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An Mi-Jin,Lee Hyun Min,Kim Chul-Hong,Shin Geun-Seup,Jo Ah-Ra,Kim Ji-Young,Kim Mi Jin,Kim Jin Ho,Park Jinhong,Hwangbo Yujeong,Kim Jeongkyu,Kim Jung-Woong 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background The transcription factor orthodenticle homeobox 2 (OTX2) has critical functions in brain and eye development, and its mutations in humans are related to retinal diseases, such as ocular coloboma and microphthalmia. However, the regulatory mechanisms of OTX2 are poorly identified. Objective The identification of JNK1 as an OTX2 regulatory protein through the protein interaction and phosphorylation. Methods To identify the binding partner of OTX2, we performed co-immunoprecipitation and detected with a pooled antibody that targeted effective kinases. The protein interaction between JNK1 and OTX2 was identified with the co-immunoprecipitation and immunocytochemistry. In vivo and in vitro kinase assay of JNK1 was performed to detect the phosphorylation of OTX2 by JNK1. Results JNK1 directly interacted with OTX2 through the transactivation domain at the c-terminal region. The protein–protein interaction and co-localization between JNK1 and OTX2 were further validated in the developing P0 mouse retina. In addition, we confirmed that the inactivation of JNK1 K55N mutant significantly reduced the JNK1-mediated phosphorylation of OTX2 by performing an immune complex protein kinase assay. Conclusion c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor through the protein–protein interaction.
Exploiting Same Tag Bits to Improve the Reliability of the Cache Memories
Jeongkyu Hong,Jesung Kim,Soontae Kim IEEE 2015 IEEE transactions on very large scale integration Vol.23 No.2
<P>With the trend of increasing transient error rate, it is becoming important to prevent transient errors and provide a correction mechanism for hardware circuits, especially for SRAM cache memories. Caches are the largest structures in current microprocessors and, hence, are most vulnerable to the transient errors. Tag bits in cache memories are also exposed to transient errors but a few efforts have been made to reduce their vulnerability. In this paper, we propose to exploit prevalent same tag bits to improve error protection capability of the tag bits in the caches. When data are fetched from the main memory, it is checked if adjacent cache lines have the same tag bits as those of the data fetched. This same tag bit information is stored in the caches as extra bits to be used later. When an error is detected in the tag bits, the same tag bit information is used to recover from the error in the tag bits. The proposed scheme has small area, energy, and performance overheads with error protection coverage of 97.9% on average. Even with large working sets and various cache sizes, our scheme shows protection coverage of higher than 95% on average.</P>
Jeongkyu Heo,Jae Choon Kim,Ki Hyuk Kim,Jae-Sung Rieh,Jin Taek Chung,Sung Woo Hwang IEEE 2008 IEEE microwave and wireless components letters Vol.18 No.5
<P>We fabricated and characterized heterojunction field effect transistor radio frequency (RF) power amplifier (PA) test fixtures, for wireless applications, with various printed circuit board (PCB) structures. The RF matching and bias circuits of the test fixtures were designed so that they had the same RF characteristics. The only source of the variation of the RF gain (S<SUB>21</SUB>) was different thermal characteristics of each PCB. The values of the junction temperature (T<SUB>J</SUB>) and the junction-to-ambient thermal resistance (R <SUB>J</SUB> <SUB>A</SUB>) of each test fixture were shown to be changed as much as 80deg C and 30deg C / W, respectively, by the change of PCB structures. The change of Rja was shown to be originated from the change of the PCB thermal resistance, assuring that the structure of the PCB was the dominant factor in determining R <SUB>J</SUB> <SUB>A</SUB> Finally, we obtained a universal relation between S<SUB>21</SUB> of the amplifier and Tj. This work suggests that thermal budget of PCB is as important as that of package in wireless RF equipments.</P>
디스크 잔류 응력 감소를 통한 브레이크 저더 개선에 대한 연구
김정규(Jeongkyu Kim),김희열(Heeyeol Kim),장호(Ho Jang) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
Brake judder is a braking induced vibration occurring in different types of vehicles. One of the main cause generating judder is a abnormal brake disc deformation during severe braking conditions. It is believed that residual stresses may change the rate of disc deformation when the disc temperature is increased significantly. In this paper, we investigated the quantitative measurement method of residual stresses and presented the reduction method of residual stress.
Inhibition of KIF20A suppresses the replication of influenza A virus by inhibiting viral entry
Hoyeon Jeon,Younghyun Lim,In-Gu Lee,Dong-In Kim,Keun Pil Kim,So-Hee Hong,Jeongkyu Kim,Youn-Sang Jung,Young-Jin Seo 한국미생물학회 2022 The journal of microbiology Vol.60 No.11
The influenza A virus (IAV) has caused several pandemics, and therefore there are many ongoing efforts to identify novel antiviral therapeutic strategies including vaccines and antiviral drugs. However, influenza viruses continuously undergo antigenic drift and shift, resulting in the emergence of mutated viruses. In turn, this decreases the efficiency of existing vaccines and antiviral drugs to control IAV infection. Therefore, this study sought to identify alternative therapeutic strategies targeting host cell factors rather than viruses to avoid infection by mutated viruses. Particularly, we investigated the role of KIF20A that is one of kinesin superfamily proteins in the replication of IAV. The KIF20A increased viral protein levels in IAV-infected cells by regulating the initial entry stage during viral infection. Furthermore, the KIF20A inhibitor significantly suppressed viral replication, which protected mice from morbidity and mortality. Therefore, our findings demonstrated that KIF20A is highly involved in the viral replication process and viral propagation both in vitro and in vivo, and could thus be used as a target for the development of novel antiviral drugs.
Personal Kiosk : 유비쿼터스 컴퓨팅 환경을 위한 모바일 서비스 모델
박정규(Jeongkyu Park),서승호(Seungho Seo),김양남(Yangnam Kim),이긍해(Keung Hae Lee) 한국정보과학회 2006 정보과학회 컴퓨팅의 실제 논문지 Vol.12 No.3
컴퓨팅 서비스가 언제 어디서나 이용 가능한 유비쿼터스 컴퓨팅에 대한 연구가 활발히 진행되고 있다. 유비쿼터스 컴퓨팅 환경을 구축하기 위해 해결해야하는 문제 중 하나는 다양한 특성의 서비스들을 어떻게 효과적으로 제공하고 이를 관리하느냐는 점이다. 기존에 제안된 유비쿼터스 서비스 제공 시스템은 특정 종류의 서비스만을 지원하는데 중점을 두고 있다. 또한 상황과 서비스의 관계 표현 방법이 복잡해 다양한 사용자가 생활하는 복잡한 공간에서 서비스를 제공하는데 어려움이 있다. 본 논문은 이런 문제에 대한 해결 방안으로 Personal Kiosk (PK) 모델을 제안한다. PK는 모바일 단말기를 통해 사용자가 언제 어디서나 유용한 서비스를 사용할 수 있게 해주는 것을 목표로 하는 유비쿼터스 서비스 모델이다. 현재 단계의 PK는 로컬지역을 대상으로 연구되고 있다. 본 논문은 로컬지역에 PK 모델을 구현하기 위해 필요한 실내에서의 정밀한 위치인식기법과 효과적인 서비스 발견기법을 설명하며 이를 바탕으로 사용자의 위치, 권한, 시간정보를 이용해 개인화된 서비스를 제공하는 방법을 설명한다. PK 모델은 서비스를 이용하기 위해 소모되는 사용자의 노력과 시간을 크게 감소시켜 보다 편리한 모바일 서비스 환경을 구축할 수 있게 한다. Last few years have seen a rapid increase in research on ubiquitous computing. Ubiquitous computing is often touted as a technology that will make computing available to the user anywhere and anytime. One important problem to be addressed in building such a ubiquitous computing environment is how to manage services and deliver them to the user in an effective manner. This paper presents our model called Personal Kiosk(PK) as a way of solving the problem. PK is a model of ubiquitous service provisioning that enables the user to use desired services anytime and anywhere. The design and implementation of the current PK in the "Local Area" setting with related technical issues are also presented. A location-sensing technique for indoor users and a personalized service provisioning based on user location and privileges are discussed in detail.
Smart ECC Allocation Cache Utilizing Cache Data Space
Hong, Jeongkyu,Kim, Soontae IEEE 2017 IEEE Transactions on Computers Vol. No.
<P>Conventional error correcting codes (ECC) for caches are applied to all cache lines and stored in dedicated SRAM storage, which incurs both space and energy overheads. In contrast, we propose a Smart ECC Allocation (SEA) cache that utilizes cache data space for low-cost error protection of last-level caches. SEA cache avoids the requirement for dedicated storage for ECC check bits, which are stored in cache lines as data. To effectively utilize cache space, we group several cache sets and manage them according to program behavior. SEA cache eliminates the considerable space overheads of conventional ECC schemes without noticeable reliability and performance degradation.</P>