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Macrophage activation syndrome in neonatal lupus presenting with fever and rash
( Ji Yoon Yu ),( Tae Hwan Kim ),( Ye Ji Kim ),( Hyun Mi Kang ),( In Hyuk Yoo ),( Jung Woo Rhim ),( Soo Young Lee ),( Dae Chul Jeong ) 대한류마티스학회 2024 대한류마티스학회지 Vol.31 No.1
Neonatal lupus can occur in infants born to mother with autoimmune disorders through transplacental auto-antibodies. Clinical manifestations in neonatal lupus include cutaneous lesions and hematologic or hepatobiliary findings resembling those seen in systemic lupus erythematosus. In autoimmune state, macrophage activation syndrome (MAS) represent a critical and potentially fatal complication that can result in mortality if not immediately identified and managed with the appropriate care. Here we present a 33-day-old girl diagnosed with neonatal lupus and serious MAS. She was delivered by a primipara mother who did not exhibit any autoimmune symptoms. The patient visited the hospital due to fever and pancytopenia. Laboratory data were compatible with MAS, including pancytopenia, high level of ferritin, soluble interleukin-2, and decreased natural killer cell activity. In addition, autoimmune study showed positive results for anti-nuclear antibody (ANA), anti-Sjogren syndrome antigen A (SSA), and SSB, The autoimmune study for mother also showed positive results for ANA, anti-SSA, and SSB. The patient recovered after she received high dose steroid and supportive care. Our case indicates that neonatal lupus should be taken into consideration when fever, erythematous skin rash, and pancytopenia are observed in infants, even if their mothers have no prior history of autoimmune conditions.
Yu Jihn Kwon,So Young Chung,Eun Joo Koo,Ji Eun Park,Dong Hyuk Seo,Yo A Lee,Yu Young Jung,Hee Eun Min,Mi Ran Kim,Eungui Kang,Jeongyun Cho,Seong Soo Park,Sun Ok Choi,Chul Joo Lim 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Genetically modified (GM) papaya (Carica papaya L.) line 55-1 (55-1), which is resistant to papaya ringspot virus infection, has been marketed internationally. Many countries such as the European Union, Japan, and Korea have a mandatory safety assessment, approval and labeling regulations for GM foods. Thus, there is a need for specific methods for detecting 55-1. In this study, we established a real-time PCR detection method applicable to 55-1 for a variety of papaya products. The limit of detection was possible for fresh papaya fruit up to dilutions of 0.005% and 0.01% (weight per weight [w/w]) for homozygous SunUp and heterozygous Rainbow cultivars, respectively, in non-GM papaya. The 55-1 event-specific detection method observed parallelism (r2>0.99) between the concentration of line 55-1 cultivars and Ct values obtained in amplification plots at concentrations of 0.005-10% for SunUp DNA and 0.01-10% for Rainbow DNA. The method was applicable to the qualitative detection in various types of processed products (cocktail fruit, dried fruit, juice, etc.) containing papaya as a main ingredient. Monitoring papaya products for the presence of GM papaya were demonstrated using a P35S and T-nos real-time PCR detection method but no amplification signals were detected.
Yu, Sung-Lim,An, Yong Jin,Yang, Hey-ji,Kang, Mi-Sun,Kim, Ho-Yeol,Wen, He,Jin, Xing,Kwon, Hyuk Nam,Min, Kyung-Jin,Lee, Sung-Keun,Park, Sunghyouk American Chemical Society 2013 JOURNAL OF PROTEOME RESEARCH Vol.12 No.4
<P>Alterations in metabolic pathways are gaining attention as important environmental factors affecting life span, but the determination of specific metabolic pathways and enzymes involved in life span remains largely unexplored. By applying an NMR-based metabolomics approach to a calorie-restricted yeast (<I>Saccharomyces cerevisiae</I>) model, we found that alanine level is inversely correlated with yeast chronological life span. The involvement of the alanine-metabolizing pathway in the life span was tested using a deletion mutant of <I>ALT1</I>, the gene for a key alanine-metabolizing enzyme. The mutant exhibited increased endogenous alanine level and much shorter life span, demonstrating the importance of <I>ALT1</I> and alanine metabolic pathways in the life span. <I>ALT1</I>’s effect on life span was independent of the TOR pathway, as revealed by a <I>tor1</I> deletion mutant. Further mechanistic studies showed that <I>alt1</I> deletion suppresses cytochrome <I>c</I> oxidase subunit 2 expression, ultimately generating reactive oxygen species. Overall, <I>ALT1</I> seems critical in determining yeast life span, and our approach should be useful for the mechanistic studies of life span determinations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2013/jprobs.2013.12.issue-4/pr300979r/production/images/medium/pr-2012-00979r_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr300979r'>ACS Electronic Supporting Info</A></P>
Mediterraneibacter butyricigenes sp. nov., a butyrate-producing bacterium isolated from human faeces
JI-SUN KIM,Keun Chul Lee,Min Kuk Suh,Kook-Il Han,Mi Kyung Eom,Juhuck Lee,SEUNG-HWAN PARK,Se Won Kang,Jam-Eon Park,Byeong Seob Oh,Seung Yeob Yu,Seung-Hyeon Choi,Dong Ho Lee,Hyuk Yoon,Byung-Yong Kim,Seu 한국미생물학회 2019 The journal of microbiology Vol.57 No.1
A Gram-stain-positive, obligately anaerobic, non-motile, nonspore- forming, and rod-shaped bacterial strain, designated KGMB01110T, was isolated from a faecal sample of a healthy male in South Korea. Phylogenetic analysis based on 16S rRNA gene showed that strain KGMB01110T belonged to Clostridium cluster XIVa and was most closely related to Mediterraneibacter glycyrrhizinilyticus KCTC 5760T (95.9% 16S rRNA gene sequence similarity). The DNA G + C content of strain KGMB01110T based on its whole genome sequence was 44.1 mol%. The major cellular fatty acids (> 10%) of the isolate were C14:0 and C16:0. The strain KGMB01110T was positive for arginine dihydrolase, β-galactosidase-6-phosphatase, and alkaline phosphatase. The strain KGMB01110T also produced acid from D-glucose and D-rhamnose, and hydrolyzed gelatin and aesculin. Furthermore, HPLC analysis and UV-tests of culture supernatant revealed that the strain KGMB01110T produced butyrate as the major end product of glucose fermentation. Based on the phylogenetic and phenotypic characteristics, strain KGMB01110T represent a novel species of the genus Mediterraneibacter in the family Lachnospiraceae. The type strain is KGMB01110T (= KCTC 15684T = CCUG 72830T).
A case of generalized pustular psoriasis: Successful treatment with Ustekinumab
( Yu Seok Jung ),( Hyuk Sun Kwon ),( Ji Hae Lee ),( Jung Min Bae ),( Gyong Moon Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Generalized pustular psoriasis is a rare, disabling variantof psoriasis. Its treatment is often challenging, as an unsatisfactory response is frequent. There are no universally accepted guidelines for management. Ustekinumab, a fully human monoclonal antibody that binds to the shared p40 subunit of interleukin 12/23, has proven to be effective and safe for the treatment of moderate-to-severe plaque-type psoriasis. We report our experience of generalized pustular psoriasis treatment with ustekinumab. A 43-year-old female presented with recurrent episodes of widespread and often generalized flares of psoriasis for 2 years. She was treated with topical steroids and calcipotrol, cyclosporine, methotrexate, acitretin, etanercept and narrow-band UVB phototherapy, showed only partial response. Physical examination revealed the extensive erythematous patches with pustules over the entire body. A biopsy showed the characteristic findings of pustular psoriasis. The patient started treatment with ustekinumab, according to a pre-established protocol. A 45mg dose of ustekinumab was administered subcutaneously, followed by a 45mg dose 4 and 12 weeks later. Positive response to ustekinumab were initially seen in 2-3 weeks after the first dose. In 4 weeks, the patient achieved a excellent improvement of the skin. We suggest that ustekinumab could be a potentially effective treatment option for pustular psoriasis refractory to conventional therapies.