverse mutations in the parkin gene are linked to early-onset autosomal-recessive forms of familial PD. We demonstrate that parkin, an E3 ubiquitin ligase, activates the 26S proteasome in an E3 ligase activity-independent manner. Furthermore, an N-terminal ubiquitin-like domain within parkin is critical for the activation of the 26S proteasome through enhancing the interaction between 19S proteasomal subunits, whereas the PD-linked R42P mutant abolishes this action. The current findings point to a novel role for parkin for 26S proteasome assembly and suggest that parkin mutations contribute to the proteasomal dysfunction in PD.</P>
Nocturia and Sleep: Focus on Common Comorbidities and Their Association with Obstructive Sleep Apnea
Um Yoo Hyun,Oh Ji-Hye,Kim Tae Won,서호준,Kim Sung-Min,Chung Jun-Soo,Jeong Jong-Hyun,Hong Seung-Chul 대한수면학회 2020 sleep medicine research Vol.11 No.2
Nocturia is a frequently encountered complaint in patients visiting sleep clinics. Nocturia and its detrimental effect on sleep continuity and quality have been frequently discussed in previous studies. Moreover, abundant research has been conducted to delineate the close relationship between nocturia and the pathophysiology of obstructive sleep apnea (OSA). In this review, we discuss the common comorbidities that can provoke nocturia and their relationship with OSA and sleep.