대식세포 NAD glycohydrolase에 관한 연구

이지영,안년형 圓光大學校 1995 論文集 Vol.30 No.2

NAD glycohydrolase (NADase:EC 3.2.2.5)는 포유류에서 형질막에 glycosylphosphatidylinositol (GPI) 결합으로 연결되어 있어 박테리아의 phosphatidylinositol-특이성 phospholipase C (PI-PLC)로 가용화 된다. 본 연구에서는 결핵 감염된 마우스로 부터 대식세포를 얻어 LPS처리후 막외 NADase가 유리되는 것을 관찰하였다. 이 활성화된 대식세포에서 NADase가 유리되기에 앞서서 대식세포에 내재하는 GPI-PLC 활성이 증가하는 사실을 관찰하였다. 이는 대식세포의 활성화에 의해 대식세포에 내재하는 GPI-PLC활성이 증가하므로써 GPI결합으로 붙어 있는 NADase가 유리됨을 의미한다. 활성화 대식세포에서 증가된 GPI-PLC 활성 분획을 DEAE column 크로마토그라피를 시행하여 단일 peak의 용출액을 얻은 후 이분획에서 활성을 확인한 결과 GPI-PLC 활성은 없음을 알았다. NAD glycohydrolase (NADase) is located on the surface of the cell via glycosylphosphatidylinositol (GPI)-linkage, which can be cleaved by bacterial PI-specific phospholipase C (PI-PLC). When macrophages primed with live or dead Mycobacterium tuberculosis were treated with liposaccharide, ecto-NADase was released from activated macrophages. The result that the release of NADase followed the increase of GPI-PLC activity in macrophages suggests that endogenous GPI-PLC can cleave the PI-linkage of NADase on the macrophages. The GPI-cleavae activity was shown as a single peak on DEAE chromatography and the activity was not inhibited by phenanthroline, a selective inhibitor of GPI-phospholipase D (GPI-PLD). There data indicate that the release of NADase from activated macrophages may be due to the activity of GPI-PLC, but not GPI-PLD.

모노드라마의 빛과 그림자 : 솔로구프와 예브레이노프의 극장 The Theatres of Fedor Sologub and Nikolai Evreinov театр Федора Сологуба и театр НИkолая Евреинова

차지원 서울대학교 러시아연구소 2006 러시아연구 Vol.16 No.1

Потребность 'общения' между сценическим представлением и зрителем предопределяет исходную эстетическую ориентацию модернистского театра в начале ХХ века в России. Влекуемаяся в проблеме соотношения сцены и зрительного зала идея 'общения' в театре, выражаясь в разных сценических опытах модернизма, поднимается как общепринятая эстетическая задача модернистского театра. Первой попыткой решения 'общения' в театре является театр 'мистерии' и 'соборный театр', понятие которых развилось у Вячеслава Иванова. При этом парадоксально что, стремление соборного театра совершить 'общение' междусценой и зрителем в театре до своего предела, т.е. его стремление достигнуть абсолютного уровня возможности 'общения' театрального сообщения обрекает 'соборный театр' на эстетический гибель. В 'соборном театре' 'абсолютное' 'общение' между сценой и зрителем падает в свою очередь в 'нулевое'. Эстетически крайную концепцию 'абсолютного' 'общения' и монологизма наследует театр монодрамы в модернистском театре, в том числе сугубо субъективный театр Федора Сологуба и экспериментальный театр Николая Евреинова. В театре Ф. Сологуба, идея монодрамы, соприкасаясь с концепцией абсолютной субъективности творческой личности, обосновывает пессимическое эстетическое мировозрение автора о творчестве как 'высокое безумие', эстетическое 'бегство' от грубой действительности. Над 'абсолютным' 'общением' в театреСологуба висят тени небытия. В связи с этим театр Н. Евреинова кажется как бы освещенным ярким лучом жизни. Монодрама Евреинова, достигнутая абсолютным общением между сценойи зрителей, пользуется как стратегия 'театрализации' жизни, которая является эстетическим лозунгом театр Евреинова. Оба театра, кажущиеся тем, что противоположно развивают идею монодрамы в краях пессимизма и оптимизма, на самом деле интергрируется к одному и тому же эстетическому тупику 'монологизма'. Оба они приводятся к 'мимикрии', в которой призыв к 'общению' поворачивается его отрицанием. Театр Сологба, в котором прячется идея эстетического бегства от действительности, который отрицает всякую возможность бытия в реальном мире, и театральная игра как 'simulation', ложное сознание иллюзии, которое смещает жизненную реальность в театре Н. Евреинова, все же рождают 'пустые' знаки, 'sigпifiапt'ы пустотыи небытия. Возможность 'общения' в театре существует ни в концепции 'абсолютного'совершенного 'общения' между сценой и зрителем, ни в монодраме, а именно в диалогизме и множественности контекстов, в полифонизме и многоголосьи, которые монологизм напрасно стремлится снимать со сцены.

이지오더 신사복에 관한 소비자 선호도 및 구매의사 조사

천종숙,허지혜,송지영 복식문화학회 2001 服飾文化硏究 Vol.9 No.3

The purpose of this study is to examine the growth potentiality of the Easy-Order System in the domestic male business suit market. This study is based on a questionnaire survey of males, who usually wear a business suit in the work place, and females whose husband wear a business suit. The pertinently answered 108 questionnaires (males: 72 and females: 36) were analyzed with SPSS 8.0. The results of this survey were as follows; 1.Gender, occupation, and height of consumers had a considerable effect on their intention of purchasing a business suit through the Easy-Order System. Average monthly earnings of consumers affected their preference of this system. 2.Subjects, who were dissatisfied with the limited option of purchasing a business suit in retail shops, had a significant intention of purchasing a business suit through the Easy-Order System. 3.It had no effect on consumers' preference and purchasing intention of the Easy-Order System whether or not they recognize this system. And the Easy-Order System is not estimated to have major repercussions over consumers by now. Key words: Easy-Order(이지오더), business suit(신사복), consumer's preference(소비자 선호도), purchasing intention(구매의사).

Effects of Coffee Intake on Incident Chronic Kidney Disease: A Community-Based Prospective Cohort Study

Jhee, Jong Hyun,Nam, Ki Heon,An, Seong Yeong,Cha, Min-Uk,Lee, Misol,Park, Seohyun,Kim, Hyoungnae,Yun, Hae-Ryong,Kee, Youn Kyung,Park, Jung Tak,Chang, Tae-Ik,Kang, Ea Wha,Yoo, Tae-Hyun,Kang, Shin-Wook Elsevier Science B.V., Amsterdam. 2018 The American journal of medicine Vol.131 No.12

Time Series Modeling Using Backpropagation Network: ARMA Model Identification

Jhee,Won-Chul 弘益大學校 1990 弘大論叢 Vol.22 No.2

경영예측을 위한 시계열 모형들 중에서 Autoregressive Moving Average(ARMA) 모형은 이론적 우수성가 예측의 정확성에도 불구하고, 적절한 ARMA모형의 선정이 어려워 실제로 많이 이용되지 못하고 있다. 본 연구에서는 적은 시간 내에 많은 종류의 시계열로부터 ARMA모형을 이용하여 자동적으로 예측치를 얻기 위해, 통계적 방법론과 신경망(Artificial Neural Network, ANN)의 효과적인 결합을 모색한다. ARMA 모형선정의 어려움을 해결하기 위해, 이를 패턴분류문제로 생각하여, 패턴분류기로써 신경망을 사용하고, 특성추출기로써 확장된 표본자기상관함수(Extended Sampl Autocorr elation Function, ESACF)를 사용하였다. 사용된 신경망 모형은 Backpropagation 네트웍이며, ESACF에 대한 전처리와 네트웍의 분리 등을 고려한 세 가지 신경망 설계 대안이 검토되었다. 실험결과는 신경망이 ARMA 모형의 선정에 효과적으로 사용될 수 있음을 보여준다.

Secondhand Smoke and CKD

Jhee, Jong Hyun,Joo, Young Su,Kee, Youn Kyung,Jung, Su-Young,Park, Seohyun,Yoon, Chang-Yun,Han, Seung Hyeok,Yoo, Tae-Hyun,Kang, Shin-Wook,Park, Jung Tak AMERICAN SOCIETY OF NEPHROLOGY 2019 CLINICAL JOURNAL- AMERICAN SOCIETY OF NEPHROLOGY Vol.14 No.4

Inhibition of microsome - mediated binding of afatoxin B1 to DNA by glutathione S transferase

Jhee, Eun Chung,Lotilkar, Prabhaker D. 생화학분자생물학회 1986 BMB Reports Vol.13 No.4

A Study of the Defrosting Behavior according to Surface Characteristics of a Fin-Tube Heat Exchanger

Jhee, Sung,Lee, Kwan-Soo The Society of Air-Conditioning and Refrigerating 2000 International Journal Of Air-Conditioning and Refr Vol.8 No.2

In this study, the defrosting behavior according to the surface characteristics of a fin-tube heat exchanger is experimentally examined. It has been found that the draining rates of the hydrophilic and hydrophobic heat exchangers are evenly dispersed during do-frosting, compared with that of the bare one. This is due to the high density frost of the hydrophilic heat exchanger, and the surface characteristics of the hydrophobic heat ex-changer, The rest periods of the hydrophilic and hydrophobic heat exchangers are shorter, and their weight of residual water is also smaller than that of the bare heat exchanger. The hydrophobic heat exchanger is the most efficient in terms of the defrosting efficiency.

Effect of CA and Si on the Microstructure and Aging Characteristics of AZ91 Alloy

Jhee, Tae-Gu Research Institute for Science & Technology, Hong- 2000 Hongik Journal of Science and Technology Vol.4 No.-

The effects of Ca and Si on the microstructures and aging characteristics were investigated in the T5 treatment of AZ91 magnesium alloys rapidly solidified in vacuum inside a stainless steel pipe. The addition of Ca(0.88%), Si(0.25%) to the AZ91 alloy reduced the dendrite cell size with the effect of Si being more effective. Si in AZ91 alloy formed Mg₂Si compound during the T5 treatment at dendrite cell boundaries as well as in the matrix and this compound decreased the precipitation rate. Ca in AZ91 alloy did not form any compound with other alloying elements and was segregated mainly around the secondary phase such as Mg_(12)Al_(7), and some of Ca formed a ternary eutectic (Mg-Al-Ca) structure. This alloy had a good precipitation property and high temperature strength. In the Ca+Si added AZ91 alloys, the element Ca promoted the homogeneous distribution of fine Mg₂Si compound. The AZ91 alloys containing Ca+Si , therefore, have much finer microstructures than those containing either Ca or Si. So AZ91 alloys containing Ca+Si were more effective at decreasing the precipitation rate and had a superior high temperature tensile strength to AZ91, AZ91+Ca and AZ91+Si alloys.

Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease

Jhee, Jong H.,Lee, Eun,Cha, Min-Uk,Lee, Misol,Kim, Hyoungnae,Park, Seohyun,Yun, Hae-Ryong,Jung, Su-Young,Kee, Youn K.,Yoon, Chang-Yun,Han, Seung H.,Yoo, Tae-Hyun,Kang, Shin-Wook,Park, Jung T. Wolters Kluwer Health 2017 Medicine Vol.96 No.44

<P><B>Abstract</B></P><P>Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m<SUP>2</SUP>. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m<SUP>2</SUP> [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.09–1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m<SUP>2</SUP> (OR, 1.11; 95% CI, 1.03–1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.</P>