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쌍태아에서 제 1태아의 분만 후 제 2태아의 지연분만 : 중례보고
김주환,서민정,유희정,노권일,조대현,박정규,이정헌,조성남,손영수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3
With the widespread use of fertility medications and techniques of in vitro fertilization, multiple gestation has become epidemic in modern obstetric practice. Delivery of the initial fetus in a multiple gestation usually is followed by delivery of the subsequent fetus or fetuses shortly thereafter. However in rare circumstances, the delivery is delayed for days due to disappearance of uterine contraction after delivery of the first fetus. When uterine activity ceases after the delivery of the first neonate, a policy of nonintervention may be considered in case of an immature or very premature delivery, in order to achieve a gestational age for the remaining fetus(es) more compatible with neonatal survival. We report a case of twin gestation with prolongation of the delivery interval between the twins for 46 days.
Jeong Jong Heon,Hyun Gyu Hwan,Park Yu Jeong,Kwon Sung Won,Lee Ai-Young 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.6
Etretinate, an acitretin metabolite, has a long retention duration in adipose tissues with a teratogenic potential. FDA advises a contraceptive period of at least three years after discontinuing acitretin. However, the effect of accumulated etretinate in adipose tissues on fetus is unknown. Although the teratogenic threshold for serum concentration of etretinate has been presented as higher than 2 ng/mL, that of acitretin is unknown. To examine factors affecting body retention of acitretin and etretinate, effects of acitretin dosage, acitretin-taking duration, elapsed time after stopping acitretin, age, sex, concomitant alcohol consumption, and foods and supplements rich in vitamin A intake on serum concentrations of acitretin and etretinate were analyzed in 14 acitretintaken patients and 58 controls without taking acitretin or etretinate. Serum concentrations of acitretin, but not etretinate, tended to be inversely related to the discontinuation duration. They were also related to old age. Different from a published result that alcohol consumption could promote the metabolism of acitretin into etretinate, alcohol intake did not affect serum concentrations of etretinate. Unexpectedly, more frequent intake of vitamin A or provitamin A-rich food and supplements was associated with higher serum acitretin, whereas less frequent intake of vitamin A or provitamin A-rich food and supplements was associated with higher serum levels of etretinate in acitretin-taken patients. Despite preliminary data, inter-individual variations in serum retention of etretinate suggest the necessity of further research before applying the same guidelines to everyone to minimize unnecessary contraception.
A clinical study using 9-valent human papilloma virus (HPV) vaccine for treatment of cutaneous wart
( Yu Jeong Park ),( Jong Heon Jeong ),( Ji Young Lee ),( Jong Soo Hong ),( Ai Young Lee ),( Seung Ho Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Warts are usually treated with cryotherapy, bleomycin injection or carbon dioxide laser ablation. Sometimes treatment of warts is a challenge when there are many and/or large lesions and the lesions develop in the special area such as periungual region. Objectives: The study was conducted to explore the therapeutic effect of 9-valent HPV vaccine for treatment of wart. Methods: Retrospective analysis was conducted using electronic medical record system, in department of dermatology, Dongguk University Ilsan Hospital, during 2018 to 2020 June. 29 patients who received 9-valent HPV vaccine (GARDASIL<sup>®</sup>9) were evaluated. Patients were given 3 injections at intervals of 0, 2 and 4 months. Results: After 1st injection, 2 patients (6.9%) were completely cured. After 2nd injection, 11 patients (37.9%) showed complete remission. 2 months after the 3rd injection, 14 patients (48.3%) were free of lesions, and 6 patients (20.7%) improved more than 50%. In 9 patients (31%), the lesions showed no change or aggravation. There was no side effect of the vaccine injection. Conclusion: The 9-valent HPV vaccine could be a safe and effective method for treating warts.
Biochemical characterization of variants of canine CYP1A1 using heterologous expression
YU, Hee Jeong,LEE, Seung Heon,LEE, Seungwoo,CHOI, Yu Jung,OH, Dayoung,NAM, Ki-Hoan,YUN, YoungMin,RYU, Doug-Young The Japanese Society of Veterinary Science 2017 The Journal of veterinary medical science Vol.79 No.8
<P>Cytochrome P450 1A1 (CYP1A1) is a heme-containing mono-oxygenase involved in metabolism of environmental contaminants. Two variants of dog CYP1A1 with a single residue difference were identified and designated Sap1 and Sap2. Compared with Sap1, Sap2 had a Trp50Leu substitution. The biochemical characteristics of the variants were comparatively analyzed using heterologous expression in <I>Escherichia coli</I>. The membrane fraction of <I>E. coli</I> expressing Sap2 exhibited higher CYP holoprotein and heme contents than the Sap1-containing membranes, although the level of total CYP1A1 protein (i.e., apoprotein + holoprotein) was comparable between the groups. As normalized to holo-CYP content, the Sap2-expressing membranes showed lower CYP1A1-specific enzyme activities, such as 7-ethoxyresorufin <I>O</I>-dealkylation (EROD), than the Sap1 group. In single substitution variants of residue 50, proteins with hydrophobic residues having mass similar to Leu exhibited lower EROD activities than those with hydrophobic residues having larger mass than Leu. In addition, variants with polar or charged residues having mass similar to Leu showed activities that were comparable to those of Sap2. Taken together, these findings suggest that the Trp50Leu substitution leads to an enhancement of holo-CYP1A1 formation, but diminishes the enzyme activity because of the small size of Leu compared with Trp.</P>